Reverse Type Research Articles

Reverse Ostrowski's type weighted inequalities for convex functions on linear spaces with applications

Reverse Ostrowski's type weighted inequalities for convex functions on linear spaces with applications

Development of a laboratory setup for destruction of oil-water emulsions

The work describes a laboratory setup developed by the authors for destruction of oil-water emulsions. The setup can be used in chemical analytical testing laboratories as new auxiliary equipment for preparing samples of crude oils, which are oil-water emulsions, for obtaining dehydrated oil. The setup includes two borosilicate glass units: heating unit and desiccating unit. The heating unit consists of a conical vessel equipped with a heating element for programmable heating and thermostating of the vessel. The desiccating unit consists of a vessel with a drain hole at the bottom, into which, if necessary, a water-absorbing reagent (calcium chloride) is placed for deeper dehydration of the separated oil phase. The units are connected to each other by a glass adapter, which is equipped with two PTFE or KhN-1 type taps, for collecting water and oil phases into different receiving bottles. Feasibility of using calcium chloride as a drying agent was confirmed by a series of experiments on a model oil sample, in which fractions that boiled away at temperatures below 300 °C were preliminary removed. The data obtained confirmed the absence of partial adsorption of resinous-asphaltene substances during the passage of the separated oil phase through the drying reagent layer. Metrological characteristics of determining separated water fraction were calculated to assess the effectiveness of the laboratory installation. The result of using the developed laboratory setup is the complete destruction of direct and reverse type water-oil emulsions of varying degrees of stability, which could not be demulsified by known laboratory methods. As a result, separated oil phases with a water content of below 1% were obtained, which allows carrying out laboratory studies of oils to determine their composition and properties both to characterize the oils themselves and to establish the reasons for stability of analyzed emulsions.

Optical activity levels of metal centers controlling multi-mode emissions in low-dimensional hybrid metal halides for anti-counterfeiting and information encryption.

In-depth insight into the electronic competition principles between inorganic units and organic ligands proves to be extremely challenging for controlling multi-mode emissions in low-dimensional hybrid metal halides (LHMHs). Herein, an efficient blue emission from organic ligand was engineered in (DppyH)2MCl4 (Dppy = diphenyl-2-pyridylphosphine, M = Zn2+, Cd2+) due to the reverse type I band alignment constructed by optically inert units with nd10 shell electrons. By contrast, the optically active [MnCl4]2- with semi-fully filled 3d5 shell electrons prompts the band alignment of type II, resulting in the narrowband green emission of Mn2+, along with an energy transfer from DppyH+ to [MnCl4]2-. Beyond that, the band alignment of (DppyH)SbCl4 is further reversed to type I due to the strong stereochemical activity of 5s2 lone-pair electrons, resulting in the triplet-state (3P1 → 1S0) self-trapped exciton (STE) emission of [SbCl4]-. The conclusion is that the electronic configurations of metal centers govern the optical activity levels of inorganic units, which in turn controls the multi-mode emissions by maneuvering the band alignments. This research provides an enlightening perspective on the multi-mode emissions with tunable photoluminescence and resulting electronic transitions of LHMHs, whose derived emitters can be employed in anti-counterfeiting and information encryption.

OmeDDG: Improved Protein Mutation Stability Prediction Based on Predicted 3D Structures.

Determining changes in the protein's thermal stability following mutations is critical in protein engineering and understanding pathogenic missense mutations. Despite the development of various computational methods to predict the effects of single-point mutations, their accuracy remains limited. In this study, we propose a new computational method, OmeDDG, that more accurately predicts mutation-induced Gibbs free energy changes in protein folding (ΔΔG). OmeDDG takes the sequences of wild-type and mutant proteins as input, utilizes OmegaFold to obtain the 3D structure, employs a convolutional neural network to extract structural features, and combines them with protein mutation features and pretraining features to predict the stability of single-point mutations in proteins. We performed a comprehensive comparison between OmeDDG and other available prediction methods on four blind test datasets, confirming that OmeDDG can effectively enhance protein mutation prediction performance. Notably, on the antisymmetric dataset Ssym, OmeDDG achieves the best performance, demonstrating favorable antisymmetry with PCC = 0.79 and RMSE = 0.96 for forward mutations and PCC = 0.77 and RMSE = 0.97 for reverse mutant types.

Numerical Investigation of the Two-Component Suspension Filtration in a Porous Medium Taking into Account Changes in the Characteristics of the Porous Medium

The paper explores a mathematical model of the filtration of dual-component suspension within a porous medium characterized by two distinct zones. This model encompasses mass balance equations of suspended particles, kinetic equations of deposition formation for both reversible and irreversible deposition types for each suspension component, and incorporates Darcy’s law. In order to solve the problem, we formulate a numerical algorithm for computer-based experimentation on the basis of the finite difference method. Through the analysis of numerical findings, we establish key features of two component suspension filtration within a porous medium. Furthermore, we examine the effects of model parameters on the transport and deposition of suspended particles in a two-component suspension within porous media. The polydispersity of the suspension and the multi-stage nature of deposition kinetics can induce effects that differ from those typically observed in the transport of onecomponent suspensions with single-stage particle deposition kinetics.

The times they are a‐changin': An experimental assessment of the causes and consequences of sudden policy U‐turns

AbstractPast research has long documented that voters dislike parties and leaders who reverse their policy positions. But would they tolerate (principled) policy U‐turns if they are motivated by external events, such as a large‐scale crisis or scientific evidence? In this study, we explore whether the motivation behind positional shifts affects voter evaluations of political parties. To do so, we seek to connect the causes and consequences of policy shifts, a synergy still unexplored in the literature. We suggest that, while U‐turns, in general, can be damaging to a party's reputation, principled changes brought about by new scientific evidence or major crises should not necessarily have negative implications, because these changes can be necessary for the public good. We conducted a nationally representative survey experiment in Germany (n = 3127) featuring two classes of policy reversals: strategic and principled. Surprisingly, however, we find that voters by and large hold negative views of different types of policy U‐turns, thus including when external circumstances suggest change may be necessary. Interestingly, our empirical analysis reveals intriguing patterns. First, voters are willing to tolerate all sorts of policy reversals if the party ends up adopting their positions, suggesting that proximity matters even in the event of exogenous events. Second, voters with high levels of political trust tolerate different types of policy reversals, even when the party changes for mere strategic office‐seeking motivations. Coming from the premise that political and societal change is imperative, these findings have direct implications for democracies.

Should Airway Hyper-Responsiveness Be Included in the Definition of Clinical Remission With Biologic Therapy in Severe Asthma

Airway hyper-responsiveness (AHR) is a tenet of the persistent asthma phenotype along with reversible airway obstruction and type 2 (T2) inflammation. Indirect acting challenges such as mannitol are more closely related to the underlying T2 inflammatory process as compared with direct challenges. In this review article, we summarise the current literature and explore the future role of mannitol AHR in clinical remission with biologics.

Estimates for Robin p-Laplacian eigenvalues of convex sets with prescribed perimeter

In this paper, we prove an upper bound for the first Robin eigenvalue of the p-Laplacian with a positive boundary parameter and a quantitative version of the reverse Faber-Krahn type inequality for the first Robin eigenvalue of the p-Laplacian with negative boundary parameter, among convex sets with prescribed perimeter. The proofs are based on a comparison argument obtained by means of inner sets, introduced by Payne, Weinberger [32] and Pólya [33].

Increasing Collagen to Bioink Drives Mesenchymal Stromal Cells-Chondrogenesis from Hyaline to Calcified Layers.

The bioextrusion of mesenchymal stromal cells (MSCs) directly seeded in a bioink enables the production of three-dimensional (3D) constructs, promoting their chondrogenic differentiation. Our study aimed to evaluate the effect of different type I collagen concentrations in the bioink on MSCs' chondrogenic differentiation. We printed 3D constructs using an alginate, gelatin, and fibrinogen-based bioink cellularized with MSCs, with four different quantities of type I collagen addition (0.0, 0.5, 1.0, and 5.0 mg per bioink syringe). We assessed the influence of the bioprinting process, the bioink composition, and the growth factor (TGF-ꞵ1) on the MSCs' survival rate. We confirmed the biocompatibility of the process and the bioinks' cytocompatibility. We evaluated the chondrogenic effects of TGF-ꞵ1 and collagen addition on the MSCs' chondrogenic properties through macroscopic observation, shrinking ratio, reverse transcription polymerase chain reaction, glycosaminoglycan synthesis, histology, and type II collagen immunohistochemistry. The bioink containing 0.5 mg of collagen produces the richest hyaline-like extracellular matrix, presenting itself as a promising tool to recreate the superficial layer of hyaline cartilage. The bioink containing 5.0 mg of collagen enhances the synthesis of a calcified matrix, making it a good candidate for mimicking the calcified cartilaginous layer. Type I collagen thus allows the dose-dependent design of specific hyaline cartilage layers.

Desain dan Simulasi Dental Implant Resistens Menggunakan Finite Elemen Analysis

Tooth decay is a developmental disorder and trauma that causes tooth extraction. The solution is to make dental implants and dentures to restore normal contours, function, comfort, aesthetics, speech, and health. However, the problem of complications that arise is also a concern to be resolved; this occurs due to damage to the dental implant component itself. Based on these problems, it is necessary to conduct research to produce dental implants with good strength and service life by considering the value of stress and force distribution. This study discusses the differences in implant designs with different thread geometries: square, buttress, standard V-thread, and reverse buttress. This study used a static test in FEA (finite element analysis) SOLIDWORKS software using the ISO 14801 standard, using a loading of 100 N, the direction of vertical loading is 00, and using TiZr (Titanium Zirconium) material in the implant. The simulation results are validated by comparing the von Mises current study value with the existing research literature with a limit of ±5%. After the validation results are appropriate, the results are analyzed. The results of this study indicate that the buttress-type dental implant design is the most suitable dental implant to be applied. This is supported by the high value of the buttress type von Mises, which is 14.4 MPa. As for the square type, standard V-thread and reverse buttress type have a von Mises value of 13.8 MPa, 12.5 MPa, and 13.8 MPa. In addition, the profile of the buttress type is also very consistent, according to some literature, because it increases the transfer of stress to the surrounding bone according to the symmetrical profile.

Long-term outcomes of patients with tachycardia-induced cardiomyopathy

Abstract Introduction Tachycardia-induced cardiomyopathy (TCM) is a reversible type of heart failure that occurs after sustained tachyarrhythmia. TCM can occur on its own (pure TCM) or superimposed on another type of CM (impure TCM). Survival data for such patients are lacking. Purpose We aimed to compare the 5-year survival rates of pure and impure TCM patients compared to other types of CM. Methods We retrospectively identified patients with reduced ejection fraction (≤50%) and/or atrial fibrillation or flutter with a left ventricular ejection fraction (LVEF) that improved from baseline (≥ 15% in LVEF at follow-up (FU)) through retrospective chart review. Patients were then divided into four groups (pure TCM, impure TCM, ischemic CM and nonischemic CM). The primary outcome was defined as a composite of death, life-threatening arrhythmia or cardiogenic shock. Secondary outcome was cardiovascular re-admission during FU. Results 238 patients were included (mean age 68 ± 12 years, 31% women). Patients were classified as pure TCM in 35%, impure TCM in 18%, ischemic CM in 24% and non-ischemic CM in 23%. Median FU was 5 (IQR 4-6) years. 13 (5.5%) patients reached the composite outcome at FU. While patients with pure TCM showed similar survival rates as patients with ischemic or nonischemic CM (Figure), a significant difference in survival was observed between impure CM and ischemic and non-ischemic CM with respect to the composite outcome (11% vs 2.7%, p = 0.024). Patients with impure CM showed comparable rates of cardiovascular re-admission during FU compared to patients with ischemic and non-ischemic CM (45% vs. 49%, p = 0.91). Conclusions TCM patients have survival rates similar to patients with another type of CM. Patients with TCM on top of a non-ischemic or ischemic CM (impure TCM) demonstrated the lowest 5-year survival rates. Early detection and treatment of cardiac arrhythmias in patients with impure TCM seem to be warranted.Figure

Abstract 15913: Takotsubo Cardiomyopathy, is It Preventable?

Introduction: Takotsubo cardiomyopathy (TCM) is a reversible type of heart failure that occurs mostly in postmenopausal women. There are no definitive preventive measures in literature for this condition. Case: A 75-year-old female with a past medical history of hypertension presented with a new intermittent pressure-like chest pain and dyspnea right after a 1000-miles road trip. she reported that she had been feeling sad after her best friend died. Physical exam showed bilateral lower lung lobes crepitation and hypoxia. Lab work up revealed troponin of 1522 ng/L trending up to 2400 ng/L on serial measurements and elevated BNP. EKG showed ST changes and inverted T wave. Chest x-ray showed pulmonary vascular congestion and small bilateral pleural effusion. TTE showed LVEF 25-30% and mid and apical LV hypokinesis. Chest CT angiography was normal. Left heart catheter showed nonoccluded coronary arteries. LV angiogram portrayed mid and apical hypokinesis. Serology and PCR of EBV, Coxsackie B virus, CMV, HSV, influenza A and B, adenovirus and parvo virus were negative. She was started on a diuretic, a Beta blocker and an ACE inhibitor. Her symptoms improved. A follow up echocardiogram after 1 month showed improved ejection fraction and resolution of LV mid and apical hypokinesis. Recent combined emotional and physical stress of driving a long distance were thought to be the cause of stress cardiomyopathy. Discussion: Approximately 1-2% of patients presenting with symptoms of MI meet the criteria for TCM. A recent systematic review by Nyman et al on triggers of TCM found that physical factors are more common than emotional factors. However, some cases had both emotional and physical stressors. This patient had combined psychological and physical stressors, which may have precipitated TCM. postmenopausal women with recent emotional stressors should be advised to avoid physical stress until emotional issues have been resolved.

Derivatives of glycyrrhetinic acid with amino acid: Modifications, structural characterization, hypoglycemic activity and mechanism

Glycyrrhetinic acid (GA) is found in the roots and rhizomes of the legume licorice genus. The sweetness of GA is 250 times of sucrose. GA has a variety of biological activities. To develop new functional additive with hypoglycemic properties, the GA was modified with amino acids. The carboxyl group in C-30 of GA was modified with glycine, aspartic acid and arginine, respectively, to successfully prepare three amino acid amide derivatives of GA. The total yields of N-glycyrrhetinylglycine, N-glycyrrhetinyl aspartic acid and N-glycyrrhetinylarginine were 43.60%, 39.33% and 35.10%, respectively. The modification of C-30 of GA was modified with amino acid can significantly reduce the logP value and promote the hydrophilicity of GA. The N-glycyrrhetinylarginine had effective inhibition on α-glucosidase and is superior to GA. The inhibition on α-glucosidase by GA and N-Glycyrrhetinyl amino acid were reversible and mixed type. The GA and N-glycyrrhetinylarginine can effectively increase glucose consumption and glycogen synthesis to regulate insulin resistance. The GA and N-glycyrrhetinylarginine can regulate the insulin resistance in HepG2-IR cells via PI3K/Akt signaling pathway.

Diarylethene Photoswitches Undergoing 6π Azaelectrocyclic Reaction: Disrotatory Thermal Cycloreversion of the Closed-Ring Isomer.

Gaining insight into the dynamics of electrocyclic reactions is very important from both fundamental and application perspectives. In this study, we developed novel diarylethene photoswitches that undergo 6π azaelectrocyclic reaction. We found that they exhibit fast thermally reversible type (T-type) photochromism, in contrast to the fact that common diarylethenes exhibit photochemically reversible type (P-type) photochromism. The quantum chemical calculations revealed that the fast T-type photochromism originates from the unprecedented disrotatory thermal cycloreversion of the closed-ring isomer. Our results provide useful information not only for the dynamics of the 6π azaelectrocyclic reaction but also for the further development of diarylethene photoswitches utilizing the 6π azaelectrocyclic reaction.

Spatiotemporal Distribution Characteristics of Actual Evapotranspiration in the Qinghai–Tibet Plateau

Evapotranspiration is a key part of the water cycle between the atmosphere and the land surface, and it is an important parameter for studying the land–atmosphere system. Change and evolution have important implications. Therefore, the understanding and research of actual evapotranspiration (AET) can profoundly affect water use, ecological environment, temperature, and precipitation. In this paper, the single-layer monthly average reanalysis meteorological data of the Qinghai–Tibet Plateau from 1981 to 2020 was used to study and calculate the actual evapotranspiration in the Qinghai–Tibet Plateau, and the temporal and spatial variation characteristics, variation laws, and changes were analyzed by methods such as cumulative anomalies and the Mann–Kendall trend test. The results showed the following: (1) The evapotranspiration gradually decreased from southeast to northwest. The evapotranspiration in the southeastern region is strong, and the maximum value appears in the Hengduan Mountains. (2) The evapotranspiration was the largest in summer and gradually decreased from southeast to northwest; the evapotranspiration in spring and autumn was relatively uniform, with little overall difference, and the evapotranspiration was the lowest in winter. (3) There were mainly three spatial distribution modes of evapotranspiration in the Qinghai–Tibet Plateau, which were characterized by a significant and consistent change centered on the Tibet region, an east–west reverse type, and an east–west “negative-positive-negative” of the distributed three-pole space. The corresponding time coefficients characterized the interdecadal and interannual variation, and the decadal variation characteristics are more significant than the annual variation characteristics. (4) The actual evapotranspiration had step change; the step change years were 1989, 2002, 2011, and 2015, and there was an interval of about 5 years.

From Tourist to Pilgrim: Theological and Pastoral Challenges in the Context of the Camino de Santiago

AbstractThis article presents an analysis of the current challenges to the identity of the Christian pilgrim in the face of the dynamic growth of religious tourism. The semantic inflation that results in every wanderer being described as a pilgrim implies a new configuration of pastoral care, especially in terms of responding to the perceived “consumerism of the sacred.” In the context of Zygmunt Bauman’s observations concerning the transformation of the pilgrim into the tourist, the article proposes a reverse type of reflection, that is, how the tourist can become a pilgrim in the reality of modern-day pilgrimage routes. The Camino de Santiago was chosen as the point of reference, and current pastoral activities – both institutional and individual – were analyzed.

DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway.

Dry eye disease (DED) is a prevalent ocular disorder with a multifactorial etiology. The pre-angiogenic and pre-inflammatory milieu of the ocular surface plays a critical role in its pathogenesis. DZ2002 is a reversible type III S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor, which has shown excellent anti-inflammatory and immunosuppressive activities in vivo and in vitro. In this study, we evaluated the therapeutic potential of DZ2002 in rodent models of DED. SCOP-induced dry eye models were established in female rats and mice, while BAC-induced dry eye model was established in female rats. DZ2002 was administered as eye drops (0.25%, 1%) four times daily (20 μL per eye) for 7 or 14 consecutive days. We showed that topical application of DZ2002 concentration-dependently reduced corneal neovascularization and corneal opacity, as well as alleviated conjunctival irritation in both DED models. Furthermore, we observed that DZ2002 treatment decreased the expression of genes associated with angiogenesis and the levels of inflammation in the cornea and conjunctiva. Moreover, DZ2002 treatment in the BAC-induced DED model abolished the activation of the STAT3-PI3K-Akt-NF-κB pathways in corneal tissues. We also found that DZ2002 significantly inhibited the proliferation, migration, and tube formation of human umbilical endothelial cells (HUVECs) while downregulating the activation of the STAT3-PI3K-Akt-NF-κB pathway. These results suggest that DZ2002 exerts a therapeutic effect on corneal angiogenesis in DED, potentially by preventing the upregulation of the STAT3-PI3K-Akt-NF-κB pathways. Collectively, DZ2002 is a promising candidate for ophthalmic therapy, particularly in treating DED.

Surgical and Functional Outcomes of the Results of Conventional Two-Screw Proximal Femoral Nail (PFN) Versus Helical-Blade Anti-rotation Proximal Femoral Nail (PFNA2).

Introduction An intertrochanteric (IT) femur fracture is an extra-capsular fracture between greater and lesser trochanters. Unstable IT fractures are those where there is poor contact between fracture fragments (especially medial and posterior cortices), comminution, and fracture pattern, such that the weight-bearing forces tend to displace the fracture further or a reverse oblique type. Proximal femoral nailing (PFN) is one of the modalities for proximal femoral fractures. A newer modality for proximal femoral fracture is PFNA2, i.e., PFN anti-rotation, which makes use of a helical blade for a better compaction of bone. Both nail designs (PFN and PFNA2) are available in short and long sizes (so a total of four variants). Only a few studies have compared the treatment of IT femur fracture concerning fracture geometry, design, and length using either of the two nail types. In our study, we assessed the surgical and functional outcomes of PFN and PFNA2. Materials and methods This prospective observational study was carried out on 30 patients who had sustained ITfractures of the femur. All cases of IT femur fractures more than 18 years of age, closed injuries, and the patients who consented to participate in this program were included in the study. All open injuries, the patients who refused to participate in this program, patients who have associated injuries, patients with a subtrochanteric femur fracture, and patients with less than six months of follow-up were excluded. The patients were randomized into two types of implant groups. All patients were operated with a standard protocol. The study was conducted for18 months from February 2021 to August 2022. The results were analyzed (of all four variants) by comparing patient demographics, implant size, implant type, locking methods, union time, and other parameters. Results Most of the patients were operated on with a 10 mm nail diameter (17/30 patients), 380 mm length (long-nail group) (five/11 patients), and 250 mm length (short-nail group). With the use of PFNA2, the overall duration of hospital stay was less. The overall operative time (incision to wound closure) with the use of the short PFNA2 was lesser than that with the use of other designs due to the use of the zig for distal screws. The use of a distal dynamic locking screw in a majority of the patients can get better compression at the fracture site once the patient starts weight bearingand decreasethe chances of the Z-effect, reverse Z-effect, screw back-out, and screw cut-out. The union time was nearly the same in the majority of the patients, with an early union seen with the use of PFNA2 nails. The overall modified Harris hip score (HHS) at the final follow-up was nearly the same with slightly better results with the use of PFNA2. Conclusions PFNA2 is the implant of choice in elderly patients with osteoporotic bone. It has less operative time, which is required in such patients with medical comorbidities; hence, it has marginal superiority over PFN. Short-nail design results in less operative time and less blood loss.

A preliminary exploration for co-detecting RNA virus and STR type on capillary electrophoresis in forensic practice.

RNA virus infection such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection shows severe respiratory symptoms on human and could be an obvious individual characteristic for investigations in forensic science. As for biological samples suspected to contain RNA virus in forensic casework, it requires respective detection of viral RNA and human DNA: reverse transcriptase polymerase chain reaction and DNA type (short tandem repeat [STR] analysis). Capillary electrophoresis (CE) has been shown to be a versatile technique and used for a variety of applications, so we preliminarily explored the co-detection of RNA virus and STR type on CE by developing a system of co-detecting SARS-CoV-2 and STR type under ensuring both the efficiency of forensic DNA analysis and safety of the laboratory. This study investigated the development and validation of the system, including N and ORF1ab primer designs, polymerase chain reaction amplification, allelic ladder, CE detection, thermal cycling parameters, concordance, sensitivity, species specificity, precision, and contrived and real SARS-CoV-2 sample studies. Final results showed the system could simultaneously detect SARS-CoV-2 and STR type, further indicating that CE has possibilities in the multi-detection of RNA viruses/STR type to help to prompt individual characteristics (viral infection) and narrow the scope of investigation in forensic science.

Donor dynamics of reverse type I core/shell nanostructure embedded in inorganic and organic polymer matrices

Donor dynamics of reverse type I core/shell nanostructure embedded in inorganic and organic polymer matrices