Proactive Interference Research Articles

Interference Effects on Procedural Memory

Three experiments were conducted assessing interference effects acting on procedural task learning and performance using the Tower of Hanoi puzzle as the target procedural task. Experiment 1 found that participants in the no retroactive interference (RI) group completed the Tower of Hanoi task faster than the RI groups, with no differences between the type of the tactile interference. These results indicate that RI may hinder procedural task performance, but does not differentiate between consolidation and retrieval. Experiment 2 addressed RI placement by manipulating the delay prior to the interference task. Subsequent analyses suggested that interfering with only consolidation or recall does not produce interference effects, but qualitative feedback regarding emotion raised further questions about the effects of affect induction. Experiment 3 attempted to address the influence of a proactive and retroactive affect induction technique, but was unsuccessful in producing a dichotomous happy versus neutral effect. However, it was noted that alertness changed across the task acquisition stage, and the change in alertness may account for enhanced procedural memory acquisition. Overall, the series of experiments conducted provides conceptual replication of some previous research while contradicting other findings. This research not only extends our current understanding but also highlights the need to replicate research and continue to explore factors that may influence the practice or acquisition of novel procedural tasks.

Geometric uncertainty in non-paraxial interference

In this article, a novel meaning for the notion of uncertainty is discussed, within the framework of the non-paraxial interference theory based on confinement in geometric states of space. This novel meaning refers to the fact that, for any set of space states whose vertices are distributed in an arbitrary array of size less than λ 10, both the excitation provided by the geometric potential and the positions of the vertices of the states are completely uncertain, such that the complete set is represented by the Lorentzian well of an individual ground state of space, with vertex at any of the points of the array, even if the set is under the maximum prepared non-locality (i.e., under a strong geometric potential). It is shown that the geometric uncertainty is different but compatible with the Heisenberg uncertainty principle. In fact, geometrical uncertainty establishes both the upper limit of momentum uncertainty and the lower limit of position uncertainty in the Heisenberg principle.

Dimensional interaction is driven by feature integration: A binding theory of garner interference.

For nearly half a century now, Garner interference has been serving as the gold standard measure of dimensional interaction and selective attention. But the mechanisms that generate Garner interference are still not well understood. The current study proposes a novel theory that ascribes the interference (and dimensional interaction in general) to episodic feature integration processes at the micro (trial-to-trial) level. The novel account builds on earlier well-established notions of "feature integration" and "object files," and is augmented by formal derivations. The sequential binding account predicts that the magnitude of Garner interference is related to the strength of feature integration along consecutive trials. Three experiments were set to test this novel binding theory. Experiment 1 and Experiment 2 tested performance with integral dimensions (chroma and value, and width and height of rectangles); whereas Experiment 3 examined performance with a pair of separable dimensions (circle's size and angle of a diameter). In addition, the time lag ensuing between consecutive trials was manipulated. The results strongly supported the predictions of the sequential binding account: (a) with integral dimensions, substantial amounts of Garner interference were correlated with large partial repetition costs (e.g., consensual markers of feature integration), but this pattern was not observed with separable dimensions, and (b) the magnitude of both Garner interference and partial repetition costs diminished as a function of the ensuing time lag between consecutive trials, pointing to a common time-dependent memory mechanism. These results adduce strong support in the predictions of the feature binding theory of Garner interference, giving currency to the idea that dimensional interaction is driven by feature integration. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Memory interference in APPswe/PS1dE9 mice: Role of astrocytic β‐adrenoreceptors

AbstractBackgroundPrevious studies have reported that long‐term β‐adrenoceptor (β‐AR) agonist, isoproterenol hydrochloride (IPE), treatment brings about beneficial effects in an induced model of Alzheimer’s disease (AD) by neutralizing microglial inflammatory morphology against soluble amyloid β oligomers (PMID: 30093491). However, we do not have a clear understanding of how such treatment impacts astrocyte morphology, and whether that afford beneficial effects. Introducing a proactive memory interference step to the classical novel object recognition (NOR) paradigm impairs long‐term memory formation in 2‐month‐old familial model of AD ‐ APPswe/PS1dE9 (APP/PS1) mice. Long‐term IPE treatment rescued long‐term memory. In this study we attempt to understand the impact of long‐term IPE treatment on astrocyte morphology, and how they bring about the reversal in cognitive deficits.Method(1) Mice were taken through a proactive interference step in which they were exposed to objects of varied shape, size and colour before taking them through NOR paradigm. (2) Mice were treated with β‐AR agonist IPE at P26 (0.05g/litre) in drinking water for 21 days till P47. (3) They were sacrificed at 2‐months of age by transcardial perfusion and 100µm coronal sections of hippocampus were stained with astrocytic markers GFAP and S100β by immunohistochemistry. The number and morphology of astrocytes were analysed using ImageJ, SMorph (PMID: 34137444) and Imaris software.ResultOur observations suggest that NOR memory is intact in 2‐month‐old APP/PS1. However, introducing an object‐based short‐term interference before NOR leads to recognition memory deficits in APP/PS1 but not in wild‐type mice. Treatment with IPE restored long‐term memory of APP/PS1 mice to normal levels, thereby protecting them from the effects of interference during the NOR task. Our preliminary findings indicate that IPE impacts the morphology of astrocytes and thus contribute to the reversal of recognition deficits in APP/PS1 at 2 months of age.Conclusionβ‐AR activation can bring about morphological changes in astrocytes that in turn can modulate memory representations.

Exploring How do Expectations Influence Learning

Memory is a core component of human cognitive functioning and is vital for learning, decision-making, and quality of life. This paper reviews the correlation between setting expectations and aiding memory, focusing on the effects of constructing, capturing, and adjusting expectations during memory on memory performance. First, the paper describes the basic principles and processes of memory and clarifies the role of setting expectations in memory. Then, the critical role of setting expectations in memory is demonstrated. Finally, the role of expectations on memory interference, memory extraction, and memory retention is discussed, as well as directions for future research.

Multifunctional terahertz device with active switching between bimodal perfect absorption and plasmon-induced transparency

In this paper, we propose a terahertz (THz) micronano device that can actively switch between bimodal absorption and plasmon-induced transparency (PIT). The device mainly consists of a continuous top layer of graphene, an intermediate layer of silica and a bottom layer of vanadium dioxide, and has a simple structure, easy tuning and wide angle absorption. Through impedance matching and electromagnetic field distribution, we explain the generation of perfect absorption with double peaks. The simulation and multiple reflection interference theory (MRIT) show that the device achieves perfect absorption at 3.02 THz and 3.68 THz, and is highly sensitive to environmental refractive index, with a sensitivity of 1.1 THz/RIU. In addition, when the PIT effect is realized through the phase change characteristic of VO2, the device not only has the function of three-frequency asynchronous optical switch, but also has a strong slow light effect, and the maximum group delay (τg) is 35.4 ps. Thus, our design allows simultaneous switching, modulation, sensing, and slow light functions in the optical path and will greatly facilitate the development of THz multifunctional devices.

Cross-cultural evaluation of learning and memory using a consonant-vowel-consonant trigram list.

Word list-learning tasks are commonly used to evaluate auditory-verbal learning and memory. However, different frequencies of word usage, subtle meaning nuances, unique word phonology, and different preexisting associations among words make translation across languages difficult. We administered lists of consonant-vowel-consonant (CVC) nonword trigrams to independent American and Italian young adult samples. We evaluated whether an auditory list-learning task using CVC nonword trigrams instead of words could be applied cross-culturally to evaluate similar learning and associative memory processes. Seventy-five native English-speaking (USA) and 104 native Italian-speaking (Italy) university students were administered 15-item lists of CVC trigrams using the Rey Auditory Verbal Learning Test paradigm with five study-test trials, an interference trial, and short- and long-term delayed recall. Bayesian t tests and mixed-design ANOVAs contrasted the primary learning indexes across the two samples and biological sex. Performance was comparable between nationalities on all primary memory indices except the interference trial (List B), where the Italian group recalled approximately one item more than the American sample. For both nationalities, recall increased across the five learning trials and declined significantly on the postinterference trial, demonstrating susceptibility to retroactive interference. No effects of sex, age, vocabulary, or depressive symptoms were observed. Using lists of unfamiliar nonword CVC trigrams, Italian and American younger adults showed a similar performance pattern across immediate and delayed recall trials. Whereas word list-learning performance is typically affected by cultural, demographic, mood, and cognitive factors, this trigram list-learning task does not show such effects, demonstrating its utility for cross-cultural memory assessment.

A high-quality broadband tunable terahertz metamaterial absorber based on graphene

We design a graphene-based broadband tunable terahertz metamaterial absorber (MMA). Its structure consists of a surface graphene pattern layer, a medium layer and an underlying metal film. CST simulation results show that the absorption bandwidth for more than 90% absorption rate reaches 2.12 THz, and the range is 3.2–5.32 THz. The absorption bandwidth for more than 99% absorption rate reaches 1.38 THz, and the range is 3.45–4.83 THz, which was not achieved by most of the previous MMA. Multiple reflection interference theory is used to confirm the simulation results. In order to explore the physical mechanism of wideband absorption, we study the surface electric field distribution of the structure. We also find that the absorber has polarization insensitivity and wide-angle incidence characteristics. The absorption frequency of the absorber can be adjusted by changing the chemical potential of graphene. Therefore, the absorber has potential applications in terahertz absorption, filtering and sensing.

Interaction between the testing and forward testing effects in the case of Cued-Recall: Implications for Theory, individual difference Studies, and application

Recall from episodic memory has been shown to enhance both memory for the retrieved information (e.g., relative to a restudy control condition; the testing effect, or TE) and memory for different, subsequently studied materials (the forward testing effect, or FTE). Hence, the TE may be subject to an FTE confound when training in a TE experiment involves either testing prior to restudy or when restudied and tested items are randomly mixed. Across two cued-recall TE experiments, we show that (1) a potent FTE confound exists in the test-first but not the mixed training design, (2) there are no other evident learning related interactions between restudied and tested items across three frequently used training phase task orderings, and (3) the predictions of the dual-memory model of test-enhanced learning – which posits that a test trial creates a memory that is separate from the initially encoded study memory, yielding two routes to retrieval for tested items – are held both when there is and is not a confounding FTE. Further, our results yielded no evidence for two accounts of the FTE (the proactive interference and reset of encoding hypotheses) as applied to cued recall but are consistent with two alternative accounts (the strategy change and increasing effort hypotheses). Through distribution analyses we identify a novel and potent FTE individual differences effect that can be accommodated by the latter accounts. Finally, we show that at least three large-n studies exploring individual differences in the TE are confounded by the FTE, compromising conclusions in those papers about the efficacy of the TE across individuals.

59 Preliminary Findings of Semantic Interference in Learning and Memory Processes in Manifest Huntington’s Disease

Objective:To explore the usefulness of the Lowenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) [Crocco et al, 2013], a novel memory-based cognitive stress test capitalizing on semantic interference, in Huntington’s Disease (HD).Participants and Methods:12 healthy adults (HA) and 14 individuals with manifest HD were administered the LASSI-L as part of an annual research visit with the UCSD Huntington’s Disease Clinical Research Center (HDCRC.) Participants in each group were well matched with regard to age and education. Individuals with manifest HD had an average MoCA score of 26, total functional capacity score of 10, and total motor score of 21 suggesting that they were in the early stages of HD. The LASSI-L examines different types of semantic interference that occur in the learning/encoding process. There are free and cued recall trials for two lists of semantically related words with certain trials specific to different aspects of semantic interference including proactive, retroactive, and failure to recover from proactive interference. T-tests for all recall trials and number of intrusions for each trial were conducted between HA and those with HD to examine whether HD renders one more prone to semantic interference in both encoding and retrieval memory processes.Results:Individuals with HD recalled fewer words on average than HA across all recall trials except for the initial free recall of the first word list. HD individuals recalled significantly fewer (∼1.5) words during the initial (t=-2.8, p=.005, Cohen’s d=2.7) and secondary (t=-2.9, p=.003, Cohen’s d=2.6) cued recall trials from the words on the first list. Individuals with HD also recalled significantly fewer words on initial free recall (t=-2.9, p=.003, Cohen’s d=2.6) and cued recall trials of the second list, with the initial cued recall (t=-2.8, p=.005, Cohen’s d=3.1) sensitive to proactive semantic interference and the second cued recall (t=-3.3, p=.001, Cohen’s d=2.6) sensitive to failure to recover from proactive semantic interference. In addition, individuals with HD also recalled significantly fewer (∼2.2) words on delayed cued recall of the first list, a measure of retroactive semantic interference, than HA (t=-4.8, p<.001, Cohen’s d=2.4). Lastly, individuals with HD recalled fewer (∼4.1) words than HA on delayed free recall of both word lists (t=-3.5, p<.001, Cohen’s d=5.9). The groups did not differ significantly with regard to number of total intrusions per trial.Conclusions:Overall, our study supports the usefulness of the LASSI-L for neuropsychological assessment of HD in clinical and research settings. In comparison to a demographically similar group of HA, individuals with manifest HD showed significant differences in frontally mediated retrieval processes as well as semantic interference processes that affect efficient encoding of novel information.

Rapid but incomplete degradation of residual visual representations over time.

While visual working memory has a short lifetime, residual representations can persist and disrupt currently maintained information. This phenomenon is known as proactive interference (PI), and the present study investigated whether the representations underpinning item-specific PI lose details over time. This would be expected if the memories underlying PI are susceptible to temporal processes such as decay, which is strongly disputed. In four experiments, a modified version of the recent probes task was used, requiring participants to determine whether a probe matched one of two recently presented targets. The probe sometimes matched an untested target from a previous trial, or varied in its resemblance to it, and the amount of time separating trials varied. Results revealed that PI was specific and highly disruptive at very short intervals, but its effect diminished over time. At longer intervals, a milder form of PI was present and produced by probes that were only similar to a recently encountered target. In summary, residual visual representations may remain accurate for a few seconds after encoding, before losing precise details and continuing to endure in an inexact state. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

88 Single Trial of Biber Figure Learning Test Captures Subjective Cognitive Decline

Objective:The Biber Figure Learning Test (BFLT) is a serial figure learning assessment previously been shown to be sensitive to various biomarkers of the aging brain. BFLT is an extensive assessment requiring about 30 minutes for administration. In this study, we investigated BFLT’s associations with subjective cognitive decline (SCD), an early marker for preclinical Alzheimer’s Disease (AD), and examined whether alternative BFLT indices could be utilized to considerably shorten the length of assessment without decreasing its sensitivity to SCD.Participants and Methods:Participants were 50 cognitively normal older adults (8% Hispanic, 92% Non-Hispanic; 78% White, 16% Black; 64% female; mean age =72.7 (SD =6.2); mean education =17.05 (SD =2.09)). SCD was measured using a 20-item age-anchored dichotomous questionnaire that assessed complaints of cognitive functioning, and the BFLT was administered in full. Pearson correlations were conducted between SCD and BFLT scores including: Trial 1 Learning (T1), Trials 1 to 2 Total Learning (T1T2), Trials 1 to 3 Total Learning (T1T3), Trials 1 to 5 Total Learning (Total Learning), Immediate Recall, Delayed Recall, Proactive Interference (Trial B – Trial 1), Retroactive Interference (Immediate Recall – Trial 5), and Total Discrimination (calculated as [Recognition Total Correct + 0.5]/16) − ([Total False Alarms + 0.5]/31]). A Fishers Exact Test was utilized to compare the correlational strength between SCD and each of the BFLT scores. Lastly, demographically adjusted (age, gender, and education) regression models were conducted to examine SCD as an individual predictor for the various BFLT scores.Results:SCD was negatively associated with BFLT T1 (r =-0.406, p =0.003), T1T2 (r =-0.331, p =0.019), T1T3 (r =-0.323, p =0.022), Total Learning (r =-0.283, p =0.046), Immediate Recall (r =-0.322, p =0.023), Delayed Recall (r =-0.318, p =0.025), and Retroactive Interference (r =-0.388, p =0.005) and positively associated with Proactive Interference (r =0.308, p =0.029). There was no significant difference in correlational strength between any of these BFLT scores and SCD. Adjusting for demographics, SCD predicted Immediate Recall (B =-0.273, p =0.029), Total Learning (B =- 0.253, p =0.040), T1 (B =-0.412, p =0.002), T1T2 (B =-0.326, p =0.010), T1T3 (B =-0.299, p =0.017), Proactive Interference (B =0.292, p =0.050), and Retroactive Interference (B =- 0.330, p =0.025).Conclusions:Eight of the nine assessed BFLT scores were strongly correlated with age-anchored SCD and age-anchored SCD predicted seven of the nine assessed BFLT indices when adjusted for demographics. Although additional work is needed, these findings suggest SCD’s sensitivity to changes in visuospatial learning and memory, supporting its use as an early marker for preclinical AD. Likewise, our results suggest that an abbreviated version of the BFLT could be utilized that shortens testing time and reduces participant fatigue without a decrease in clinical relevance. Through ongoing longitudinal work, we hope to further disentangle the relationship between SCD and visuospatial learning and memory as measured through the BFTL and to examine how associations between SCD and the BFLT assessment change over time.

Hippocampal subfield volumes contribute to working memory interference control in aging: Evidence from longitudinal associations over 5 years

In memory, familiar but no longer relevant information may disrupt encoding and retrieval of to-be-learned information. While it has been demonstrated that the ability to resolve proactive interference (PI) in working memory (WM) is reduced in aging, the neuroanatomical components of this decline have yet to be determined. Hippocampal (HC) involvement in age-related decline in control of PI is currently not known. In particular, the association between HC subfield volumes and control of PI in WM has not been examined previously. Here we investigate the associations between mean level and 5-year trajectories of gray matter subfield volumes and PI in WM across the adult life span (N = 157). Longitudinal analyses over 5-years across all participants revealed that reduced volume in the subiculum was related to impaired control of PI. Age-stratified analyses showed that this association was most pronounced in older adults. Furthermore, we found that in older adults the effect of age on PI was mediated by GM volume in the HC. The current results show that HC volume is associated with the ability to control PI in WM, and that these associations are modulated by age.

Enhanced reactive inhibition in adolescents with non-suicidal self-injury disorder.

To investigate whether the core of the pathophysiology underlying non-suicidal self-injury (NSSI) relates to poor impulse control due to impaired motor inhibition (i.e. the ability to inhibit a preplanned motor response). We conducted a case-control study to compare the proficiency of two domains of motor inhibition, that is, reactive and proactive inhibition, by giving the reaching arm version of the stop-signal task and a go-only task to 28 drug-naive adolescents with NSSI disorder (NSSID) (mean age [SD] 15 years 8 months [1 year 4 months]; three males and 25 females) and 28 typically developing adolescents (mean age 15 years 8 months [1 year 5 months]; three males and 25 females). Reactive inhibition, as determined by the duration of the stop-signal reaction time, was enhanced in adolescents with NSSID compared to typically developing controls (194.2 [22.5 ms] vs 217.5 [17.3 ms], p < 0.001). By contrast, proactive inhibition was similar in both groups. Lastly, the level of impulsivity, assessed using the Barratt Impulsiveness Scale Version 11, did not differ between typically developing adolescents and adolescents with NSSID. However, adolescents with NSSID were more impulsive than controls in a subscale of the UPPS-P Impulsive Behavior Scale. NSSID is not driven by heightened motor impulsivity. Instead, adolescents with NSSID exhibited greater proficiency in reactive inhibition, a proxy for motor impulsivity. We suggest that the enhancement of reactive inhibition strengthens action control, allowing adolescents to suppress their self-protection instinct and perform NSSI behaviours.

Low-temperature electron transport of rutile-type GexSn1−xO2

Rutile-type wide and ultrawide band-gap oxide semiconductors are emerging materials for high-power electronics and deep ultraviolet optoelectronics applications. A rutile-type GeO2-SnO2 alloy (r-GexSn1–xO2) recently found is one of such materials. Herein, we report low-temperature electron transport properties of r-GexSn1−xO2 thin films with x = 0.28 and 0.41. Based on resistivity and magnetoresistance measurements, along with the theory of quantum interference, it is suggested that Efros–Shklovskii variable-range hopping, i.e., hopping over the states within the Coulomb gap, is dominant at lower temperatures (T ≤ 10 and 15 K) in both r-Ge0.41Sn0.59O2 and r-Ge0.28Sn0.72O2. The negative and positive magnetoresistances observed at low temperatures are attributable to the quantum interference and field-induced spin alignment, respectively. The magnetoresistance measurements at higher temperatures suggest that both Mott variable–range hopping and thermally activated band conduction occur at T &amp;lt; 100 K and that almost pure thermally activated band conduction takes place at T ≥ 150 K.

Influence of ring gear flexibility on the fatigue reliability of planetary gear systems in heavy helicopters

Flexibility of ring gear rims significantly affects the mechanical properties of planetary transmissions at both levels of gear tooth meshing and system power sharing, and is one of the important design factors determining the service reliability of large aviation planetary systems. Therefore, to analyze the mechanism by which the flexibility of ring gear rims affects the fatigue reliability of planetary systems, in the framework of the stress-strength interference theory, a reliability assessment model for the planetary system is constructed based on a calculation logic extension for the full probability formula. Starting from balancing evaluation accuracy and evaluation cost, a hybrid finite element method and a gear tooth lifetime transformation test are employed to provide load and strength input variables for the reliability model respectively. Finally, a mapping relationship from ring gear rim flexibility to planetary system fatigue reliability is established. For the specific design scheme of planetary systems, a lower limit of the ring gear rim thickness can be determined according to the requirements of reliability indexes, so that the balance between reliability and lightweight can be achieved to some extent.

Agreement attraction in comprehension: do active dependencies and distractor position play a role?

ABSTRACT Across four eye-tracking studies and one self-paced reading study, we test whether attraction in subject-verb agreement is affected by (a) the relative linear positions of target and distractor, and (b) the active dependency status of the distractor. We find an effect of relative position, with greater attraction in retro-active interference configurations, where the distractor is linearly closer to the critical verb (Subject…Distractor…V) than in pro-active interference where it is more distant (Distractor…Subject…V). However, within pro-active interference configurations, attraction was not affected by the active dependency status of the distractor: attraction effects were similarly small whether or not the distractor was waiting to complete an upcoming dependency at the critical verb, with Bayes Factor analyses showing evidence in favour of a null effect of active dependency status. We discuss these findings in terms of the decay of activation, and whether such decay is affected by maintenance of features in memory.

Early Intervention in Cognitive Aging with Strawberry Supplementation.

Late-life dementia is a growing public health concern lacking effective treatment. Neurodegenerative disorders such as Alzheimer's disease (AD) develop over a preclinical period of many years beginning in midlife. The prevalence of insulin resistance, a prominent risk factor for late-life dementia, also accelerates in middle-age. Consumption of berry fruits, including strawberries, has been shown to influence metabolism as well as cognitive performance suggesting potential to mitigate risk for dementia. In this controlled trial, we enrolled overweight middle-aged men and women with insulin resistance and subjective cognitive decline and performed a 12-week intervention with daily administration of whole-fruit strawberry powder. Diet records showed that participants in both groups maintained the prescribed abstinence from berry product consumption outside the study. We observed diminished memory interference (p = 0.02; Cohen's f = 0.45) and a reduction of depressive symptoms (p = 0.04; Cohen's f = 0.39) for the strawberry-treated participants; benefits consistent with improved executive ability. However, there was no effect of the intervention on metabolic measures, possibly a consequence of the sample size, length of the intervention, or comparatively low anthocyanin dose. Anti-inflammatory actions of anthocyanins were considered as a primary mechanistic factor. The findings support the notion that strawberry supplementation has a role in dementia risk reduction when introduced in midlife. However, further investigation with longer intervention periods, larger samples, and differing dosing regimens will be required to assess the benefits of strawberry intake with respect to cognition and metabolic function in the context of aging.

Reducing Catastrophic Forgetting With Associative Learning: A Lesson From Fruit Flies.

Catastrophic forgetting remains an outstanding challenge in continual learning. Recently, methods inspired by the brain, such as continual representation learning and memory replay, have been used to combat catastrophic forgetting. Associative learning (retaining associations between inputs and outputs, even after good representations are learned) plays an important function in the brain; however, its role in continual learning has not been carefully studied. Here, we identified a two-layer neural circuit in the fruit fly olfactory system that performs continual associative learning between odors and their associated valences. In the first layer, inputs (odors) are encoded using sparse, high-dimensional representations, which reduces memory interference by activating nonoverlapping populations of neurons for different odors. In the second layer, only the synapses between odor-activated neurons and the odor's associated output neuron are modified during learning; the rest of the weights are frozen to prevent unrelated memories from being overwritten. We prove theoretically that these two perceptron-like layers help reduce catastrophic forgetting compared to the original perceptron algorithm, under continual learning. We then show empirically on benchmark data sets that this simple and lightweight architecture outperforms other popular neural-inspired algorithms when also using a two-layer feedforward architecture. Overall, fruit flies evolved an efficient continual associative learning algorithm, and circuit mechanisms from neuroscience can be translated to improve machine computation.

Patterns of proactive interference in CVLT-II: evidence of a low-organized, disorganized, and highly organized learning style

ABSTRACT Objective Previous studies have interpreted proactive interference (PI) either as indicating executive dysfunction or a normal process indicating deep level encoding. We investigated these competing models of PI in a large clinical sample using cluster analyses. We expected to find clusters defined by high PI but otherwise characterized by either EF impairment or of good memory performance. Method File records of 731 patients with neurological or psychiatric disorders were analyzed. PI-scores, false positive recognition errors, and semantic organization scores on the California Verbal Learning Test-II (CVLT-II) were subjected to cluster analyses. Clusters were compared regarding buildup and release from PI, memory performance and strategy measures, measures of intelligence, EF, and processing speed. Results The analyses revealed six analyzable clusters. Two clusters showed no buildup of PI and normal release from PI. Discriminability was impaired both in List A and B. Learning acquisition and speeded measures of EF were reduced. One cluster showed both buildup of PI and problems with releasing from PI, and particularly impaired discriminability of List B. Semantic organization was low. Learning consolidation and EF speeded measures were impaired. Two other clusters showed buildup of PI, but no problem with release. Learning was highly organized, and they showed good memory and normal neuropsychological performance. Conclusions Results shows differentiation between a low organized EF dysfunction pattern with no PI, a disorganized PI pattern also indicating EF dysfunction and a highly organized pattern where PI seems to be the price to pay for high effort put into the learning process.