Retention Of 47Ca Research Articles

Comparison of Whole-Body Liquid Scintillometry, Radiography, and Clinical Chemical Tests in the Evaluation of the Effect of Chronic Corticoid Dosing on Calcium in Beagles

Chronic doses of 6α-methylprednisolone were administered to beagles for 106 days to bring about changes in calcium balance. During the initial 64 days of corticoid treatment, no outstanding changes were observed in the blood levels of calcium, phosphorus, or alkaline phosphatase. Radiographic changes in the skeleton were not seen after 64 days of treatment. Significant changes in 47Ca retention were detected by whole-body liquid scintillometry after only 13 and 28 days of corticoid administration. On day 64 of the study, the dosage of 6α-methylprednisolone was increased. Decreased levels of calcium in blood plasma and increased levels of plasma alkaline phosphatase were observed after the dose of corticoid was increased. A great reduction in whole-body 47Ca retention was also observed, and thinning of the cortices of the long bones of the legs was apparent. The results of the investigation indicate that whole-body liquid scintillation counting of 47Ca is a sensitive indicator of alterations of calcium metabolism in relation to other diagnostic methodology.

Retention of orally administered 47Ca in man measured in a whole-body counter.

A method is described for studying the retention of orally administered 47Ca using a whole-body counter. Two μCi 47Ca were given after an overnight fast together with calcium carrier as CaCl2 in water, and the retention was measured after one and two weeks. The error due to geometric and biologic variations was 1.7 per cent of the given dose. In 27 healthy subjects the retention of 47Ca one week after the administration was 35.7 ± 7.6 (S. D.) per cent of the given dose and after two weeks 29.3 ± 7.4 (S. D.) per cent.

Retention of oral 47calcium in patients with rheumatoid arthritis and osteopenia.

SummaryCalcium retention was studied in eight patients with RA and generalized osteopenia, three of whom were treated with small doses of corticosteroids, seven with salicylates, and one with indomethacine. The retention of orally administered 47Ca + 135 mg. 40Ca after an overnight fast was measured in a whole body counter after one and two weeks. The whole group of patients showed a lowered value of 47Ca retention. This finding may be due to a decreased intestinal absorption of calcium, although other causative factors cannot be excluded.

Calcium Absorption and Bone Disease in Obstructive Jaundice.

s1 May 1968Calcium Absorption and Bone Disease in Obstructive Jaundice.C. D. Holdsworth, M.R.C.P., K. A. Kehayoglou, M.D., Sheila Sherlock, F.R.C.P.C. D. Holdsworth, M.R.C.P.Search for more papers by this author, K. A. Kehayoglou, M.D.Search for more papers by this author, Sheila Sherlock, F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1188_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCalcium absorption and bone disease were studied in 12 patients with primary biliary cirrhosis before and after treatment with intramuscular vitamin D. Calcium absorption was assessed by plasma levels of 47Ca and whole-body retention of 47Ca after an oral dose of 47CaCl2 dissolved in water. Before treatment calcium absorption was subnormal in 4 patients. Impairment of calcium absorption correlated well with the depth of jaundice but was unrelated to duration of jaundice. After vitamin D, absorption of 47CaCl2 was significantly improved and became normal in all patients.Retention in the body of an intravenous infusion of calcium was greater than... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1188-1188KeywordsBlood plasmaBoneCalciumPrimary biliary cirrhosisVitamin D Issue Published: 1 May 1968 PDF DownloadLoading ...

Reduction in the absorption and retention of dietary strontium in man by alginate.

SummaryThe absorption and retention of 47Ca and 85Sr have been compared for four volunteers on a normal diet with and without a supplement of sodium alginate. The alginate was given for 7 days in amounts approximately chemically equivalent to the dietary calcium.Alginate decreased the retention of 85Sr and 47Ca by about 70 per cent and 7 per cent respectively.The mean ratio for the absorption of 85Sr on the supplemented to that on the unsupplemented diet was 0·23. This ratio was greater than that derived from earlier results for subjects given alginate in milk alone.The urinary and faecal excretion as well as the plasma concentration of stable sodium, potassium, magnesium, calcium, strontium, barium and phosphorus, were measured.

Intestinal Absorption and Body Retention of 47Ca in Rats: Evaluation of the method

A method is described to study intestinal absorption and body retention of calcium in rats which requires the use of oral 47Ca and monitoring of body radioactivity by a whole body counter. Extrapolation to zero time of the monoexponential portion of the body retention curve of 47Ca was used to estimate net intestinal absorption. The slope of this curve provided an index of body retention of calcium. The validity of the estimate of intestinal absorption was confirmed by direct analysis of fecal, intestinal tract and carcass content of 47Ca after oral administration. Quantitative data on intestinal absorption and body retention of 47Ca after oral dose were obtained in various groups of normal rats of increasing weight and age. Growth and maturation had a depressing effect on both intestinal absorption and whole body retention of 47Ca.