Psychometric Test Results Research Articles

Adaptation of the Five-by-Five Resilience Scale in Indonesian

Resilience is the ability of individuals to be able to adapt and rise from difficult conditions or situations. The Five-by-Five Resilience Scale is a measurement tool developed by DeSimone et al (2016) to measure individual resilience. There are five protective factors of resilience, namely adaptation, emotional regulation, optimism, self-efficacy and social support. This research aims to adapt the Five-by-Five Resilience Scale into Indonesian. This research was conducted because there has been no testing of the Indonesian version of the Five-by-Five Resilience Scale. The subjects involved in the study were 267 subjects with an age range of 18 - 25 years who were domiciled in Indonesia. Based on the results of psychometric testing through Exploratory Factor Analysis (EFA), 4 factors were obtained that build the Five-by-Five Resilience Scale. The results also show that the Five-by-Five Resilience Scale has a correlation with other measuring tools in convergence validity testing. The reliability test results show that the dimensions on the Five-by-Five Resilience Scale as a whole have a reliability > 0.7.

When fatigue and cognitive impairment persist- a neurological follow-up-study in patients with Post-COVID syndrome

Considering the relevance for patients, economics and public health data about the course of the neurological Post-COVID Syndrome (PCS) are urgently needed. In this study 94 PCS patients (73% female, age in median 49 years) were examined in median 9.4 (T1) and for a second time 14 months (T2) after mild to moderate SARS-CoV-2 infection. Mood, sleep quality and health related quality of life (QoL) were evaluated via structured anamnesis and self-report questionnaires; attention, concentration and memory via psychometric tests. 47% of the patients reported an improvement of their symptoms over time, but only 12% full recovery. 4% noticed deterioration and 49% no change. Main disturbances at both time points were fatigue, deficits in concentration and memory. In patients with perceived improvement QoL significantly increased between T1 and T2, although their test performance as well as the fatigue score remained unchanged. In patients with persisting impairment QoL, fatigue scores and psychometric test results did not change significantly. Abnormal psychometric tests were more frequent at both time points in the group without improvement. But, significant fatigue and cognitive impairment persisted for more than 1 year after SARS-CoV-2 infection in both groups.

Опросник «Шкала воспринимаемого стресса для детей» (ШВС-Д): Адаптация и психометрические показатели

<p>The article presents the results of adapting and testing of the “Perceived Stress Scale for Children” (PSS-C) on a Russian-speaking sample of adolescents aged 11 to 16 (n = 612). The study sample consisted of students from grades 5 to 8 in secondary schools in various regions of the Russian Federation (Trans-Baikal Territory, Altai Territory, Moscow Region, Leningrad Region). The results of psychometric testing indicate that the questionnaire has good internal consistency with correlations between the final score and stand alone questions being rs = [0.4; 0.64], p < 0.01; the half-form reliability rt = 0.78; the Cronbach's α = 0.741. A direct relationship between the perceived stress level and situational anxiety was shown (rs = 0.67, p < 0.01), which persisted when taking into account the age, gender, and region of residence of the respondents. These findings suggest that PSS-C has convergent validity. Factor analysis of the questionnaire revealed the presence of two factors in the perceived stress structure: 1) “Tension” and 2) “Resources”. The two-factor model of perceived stress was confirmed using confirmatory factor analysis (RMSEA = 0.058, 90% CI [0.045, 0.072], CFI = 0.952, GFI = 0.977). The discriminativeness of the questionnaire was δ = 0.97. Gender differences in the level of perceived stress are shown; age differences are due to an increase in study load. The “Perceived Stress Scale for Children” questionnaire is a valid and reliable technique for diagnosing stress in adolescents aged 11 to 16. It can be used both in individual assessments and group diagnostics for monitoring of stress levels in adolescence.</p>

Evaluation of mental performance and cognitive functions of children and adolescents diagnosed with radiologically isolated syndrome

BackgroundRadiologically isolated syndrome (RIS) is a condition characterized by asymptomatic, incidentally detected demyelinating plaques in the CNS in a patient without typical clinical findings of multiple sclerosis (MS). This study aimed to compare the mental status and cognitive functions of child and adolescent RIS cases with healthy controls and to investigate the relationship between psychometric test results and the demyelinating lesion characteristics. MethodsThe mental status and cognitive functions of 12 RIS cases and 12 healthy controls were compared. Semi-structured interviews, behavioral evaluations, depression and anxiety scales, neuropsychological test battery, and an intelligence test were applied for the evaluation of mental state and cognitive functions. These results were compared with the number and localization of demyelinating lesions. ResultsSustained attention, visual-motor coordination, short-term memory skills, and ability to use visual-spatial information were found worse in the RIS group. There was no correlation between mental state and cognitive functions, and the number and localization of demyelinating lesions. ConclusionOur study showed that pediatric RIS cases may have worse cognitive performance than healthy controls, but no correlation was found between the number and location of demyelinating lesions and psychiatric findings. Although it is controversial whether psychiatric disorders and cognitive disabilities have predictive value in terms of MS conversion in pediatric RIS cases, these subjects were not included in the scope of this study.

Cortical excitability in patients with migraine with aura and depressive symptoms: a visual evoked potentials study

Background: Migraine is a brain disorder characterized by recurring headache attacks, and emotional comorbidities, such as anxiety and depression, may influence the repetition of these attacks. The lack of sensory habituation is a common neurophysiological abnormality in migraine, and research suggests that it is under the influence of serotonin and other monoamines that are also involved in mood disorders. This study aimed to investigate the influence of emotional symptoms on cortical information processing in patients with migraine with aura by correlating cortical activity with self-perceived emotional distress. Methods: Visual evoked potentials from monocular stimulation were recorded in 16 patients with migraine with aura (MA) and 22 healthy volunteers (HV). The visual stimulus consisted of a full-screen black-and-white checkerboard pattern with a reversal rate of 1.55 Hz. 600 consecutive traces were collected and divided into six sequential blocks of 100 sweeps. Before the recording session, both MA patients and HV completed the Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI). Pearson's correlation test was used to find correlations between electrophysiological and psychometric variables in HV and MA patients. Results: Compared to HV, MA patients showed a significant difference in the degree of habituation to repeated visual stimulation between the two groups, resulting in a habitation deficit. Psychometric test results showed that trait STAI and BDI values were significantly higher in MA patients. In the MA group, BDI correlated negatively with the amplitude of the first block and positively with the degree of habituation. Conclusions: These results highlight a link between the level of brain responsiveness and depressive symptoms in patients with MA. Further research is required to confirm whether the same correlations exist in patients with other headache disorders.

Cравнительная эффективность различных режимов терапии рифаксимином-α у пациентов с минимальной печеночной энцефалопатией и циррозом печени (анализ шестимесячного наблюдения)

Minimal hepatic encephalopathy (MHE) is the earliest and mildest form of hepatic encephalopathy (HE), however, its occurrence is associated with an unfavorable prognosis for cirrhosis in patients in this category. MHE increases the number of falls, injuries, patients getting into road traffic accidents, and accidents, which has serious consequences for the quality of life, and also affects the increase in the frequency of hospitalizations and mortality in patients in this category. Timely correction of cognitive impairment is the key to treating and reversing MHE, as well as improving the quality of life in patients with cirrhosis. Objectives. To study the optimal regimens for the use of rifaximin-α and study its effect on the main clinical and laboratory parameters and quality of life of patients with MHE against the background of cirrhosis during long-term treatment. Material and methods. Inclusion criteria: men and women from 18 to 75 years old; availability of CPU; presence of MHE; signed voluntary informed consent. Non-inclusion criteria: refusal to participate in the study; acute hepatitis; HIV co-infection; severe comorbid pathology; mental illness; Wilson – Konovalov disease. Research methods: clinical examination (analysis of patient complaints, assessment of objective status); laboratory tests (ammonia levels); assessment of the severity of liver disease according to the Child – Pugh scale; assessment of the degree of HE based on the results of psychometric tests (number connection test, animal naming test, brief mental status scale); quality of life questionnaire (SF-36). Results. In the absence of rifaximin-α therapy, there is a deterioration in the quality of life due to a decrease in indicators of the mental component of health, as well as an increase in time in performing the psychometric number connection test. Against the background of continuous and cyclic therapy with rifaximin-α in patients with cirrhosis and MHE during 6 months of observation, the level of capillary blood ammonia decreases. Conclusions. When comparing the effectiveness of continuous and course therapy with rifaximin-α, the results did not show significant differences, which indicates the equivalence of these treatment regimens after 6 months of observations.

Cannibalism in psychotic disorder: a rare case presentation

ABSTRACT The aim of this study is to investigate the phenomenon of cannibalism in psychotic disorders through a case presentation. According to the statement obtained after the incident, a 35-year-old female patient claimed that she killed her mother by slitting her throat at the request of spiritual entities. She then decapitated her mother’s head and boiled it in a pot. She also mentioned eating pieces of flesh that had been cut off her leg, while keeping some pieces in the fridge. The results of psychometric tests indicated paranoid features on the Rorschach, together with evidence of personality organisation at a psychotic level. In addition, MMPI test results showed above-normal scores on the Hysteria subtest, indicating psychotic deviation, and on the Paranoia subtest, suggesting abnormality in these areas. The psychiatric examination revealed moderate self-care skills and limited emotional expression, as well as paranoid ideation and persecutory delusions within thought content. In addition, observations noted the patient’s difficulties with goal-directed thinking and cognitive functioning, including attention span, calculation, judgment, and abstract reasoning. Based on these findings, the individual received a diagnosis of ‘psychotic disorder (schizophrenia)’ and was deemed not criminally responsible. In forensic psychiatric evaluations of such cases, it is important not to overlook the potential contribution of psychometric testing alongside clinical examination, as cannibalism should be considered as a possible manifestation of psychosis.

Credit Risk Prediction Based on Psychometric Data

In today’s financial landscape, traditional banking institutions rely extensively on customers’ historical financial data to evaluate their eligibility for loan approvals. While these decision support systems offer predictive accuracy for established customers, they overlook a crucial demographic: individuals without a financial history. To address this gap, our study presents a methodology for a decision support system that is intended to assist in determining credit risk. Rather than solely focusing on past financial records, our methodology assesses customer credibility by generating credit risk scores derived from psychometric test results. Utilizing machine learning algorithms, we model customer credibility through multidimensional metrics such as character traits and attitudes toward money management. Preliminary results from our prototype testing indicate that this innovative approach holds promise for accurate risk assessment.

Associations between the Avatar Characteristics and Psychometric Test Results of VK Social Media Users

Online social media has an increasing influence on people’s lives, providing tools for communication and self–representation. People’s digital traces are gaining attention as a reflection of their personality traits, enhancing the personality computing tasks in various areas. This study aims at the identification of statistical associations between psychometric scores from three questionnaires—the Big Five Inventory, Plutchik’s Lifestyle Index and the Eysenck Personality Questionnaire—and a set of graphical features of avatar images from the VK online social media that include the pixel characteristics from the HSV and RGB color models and the number of persons and faces depicted in an avatar. The problem is considered from the statistical point of view. The dependency between psychometric scores and the number of faces/persons is assessed with the Kruskal–Wallis test with Dunn test pairwise comparisons. The color-pixel characteristics that are associated with the psychometric scores are selected with several fits of the regularized regression with L2 and MCP penalties. The data for the study were collected via a specially developed application for the online social media platform VK. The results of the analysis support existing research on how colors express personality and discover certain color-pixel image characteristics that could be used for personality computing models.

Pengembangan Alat Ukur Kepuasan Kerja dalam Pengaturan Kerja Teleworking

Flexible work settings using connection-based and technological devices, commonly referred to as teleworking, have become increasingly prevalent since the COVID-19 pandemic. This change in work settings may affect various aspects of job satisfaction among employees, necessitating adjustments in measuring employee job satisfaction. This study aims to develop a measurement instrument for job satisfaction within the context of teleworking, knowns as the Work Engagement Scale (WES). The development of the WES measurement instrument is based on the nine dimensions of job satisfaction proposed by Spector (1985). The participants in this research were 146 workers who had been teleworking for at least one year in private companies, government institutions, state-owned enterprises, or nonprofit organizations. The result of realibility testing indicate that the WES measurement instrument, both overall and in its six dimensions, demonstrated high internal consistency. Construct validity testing shows that WES measurement instrument, both overall and in each dimension, is valid for measuring job satisfaction. Furthermore, the items in the Job Satisfaction measurement instrument, both per dimension and overall, exhibited good discrimination and were evenly distributed. Overall, the psychometric testing results of the WES measurement instrument suggest that it has the potential to effectively measure job satisfacton among employees using teleworking system.

Adaptation and validation of the encoding of observations using CONSUL-MCC: A self-determination theory-based tool to observe consultations in maternity care

ObjectiveDuring autonomy-supportive consultations, professionals use a need-supportive interaction style to facilitate patients' self-regulated behaviour. To improve maternity care professionals' need-supportive interactions, it is important to provide insights into their interaction style. No tool is currently available for measuring need-supportive interactions in maternity care. Therefore, the aim of this study was to adapt the COUNSEL-CCE to evaluate need-supportive interactions in maternity care and to validate their measurements. MethodsA five-step adaptation and validation process was performed based on the guideline of Sousa and Rojjanasrirat: 1) adaptation of COUNSEL-CCE by two authors independently; 2) development of a consensus-based tool: CONSUL-MCC; 3) qualitative assessment of CONSUL-MCC; 4) pilot testing of CONSUL-MCC in the target population (N = 10) and 5) psychometric testing in the target population (N = 453). ResultsAll indicators of the original tool remained relevant. Four items were rephrased, one indicator was added, and all examples were adapted to maternity care. The results of psychometric testing indicated good construct validity. However, the data characteristics made it impossible to prove the presumed factor structure and perform an accurate intraclass correlation. Conclusions and innovationCOUNSEL-CCE proved to be a new instrument to gain insights into professionals' interactions and be applied to maternity care.

A prospective investigation of impacts of comorbid attention deficit hyperactivity disorder (ADHD) on clinical features and long-term treatment response in adult patients with obsessive-compulsive disorder (OCD)

BackgroundA close association between obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in children and adolescents has been investigated in previous studies. However, few studies examined the relationship between lifetime comorbidity of ADHD and OCD in adults. Therefore, we sought to investigate the clinical and psychopathological features related to comorbid ADHD in Japanese adult patients with OCD. MethodsWe assessed lifetime comorbidity of ADHD in 93 adult Japanese patients with OCD. Additionally, we used the Japanese version of Conners' Adult ADHD Rating Scales to assess the characteristics and severity of ADHD in each participant. According to the results, we excluded OCD patients that did not have ADHD but who exhibited elevated levels of ADHD traits. We compared OCD patients with ADHD (ADHD+ group) and those without ADHD or its trait (ADHD− group) in terms of background profiles and clinical features, such as OCD symptomatology and psychometric test results. Additionally, the 6-month treatment outcome was compared prospectively between groups. ResultsOf the 93 OCD participants, the prevalence of lifetime comorbidity of ADHD was estimated as 16.1%. Compared with the ADHD− group, participants in the ADHD+ group had an earlier age of onset of OCD, higher frequencies of hoarding symptoms, higher levels of depressive and anxiety symptoms and lower quality of life, more elevated levels of impulsivity, and higher rates of substance or behavioral addiction and major depression. Finally, the mean improvement rate on the Yale-Brown Obsessive Compulsive Scale after 6 months of standardized OCD treatment in the ADHD+ group (16.1%) was significantly lower than that in the ADHD− group (44.6%). ConclusionThe lifetime comorbidity of ADHD is likely to exert a significant effect on clinical features and treatment outcome in adult patients with OCD. It is important to consider that underlying ADHD pathology may function as a facilitator for increased severity of global clinical features and treatment refractory conditions in OCD patients. Further studies are required to examine treatment strategies for such patients.

The Prevalence of Minimal Hepatic Encephalopathy in an Outpatient Hepatology Clinic.

Minimal hepatic encephalopathy can only be detected by specific psychometric or neuropsychological tests. We aimed to determine the prevalence of minimal hepatic encephalopathy in a hepatology outpatient clinic of a tertiary center. A total of 82 patients with chronic liver disease were involved prospectively in this study. Control groups consisted of healthy volunteers (n = 123) and chronic renal failure patients (n = 28). We used 2 different methods to detect minimal hepatic encephalopathy. First method was a battery of 5 psychometric tests (number connection tests A and B, digit symbol test, serial dot test, line tracing test) which was filled by all patients. The second method was critical flicker frequency test. Both methods were used in the whole group (n = 233). We applied linear regression analysis to the results of psychometric tests of healthy volunteers to establish equations to calculate the expected values of each test. Test results of the patients were evaluated according to the expected results obtained from these equations. The prevalence of minimal hepatic encephalopathy detected by psychometric tests and critical flicker frequency test was 13% and 14%, respectively. When the positivity of both tests was deemed necessary to diagnose minimal hepatic encephalopathy, the rate of minimal hepatic encephalopathy was 3.6% (n = 3) in a chronic liver disease patient group. Minimal hepatic encephalopathy is a difficult clinical condition to diagnose, and it is more appropriate to use psychometric tests and critical flicker frequency test together.

Identifying neurodevelopmental disabilities from nationalised preschool health check.

Models of psychometric screening to identify individuals with neurodevelopmental disabilities (NDDs) have had limited success. In Aotearoa/New Zealand, routine developmental surveillance of preschool children is undertaken using the Before School Check (B4SC), which includes psychometric and physical health screening instruments. This study aimed to determine whether combining multiple screening measures could improve the prediction of NDDs. Linked administrative health data were used to identify NDDs, including attention deficit hyperactivity disorder, autism spectrum disorder and intellectual disability, within a multi-year national cohort of children who undertook the B4SC. Cox proportional hazards models, with different combinations of potential predictors, were used to predict onset of a NDD. Harrell's c-statistic for composite models were compared with a model representing recommended cutoff psychometric scores for referral in New Zealand. Data were examined for 287,754 children, and NDDs were identified in 10,953 (3.8%). The best-performing composite model combining the Strengths and Difficulties Questionnaire, the Parental Evaluation of Developmental Status, vision screening and biological sex had 'excellent' predictive power (C-statistic: 0.83) compared with existing referral pathways which had 'poor' predictive power (C-statistic: 0.68). In addition, the composite model was able to improve the sensitivity of NDD diagnosis detection by 13% without any reduction in specificity. Combination of B4SC screening measures using composite modelling could lead to significantly improved identification of preschool children with NDDs when compared with surveillance that rely on individual psychometric test results alone. This may optimise access to academic, personal and family support for children with NDDs.

Psychosomatic response to acute emotional stress in healthy students.

The multidimensionality of the stress response has shown the complexity of this phenomenon and therefore the impossibility of finding a unique biomarker among the physiological variables related to stress. An experimental study was designed and performed to guarantee the correct synchronous and concurrent measure of psychometric tests, biochemical variables and physiological features related to acute emotional stress. The population studied corresponds to a group of 120 university students between 20 and 30years of age, with healthy habits and without a diagnosis of chronic or psychiatric illnesses. Following the protocol of the experimental pilot, each participant reached a relaxing state and a stress state in two sessions of measurement for equivalent periods. Both states are correctly achieved evidenced by the psychometric test results and the biochemical variables. A Stress Reference Scale is proposed based on these two sets of variables. Then, aiming for a non-invasive and continuous approach, the Acute Stress Model correlated to the previous scale is also proposed, supported only by physiological signals. Preliminary results support the feasibility of measuring/quantifying the stress level. Although the results are limited to the population and stimulus type, the procedure and methodological analysis used for the assessment of acute stress in young people can be extrapolated to other populations and types of stress.

Development and Psychometric Evaluation of a Chinese Instrument of Knowledge, Attitude and Preventive Practice on Dementia Care in Macao.

Very few instruments to integrate knowledge, attitude and practice into dementia care as a holistic perspective were available to the Chinese. This article documented the development of a 30-item self-administered Chinese instrument of knowledge, attitude and preventive practice on dementia care and reported the results of psychometric testing among 1500 Chinese in Macao Special Administrative Region (SAR), including 234 primary health professionals, 272 staff working at day-care centers and nursing homes, 586 high school students and 408 community-dwelling older people. The Chinese instrument was developed through literature review and committee review. The psychometric methods were used to evaluate the reliability and validity of the Chinese instrument as measures of knowledge, attitude and preventive practice on dementia care for the Chinese. The preliminary results indicated that the Content Validity Index of the Chinese instrument was .973 and Cronbach's alpha coefficient of the Chinese instrument was .842, among which Knowledge subscale, Attitude subscale and Preventive Practice subscale were .749, .633 and .845 respectively. The means and standard deviation were 65.13 ± 24.56 for Knowledge subscale, 74.76 ± 8.37 for Attitude subscale, 73.22 ± 14.05 for Preventative Practice subscale, and 70.99 ± 11.27 for the Chinese instrument. The 30-item self-administered Chinese instrument of knowledge, attitude and preventive practice on dementia care had satisfied the psychometric evaluation well enough to warrant further use, and could also have particular implications for other Chinese populations all over the world.

The Usefulness of Optical Coherence Tomography in Disease Progression Monitoring in Younger Patients with Relapsing-Remitting Multiple Sclerosis: A Single-Centre Study.

The purpose of the study was to assess the usefulness of optical coherence tomography (OCT) in the detection of the neurodegenerative process in younger patients with multiple sclerosis (MS). The study group consisted of 61 patients with a relapsing remitting course of MS (mean age 36.4 ± 6.7 years) divided into two groups: short (≤5 years) and long (>10 years) disease duration. OCT, P300 evoked potential, Montreal Cognitive Assessment, and performance subtests (Picture Completion and Digit Symbol) of the Wechsler Adult Intelligence Scale were performed in all patients. Mean values of most parameters assessed in OCT (pRNFL Total, pRNFL Inferior, pRNFL Superior, pRNFL Temporalis, mRNFL, GCIPL, mRNFL+GCIPL) were significantly lower in MS patients in comparison to controls. And in patients with longer disease duration in comparison to those with shorter. Most OCT parameters negatively correlated with the EDSS score (p < 0.05). No significant correlation was found between OCT results and both P300 latency and the results of psychometric tests. OCT, as a simple, non-invasive, quick, and inexpensive method, could be useful for monitoring the progression of disease in MS patients.

Pet Insects May Improve Physical Performance and Sleep in Community-Dwelling Frail Elderly People with Chronic Diseases: A Single-Arm Interventional Pilot Study.

Animal-assisted intervention (AAI) is an effective intervention that improves the mental and physical health. However, few have examined the efficacy of pet insects as a form of AAI for prefrail and frail elderly. This study aimed to ascertain the effects of pet insects on physical performance and psychological health in community-dwelling frail elderly individuals with a chronic disease. This study was an 8 week prospective single-arm interventional pilot study that enrolled prefrail and frail community-dwelling adults aged 70 years and older, all of whom had a chronic disease and attended a daycare facility. Pet insects and appropriate equipment were provided, and supporting programs were used to educate participants about how to rear the insects and how to get close to them. Pre- and post-interventional physical and psychological functions were evaluated. A total of 23 subjects (mean age, 82.78 years) were enrolled in the final analysis. The timed up-and-go-test (TUG) was used to measure functional mobility, and grip strength was used as a measure of muscle strength; both showed significant changes after the 8-week intervention (Δ = -0.35±0.73 sec, P = 0.034; and Δ = 0.73±0.99 kg, P = 0.002, respectively). In addition, the insomnia severity index (ISI) and average sleep duration improved significantly (Δ = -2.91±5.64, P = -0.021; and Δ = 0.87±1.98, P = 0.047, respectively). There were no significant changes in the results of other psychometric tests. Logistic regression analysis using the forward stepwise selection method revealed that the baseline ISI score and the absence of other comorbidities were significantly associated with the probability of positive changes in both the TUG and HS tests after the intervention. Pet insects may be an effective and easily applicable type of AAI, which improves physical function and sleep in prefrail and frail elderly individuals.

Subclinical cognitive impairment in chronic kidney disease is associated with frailty and reduced quality of life.

Cognitive impairment (CI) in chronic kidney disease (CKD) is highly prevalent and is associated with multiple limitations to patients as well as a higher mortality, more days of hospitalisation and a lower quality of life. Frailty in CKD is associated with adverse health outcomes and is also highly prevalent. The aim of our study was to determine the prevalence and characteristics of CI and relate the findings to frailty, mobility, muscle strength and health-related quality of life (HRQOL). Non-dialysis patients with CKD stages 3-5 were prospectively evaluated for inclusion. Excluded were patients with other cognitive disorders, signs of overt uraemic encephalopathy, severe infection and hyponatraemia. All patients underwent psychometric testing (five different tests): assessments of mobility, strength and frailty and an evaluation of HRQOL. Based on the number of pathological psychometric test results, we established two different definitions of CI: subclinical uraemic encephalopathy 1 (SUE1: one pathological test) and subclinical uraemic encephalopathy 2 (SUE2: two or more pathological test results). Sixty-two patients were included [median age 66years (interquartile range 57-75), male 55%]. Most patients had CKD stage 3 (48%; stage 4: 32%; stage 5: 19%). CI was highly prevalent (SUE1: 60%; SUE2: 42%) and associated with a higher risk of falls (pathological tandem gait test; SUE1: 50% versus 16%, P=.023; SUE2: 69% versus 15%, P=.001), lower muscle strength (SUE2-pathological: 39% versus 7%, P=.008), frailty (SUE1: 59% versus 28%, P=.038; SUE2: 67% versus 33%, P=.028) and HRQOL. CI is highly prevalent in non-dialysis CKD patients. Even mild CI is associated with decreased mobility, muscle strength and HRQOL and increased frailty.

The effect of apoprotein E gene polymorphism on neurocognitive functions of children with CHD.

Studies have demonstrated an association between CHD and neurodevelopmental delay. This delay is associated with many factors like reduced blood flow and oxygen, cardiac catheterisations, and genetic factors. Apo E gene polymorphism is one of these genetic factors. This study aims to show the effect of Apo E gene polymorphism on neurodevelopmental process in children having CHD. A total of 188 children having CHD were admitted to the study. Apo E gene polymorphism of these patients was determined, and psychometric evaluation was performed. The relationship between psychometric test results and gene polymorphism was evaluated. This study shows that, similar to the literature, patients having cyanotic CHD have worse scores than acyanotic patients, and the children with CHD are under risk in terms of neuropsychiatric disorders. Other novel and important findings of this study were the lower verbal scores of ε2 allele carriers than ε4 carriers in Wechsler Intelligence Scale for Children-Revised group and the worse test score of patients having VSD than other acyanotic patients. Besides, some special disorders may be seen in this patient group.