Global and local changes associated with the orientation of the economy for modernization and innovative development, with an increase in the unpredictability of market processes, with the development of business and interpenetration of economies, raise a number of problems in managing the operating activities of industry enterprises. One of the most important conditions for the prosperity of the domestic economy is the high efficiency of production processes, implying the rational use of all resources, improving operational processes, strategic operating planning, taking into account the uncertainty factor, improving the quality and competitiveness of products. The production and technological aspect of development is often undeservedly remains in the shadow of new scientific trends, however, it is the operational activity that is the basis, without rationalizing which it is impossible to build an effective structure of the post-industrial economy. Moreover, it is not only about the need to upgrade the main funds of industry, to increase the technical level of production, on the involvement of employees in the processes of improving the quality and awareness of the need for radical restructuring of production, but also that new approaches to the management of an industrial enterprise and its operating activities are required. Since the operational management is associated with processes directly generating a consumer value of products, and expresses the main competence of an industrial enterprise, it should take into account, first of all, such a significant factor of economic relations as uncertainty. Under the influence of dynamic transformations occurring in the post-industrial economy, the properties of the uncertainty of the external environment are also modified, namely, from discrete and non-benefit changes began to turn into systemic when the rates of renewal of products are accelerated, technological breakthroughs occur, the traditional borders of industries are changed, the competition turns into hyperconusation. The need to substantiate operating strategies for enterprises and transformations of management approaches to operating activities under systemic uncertainty led to the relevance of the topic of research. The article analyzes operational management in the enterprise management system. The fundamental principles of operational management and their impact on the effective functioning of the enterprise in the context of a modern market economy are considered.