Event Abstract Back to Event Restoration of segregated, physiological neuronal connectivity by desynchronizing stimulation Christian Hauptmann1* and Peter Tass1 1 Forschungszentrum Jülich, Institut für Neurowissenschaften und Medizin, Germany The loss of segregation of neuronal signal processing pathways is an important hypothesis for explaining the origin of functional deficits as associated with Parkinson’s disease. A modeling approach is utilized to study the influence of deep brain stimulation on the restoration of segregated activity in the target structures. Besides the spontaneous activity of the target network, the model considers weak sensory input mimicking signal processing tasks, electrical deep brain stimulation delivered through a standard DBS electrode and synaptic plasticity. We demonstrate that the sensory input is capable to induce a modification of the network structure which results in segregated microcircuits if the network is initialized in the healthy, desynchronized state. Depending on the strength and coverage, the sensory input is capable to restore the functional sub-circuits even if the network is initialized in the synchronized, pathological state. Weak coordinated reset stimulation, applied to a network featuring a loss of segregation caused by global synchronization, is able to restore the segregated activity and to resolve the pathological, synchronized activity. Based on these results we discuss novel technical concepts for the stimulation of neuronal structures with the aim to establish therapeutic deep brain stimulation. References Tass PA1999 Phase resetting in medicine and biology: Stochastic modelling and data analysis Springer Verlag, Berlin Tass PA 2003 Biol. Cybern. 89 81-88 Tass PA, Majtanik M 2006 Biol. Cybern. 94 58-66 Hauptmann C and Tass PA 2007 BioSystems 89 (2007) 173–181 Hauptmann C and Tass PA 2009 J. Neural Eng. 6 (2009) 016004 Tass PA and Hauptmann C 2009 Restorative Neurology and Neurosci. 27 589 Hauptmann C et al. 2009 J. Neural Eng. 6 066003 Tass PA et al. 2009 Phys. Rev. E 80, 011902 Keywords: computational neuroscience Conference: Bernstein Conference on Computational Neuroscience, Berlin, Germany, 27 Sep - 1 Oct, 2010. Presentation Type: Presentation Topic: Bernstein Conference on Computational Neuroscience Citation: Hauptmann C and Tass P (2010). Restoration of segregated, physiological neuronal connectivity by desynchronizing stimulation. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference on Computational Neuroscience. doi: 10.3389/conf.fncom.2010.51.00070 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Sep 2010; Published Online: 23 Sep 2010. * Correspondence: Dr. Christian Hauptmann, Forschungszentrum Jülich, Institut für Neurowissenschaften und Medizin, Jülich, Germany, christian.hauptmann@me.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Christian Hauptmann Peter Tass Google Christian Hauptmann Peter Tass Google Scholar Christian Hauptmann Peter Tass PubMed Christian Hauptmann Peter Tass Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.