Introduction. The study of the physiological status of representatives of power structures at different stages of service is very relevant.Purpose: a comprehensive assessment of the functional state of the body of OMON fighters before and after a 4-month business trip on perform a special task associated with health and life risks. Materials and methods. 34 OMON fighters of the Komi Republic were examined before the trip and after a 4-month trip to the North Caucasus, where they constantly experienced stress. To assess the functional state of the body, a complex of anthropometric, physiometric, psychophysiological, physiological and biochemical studies was used.Results and its discussion. Before the trip, the fighters showed an increase in the time of the visuomotor reaction, the index of functional changes, the myocardium index, the centralization index, the activity index of regulatory systems, blood pressure indicators and other changes that indicate the activation of free radical oxidation processes, and the appearance in individuals of prenosological and even premorbid conditions. In most of the examined patients, a shift in the autonomic balance was found towards strengthening the sympathetic link in the regulation of heart rhythm. Hypovitaminosis was found in many fighters. After a trip, the functional state deteriorated in most indicators (increased blood pressure, personal anxiety, cholesterol, etc., decreased life index and hemoglobin content, etc.) and the number of people with depleted regulatory systems almost doubled.Conclusion. In general, the body of OMON fighters experiences increased functional stress with signs of obvious stress both before a trip to an area dangerous for health and life, and in the first days after returning to places of permanent residence in the North. In this regard, they need additional health and rehabilitation measures related to optimization of the regime of work and rest, activation of physical education, rationalization of nutrition and strengthening the work on the psychological impact.