Objective To observe the clinical efficacy of ventilator-assisted breathing for the treatment of respiratory failure brainstem hemorrhage.Methods Clinical data of 29 cases of brainstem hemorrhage complicated with respiratory failure were retrospectively analyzed.Patients were treated with conventional symptomatic treatment based on ventilator-assisted breathing therapy and before and after treatment of ventilator-assisted breathing index changes were analyzed.Results After treatment,29 patients improved and discharged 11 patients(37.9%),and automatically discharged 10 patients(34.5 %),8 patients died(27.5%);R,PaO2,PaCO2,SaO2 significantly improved than before treatment(t=4.932,4.393,3.784,3.297,all P<0.05);compared with pre-treatment plasma albumin level,Glasgow score improved significantly(t=2.675,4.947,all P<0.05),blood glucose level before and after treatment,peripheral blood leukocytes count had no statistically significant differences(t=1.037,0.852,all P>0.05).Conclusion Ventilator-assisted respiratory therapy brainstem hemorrhage complicated with respiratory failure can significantly improve various respiratory indicators,improve the survival rate. Key words: Brain stem hemorrhage; Respiratory insufficiency; Respiration,artificial