Abstract
The neural pathways mediating respiratory load compensation in conscious rats are unknown. The current study determined brainstem and suprapontine neural activation associated with TO. TO were performed in conscious rats instrumented with an abdominal blood pressure telemetry probe, diaphragm electromyography electrodes, and a tracheal cuff. In experimental animals, the trachea was obstructed 60 times for 3–8 seconds per episode over the course of a 20 minute time period. This was repeated once a day for 10 days. Control animals were instrumented but received no obstructions. Animals were sacrificed after the 10th day of TO and brains were immediately removed, blocked, and placed in paraformaldehyde for later cytochrome oxidase (CO) staining. Respiratory‐related brainstem and suprapontine nuclei were stained intensely for CO in experimental animals. These results indicate that TO conditioning in conscious rats modulates respiratory brainstem and suprapontine discriminative and affective neural pathways.
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