Program Resources Research Articles

Bailed out: Defendants’ and stakeholders’ experiences of a bail support programme

AbstractDespite dropping crime rates and prison muster, pretrial population rates in New Zealand are growing faster than in other OECD nations, risking negative impacts on defendants and communities. Fourteen defendants and 18 stakeholders were interviewed about a bail support service's strengths and weaknesses. Officer‐training quality, communication between stakeholders and access to practical and cultural resources were crucial to success. Defendants reported that professional staff support and having access to services were the most helpful aspects. Changes were positive overall, but the programme's implementation, resources (especially lack of housing suitable for bail), and structure (within changing pretrial legislation) were of concern.

Initiating a Fetal Cardiac Program from Scratch in Low- and Middle-Income Countries: Structure, Challenges, and Hopes for Solutions.

Although fetal cardiac programs are well established in developed countries, establishing an efficient program in low- and middle-income countries (LMICs) is still considered a significant challenge. Substantial obstacles usually face the initiation of fetal cardiac service from scratch in LMICs. The primary structural frame of a successful fetal cardiac program is described in detail, emphasizing the required team members. The potential challenges for starting fetal cardiac services in LMICs include financial, awareness-related, prenatal obstetric screening, sociocultural, psychosocial, and social support factors. These challenges could be solved by addressing these barriers, such as collecting funds for financial support, raising awareness among families and health care providers, telemedicine, building international health partnerships, modifying training protocols for fetal cardiologists and sonographers, and initiating support groups and social services for families with confirmed fetal cardiac disease. Initiating a successful fetal cardiac program requires multi-aspect structural planning. The challenges for program initiation require diverse efforts, from modified training and promoting awareness of care providers and the community to governmental and nonprofit organizations' collaborations for proper building and utilization of program resources.

Intimate partner violence and quality of life among mothers in Jordan during COVID-19 era.

The study aims to examine the correlation between intimate partner violence [IPV] and quality of life [HRQoL] of mothers during COVID-19 era. This study is a cross-sectional correlational study. The inclusion criteria was Jordanian women with at least 18 years old, who read and write in Arabic language and able to participate. The collection of data was done through a self-reported questionnaire distributed and completely filled with 300 married Jordanian women using social media. This study was conducted between the months of October and December 2020. The participants signed consent after being informed of their rights to exit at any point during the study and the study methods. The prevalence of IPV among women was 28.3. The mean of quality of life is 86.0 [SD = 13.1) and the mean of violence is 11.9 [SD = 3.01). There was a significant negative relationship between violence and quality of life (r2 = .224, p = .001). This means as the violence increases, the quality-of-life decreases. In conclusion, there is an association between IPV and HRQoL among married people. Providing an education program and vital resources for women with the goal of preventing COVID-19 violence and assisting Jordanians become very essential.

In Vitro Collection for the Safe Storage of Grapevine Hybrids and Identification of the Presence of Plasmopara viticola Resistance Genes.

This paper focuses on the creation of an in vitro collection of grapevine hybrids from the breeding program of the Kazakh Scientific Research Institute of Fruit Growing and Viticulture and investigates the presence of Plasmopara viticola resistance mediated by Rpv3 and Rpv12 loci. We looked at the optimization of in vitro establishment using either shoots taken directly from field-grown plants or from budwood cuttings forced indoors. We further screened for the presence of endophyte contamination in the initiated explants and optimized the multiplication stage. Finally, the presence of the resistance loci against P. viticola was studied. The shoots initiated from the field-sourced explants were the more effective method of providing plant sources for in vitro initiation once all plant accessions met the goal of in vitro establishment. The concentration of phytohormones and the acidity of the culture medium have a great effect on the multiplication rate and the quality of in vitro stock cultures. Out of 17 grapevine accessions, 16 showed the presence of single or combined resistance loci against P. viticola. The grapevine accessions identified as carrying Rpv3 and Rpv12 alleles represent important genetic resources for disease resistance breeding programs. These accessions may further contribute to the creation of new elite cultivars of economic interest.

Relational Durkheim: Homo Duplex as the Foundation of a Formalist Cultural Sociology

I propose that the sociology of Émile Durkheim can serve as a useful foundation for a formalist cultural sociology. Durkheim’s homo duplex model of human cognition directs analytic attention to the relative balance of opportunities that the moral integration of society as a system of representations affords for establishing moral unity with others, on one hand, and realizing personal autonomy, on the other. This apriority, like Simmel’s forms, operates independently of any specific representational contents to produce outcomes related to solidarity, well-being, affect, and existential security. Accordingly, Durkheim provides conceptual resources for a hypothetico-deductive research program that promotes the development of testable hypotheses grounded in intuitions about how individuals phenomenologically experience formal properties of belief networks or other systems of social ideation.

A WOX homolog disrupted by a transposon led to the loss of spines and contributed to the domestication of lettuce.

The loss of spines is one of the most important domestication traits for lettuce (Lactuca sativa). However, the genetics and regulation of spine development in lettuce remain unclear. We examined the genetics of spines in lettuce using a segregating population derived from a cross between cultivated and wild lettuce (Lactuca serriola). A gene encoding WUSCHEL-related homeobox transcription factor, named as WOX-SPINE1 (WS1), was identified as the candidate gene controlling the spine development in lettuce, and its function on spines was verified. A CACTA transposon was found to be inserted into the first exon of the ws1 allele, knocking out its function and leading to the lack of spines in cultivated lettuce. All lettuce cultivars investigated have the nonfunctional ws1 gene, and a selection sweep was found at the WS1 locus, suggesting its important role in lettuce domestication. The expression levels of WS1 were associated with the density of spines among different accessions of wild lettuce. At least two independent loss-of-function mutations in the ws1 gene caused the loss of spines in wild lettuce. These findings provide new insights into the development of spines and facilitate the exploitation of wild genetic resources in future lettuce breeding programs.

Molecular mapping of the broad bean wilt virus 2 resistance locus bwvr in Capsicum annuum using BSR-seq

Key messageBulked segregant RNA seq of pools of pepper accessions that are susceptible or resistant to Broad bean wilt virus 2 identifies a gene that might confer resistance to this devastating pathogen.The single-stranded positive-sense RNA virus Broad bean wilt virus 2 (BBWV2) causes substantial damage to pepper (Capsicum annuum) cultivation. Here, we describe mapping the BBWV2 resistance locus bwvr using a F7:8 recombinant inbred line (RIL) population constructed by crossing the BBWV2-resistant pepper accession ‘SNU-C’ with the susceptible pepper accession ‘ECW30R.’ All F1 plants infected with the BBWV2 strain PAP1 were susceptible to the virus, and the RIL population showed a 1:1 ratio of resistance to susceptibility, indicating that this trait is controlled by a single recessive gene. To map bwvr, we performed bulked segregant RNA-seq (BSR-seq). We sequenced pools of resistant and susceptible lines from the RILs and aligned the reads to the high-quality ‘Dempsey’ reference genome to identify variants between the pools. This analysis identified 519,887 variants and selected the region from 245.9–250.8 Mb of the Dempsey reference genome as the quantitative trait locus region for bwvr. To finely map bwvr, we used newly designed high-resolution melting (HRM) and Kompetitive allele specific PCR (KASP) markers based on variants obtained from the BSR-seq reads and the PepperSNP16K array. Comparative analysis identified 11 SNU-C-specific SNPs within the bwvr locus. Using markers derived from these variants, we mapped the candidate bwvr locus to the region from 246.833–246.949 kb. SNU-C-specific variants clustered near DEM.v1.00035533 within the bwvr locus. DEM.v1.00035533 encodes the nitrate transporter NPF1.2 and contains a SNP within its 5′ untranslated region. The bwvr locus, which contains four genes including DEM.v1.00035533, could represent a valuable resource for global pepper breeding programs.

Post-fire Pinus radiata invasion in a threatened biodiversity hotspot forest: A multi-scale remote sensing assessment

Biological invasions are one of the most relevant factors of biodiversity loss, especially after fire disturbances. Wildfires can accelerate invasions of fire-prone species, like Pinus radiata, and dramatically alter ecosystems. However, how to assess the main impacts of this invasion process on the composition, structure, and functionality of ecosystems, including the post-fire revegetation processes, has not been fully resolved. This study aimed to evaluate the impacts of P. radiata invasion on fire-damaged forest ecosystems using combined remote sensing and in situ data, focusing particularly on changes in biodiversity, ecosystem structure, and functionality. The recovery of forest leaf area index (LAI) and the fraction of photosynthetically active radiation (FPAR) were monitored using Sentinel-2 time series products. Then the pre- and post-fire native community composition and the relationships of invasion and biodiversity with biotic and abiotic components were characterized using structural equation modeling (SEM). The postfire P. radiata density was mapped to quantify invasion intensity in three burned native forest fragments using generalized additive modeling (GAM) regressions based on UAS multispectral data. Biophysical metrics indicate that all forest fragments impacted by high, medium-high, and medium-low severity fires achieved a partial recovery of their canopy. The SEM model showed that microtopographic features and vegetation height explain native species diversity under pre-fire conditions due to their close relationship with favorable microclimatic conditions for species establishment. Vegetation height determined the abundance of P. radiata in post-fire conditions, and it negatively impacted diversity by promoting the homogenization of vegetation cover and altering diversity patterns. The general composition and abundance metrics also showed a substantial modification associated with the heavy (significant) invasion of P. radiata species. Predictive mapping of P. radiata density showed high accuracies (R2 =0.73 and explained deviation of 80%). The maps depicted an intense concentration of the invasive tree with a mean density of 76,217 individuals per ha−1 and high invasion spots with more than 176,000 individuals per ha−1. The quantification of invasion and mapping is a fundamental input for prioritizing areas and resources for a large-scale restoration program, and is a priority to avoid the loss of these highly threatened forest ecosystems.

Population genomics highlights structural variations in local adaptation to saline coastal environments in woolly grape.

Structural variations (SVs) are a feature of plant genomes that has been largely unexplored despite their significant impact on plant phenotypic traits and local adaptation to abiotic and biotic stress. In this study, we employed woolly grape (Vitis retordii), a species native to the tropical and subtropical regions of East Asia with both coastal and inland habitats, as a valuable model for examining the impact of SVs on local adaptation. We assembled a haplotype-resolved chromosomal reference genome for woolly grape, and conducted population genetic analyses based on whole-genome sequencing (WGS) data from coastal and inland populations. The demographic analyses revealed recent bottlenecks in all populations and asymmetric gene flow from the inland to the coastal population. In total, 1,035 genes associated with plant adaptive regulation for salt stress, radiation, and environmental adaptation were detected underlying local selection by SVs and SNPs in the coastal population, of which 37.29% and 65.26% were detected by SVs and SNPs, respectively. Candidate genes such as FSD2, RGA1, and AAP8 associated with salt tolerance were found to be highly differentiated and selected during the process of local adaptation to coastal habitats in SV regions. Our study highlights the importance of SVs in local adaptation; candidate genes related to salt stress and climatic adaptation to tropical and subtropical environments are important genomic resources for future breeding programs of grapevine and its rootstocks.

Automated Text Message–Based Program and Use of Acute Health Care Resources After Hospital Discharge

Postdischarge outreach from the primary care practice is an important component of transitional care support. The most common method of contact is via telephone call, but calls are labor intensive and therefore limited in scope. To test whether a 30-day automated texting program to support primary care patients after hospital discharge reduces acute care revisits. A 2-arm randomized clinical trial was conducted from March 29, 2022, through January 5, 2023, at 30 primary care practices within a single academic health system in Philadelphia, Pennsylvania. Patients were followed up for 60 days after discharge. Investigators were blinded to assignment, but patients and practice staff were not. Participants included established patients of the study practices who were aged 18 years or older, discharged from an acute care hospitalization, and considered medium to high risk for adverse health events by a health system risk score. All analyses were conducted using an intention-to-treat approach. Patients in the intervention group received automated check-in text messages from their primary care practice on a tapering schedule for 30 days following discharge. Any needs identified by the automated messaging platform were escalated to practice staff for follow-up via an electronic medical record inbox. Patients in the control group received a standard transitional care management telephone call from their practice within 2 business days of discharge. The primary study outcome was any acute care revisit (readmission or emergency department visit) within 30 days of discharge. Of the 4736 participants, 2824 (59.6%) were female; the mean (SD) age was 65.4 (16.5) years. The mean (SD) length of index hospital stay was 5.5 (7.9) days. A total of 2352 patients were randomized to the intervention arm and 2384 were randomized to the control arm. There were 557 (23.4%) acute care revisits in the control group and 561 (23.9%) in the intervention group within 30 days of discharge (risk ratio, 1.02; 95% CI, 0.92-1.13). Among the patients in the intervention arm, 79.5% answered at least 1 message and 41.9% had at least 1 need identified. In this randomized clinical trial of a 30-day postdischarge automated texting program, there was no significant reduction in acute care revisits. ClinicalTrials.gov Identifier: NCT05245773.

Costing of a Combination Intervention (Kyaterekera) Addressing Sexual Risk-Taking Behaviors among Vulnerable Women in Southern Uganda.

In Uganda, women engaged in sex work (WESW) are a marginalized population at the intersection of multiple vulnerabilities. The Kyaterekera intervention is targeted at WESW in Rakai and the greater Masaka regions in Uganda and combines a traditional HIV risk-reduction approach with a savings-led economic empowerment intervention and financial literacy training. We estimated the economic costs of the Kyaterekera intervention from a program provider perspective using a prospective activity-based micro-costing method. All program activities and resource uses were measured and valued across the control arm receiving a traditional HIV risk-reduction intervention and the treatment arm receiving a matched individual development savings account and financial literacy training on top of HIV risk reduction. The total per-participant cost by arm was adjusted for inflation and discounted at an annual rate of 3% and presented in 2019 US dollars. The total per-participant costs of the control and intervention arms were estimated at $323 and $1,435, respectively, using the per-protocol sample. When calculated based on the intent-to-treat sample, the per-participant costs were reduced to $183 and $588, respectively. The key cost drivers were the capital invested in individual development accounts and personnel and transportation costs for program operations, linked to WESW's higher mobility and the dispersed pattern of hot spot locations. The findings provide evidence of the economic costs of implementing a targeted intervention for this marginalized population in resource-constrained settings and shed light on the scale of potential investment needed to better achieve the health equity goal of HIV prevention strategies.

Supporting companies to reform nutrition policies and practices (REFORM): a multi-centre cluster randomised controlled trial

Unhealthy food environments are major drivers of obesity and diet-related diseases(1). Improving the healthiness of food environments requires a widespread organised response from governments, civil society, and industry(2). However, current actions often rely on voluntary participation by industry, such as opt-in nutrition labelling schemes, school/workplace food guidelines, and food reformulation programmes. The aim of the REFORM study is to determine the effects of the provision of tailored support to companies on their nutrition-related policies and practices, compared to food companies that are not offered the programme (the control). REFORM is a two-country, parallel cluster randomised controlled trial. 150 food companies were randomly assigned (2:1 ratio) to receive either a tailored support intervention programme or no intervention. Randomisation was stratified by country (Australia, New Zealand), industry sector (fast food, other packaged food/beverage companies), and company size. The primary outcome is the nutrient profile (measured using Health Star Rating [HSR]) of foods and drinks produced by participating companies at 24 months post-baseline. Secondary outcomes include company nutrition policies and commitments, the nutrient content (sodium, sugar, saturated fat) of products produced by participating companies, display of HSR labels, and engagement with the intervention. Eighty-three eligible intervention companies were invited to take part in the REFORM programme and 21 (25%) accepted and were enrolled. Over 100 meetings were held with company representatives between September 2021 and December 2022. Resources and tailored reports were developed for 6 touchpoints covering product composition and benchmarking, nutrition labelling, consumer insights, nutrition policies, and incentives for companies to act on nutrition. Detailed information on programme resources and preliminary 12-month findings will be presented at the conference. The REFORM programme will assess if provision of tailored support to companies on their nutrition-related policies and practices incentivises the food industry to improve their nutrition policies and actions.

A Nonrandomized Pilot Implementation Trial of the CLASS PAL (Physically Active Learning) Project

ABSTRACT Purpose To determine the a) implementation of CLASS PAL (Physically Active Learning), b) implementation process of CLASS PAL, and c) influence of the inner setting (i.e., school) and individuals (teachers and pupils) on the implementation of CLASS PAL. Methods CLASS PAL is a co-produced movement integration (MI) intervention that includes a professional development workshop for teachers and bespoke teaching resources. This study was a nonrandomized pragmatic pilot implementation trial using a mixed-methods design. Ten year-5 teachers and 232 pupils from seven state-funded UK primary schools participated. Data were collected over one academic year via mixed methods at multiple levels (school and individual) and timepoints. All qualitative data were analyzed using a priori thematic analyses, and quantitative data were summarized using descriptive statistics. Results Implementation: Teacher-reported MI activities were delivered on average 2 d·wk−1 (and once per day). The most frequently delivered activities were movement breaks (2.8 d·wk−1) and physically active routines (2.4 d·wk−1), with the majority lasting <5 min. One hundred percent of attendees rated both the professional development workshop and practical content of the workshop as “quite useful/very useful;” however, the resources on the website were only utilized by 30% of teachers. Implementation process: Teachers primarily amended personal resources, with only 5% of deliveries supported by resources from the CLASS PAL website/workshop. Inner setting/individuals: Teachers reported barriers including classroom misbehavior, curriculum pressures, and access to resources. Facilitators to MI included the intervention workshop and senior school leadership support. Conclusion Teachers receiving a low touch professional development and resource program reported regular implementation of MI. A key implementation strategy was teacher-level decisions. In relation to the influence of the inner setting/individuals, a range of factors which operated at pupil, school, and teacher levels were identified. Further work is required to understand how best to support MI implementation.

What Does the Military Health System Need to Support Future Combat Operations? Lessons From Aeromedical Evacuations From 2008 to 2020.

Aeromedical evacuations from the past few decades have yielded massive amounts of data that may inform the Military Health System (MHS) on patient needs, specifically for understanding the inpatient and outpatient needs of evacuees. In this study, we evaluate inpatient and outpatient trends based on aeromedical evacuation data from recent conflicts. We anticipate that evacuations requiring MHS inpatient beds are primarily trauma-related and necessitate an increased need for inpatient trauma care. We conducted a descriptive analysis of aeromedical evacuations using the U.S. Transportation Command Regulating and Command & Control Evacuation System database. We queried the database for aeromedical evacuations originating from the U.S. EUCOM and ending in the CONUS, from January 1, 2008 to June 4, 2020. With the resultant data, evacuee demographics were characterized by gender, age, active duty (AD) versus non-AD, and branch of service. Following this, the proportion of battle injury to disease and non-battle injury was categorized by both patient age ranges and year. Additionally, evacuations were stratified by their ICD codes, as well as the primary specialty responsible for care. Lastly, evacuations were categorized by inpatient and outpatient care status. The final dataset yielded 32,485 unique patients. The majority of evacuees were male (86.9%) with a mean age of 29.0 ± 9.6 years. Evacuees were primarily AD Military (96.7%), with the majority of those personnel being in the Army (70.2%). The total number of evacuations steadily increased from 2008 (n = 3,703) until a peak in 2010 (n = 4,929), which was also the peak year for battle injury (n = 1,472). Battle injury was also most prevalent in the 21 to 24 age group (24.7%) and declined in older age groups. Regarding diagnoses, the leading categories were injury/poisoning (33.1%), psychiatric (28.1%), and musculoskeletal (12.1%). As for specialty care of evacuees, psychiatry received the largest share of total evacuations (28.1%), followed by orthopedic surgery (22.7%) and general surgery (8.6%). Looking at proportions of inpatient and outpatient care, the majority of evacuees required outpatient care (65.6%) with a sizable minority requiring inpatient care (34.4%). Inpatient evacuations peaked in 2010 (n = 2,013), accounting for 40.8% of all evacuations that year. Orthopedic surgery had the largest share of inpatient evacuations (27.3%), followed by psychiatry (21.5%) and general surgery (18.2%). As for outpatient care, the specialties with the largest proportion of outpatient evacuations were psychiatry (33.6%), orthopedic surgery (20.3%), and neurology (9.8%). The results of this study reveal what the MHS can expect in future conflicts. Most evacuations are for psychiatric-/injury-/musculoskeletal-related diagnoses, typically requiring care by psychiatrists, orthopedic surgeons, or general surgeons. Outpatient care is important, though it is critical to bolster inpatient care requirements as future conflicts may bring extensive numbers of inpatient casualties. The MHS should program and plan resources accordingly, planning for the care of surgical/injured and psychiatric patients.

Telaah Faktor-Faktor Anteseden Job Engagement Karyawan PT Z

Job engagement is one aspect of employment that is crucial to pay attention, to maintain, and to increase its intensity of every employee who works in a company, considering the many positive impacts it can have. Through this research, job engagement will be studied as a result of intrinsic and extrinsic work motivation, work flexibility, and work-life balance. A total of 88 employees who work at PT Z, an e-commerce company in Indonesia, were surveyed regarding their perceptions regarding their work attitudes related to their experience at the company. Using multiple linear regression analysis, it has been proven that job engagement is influenced by intrinsic work motivation, work-life balance, and work flexibility. These results imply that companies need to implement human resource programs and policies that can maintain and improve employees' intrinsic work motivation, the ability and quality of employees in balancing their career and personal life, as well as designing more flexible work in line with current developments and the dynamics of employee needs.

Five years of local democracy in federal Nepal (2017–2022)

AbstractNepalʼs 2015 federal constitution empowers local governments with significant autonomy, power, and resources for local policymaking, developmental programs, and public services. This research examines this new landscape of local governance as experienced during the first electoral tenure from 2017 to 2022, exploring the quality of local democracy in Nepal. Designed as interpretive research and analysed through a set of participatory democracy frameworks, the findings uncover mixed progress in the capacity of local democratic institutions to utilise constitutionally guaranteed power and resources. The findings of this study offer fresh academic and professional insights on Nepalʼs local democracy, participatory governance, and federalism.

How an international research programme can contribute to improvements in the research environment: the perspective of doctoral students in sub-Saharan Africa.

The Africa Capacity Building Initiative (ACBI) programme aimed to 'strengthen the research and training capacity of higher education institutions and support the development of individual scientists in sub-Saharan Africa through UK-Africa research collaborations' including by funding PhD studentships. We conducted research to understand students' experiences and to see how consortia-based programmes such as ACBI and their own institutions can enhance PhD students' research environment and progress. In-depth interviews with 35 ACBI-funded PhD students explored their perspectives about how their research and personal development benefitted from belonging to a research consortium. Questionnaires were used to corroborate interview findings. Students recognised that membership of a research consortium provided many benefits compared to less well-resourced peers. By drawing on the programme and consortiums' resources, they were often able to overcome some limitations in their own institution's systems and facilities. Through their consortia they could access a wide range of international expertise and support from mentors and colleagues for their technical and psychosocial needs. Multiple consortia opportunities for engaging with the international scientific community and for networking, gave them confidence and motivation and enhanced their career prospects. Our study and its recommendations highlight how the breadth and diversity of resources available to PhD students through research consortia can be harnessed to facilitate students' progress and to create a supportive and conducive research environment. It also underlines how, through a multi-level approach, consortia can contribute to longer-term improvements in institutional research environments for PhD students.

National medical eligibility criteria for contraceptive use 2023: review

Individual sexual and reproductive life management has been сonfirmed by medical and state communities since 1990s. Every citizen officially received rights for access to appropriate goods and services. Such international agreements as 1994 International Conference on Population and Development (ICPD, Cairo, Egypt) and 2004 WHO Reproductive health strategy, estimated reproductive health and family planning as priorities. Worldwide agreement on the 2005 summit declares achieving of female reproductive health before year 2015 as worldwide progress.WHO created complex of international eligibility criteria for male and female contraception with the aim of medical aid improvement. According to WHO plan, those criteria should be used by countries considering policy, needs, priorities and resources of national healthcare programs. For example, USA, United Kingdom, Russia etc. have successfully adopted medical eligibility criteria for contraception on the national level.The present review is summary product created by interdisciplinary expert group including representers of federal and regional healthcare establishments, medical universities, and international medical organizations.

Optimization of carbon and nitrogen partitioning in DP202216 maize hybrids

ContextThe photoassimilates and nitrogen (N) allocation in grain crops can be studied via the harvest index (HI) and the N harvest index (NHI). These two variables should be considered in breeding programs seeking more effective use of resources in maize (Zea mays L.) and other grain crops. Molecular biotechnology has emerged as a complement to improve not only maize grain yield but also resource utilization efficiency. A recent study reported a beneficial impact of increasing and extending the expression of a maize MADS-box transcription factor (zmm28) on the NHI. ObjectiveThis research aimed to further identify enhancements of C-N partitioning (HI, NHI) in DP202216 maize hybrids recognizing the main physiological and morphological traits associated to the C-N dynamics via in-season intra-canopy measurements. MethodsTwo DP202216 elite hybrids were evaluated with their respective wild-type (WT) controls during two field growing seasons under two N regimes. The N nutrition index (NNI), as crop N status, was quantified to avoid misinterpretations of the results. ResultsThe DP202216 trait showed, on average, a ∼6% increase in the HI with a concomitant positive impact of ∼9% in the NHI across hybrids, N regimes, and seasons. Those increases were consistent at different crop NNI. After accounting for the NNI, it was shown that the increases in both HI and NHI were supported by the accumulation of more N in leaves (mainly in both lower and middle sections of the canopy vertical profile) and more water-soluble carbohydrates (WSC) in stems before flowering, combined with more aggressive post-anthesis remobilization. ConclusionIn this study, it was shown an increase in the efficient use of crop resources in DP202216 hybrids with respect to their isogenic WT controls at similar NNI via increments in C and N partitioning (HI and NHI). ImplicationsThis physiological and morphological understanding of C- and N-related traits addressed the challenge of optimizing the effective use of resources in maize breeding programs. To better understand traits by management interactions with yield and yield stability, DP202216 hybrid evaluations across a broad range of commercially relevant N scenarios would be valuable.

Pregnant Women's Experiences of Seeking Treatment for Opioid Use.

The purpose of this study was to describe women's experiences seeking treatment for opioid use disorder during pregnancy. This was an exploratory multi-method study to understand women's experiences seeking treatment for opioid use disorder during pregnancy using surveys and interviews. Women pregnant within the past 5 years while using opioids were recruited from a private Facebook group for mothers on medication for opioid use disorder. Members of this group assisted with the development of the survey. Descriptive statistics were used for the 18-question survey and interviews were recorded, transcribed, and analyzed for themes. Twenty-one women completed an online survey, and six participated in an in-depth virtual interview about their experience. Five themes describing their experiences were identified: (1) fear of child protective services, (2) family and partner support, (3) health care providers' reactions, (4) accessing treatment centers, and (5) awareness of support services during pregnancy . Participants reported an overall negative experience seeking treatment for opioid use disorder during pregnancy. Nurses can improve the outcomes for pregnant women with opioid use disorder by using a non-stigmatizing approach, promoting early identification, and providing information, including harm reduction education. Facilitation of resources for treatment, mother and child programs, and advocating for partner treatment can improve maternal and neonatal outcomes.