Resonant Response Research Articles

The nonlinear instability of transverse vibration behavior of functionally graded materials sandwich rectangular plates of under a harmonic loading and subsonic flow

This work is devoted to studying the combined action of periodic in-plane load and tangential subsonic flow on the nonlinear mechanism of the out-plane deformation of the functionally graded composite plate. Three distribution functions are proposed to investigate the distribution of the transverse shear strains and stresses across the thickness of the plates. By using Hamilton’s variational principle, the equations governing the plate instability boundaries are formulated. A nonlinear differential equation describing the first mode of the plate dynamic instability behavior by employing Galerkin’s method. The method of multiple time scales is used to obtain a periodic one-mode solution, which directly leads to the solvability condition. The different resonance cases for the interaction between the frequency of out- plane deformation and the external forces are discussed to discover the extent of the sandwich functionally graded material (FGM) rectangular plate resistance in the presence of external influences. Various bifurcation diagrams for different cases of resonance are obtained versus the basic parameters. In view of this study, we could get a deeper look at the complexity of frequency components in resonance responses of the sandwich FGM rectangular plate. The results could provide some suggestions for the sandwich plate’s vibration reduction design or fault diagnosis field or design fault diagnosis.

Dynamic Amplification of Railway Bridges under Varying Wagon Pass Frequencies

Train configurations give rise to a primary wagon pass forcing frequency and their multiples. When any one of these frequencies coincides with the natural frequency of vibration of the bridge, a resonant response can occur. This condition can amplify the dynamic response of the bridge, leading to increased levels of displacement, stresses and acceleration. Increased stress levels on critical bridge structural elements increases the rate at which fatigue damage accumulates. Increased bridge acceleration levels can affect passenger comfort, noise levels, and can also compromise train safety. For older bridges the effects of fatigue, and being able to predict the remaining life, has become a primary concern for bridge engineers. Better understanding of the sensitivity of fatigue damage to the characteristics of the passing train will lead to more accurate remaining life predictions and can also help to identify optimal train speeds for a given train–bridge configuration. In this paper, a mathematical model which enables the dynamic response of railway bridges to be assessed for different train configurations is presented. The model is based on the well established closed from solution of the Euler–Bernoulli Beam (EBB) model, for a series of moving loads, using the inverse Laplace–Carson transform. In this work the methodology is adapted to allow different train configurations to be easily implemented into the formulation in a generalised form. A generalised equation, which captures the primary wagon pass frequency for any train configuration, is developed and verified by presenting the results of the bridge response in the frequency domain. The model, and the accuracy of the equation for predicting the primary wagon pass frequency, is verified using independently obtained measured field train–bridge response data. The main emphasis of this work is to enable the practicing engineer, railway operators and bridge asset owners, to easily and efficiently make an initial assessment of dynamic amplification, and the optimal train speeds, for a given bridge and train configuration. This is visually presented in this work using a Campbell diagram, which shows dynamic amplification and compares this with those calculated based on the design code, across a range of train speeds. The diagram is able to identify train speeds at which a resonance response can occur, and the wagon pass frequency, or its multiples, which are causing the increased dynamic amplification. The model is implemented in Matlab and demonstrated by analysing a range of short- to medium-single span simply supported plate girder railway bridges, typically found on the UK railway network, using the standard BS-5400 train configurations. The model does not consider the effects of the train mass and suspension system as this would require a non-closed form numerical solution of the problem which is not practical for the purposes of an initial assessment of the train–bridge interaction problem.

Transmission electron microscopy reveals clusters of Au–Ag nanoparticles formed in TiO2 thin film, with enhanced plasmonic response

This work reports on the influence of nanoparticle (NP) size distribution and the chemical nature of gold (Au) and/or silver (Ag) NPs in the localized surface plasmon resonance (LSPR) responses. The NPs were produced embedded in a titanium dioxide (TiO2) thin film, deposited by reactive magnetron sputtering technique followed by in-vacuum thermal treatment at 400 °C. High-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) gave quantitative key information in terms of both the size and distribution of the noble metal NPs. The average Feret diameter was 17 nm (σ = 8) and 55 nm (σ = 28) for Au/TiO2 and Ag/TiO2 films, respectively, while the Au–Ag/TiO2 film showed intermediate values, with an average size of 22 nm (σ = 9). HAAD-STEM, complemented by EDX chemical mapping, revealed an unusual formation of cluster structures containing local distributions of bimetallic (alloyed) Au–Ag NPs. The synergetic characteristics and properties of such bimetallic Au–Ag NPs resulted in an outstanding LSPR sensitivity compared to the monometallic counterparts. Furthermore, the analysis of the average nearest neighbor distances (about one order of magnitude lower than counterparts) suggests the existence of plasmonic hotspots relevant to be explored in sensing and surface-enhanced spectroscopies.

Evaluating the impact of artificial maturation on the petrophysical and geochemical properties of unconventional shale formations by integrating dielectric and NMR measurements

This paper addresses challenges in characterizing unconventional shale reservoirs. For the first time, the nuclear magnetic resonance (NMR) and dielectric responses are integrated to characterize intact, saturated, and kerogen-rich subsurface shale samples at various maturation stages. The NMR and dielectric were measured separately using independent pieces of equipment, and all NMR and dielectric measurements were carried out at surface conditions. A comprehensive assessment is provided to address the changes induced by maturation through combined geochemical and petrophysical analyses. Shale samples from the Upper Cretaceous sequence of Jordan were characterized using Rock-Eval analysis, before and after maturation treatments. The total organic carbon (TOC) was decreased from 17.4 to 13.8 and 11.3 wt% and the pyrolyzed sulfur content was decreased from 3.32 to 0.25 and 0.15 3.18%, after maturing the samples at 250 °C for 1 and 5 days, respectively. The study employed NMR to track changes in pore structure via T2 relaxation time and measured dielectric properties and conductivity dispersion across frequencies from 10 MHz to 1 GHz using a wideband open-ended coaxial probe. After the maturation treatments, the dielectric constant of saturated shale samples doubled, and the conductivity increased by over three times. These changes in dielectric properties can be attributed to increased fluid-rock interfacial polarization and the formation of new pore spaces during maturation. NMR findings also indicated the emergence of a new pore system within the organic matter and the development of new fractures, resulting in a 6 to 12% increase in total porosity. The results obtained indicate that maturation-induced microstructural changes have a more significant influence on the dielectric responses than alterations on total organic carbon.

An Analysis of Split-Ring Resonators and Potential Barcode Application

This paper presents an analysis of various split-ring resonator (SRR) configurations coupled with coplanar waveguides (CPW). Three distinct resonant structures are presented, namely, the S-shaped split-ring resonator (S-SRR), the conventional split-ring resonator (SRR), and a pair of SRR. Among the examined resonant structures, it is observed that the S-SRR exhibits the smallest electrical size with the corresponding resonant frequency of 1.37 GHz, while the conventional SRR has the largest electrical size with the corresponding resonant frequency of 3.34 GHz. On the other hand, the resonant frequency of a dual SRR is 2.37 GHz. However, the transmission coefficient of a dual SRR is -11.43 dB, which is higher than S-SRR (-10.02 dB) and SRR (-8.18 dB). Furthermore, this study extends the analysis between a square dual SRR and a circular dual SRR with retained area. The square SRR demonstrates a lower resonance frequency (2.23 GHz) relative to its circular counterpart (2.37 GHz). The comparison also shows that the transmission coefficient of the square configuration is -13.88 dB, which is higher than its circular counterpart (-11.43 dB). The realization of a barcode application is achieved by loading multiple S-shaped split ring resonators (S-SRRs) with varying geometric parameters adjacently onto the transmission line. By individually rotating each of these S-SRRs, it becomes possible to alter the notch magnitude, thereby positioning it within a specific designated range corresponding to a particular code. In the case of a configuration involving rotations of (0°, 45°, 90°, 0°, 45°, 90°), this approach results in the creation of a barcode denoted as "100 010 000 100 011 000". This methodology enables the encoding of information in the form of distinctive resonant responses, providing a versatile and compact means of realizing barcode applications.

Underwater Thermoacoustic Generation by a Hierarchical Tetrapodal Carbon Nanotube Network.

Solid-state fabricated carbon nanotube (CNT) sheets have shown promise as thermoacoustic (TA) sound generators, emitting tunable sound waves across a broad frequency spectrum (1-105 Hz) due to their ultralow specific heat capacity. However, their applications as underwater TA sound generators are limited by the reduced mechanical strength of CNT sheets in aqueous environments. In this study, we present a mechanically robust underwater TA device constructed from a three-dimensional (3D) tetrapodal assembly of carbon nanotubes (t-CNTs). These structures feature a high porosity (>99.9%) and a double-hollowed network of well-interconnected CNTs. We systematically explore the impact of different dimensions of t-CNTs and various annealing procedures on sound generation performance. Furnace-annealed t-CNTs, in contrast to directly resistive Joule heating annealing, provide superior, continuous, and homogeneous hydrophobicity across the surface of bulk t-CNTs. As a result, the t-CNTs-based underwater TA device demonstrates stable, smooth, and broad-spectrum sound generation within the frequency range of 1 × 102 to 1 × 104 Hz, along with a weak resonance response. Furthermore, these devices exhibit enhanced and more stable sound generation performance at nonresonance frequencies compared to regular CNT-based devices. This study contributes to advancing the development of underwater TA devices with characteristics such as being nonresonant, high-performing, flexible, elastically compressible, and reliable, enabling operation across a broad frequency range.

Improving magnetic-field resilience of NbTiN planar resonators using a hard-mask fabrication technique

High-quality factor microwave resonators operating in a magnetic field are a necessity for some quantum sensing applications and hybrid platforms. Losses in microwave superconducting resonators can have several origins, including microscopic defects, usually known as two-level-systems. Here, we characterize the magnetic field response of NbTiN resonators patterned on sapphire and observe clear absorption lines occurring at specific magnetic fields. We identify the spin systems responsible for these features, including a yet unreported spin with g = 1.85 that we attribute to defects in the NbTiN thin film. We develop mitigation strategies involving, namely, an aluminum etch mask, resulting in maintaining quality factors above Q>2×105 in the range of 0–0.3 T.

MRI-guided cell membrane-camouflaged bimetallic coordination nanoplatform for combined tumor phototherapy

Nanotechnology for tumor diagnosis and optical therapy has attracted widespread interest due to its low toxicity and convenience but is severely limited due to uncontrollable tumor targeting. In this work, homologous cancer cell membrane-camouflaged multifunctional hybrid metal coordination nanoparticles (DRu/Gd@CM) were prepared for MRI-guided photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors. Bimetallic coordination nanoparticles are composed of three functional modules: dopamine, Ru(dcbpy)3Cl2 and GdCl3, which are connected through 1,4-Bis[(1H-imidazole-1-yl)methyl]benzene (BIX). Their morphology can be easily controlled by adjusting the ratio of precursors. Optimistically, the intrinsic properties of the precursors, including the photothermal properties of polydopamine (PDA), the magnetic resonance (MR) response of Gd3+, and the singlet oxygen generation of Ru(dcbpy)3Cl2, are well preserved in the hybrid metal nanoparticles. Furthermore, the targeting of homologous cancer cell membranes enables these coordinated nanoparticles to precisely target tumor cells. The MR imaging capabilities and the combination of PDT and PTT were demonstrated in in vitro experiments. In addition, in vivo experiments indicated that the nanoplatform showed excellent tumor accumulation and therapeutic effects on mice with subcutaneous tumors, and could effectively eliminate tumors within 14 days. Therefore, it expanded the new horizon for the preparation of modular nanoplatform and imaging-guided optical therapy of tumors.

Multimodal Resonance Response of Incompressible Hyperelastic Moderately Thick Cylindrical Shells

Based on the modified third-order shear deformation theory, the harmonic balance method, and the pseudo-arclength continuation method with two-point prediction, the nonlinear forced vibration response of incompressible hyperelastic moderately thick cylindrical shells subjected to a concentrated harmonic load at mid-span and simply supported boundary conditions at both ends is investigated. The algorithmic procedure for solving steady-state periodic solutions of strongly nonlinear systems of differential equations is presented. The structural response characteristics of shells under different excitation amplitudes and structural parameters are analyzed. The numerical results indicate that the aspect ratio of moderately thick hyperelastic cylindrical shells has a significant effect on the natural frequency ratio. Different frequency ratios lead to varying nonlinear mode coupling effects. The coupling effects among modes result in complex nonlinear behavior in the vibration response of each mode, leading to abundant multi-valued phenomena in the response curve.

1/2 and 1/3 Subharmonic Resonance Behaviors of a Rotating FG-CNTRC Beam with Geometric Imperfections

This paper aims at investigating 1/2 and 1/3 subharmonic resonances of a rotating functionally graded carbon nanotube-reinforced composite (FG-CNTRC) beam in the presence of geometric imperfections. A general function is introduced to denote three types of imperfections containing sine, global, and local modes. At first, based on the von-Kármán geometric nonlinearity assumption, the forced vibration equation is set up. Then, the Galerkin method and multiple scale method are utilized to study subharmonic resonance behaviors. Finally, coupled effects of FG-CNTRCs, rotating motion, and geometric imperfections on subharmonic resonance responses are investigated. It is found that a specific range of the excitation amplitude and frequency motivates the subharmonic resonance behavior. The coupling of geometric imperfections and geometric nonlinearities generates the 1/2 resonance phenomena, and geometric nonlinearities result in the 1/3 resonance behavior. Both the imperfection mode and amplitude can affect the resonance response and resonance regions. Moreover, in contrast with the 1/3 subharmonic resonance, geometric imperfections produce greater influence on the 1/2 subharmonic resonance.

A parametric study on the effect of ring damper on wheel damping

Ring dampers have been widely applied to control vibration of, and noise from, train wheels due to the simple structure, negligible impact on operational safety and potential in vibration and noise reduction. Yet, parameters affecting the vibro-acoustic performance of a ring-damped wheel are not adequately studied. In this paper, the apparent modal damping ratios of a ring-damped wheel are studied numerically using a finite element model allowing for frictional nonlinearity. Studied parameters include the impact force used to excite the wheel, the preload in the ring, the friction coefficient of the interface between the ring and the wheel, and the number of rings installed. Several findings can be drawn from the study. Installation of one or two rings to the wheel does not change the resonance frequencies (they are also termed the modal frequencies of the ring-damped wheel) but reduces the resonance responses by generating extra damping to the modes. The ring is more effective for radial excitation than for axial excitation. At most modal frequencies, damping with double rings is higher than with a single ring. Although there are few modal frequencies at which the modal damping ratios are reduced by installing the second ring, the average damping ratio with two rings is much higher, by a factor of 2.37 for axial excitation and 1.73 for radial excitation, than that with a single ring. The apparent damping of the ring-damped wheel increases with the level of the impact force, especially for radial excitation. There is an optimal combination of the preload in the ring and the frictional coefficient with which damping induced by the ring is the highest. Besides, the average damping ratios of the modes above 2000 Hz are proposed to be an indicator of the effectiveness of the performance of a ring-damped wheel in noise reduction.

Nonlinear vibrations of porous-hyperelastic cylindrical shell under harmonic force using harmonic balance and pseudo-arc length continuation methods

The resonant responses are investigated for the porous-hyperelastic Mooney–Rivlin cylindrical shell subjected to a radial harmonic excitation. Considering the higher-order shear deformation theory (HSDT), fourth-order strain-displacement relations are derived, which include the radial geometric imperfections varying along the thickness direction. Using the porous-hyperelastic Mooney–Rivlin constitution relation and Lagrange equation, the differential governing equations of motion are obtained for the porous-hyperelastic cylindrical shells. The resonant conditions are presented and the accuracy of the mathematical models is verified. The harmonic balance and pseudo-arc length continuation methods are used to obtain the amplitude-frequency and forced-amplitude curves. The stability of the solutions is analyzed by Floquet theory. The effects of the external excitation amplitudes, structure parameters and porosity infill parameters on the linear frequencies, amplitude-frequency responses and force-amplitude responses are discussed for the imperfect porous-hyperelastic cylindrical shells. The results show that the linear frequencies of the porous-hyperelastic cylindrical shells increase obviously as the uniform and sigmoid function porosity parameters reach the certain values. The increase of the structure parameters enhances the response amplitudes of the first-order mode and minified response amplitudes of the second-order mode. The decreasing porosity ratios weaken the softening nonlinear behaviors of the porous-hyperelastic cylindrical shells. With the changes of the external excitation amplitudes and structure parameters, the motion of the porous-hyperelastic cylindrical shell indicates that the synchronous vibrations occur with the period and chaotic vibrations alternately.

Resonant response of a flexible semi-submersible floating structure: experimental analysis and second-order modelling

The dynamics and nonlinear wave forcing of a flexible floating structure are investigated experimentally and numerically. The floater was designed to match sub-harmonic rigid-body natural frequencies of typical floating wind turbine substructures, with the addition of a flexible bending mode. Experiments were carried out for three sea states with phase-shifted input signals to allow harmonic separation of the measured response. We find for the weakest sea states that sub-harmonic rigid-body motion is driven by even-harmonic difference frequency forcing, and by linear forcing for the strongest sea state. The flexible mode was tested in a soft, linearly forced layout, and a stiff layout, forced by second-, third- and fourth-harmonic frequency content, for increasing severity of the sea state. Further insight is gained by analysis of the amplitude scaling of the resonant response. A new simplified approach is proposed and compared with the recent method of Orszaghova et al. (J. Fluid Mech., vol. 929, 2021, A32). We find that resonant surge and pitch motions are dominated by even-harmonic potential-flow forcing and that odd-harmonic response is mainly potential-flow driven in surge and mainly drag driven in pitch. The measured responses are reproduced numerically with second-order forcing and quadratic drag loads, using a recent and computationally efficient calculation method, extended here for the heave, pitch and flexible motions. We are able to reproduce the response statistics and power spectra for the measurements, including the subharmonic pitch and heave modes and the flexible mode. Deeper analysis reveals that inaccuracies in the even-harmonic forcing content can be compensated by the odd-harmonic loads.

On the nonlinear moonpool responses in a drillship under regular heading waves

In this study, the nonlinear and viscous damping effects on the free-surface elevations of the recess-type moonpool inside a drillship are investigated. Based on a three-dimensional nonlinear potential flow (NPF3D) model, the nonlinear moonpool responses excited by regular heading waves are simulated in the time domain. To consider the vortex-shedding damping effects, induced by nonlinear moonpool responses, the pressure drop model of Chu et al. [Chu et al., “Effects of nonlinearity and viscous damping on the resonant responses in two-dimensional moonpools with a recess,” Appl. Ocean Res. 127, 103295 (2022)] is extended to three-dimensional and combined with NPF3D to form a viscous modified nonlinear potential flow model (referred to as NPF3D_V). The pressure drop model is composed of two parts in order to account for the energy loss from the first harmonic (piston-mode motions) and higher harmonics (sloshing-mode motions), respectively. The investigation focuses on the piston-mode resonance and secondary resonances of the first and second longitudinal sloshing modes. The response amplitude operators of the higher harmonics, by which the nonlinear effects are evaluated, are computed by the NPF3D_V model. It is found that the higher harmonics are noticeable at the excitation frequencies ωn0/m, where secondary resonances of the nth longitudinal sloshing mode are triggered. In addition, it is found that increasing the length of the recess can promote the nonlinear response of the moonpool significantly. For the moonpool with a long recess, the higher harmonics at secondary resonance are comparable to the first harmonics.

Investigating the resonance response of a system of two ultrasound-driven lipid encapsulated microbubbles confined within a viscoelastic vessel

Lipid encapsulated microbubbles, strongly characterized by the initial phospholipid concentration, are clinical ultrasound imaging agents. These microbubbles are commonly used as an ultrasound contrast agent and are being developed for therapeutic applications. In this work, we investigate the vibration dynamics of two microbubbles confined within a viscoelastic vessel. We developed a finite element model to study radial microbubble dynamics in a two-bubble system, as typical clinical doses result in closely spaced bubbles. Specifically, we study the effect of the vessel wall viscosity on the resonance behaviour of microbubbles in the frequency range of 2– 8 MHz. For two identical microbubbles, we observed a decrease in 50% in resonance amplitude as we increased the vessel viscosity from 0.1 to 1 Pa s as well as an 8% shift of peak resonance activity towards higher frequencies. Furthermore, we investigated the same system consisting of microbubbles with a lower initial phospholipid concentration and showed the same decrease in amplitude; however, the direction of shift of peak resonance was towards lower frequencies by 4%. Our work suggests that microbubble resonance behaviour is greatly affected by the vessel viscosity and that the extent and direction of bubble dynamics changes are dependent on shell characteristics.

3D-printed biosensors in biomedical applications exploiting plasmonic phenomena and antibody self-assembled monolayers.

In this work, a 3D-printed plasmonic chip based on a silver-gold bilayer was developed in order to enhance the optical response of the surface plasmon resonance (SPR) probe. More specifically, numerical and experimental results were obtained on the 3D-printed SPR platform based on a silver-gold bilayer. Then, the optimized probe's gold plasmonic interface was functionalized with a specific antibody directed against the p27Kip1 protein (p27), an important cell cycle regulator. The 3D-printed plasmonic biosensor was tested for p27 detection with good selectivity and a detection limit of 55 pM. The biosensor system demonstrated performance similar to commercially available ELISA (enzyme-linked immunoassay) kits, with several advantages, such as a wide detection range and a modular and simple-based architecture. The proposed biosensing technology offers flexible deployment options that are useful in disposable, low-cost, small-size, and simple-to-use biochips, envisaging future applications in experimental and biomedical research.

Piezo inkjet formation of Ag nanoparticles from microdots arrays for surface plasmonic resonance

The study aims to explore a novel approach for fabricating plasmonic nanostructures to enhance the optical properties and performance of various optoelectronic devices. The research begins by employing a piezo-inkjet printing technique to deposit drops containing Ag nanoparticles (NPs) onto a glass substrate at a predefined equidistance, with the goal of obtaining arrays of Ag microdots (Ag-µdots) on the glass substrate. This process is followed by a thermal annealing treatment. The printing parameters are first optimized to achieve uniform deposition of different sizes of Ag-µdots arrays by controlling the number of Ag ink drops. Subsequently, the printed arrays undergo thermal annealing at various temperatures in air for 60 min, enabling precise and uniform control over nanoparticle formation. The printed Ag nanoparticles are characterized using field emission scanning electron microscopy and atomic force microscopy to analyze their morphological features, ensuring their suitability for plasmonic applications. UV–Vis spectrophotometry is employed to investigate the enhanced surface-plasmonic-resonance properties of the printed AgNPs. Measurements confirm that the equidistant arrays of AgNPs obtained from annealing Ag microdots exhibit enhanced light-matter interaction, leading to a surface plasmon resonance response dependent on the Ag NPs’ specific surface area. These enhanced surface plasmonic resonances open avenues for developing cutting-edge optoelectronic devices that leverage the benefits of plasmonic nanostructures, thereby enabling new opportunities for future technological developments across various fields.

Time-delay feedback control of a suspended cable driven by subharmonic and superharmonic resonance

The longitudinal time-delay feedback control strategy is implemented to suppress the subharmonic and superharmonic responses of the suspended cable. Formulated based on the Hamilton variational principle and the longitudinal time-delay feedback strategy, the in-plane nonlinear differential equations for a suspended cable are formulated, and Galerkin method is utilized to transform the equations into delayed differential equations. By using the method of multiple scales, approximate solutions for the 1/2-subharmonic and second-order superharmonic resonance responses of the controlled suspended cable were derived. The effects of the time delay and control gain are obtained through numerical examples. The research results demonstrate that through the adjustment of control gain and time delay, resonance regions can be avoided, effectively suppressing large-amplitude vibrations in the suspended cable, thereby achieving favorable control performance.

Thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of EGF to inhibit cervical cancer recurrence

Overexpression of epidermal growth factor receptor (EGFR) in cancer is a key cause of recurrence of cervical cancer (CC). Although the EGF-EGFR pathway has been studied for decades, preventing tumor growth and recurrence caused by peripheral EGF remains a great challenge. In this work, a strategy is proposed to reduce the stimulation of high concentration EGF on tumor growth by using a thermo-sensitive hydrogel. The hydrogel is a triblock copolymer composed of polyethylene glycol (PEG) and poly (lactide glycolide) (PLGA). Based on the excellent temperature sensitivity, carrier capacity, swelling property and biocompatibility, the hydrogel can absorb the liquid around the tumor by injection and release EGF continuously at low concentration. The inhibitory effect of hydrogel on tumor growth is fully confirmed by an implanted tumor mouse model with human cervical cancer cell lines (HeLa) using triple-immunodeficient NCG mice. Compared with free EGF, the EGF-loaded hydrogel can hardly induce surface plasmon resonance (SPR) response, which proves that hydrogel can effectively weaken cytoskeleton rearrangement and inhibit cell migration by continuously releasing low concentration EGF. In addition, the EGF-loaded hydrogel can reduce cell proliferation by delaying the progress of cell cycle progression. Taken together, the hydrogel can effectively protect tumor microenvironment from the stimulation of high concentration EGF, delay cancer cellular processes and tumor growth, and thus providing an approach for inhibiting tumor recurrence of CC.

Real-Time Tracking of Carbon Dioxide Concentration Using an Optical Microsphere Resonator Sensor.

Whispering gallery mode resonator sensors are nondisruptive optical sensors that can detect and monitor perturbations in a gaseous environment. Through its resonant properties of peak wavelength, amplitude, and quality factor (Q factor), changes in concentration can be quantified within seconds and monitored over days with great stability. In addition, the small footprint, low cost, and high sensitivity are ideal properties for a disposable sensor that can be utilized in extreme environments. The large Q factor of the resonant cavity enables long interaction lengths and amplifies the effect of small changes in the background refractive index, which is detectable in picometer shifts of the resonance wavelength. However, this measurement is susceptible to changes in other environmental factors such as temperature, pressure, and humidity, which manifest on the picometer wavelength scale, reinforcing the need to decouple the variables. In this work, we compare the spectral response of different diameter resonators to carbon dioxide, nitrogen, and its mixtures, observing the spectral shifting and broadening of the cavity resonance near 1550 nm. In addition, the effect of environmental temperature on spectral shifting due to the thermo-optic effect is characterized and quantified. Lastly, the gas concentrations are changed in real time to showcase the tracking and recovery capabilities of the resonator sensor.