Management of phosphine resistance in the cigarette beetle Lasioderma serricorne (F.) has become a topic of great interest to the tobacco industry in recent years. Effective use of contact insecticides with modes of action different from that of phosphine can be a key element in preventing or delaying the evolution of phosphine resistance. This study was conducted to ascertain whether five insecticides selected from three mode-of-action classes (fenitrothion, pirimiphos-methyl, permethrin, bifenthrin, and spinosad) can be incorporated into a phosphine-resistance management strategy. Specifically, we examined the contact efficacy of the insecticides to a phosphine-susceptible strain and six resistant strains (38–184-fold in resistance ratio based on LC50). Susceptibility to organophosphates (fenitrothion, pirimiphos-methyl) and spinosad was not significantly different between phosphine-susceptible and phosphine-resistant strains (within 2.3-fold resistance ratio). The absence of the cross-resistance between these insecticides and phosphine makes them ideal for resistancemanagement programmes. However, high resistance to synthetic pyrethroids (>145-fold for permethrin and >1697-fold for bifenthrin) was found in three of six phosphine-resistant strains. Based on these results, synthetic pyrethroids cannot be recommended as insecticides of primary choice.