The aircraft structure would be suffered high temperature during the hypersonic flight. To solve the problem of high temperature resistance of hypersonic aircraft, the mechanical properties of different structural materials at different temperatures are studied. The tensile strength and tensile modulus of structural steel, aluminum alloy, titanium alloy, resin matrix composites and polyimide composites are analyzed, and the performance of the materials at high temperature is compared. The results show that the properties of typical materials will decrease with the increase of temperature. The high-temperature mechanical properties of structural steel and aluminum alloy are poor, and the titanium alloy can withstand higher temperature. Polyimide resin composites can work at higher temperature for a long time compared with epoxy resin and bismaleimide resin composites, and it has more obvious advantages than titanium alloy at 400 °C. Polyimide resin composite has great potential to replace traditional materials as load-bearing structural material of hypersonic aircraft.