ABSTRACT Enhancing the resilience of urban agglomerations is crucial for regional sustainable development. By analyzing the regional resilience of Chengdu-Chongqing Twin Cities Economic Circle (CCEC) from 2006 to 2018, this paper explores the development level of regional resilience, and tries to apply the new perspective of niche related method to the research of regional resilience. Based on the urban resilience theory and the ecological niche theory, this paper constructs the regional resilience index (RRI) from the four dimensions of ecology, economy, society and resources, and selects the suitability, robustness and diversity indicators to construct the regional resilience evaluation index system. The results show that the regional suitability of the central urban area shows a positive trend, showing that the suitability of urban development in the core area is better, and the suitability of urban development in the second edge area is weaker. From the perspective of regional robustness characteristics, the differences in the four dimensions of ecology, economy, society and resources are on the rise, and there are certain risks of system robustness. From the characteristics of regional diversity, the interaction between cities at the same level is more frequent, the competition between core cities is fierce, the secondary cities are homogeneous, the system function and structure similarity within the region is high, and the diversity of regional resilience is poor. Finally, the current situation of resilience in the CCEC region is discussed and suggestions for optimization are made.