Conventional Fenton oxidation technique utilized for the treatment of antibiotics is plagued by issues such as extra H2O2 requirement and harsh reaction conditions. In this work, an “all-in-one” membrane reactor with H2O2 self-supply and self-catalysis at natural pH conditions for multiplex antibiotic residues degradation was developed by loading bifunctional composite Pt/CuO2 Janus nanoparticles (Pt/CuO2 JNPs) on the surface of the PVDF membrane. Specifically, the Fenton reagents H2O2, which was generated from the decomposition of the functional material CuO2 NPs in a near natural pH condition without extra addition, was synergistic activated by nano-enzyme Pt NPs and Cu2+. This, in turn, greatly improves the practicability of the reactor. Notably, the large number of nanopores present on the surface of the reactor endows it with a confined self-enhancing effect, which could greatly improve its catalytic degradation efficiency of antibiotics. The developed membrane reactor is capable of degradation 97.6 % of chloramphenicol (CAP) residues after several cycles of filtration. The apparent rate constant of the developed membrane reactor for CAP is approximately folded for the bulk reaction system. What’s more, the developed membrane reactor features favorable usability and preservability and superior universality for common antibiotics.