Membrane distillation (MD) is a promising method for liquid desiccant (LD) regeneration as it can mitigate LD carryover and produce freshwater as a by-product. Previous research on MD regeneration was mainly focused on performance evaluation and optimization of the regenerator itself. This paper proposed a hybrid solar-driven direct contact MD (DCMD) regeneration-assisted liquid desiccant air conditioning (LDAC) system for air dehumidification, cooling, and freshwater production. A mathematical model for the DCMD regenerator was first developed by considering both temperature and concentration polarizations. This model was validated against the experimental data in terms of the outlet channel temperature and LD solution concentration in the feed tank with relative deviations of ± 9.8 % and ± 0.5 %, respectively. The DCMD model was further integrated into an LDAC system with a batch-wise operation. To investigate the technical feasibility of the proposed system, a one-week simulation was conducted in a residential house during summer in a tropical climate area of Australia. The results showed that the latent heat load was effectively removed from the process air and the regenerated liquid desiccant solution can meet the dehumidification requirement with a concentration over 30.0 wt%. The dehumidification rate and regeneration rate were at 0.49–1.25 kg/h and 0.95–4.25 kg/h, respectively. Solar energy contributed to 52 %-78 % of the total system thermal energy consumption. Furthermore, this system can produce 11.0–12.8 kg of water daily.