Abstract The construction industry is a major contributor to environmental degradation, resource depletion, and energy consumption. As global concerns about sustainability and environmental impact continue to rise, it becomes imperative to reassess the materials used in building construction. This research paper presents a comprehensive life cycle assessment (LCA) using the Belgian TOTEM tool according to EN15804+A2 for evaluating material choices in building construction with a focus on the renovation of residential buildings in Belgium. The study aims to provide a holistic understanding of the environmental implications associated with biobased construction materials enabling informed decision-making for sustainable building practices. To achieve this, we conducted an analysis of the life cycle environmental performance of biobased materials used in external walls of a renovation case study project and compared it to common built-up scenarios of conventional construction materials applied in the same case study. The research results show that using biobased materials for renovation can significantly reduce embodied GHG emissions but can lead to burden shifting such as resulting in an increased impact on land use, particulate matter emissions, depletion of abiotic resources and eco-toxicity. The study not only underscores the importance of comprehensive cradle-to-grave life cycle thinking but also provides valuable insights for stakeholders in the construction industry.