The unscrupulous and unregulated use of antibiotics in medical and veterinary medicine has given rise to the problems of antimicrobial resistance (AMR) that poses a significant threat to the health control measures for both humans and animals. Despite being considered the defining organ for many gut and extra-gastrointestinal diseases, the gut microbiome also serves as a reservoir of antibiotic-resistance genes, which could potentially transfer to pathogens and contribute to the emergence of drug-resistant bacteria. In this context, probiotics and related products (prebiotics, synbiotics and eubiotics, etc.), which bring about their positive effects through the modulatory role(s) on the gut microbiome, constitute a potential nutritional approach for mitigation of AMR. This brief review aims to highlight the concept of using probiotics and related products to moderate AMR through elucidation of their role in health promotion and disease prevention while underlining the complexities of the relationship attributable to several intrinsic and extrinsic factors. The primary role of nutrition, which provides vital nutrients for the body's growth and development, has extended further to cover functions like health maintenance and illness prevention. Backed by extensive research in food bioscience, nutrition is now recognized as a crucial factor in the onset (and therefore management) of numerous health problems, including obesity, allergies, cardiovascular illnesses, and cancer, etc. Nutritional strategies, thus, are becoming one of the critical approaches for the prevention and management of many infectious and non-infectious diseases in humans and animals. The use of probiotics in augmenting the health of man and animals comes under this extended definition of nutrition. It is now universally accepted for its myriad health benefits extending beyond the gastrointestinal (GI) tract. Further to the health benefits per se, probiotics are also being looked into as potential alternatives to antibiotic growth promoters (AGP) in farm animal production and antibiotic use in human and veterinary medicine that has led to the emergence of antimicrobial resistance (AMR).