The physical and mechanical properties of the reservoir bank slope deteriorate under the fluctuation of water level, causing bank debonding and slippage, which can produce different degrees of damage to the bridge foundation, piers, and superstructure, a condition that is difficult to treat. In this paper, for a Yangtze River Bridge bank slope instability problem in the Three Gorges reservoir area, a numerical model of the bank slope and bridge was established using the finite element-SPH conversion coupling algorithm, and the pile pier damage development law and damage mode (deformation and stress–strain curves of the bank slope and pile foundation) were obtained according to the geological conditions of the bridge location. Additionally, combined with the characteristics of bank destabilization in the reservoir area of the Three Gorges Yangtze River Bridge, landslide management is proposed by using soil drainage and anti-slip pile reinforcement measures. In addition, for the characteristics of bridge pier deflection, a comprehensive deflection correction reinforcement method of pushing deflection correction, adding pile foundation, expanding pile bearing, and increasing pier cross-sectional area is proposed, so as to provide a theoretical basis for the prevention and control of reservoir bank landslides, the service life of pile structure, and the disposal of diseases.