Reserve In Women Of Reproductive Age Research Articles

Exposure to heavy metallic and trace essential elements and risk of diminished ovarian reserve in reproductive age women: A case-control study

The associations between metallic elements and ovarian reserve function have remained uncertain yet. In this case-control study, we involved 149 women with diminished ovarian reserve (DOR) and 151 women with normal ovarian reserve, and assessed the levels of six heavy metallic (Cr, Cd, As, Hg, Pb, and Mn) and seven trace essential (Se, Fe, Zn, Co, Mo, Cu, I) elements in their follicular fluid with inductively coupled plasma mass spectrometry. Associations were examined with logistic regressions and Bayesian kernel machine regression (BKMR). As a result, we found that the medium and the highest tertiles of Pb were significantly associated with an increased likelihood of DOR compared to the lowest tertile, while the medium or/an the highest tertiles of Cu, I, and Fe showed significantly lower likelihoods of DOR compared to the lowest tertiles. Cu and Pb showed significantly non-linear associations with ovarian reserve markers such as follicle-stimulating, anti-mullerian hormone levels, and antral follicle count. With the rising overall concentrations of heavy metals, the likelihood of DOR increased although not significant. There was a trend of a "U-shaped" association across the whole concentration range of trace essential elements and the likelihood of DOR. Our study revealed that avoiding heavy metallic elements and properly supplementing trace essential elements are conducive to ovarian function.

EFFECT OF SURGICAL TREATMENT ON SERUM AMH LEVELS IN OVARIAN DISEASES

Introduction The relationship between various ovarian diseases and its treatment on ovarian reserve is a subject of debate. It is difcult to determine the real impact of the ovarian surgery on future fertility of women. This study aimed to assess the effect of conservative ovarian surgeries on ovarian reserve in reproductive age women by correlation of preoperative and post operative S.AMH. Materials And Methods: This prospective study included 66 patients of reproductive age with various ovarian diseases. Ethical clearance was obtained from Institutional ethics committee and informed consent from all recruited patients. They were grouped into inammatory or benign disease, malignant disease and ovarian endometrioma by histology. S. AMH was compared in the three groups pre-operatively, after 4 weeks and after 3-6 months of surgery. The statistical analysis was done with SPSS version 15. Result: Mean decline in S> AMH at 4 weeks was 0.16, 0.40 and 0.33 respectively for inammatory/benign, malignant and endometrioma groups. Similarly, after 3-6months, it was 0.17, 0.75 and 0.37 respectively for the three groups. Statistically, both malignant and endometrioma groups showed signicantly higher decline as compared to inammatory/benign group (p<0.001). Conclusion: Baseline S.AMH levels are signicantly lower in endometrioma and malignant ovarian tumours as compared to benign ovarian tumours. They show a signicant decline following surgical treatment in all ovarian diseases but the decline is signicantly more endometrioma and malignancy.

Dietary patterns are associated with improved ovarian reserve in overweight and obese women: a cross-sectional study of the Lifestyle and Ovarian Reserve (LORe) cohort

BackgroundGrowing evidence suggests that adherence to certain dietary patterns is associated with improved fecundity and reproductive outcomes in the general population and infertile couples assisted reproductive treatments. The objective of this study was to assess if dietary patterns are associated with ovarian reserve in reproductive age women without a history of infertility.MethodsThis was a cross-sectional study of 185 women in the Lifestyle and Ovarian Reserve (LORe) cohort. Women aged 18–44 without a history of infertility were recruited from the local community at an academic medical center. Subjects completed validated food frequency and physical activity questionnaires to assess patterns over the year prior to presentation. Dietary patterns including a Western (including meat, refined carbohydrates, high-calorie drinks), prudent (including fruits, vegetables, olive oil and nuts), fertility (lower intake of trans fat with higher intake of monounsaturated fatty acids, increased intake of plant based protein, high-fat dairy, lower glycemic load carbohydrates and supplemental iron) and profertility diet (PFD) (characterize by whole grains, soy and seafood, low pesticide residue produce, supplemental folic acid, B12 and vitamin D) were identified through principal component analysis. Main outcome measures were serum antimullerian hormone concentration (AMH) (ng/mL) and antral follicle count (AFC) obtained by transvaginal ultrasound.ResultsAfter stratifying by BMI, adjusting for age, smoking and physical activity, dietary patterns were not associated with ovarian reserve in normal weight women. Increased adherence to a profertility diet in overweight and obese women (BMI ≥ 25 kg/m2) was associated with a significantly higher AMH. Women in the third and fourth quartiles of PFD adherence had a mean AMH concentration of 1.45 ng/mL (95%CI 0.33–2.56, p = 0.01) and 1.67 ng/mL (95%CI 0.60–2.74, p = 0.003) higher than women in the lowest quartile respectively. The highest adherence to PFD was also associated with a higher AFC in women with a BMI ≥ 25 kg/m2 (β = 7.8, 95%CI 0.003–15.34, p < 0.05). Other common dietary patterns were not significantly associated with ovarian reserve.ConclusionsIncreased adherence to a profertility diet is associated with improved markers of ovarian reserve in overweight and obese women. These findings provide novel insight on potential modifiable lifestyle factors associated with ovarian reserve.

A predictive model for chemotherapy-related diminished ovarian reserve in reproductive-age women

To develop and internally validate a clinical predictive tool to assess the likelihood that a young cancer patient will experience diminished ovarian reserve (DOR) after chemotherapy. Prospective cohort study. University hospitals. Postpubertal adolescent and young adult women with a new diagnosis of cancer requiring chemotherapy. None. Diminished ovarian reserve after completion of and recovery from chemotherapy, defined as serum antimüllerian hormone (AMH) <1 ng/mL at 8-24 months after completion of chemotherapy. A multivariable logistic regression model which includes age, cancer type, exposure to an alkylating agent, and baseline AMH value accurately predicts the diagnosis of DOR after chemotherapy with an area under the receiver operating characteristic curve of 0.89. Pretreatment information on age, cancer type, use of an alkylating agent, and baseline AMH levels make up a clinically useful predictive tool to identify which women are most at risk for DOR caused by chemotherapy.

Anti Mullerian hormone levels in women of central Madhya Pradesh- A retrospective analysis

Introduction: Anti Mullerian Hormone(AMH) is homodimeric protein that is classified under the superfamily of transforming growth factor beta(TGF-b ). The granulose cells of the primary, preantral and small antral follicles of the ovary express this hormone. AMH levels remain fairly constant throughout the cycle which makes it a favourable and suitable marker for determining the ovarian reserve in women of reproductive age. The present retrospective study was carried out with the aim of studying the AMH levels in women upto 50 years of age coming to our diagnostic centre for AMH screening for different reasons Materials and Methods: This was a retrospective study conducted between January to August 2019 in women upto 50 years of age coming to our diagnostic centre for AMH screening test. They were divided into further classified as 10.0 ng /ml .The mean and median values were calculated for each group. Results: AMH levels below 1 ng/ml were observed in 102/400(25.5%) patients. AMH levels between 1-4 ng/ml was observed in 171/400 (42.75%) women. High AMH values between 4-8 ng/ml were observed in 90/400(22.5%) women out of which66/90(73.33%)were in 21-30 years age range, followed by 18.89% in 31-40 years, 6.67% below 20 years and 1.11?ove 40 years of age Conclusion: Since AMH levels do not vary with the days of the menstrual cycle in women, it is one of the best markers available in the current scenario for assessing the ovarian reserve in women of reproductive age group. Our study emphasizes the observation that PCOS is a growing health problem in women of reproductive age due to several factors like sedentary life style, lack of exercise and unhealthy eating habits which can be easily managed by lifestyle changes. Keywords: Anti Mullerian hormone, LH, FSH, PCOS.

P754 Ovarian reserve in reproductive age women with Crohn’s disease

P754 Ovarian reserve in reproductive age women with Crohn’s disease

Ovarian reserve in reproductive age women with type 1 diabetes

Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process.&#x0D; Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with healthy women.&#x0D; Materials and methods: This study evaluated 224 Caucasian women, age 1837 years with type 1 diabetes and 230 healthy women of comparable age. Serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and testosterone were compared on the 23 day of menstrual cycle as ovarian volume and antral follicle count (AFC). In addition, glycated hemoglobin level (HbA1c%) was evaluated.&#x0D; Results: We reveal statistically significant difference in following parameters in diabetic women in comparison with healthy women: AMH, AFC. But even in diabetic patients parameters remained within reference ranges. There was a pronounced negative relationship between the levels of HbA1c% and AMG.&#x0D; Conclusions: Ovarian reserve function parameters decrease in young women with type 1 diabetes in comparison with healthy women, but ovarian reserve parameters are in normal reference range. These findings are important in pregnancy planning consulting by gynecologists and endocrinologists. We must recommend to women with type 1 diabetes more early planning of natural pregnancy for treatment with reproductive technology in cases of prolog absence of nature pregnancy.

Association between parity and ovarian reserve in reproductive age women

ObjectiveA number of factors affect ovarian reserve. In this study, we investigate the association between parity and ovarian reserve in reproductive age women. Materials and methodsThis cross-sectional study was conducted on 186 women aged 20–35 years. The participants were divided into two main groups. Group A (n=93) included women with at least one parity (pregnancy after 28 weeks), while group B (n=93) included women with no history of pregnancy. We evaluated the following factors related to ovarian reserve: follicle-stimulating hormone (FSH), ovarian antral follicles, anti-Müllerian hormone (AMH), and ovarian volume. ResultsA total of 186 women with a mean age of 27.83±4.49years enrolled in this study. There was a difference in mean AMH between the nulliparous (2.53±1.90ng/ml) and multiparous (3.54±1.42ng/ml) groups (p<0.001). FSH levels were from 5.27±1.8mIU/mL in nulliparous women to 5.01±1.9mIU/mL in multiparous women, which did not significantly differ (p=0.36). Antral follicles and ovarian size in multiparous women increased significantly (p<0.001). ConclusionParity has a significant association with higher levels of ovarian reserve markers.