EFFECT OF SURGICAL TREATMENT ON SERUM AMH LEVELS IN OVARIAN DISEASES

Abstract

Introduction The relationship between various ovarian diseases and its treatment on ovarian reserve is a subject of debate. It is difcult to determine the real impact of the ovarian surgery on future fertility of women. This study aimed to assess the effect of conservative ovarian surgeries on ovarian reserve in reproductive age women by correlation of preoperative and post operative S.AMH. Materials And Methods: This prospective study included 66 patients of reproductive age with various ovarian diseases. Ethical clearance was obtained from Institutional ethics committee and informed consent from all recruited patients. They were grouped into inammatory or benign disease, malignant disease and ovarian endometrioma by histology. S. AMH was compared in the three groups pre-operatively, after 4 weeks and after 3-6 months of surgery. The statistical analysis was done with SPSS version 15. Result: Mean decline in S> AMH at 4 weeks was 0.16, 0.40 and 0.33 respectively for inammatory/benign, malignant and endometrioma groups. Similarly, after 3-6months, it was 0.17, 0.75 and 0.37 respectively for the three groups. Statistically, both malignant and endometrioma groups showed signicantly higher decline as compared to inammatory/benign group (p<0.001). Conclusion: Baseline S.AMH levels are signicantly lower in endometrioma and malignant ovarian tumours as compared to benign ovarian tumours. They show a signicant decline following surgical treatment in all ovarian diseases but the decline is signicantly more endometrioma and malignancy.