Regulation of the concentration of toxic substances derived from tobacco products is carried out to reduce the incidence of deaths and diseases caused by the use of tobacco cigarettes, as well as to decrease attractiveness, addiction, and toxicity. In this context, modified risk tobacco products (MRTPs) have been developed to provide alternative products that have the potential to reduce the risk and harm to the population when compared to smoking conventional cigarettes. One example of an MRTP is the Tobacco Heating System (THS2.2), which, unlike conventional cigarettes, heats the tobacco instead of burning it, producing a significantly reduced amount of harmful and potentially harmful constituents (HPHCs). To review the data on the content of HPHCs in the aerosols and smoke of conventional cigarettes and those of the THS2.2 type, a critical review of scientific publications in this field was conducted from January 2015 to May 2022. The selection of scientific publications from open sources was carried out from the Scopus, Web of Science, Google Scholar, PubMed, MedLine databases, and others. A similar analysis was carried out on the information already available on the websites of Philip Morris International (PMI), Elsevier, Springer, and other relevant web resources that include information on the use of the THS2.2. After conducting a comprehensive analysis of results from both independent and industry-sponsored studies, it was noted that HPHCs are not completely eliminated from the aerosol produced by heated tobacco products (HTPs). However, the levels of these HPHCs from the PMI List of 58 Constituents (PMI-58 list) are consistently lower and significantly reduced when compared to the mainstream smoke emitted by conventional cigarettes. This suggests that while HTPs present reduced emissions of toxicants in comparison, they are not completely free from risks.
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