World Health Organization Reports Research Articles

MOF-Based Platform for Kidney Diseases: Advances, Challenges, and Prospects.

Kidney diseases are important diseases that affect human health worldwide. According to the 2020 World Health Organization (WHO) report, kidney diseases have become the top 10 causes of death. Strengthening the prevention, primary diagnosis, and action of kidney-related diseases is of great significance in maintaining human health and improving the quality of life. It is increasingly challenging to address clinical needs with the present technologies for diagnosing and treating renal illness. Fortunately, metal-organic frameworks (MOFs) have shown great promise in the diagnosis and treatment of kidney diseases. This review summarizes the research progress of MOFs in the diagnosis and treatment of renal disease in recent years. Firstly, we introduce the basic structure and properties of MOFs. Secondly, we focus on the utilization of MOFs in the diagnosis and treatment of kidney diseases. In the diagnosis of kidney disease, MOFs are usually designed as biosensors to detect biomarkers related to kidney disease. In the treatment of kidney disease, MOFs can not only be used as an effective adsorbent for uremic toxins during hemodialysis but also as a precise treatment of intelligent drug delivery carriers. They can also be combined with nano-chelation technology to solve the problem of the imbalance of trace elements in kidney disease. Finally, we describe the current challenges and prospects of MOFs in the diagnosis and treatment of kidney diseases.

Environmental sensitivity in the 27 National Roma Integration Strategies of the European Union member states

ABSTRACT The Roma people, particularly in Central and Eastern European countries, often live ethnically segregated in inadequate housing or without access to basic services (water, sewage system, electricity). Exposure to these harmful environmental factors jeopardizes their health and hinders their social integration. This study delves into the sensitivity of the National Roma Integration Strategies (NRIS) (2012–2020) regarding the environmental factors that affect the Roma population. Previous studies have explored gender or identity in the strategies, but few have analysed environmental sensitivity. Based on World Health Organization (WHO) reports, we consider the following environmental factors: housing, access to basic services, urban environment, working environment and injuries at home. The sensitivity of the 27 NRIS to these factors was quantified in all crucial areas (housing, health, education, employment). An inductive analysis of the operational content (measures, actions) was conducted on nine NRIS. The Member States in the southeast of the European Union were more environmentally sensitive than their counterparts in the northwest. The salient environmental factors were housing and basic services. The nine NRIS analysed show two approaches (western/eastern) in addressing the environmental conditions of the Roma population. Finally, although we identified environmental factors in the NRIS, this issue was not systematically addressed.

Eutectic mixtures containing the active pharmaceutical ingredient ezetimibe: Phase diagrams, solid state characterization and dissolution profiles

Cardiovascular disease represents the leading cause of death worldwide, according to the World Health Organization (WHO) report. One of the treatment strategies is the use of the drug ezetimibe (EZT). This drug is a cholesterol absorption inhibitor with low aqueous solubility, which affects its therapeutic efficacy. The purpose of this paper was to obtain eutectic materials of EZT with methylparaben (MPB), salicylic acid (SCA) and nicotinamide (NTM) coformers, and to study their phase diagrams, dissolution properties and hygroscopicity to assess possible enhancements. Phase and Tamman diagrams were constructed using differential scanning calorimetry (DSC) results. The eutectic materials were characterized by powder X-ray diffraction (PXRD) and polarized light optical microscopy (OM). The hygroscopicity of the materials was assessed at different relative humidities (RH) through dynamic vapor sorption (DVS). The dissolution study was conducted with the materials in powder form, with paddle dissolution, rotating at 50 rpm, in 900 mL of aqueous buffer solution at pH 6.8 and 37 °C. The phase diagrams demonstrated that EZT formed eutectic systems with eutectic molar fractions of 0.59, 0.67 and 0.69 for EZT-SCA, EZT-NTM and EZT-MPB, respectively. The three eutectic materials are characterized as microcrystalline conglomerates of their components. In terms of the hygroscopic behavior of EZT at different RHs, eutectic materials demonstrated lower susceptibility to monohydrate formation compared to the anhydrous form. In dissolution studies, EZT-SCA and EZT-MPB solubilized EZT in amounts 22 % higher than the pure drug in 15 min. On the other hand, EZT-NTM eutectic suppressed the dissolution of EZT down to 56 % at the same time. The results indicated the possibility of obtaining materials with enhanced properties using eutectic mixtures, with improved dissolution rates and hygroscopic stability.

Metabolic Management of Cancer Disease – A Review

The US National Cancer Institute (NCI) define cancer as a disease in which some of the body’s cells are growing uncontrollably and are also spreading to other parts of the body. Cancer disease is a major cause of deaths worldwide and from the World Health Organization (WHO) report, in year 2020 alone, cancer caused about 10 million deaths globally. Also from a WHO report, cancer disease is responsible for 1 out of every 4 to 5 deaths worldwide. Conventionally, the treatment of cancer is based on three major approaches, viz; chemical therapy, surgery and radiation therapy. But, the outcome and prognosis of the conventional treatment of cancer disease is limited in its effectiveness, so there is an urgent need for more research based therapies that can effectively treat and manage cancer disease. With that, the treatment outcome and the survival rate of cancer will likely increase. Meanwhile, the term tumour was originally applied to the swelling caused by inflammation and there are two types of tumours; benign tumours and malignant tumours. Cancer is the common term for malignant tumours and the normal progression of most malignant tumours can be divided into four phases, which are; malignant change in the target cells, growth of the changed cells, local invasion of the surrounding tissues and organs by the changed cells, and distant metastases of the changed cells to other organs. In the clinical diagnosis of cancer disease, systems have been developed to express the level of differentiation of cancer within a patient (grade) and also the extent of spread of cancer within a patient (stage). The staging of cancers is based on the; size of the primary lesion, its extent of spread to regional lymph nodes, and the presence or absence of blood-borne metastases. Two major staging systems are quite common and the first was developed by the America Joint Committee (AJC) on Cancer Staging, while the second was by the Union Internationale Contre Cancer (UICC). The UICC employs a classification called the TNM system. Normal cells use the sophisticated process of respiration for their cellular energy production, but cancer cells use the primitive process of fermentation. However, no cell in its right conditions would ever use fermentation when there is enough oxygen, especially considering that fermentation does not produce as much energy as respiration, and it also creates toxic by-products. So, fermentation is primitive and wasteful. But, surprisingly, cancer cells use fermentation even when there is plenty of oxygen around. That very observation is the basis of the explanation for the Warburg effect, which is considered to be the metabolic signature of most cancer cells. From the meta-analysis research done on cancer at the University of Cambridge, UK, it was concluded that cancer is a mitochondrial disease and one of the effective ways of managing it is through diets. So, it was concluded from the meta-analysis that cancer growth and progression can be managed through a whole body transition from fermentable metabolites made up of basically glutamine and glucose, to respiratory metabolites made up of majorly ketone bodies.

Potentially Toxic Metals: Their Effects on the Soil-Human Health Continuum

As the foundation of nutritious foods lies in the soil, the consumption of crops grown in contaminated soils may pose an elevated risk of health issues through the soil-plant-human pathway. The impact of heavy metals (HMs) and metalloids on the physiological and biochemical responses of plants can have adverse effects on both growth and yield. The excessive accumulation of these substances in plant tissues poses a significant challenge to public health. HMs possess the capability not only to function as carcinogens but also to act as co-carcinogens, thereby activating specific chemical compounds. According to the World Health Organization (WHO) reports, the target values, representing the desirable maximum concentrations of HMs in the soil, follow the order: Cr>Pb>Zn>Cu>Ni>Cd. This implies that Cd poses the highest potential risk, given its target value of 0.8 mg/kg, while Cr carries the lowest potential risk, with a target value of 100 mg/kg. Various agricultural management practices are recognized as significant pathways that induce the accumulation of metals in the soil and the surrounding environment. Hence, understanding the origin and status of HMs in the environment, along with assessing their potential risks and developing strategies to mitigate these risks, becomes crucial. This study aims to evaluate different facets of the soil-human health continuum concerning potentially toxic metals.

THE ANTICANCER POTENTIAL OF VAN LAKE BASIN PLANTS

Abstract: For centuries, people have used plants in their environment for food and various needs, as well as for treating diseases. The main reason for the increasing demand for herbal resources in recent years is that synthetic drugs cause negative consequences that can damage various organs of the body while treating diseases. The World Health Organisation (WHO) reports that 80% of the world's population primarily uses medicinal plants to prevent and cure diseases. Cancer, a disease with a rapidly increasing incidence and mortality rate, is currently second only to cardiovascular diseases. The toxicity of modern chemotherapy and the resistance of cancer cells to anticancer agents have led the scientific world to search for new treatments and prevention methods for this insidious disease. The therapeutic properties of plants, which generally do not have significant side effects, are associated with biologically active organic compounds, and the geochemical composition of the region where they grow. Van Lake Basin has a rich plant diversity thanks to its climate, geographical features, and soil content. This region is home to many medicinal plant species that are used by the people but have not yet been investigated and their phytochemical structure is not fully understood. Although the plants in this region have been used for centuries by the people, as seen from their ancestors, studies need to prove their therapeutic effects in vivo and in vitro. This study presents the anticancer potentials of some crucial plants (Eryngium billardieri Delar., Cichorium intybus, Bongardia chrysogonum (L.) Spach, Bryonia multiflora Boiss. & Heldr., Euphorbia macroclada Boiss., Scutellaria orientalis L., Plantago major L., and Primula auriculata Lam.) reported to be used in treating various diseases in the Van Lake Basin by analyzing the in vitro and in vivo anticancer studies conducted with the same plants in the literature.

Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery.

According to the latest World Health Organization (WHO) report, an estimated 10.6 million people were diagnosed with tuberculosis (TB) in 2022, and 1.30 million died. A major concern is the emergence of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains, fueled by the length of anti-TB treatment and HIV comorbidity. Innovative anti-TB agents acting with new modes of action are the only solution to counteract the spread of resistant infections. To escape starvation and survive inside macrophages, Mtb has evolved to become independent of the host by synthesizing its own amino acids. Therefore, targeting amino acid biosynthesis could subvert the ability of the mycobacterium to evade the host immune system, providing innovative avenues for drug discovery. The aim of this review is to give an overview of the most recent progress in the discovery of amino acid biosynthesis inhibitors. Among the hits discovered over the past five years, tryptophan (Trp) inhibitors stand out as the most advanced and have significantly contributed to demonstrating the feasibility of this approach for future TB drug discovery. Future efforts should be directed at prioritizing the chemical optimization of these hits to enrich the TB drug pipeline with high-quality leads.

A Study For: Socio-cultural Environment and the Microinsurance

The poor are much more exposed to the dangers from their surroundings. They live in unhealthy environment where even proper sanitation is not available. Natural calamities like floods, drought, earth quake etc. hit them the hardest. An unfortunate event like Illness or death in the family can change the living standard of the poor for the worse. Cost of medical care being prohibitive, s/he consumes lots of (already diminished) resources from the family. Since they do not have adequate savings, such an episode drives them to either sell their assets or borrow money from local money lenders at high interest rates. According to World Health Organization report (2006), out of total health expenditure in India, 73% happens through out-of pocket spending. This is a very precarious situation as it exposes the poor household to sudden spurt in unplanned and unexpected medical expenses. So, how do we ensure that the poor, or the ‘excluded’ face this ever-threatening risk to their lives and livelihood? Insurance as a concept was introduced in 19th century to do exactly that - protect the poor! But over a period of time, it became a financial tool for the rich. Affordability being one of the prime reasons but exposure and access being other important reason for low penetration in this segment.

Effects of Gluteal Muscle Strengthening Exercise-Based Core Stabilization Training on Pain and Quality of Life in Patients with Chronic Low Back Pain.

Background: The World Health Organization reports that back pain is a major cause of disorder worldwide. It is the most common musculoskeletal disorder with limited pain, muscle tension, and stiffness, and 70-80% of all individuals experience it once in their lifetime, with higher prevalence in women than in men. This study aimed to investigate the effects of gluteal muscle strengthening exercise- based core stabilization training (GSE-based CST) on pain, function, fear-avoidance patterns, and quality of life in patients with chronic back pain. Methods: This study included 34 patients with non-specific chronic low back pain. Seventeen individuals each were included in GSE-based CST and control groups. The GSE-based CST group performed GSE and CST for 15 min, three times a week for four weeks, and the control group performed CST for 30 min a day, three times a week for four weeks. The numeric pain rating scale was used to evaluate pain before and after treatment, Roland-Morris disability questionnaire was used to evaluate function, fear-avoidance beliefs questionnaire was used to evaluate fear-avoidance patterns, and quality of life was measured using the short form-36. Results: In this study, pain, function, and fear-avoidance pattern decreased significantly in both groups (All p < 0.05). During the evaluation of quality of life, both groups showed significant increase in physical and mental factors (p < 0.05). There were significant differences in pain and quality of life (p < 0.05) between the GSE-based CST and control groups. Conclusions: Therefore, GSE-based CST can be used as a basis for effective intervention to enhance pain, function, fear-avoidance patterns, and quality of life, emphasizing the need for gluteal muscle strengthening exercises in patients with non-specific chronic back pain in the future.

Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries

Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% of these sepsis deaths could be prevented through improved treatment, the efficacy of the currently recommended first- and second-line treatment regimens for this condition is increasingly affected by high rates of drug resistance. Here we assess three well known antibiotics, fosfomycin, flomoxef and amikacin, in combination as potential antibiotic treatment regimens by investigating the drug resistance and genetic profiles of commonly isolated GNB causing neonatal sepsis in LMICs. The five most prevalent bacterial isolates in the NeoOBS study (NCT03721302) are Klebsiella pneumoniae, Acinetobacter baumannii, E. coli, Serratia marcescens and Enterobacter cloacae complex. Among these isolates, high levels of ESBL and carbapenemase encoding genes are detected along with resistance to ampicillin, gentamicin and cefotaxime, the current WHO recommended empiric regimens. The three new combinations show excellent in vitro activity against ESBL-producing K. pneumoniae and E. coli isolates. Our data should further inform and support the clinical evaluation of these three antibiotic combinations for the treatment of neonatal sepsis in areas with high rates of multidrug-resistant Gram-negative bacteria.

Development in the Inhibition of Dengue Proteases as Drug Targets.

Viral infections continue to increase morbidity and mortality severely. The flavivirus genus has fifty different species, including the dengue, Zika, and West Nile viruses that can infect 40% of individuals globally, who reside in at least a hundred different countries. Dengue, one of the oldest and most dangerous human infections, was initially documented by the Chinese Medical Encyclopedia in the Jin period. It was referred to as "water poison," connected to flying insects, i.e., Aedes aegypti and Aedes albopictus. DENV causes some medical expressions like dengue hemorrhagic fever, acute febrile illness, and dengue shock syndrome. According to the World Health Organization report of 2012, 2500 million people are in danger of contracting dengue fever worldwide. According to a recent study, 96 million of the 390 million dengue infections yearly show some clinical or subclinical severity. There is no antiviral drug or vaccine to treat this severe infection. It can be controlled by getting enough rest, drinking plenty of water, and using painkillers. The first dengue vaccine created by Sanofi, called Dengvaxia, was previously approved by the USFDA in 2019. All four serotypes of the DENV1-4 have shown re-infection in vaccine recipients. However, the usage of Dengvaxia has been constrained by its adverse effects. Different classes of compounds have been reported against DENV, such as nitrogen-containing heterocycles (i.e., imidazole, pyridine, triazoles quinazolines, quinoline, and indole), oxygen-containing heterocycles (i.e., coumarins), and some are mixed heterocyclic compounds of S, N (thiazole, benzothiazine, and thiazolidinediones), and N, O (i.e., oxadiazole). There have been reports of computationally designed compounds to impede the molecular functions of specific structural and non-structural proteins as potential therapeutic targets. This review summarized the current progress in developing dengue protease inhibitors.

Abdominal Injuries Detection

Abstract: Abdominal trauma refers to physical injuries or damage to the abdominal region, which includes the area between the casket and pelvis. This can involve colorful structures within the tummy, similar as the organs (e.g., liver, spleen, bowel, kidney, and extravasation). Traumatic injury affects individualities across all age groups and stands as one of the primary causes of mortality encyclopedically. The World Health Organization reports that nearly 5 million individualities succumb to traumatic injuries annually. The main ideal of an abdominal injuries’ discovery design is to ameliorate the early and accurate identification of abdominal injuries performing from trauma. This design generally involves the development and perpetration of colorful tools, ways, and protocols to achieve the objects like perfecting the delicacy of CT for detecting abdominal trauma and prognosticate the probability of specific traumatic injuries to abdominal organs. Diagnosing abdominal trauma clinically through physical examination, patient symptoms, or laboratory tests can frequently be grueling. thus, timely opinion using medical imaging plays a pivotal part in patient care. Our design will identify whether the case is suffering from abdominal trauma or not and help the cases by informing when immediate surgery is needed. Abdominal trauma discovery generally involves analysis of CT images to prognosticate the probability of specific traumatic injuries to abdominal organs, similar as the bowel, extravasation (generally refers to bleeding from blood vessel), liver.

Influence of metal ions (Me: Fe, Cu, Co, Ni, Mn, Cr) on direct Z-scheme photocatalysts CN/Me-BTC on the degradation efficiency of tetracycline in water environment

BackgroundThe World Health Organization (WHO) reports that antibiotic resistance contributes to approximately 700,000 deaths yearly, with estimate suggesting a rise to 10 million deaths over the next 35 years. MethodsIn this study, direct Z-scheme heterojunction photocatalysts CN/Me-BTC (CN: graphite carbon nitride, Me: metal ions, BTC: benzene-1,3,5-tricarboxylic acid) were successfully synthesized using a hydrothermal combined microwave method, eliminating the need for toxic solvents and featuring a short crystallization time and low reaction temperature. Significant findingsThe study also explores the influence of various metal ions (Fe, Ni, Co, Mn, Cr, and Cu) on the morphological, physicochemical properties, and photocatalytic efficiency of tetracycline (TC) degradation. The CN/Me-BTC photocatalysts exhibit remarkable characteristics, including high visible light absorption, high surface area, low recombination rate between electrons and holes, and fast charge transfer ability.Among the synthesized photocatalysts, CN/FeBTC stands out with the highest efficiency in TC degradation (97.18 %) and degradation rate (decay constant k = 0.0197 min−1), surpassing CN by four times. The study comprehensively investigates factors influencing the TC degradation process, including catalyst mass, pH, antibiotic concentration, participating radicals, anions, and water sources. The mechanism of the photocatalytic process is elucidated based on radical quenching experiments and electrochemical properties.

Modeling spillover dynamics: understanding emerging pathogens of public health concern

The emergence of infectious diseases with pandemic potential is a major public health threat worldwide. The World Health Organization reports that about 60% of emerging infectious diseases are zoonoses, originating from spillover events. Although the mechanisms behind spillover events remain unclear, mathematical modeling offers a way to understand the intricate interactions among pathogens, wildlife, humans, and their shared environment. Aiming at gaining insights into the dynamics of spillover events and the outcome of an eventual disease outbreak in a population, we propose a continuous time stochastic modeling framework. This framework links the dynamics of animal reservoirs and human hosts to simulate cross-species disease transmission. We conduct a thorough analysis of the model followed by numerical experiments that explore various spillover scenarios. The results suggest that although most epidemic outbreaks caused by novel zoonotic pathogens do not persist in the human population, the rising number of spillover events can avoid long-lasting extinction and lead to unexpected large outbreaks. Hence, global efforts to reduce the impacts of emerging diseases should not only address post-emergence outbreak control but also need to prevent pandemics before they are established.

Analyzing the Capacity of the Healthcare System in Gaza to Address Gaza Residents Needs

The present humanitarian crisis in Gaza has resulted in the devastation of medical facilities and health infrastructure. As of January 2024, the World Health Organization reports that 78% of primary care clinics funded by the United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA, 2024) have ceased operations, and hospitals’ bed capacity throughout Gaza has decreased by more than 59% (World Health Organization, 2024). Direct military attacks on medical facilities as well as the blockade of medical supplies and humanitarian aid pose the largest obstacles to greater healthcare attainment in Gaza (IRC, 2024). Over the course of the conflict, there has been a surge in the number of people suffering from war injuries, which now totals 71,377 (Shurafa, 2024). The rise in the number of patients who require access to medical services in combination with the limited hospital functionality in the Gaza Strip is putting a massive strain on their already limited healthcare system; before the over 6 month long duration of direct military attacks by the Israeli Defence Forces (IDF) on hospitals in Gaza, data indicated a maximum ratio of 1.55 hospital beds per 1000 individuals across the entire region of the Gaza Strip, while the ratio in the US is around 2.35 hospital beds per 1000 individuals (Taylor, 2024). The already poor living conditions of the demographic–most of whom are housed in temporary structures in severe weather conditions with a lack of access to food and water for sustenance or hygiene–signify a need for a more robust healthcare system. However, triage conditions prioritize treatment of the most severe war injuries, which has forced hospitals to abandon previously established vaccination projects and disease surveillance programs, leaving the remaining population to suffer from preventable diseases such as chickenpox, upper respiratory infections, scabies, and Hepatitis A (Soni, 2024). Individuals who do receive medical care face higher levels of infection due to a lack of adequate sanitation, waste management measures, and basic hygiene supplies (The Economist, 2024).

Impacts of gait freeze on quality of life in Parkinson’s disease, from the perspectives of patients and their carers

BackgroundThe World Health Organisation (WHO) reports that morbidity and mortality due to Parkinson’s disease (PD) are increasing faster than for other neurodegenerative conditions. People with Parkinson’s (PwP) present with a variety of motor symptoms, such as tremor, bradykinesia, and rigidity. Freezing of gait (FoG) is a significant motor symptom that manifests as temporary episodes of inability to move one’s feet, despite the intention to walk.AimsThis study examined the impact of FoG on quality of life (QoL) within an Irish cohort of PwP, from the perspectives of both PwP and their carers, using validated questionnaires that had been adapted for online use.MethodsPwP and their carers were recruited by outreach to the Irish Parkinson’s Community. Anonymous online questionnaires were distributed, which combined a demographic survey with several clinically validated surveys, including Freezing of Gait Questionnaire (FoG-Q), Parkinson’s Disease Questionnaire 8 (PDQ-8), and Parkinson’s Disease Carer Questionnaire (PDQ-C).ResultsThere was a strong correlation (p < 0.001) between severity of FoG and lower QoL among PwP. Significant correlation was also found between FoG severity and several motor symptoms, such as postural instability and difficulty with balance, and non-motor symptoms, such as cognitive changes and pain/discomfort. FoG severity correlated with disease progression. Significant correlation was also found between FoG and symptoms, as assessed from the perspective of the patients’ carers.ConclusionsThis study shows that FoG is a significant detriment to the QoL of PwP, from the perspectives of patients and carers. This method of assessing FoG and QoL using online questionnaires has potential to enhance the reach and flexibility of this type of research. These findings will inform future studies on larger cohorts and highlight unmet clinical needs in PwP.

WHO’s end of TB targets: unachievable by 2035 without addressing under nutrition, forced displacement, and homelessness: trend analysis from 2015 to 2022

Tuberculosis (TB) remains a significant global health challenge, despite the World Health Organization (WHO) actively working towards its eradication through various initiatives and programs. Undernutrition, forced displacement, and homelessness worsen TB’s burden and challenge control efforts; however, there is still no adequate research that shows the trend of these underlying factors to attain the WHO’s ambitious TB targets. So, this study aims to analyze the trend analysis of these underlying factors worldwide from 2015 to 2022 and their impact on the feasibility and implications of reaching the End TB targets by 2035. We utilized international databases, including UNHCR, FAO, and WHO reports, as secondary data sources. Data were extracted chronologically from 2015 to 2022 to illustrate trends in undernutrition, forced displacement, and homelessness on a global level.This trend analysis reveals that undernutrition, forced displacement, and homelessness have worsened over time. Undernutrition rose from 8.4 to 9.8% globally between 2015 and 2021, affecting 22.7 million additional individuals each year. In 2022, undernutrition affected 735 million people globally. Africa (21.9%) and Asia (10.6%) had the highest rates, while Western Europe and North America had lower rates than the global average: 3.4% and 2.5%, respectively.Similarly, the global rate of forced displacement increased from 65.1 million people in 2015 to 108.4 million in 2022, a 21% increase from 2021. This means that an extra 19 million people were displaced in 2021. Globally, homelessness, affecting 1.6 billion people, has worsened over time. Despite being a highly vulnerable group to TB, homeless individuals are often neglected in TB control efforts. Our findings underscore the critical importance of addressing undernutrition, forced displacement, and homelessness in achieving the World Health Organization’s ambitious End TB targets by 2035, as highlighted through trend analysis from 2015 to 2022. Implementing policies focusing on nutrition, stable housing, and the challenges faced by displaced populations is imperative for progress toward a TB-free world.

"I Can’t Exercise Because My Foot Hurts Me Too Much." Does BMI Change after Common Foot and Ankle Surgeries? A Retrospective Review

Introduction/Purpose: The World Health Organization reports that 1.9 billion people worldwide have a body mass index (BMI) that classifies them as being either overweight (BMI &gt; 25) or obese (BMI &gt; 30). Patients often claim, prior to orthopaedic surgery, that their physical activity and exercise is negatively impacted by their orthopaedic condition. Hip and Knee arthroplasty literature has established that patients with high preoperative BMI continue to have high BMI post-operatively, despite also reporting improvements in their joint pain. No such studies exist in foot and ankle surgery. The purpose of this study was to analyze changes in BMI after many common foot and ankle surgeries. Methods: A retrospective review of all patients undergoing bunion correction, flatfoot correction, 1st MTP arthrodesis, and midfoot arthrodesis procedures between November 2018 and December 2022 was conducted in this IRB approved, single center study. BMI data was collected from the electronic medical record for preoperative and 12 months postoperative time points. Descriptive statistics were reported for age, gender, diabetes, A1c for diabetic patients, smoking status, and overall follow up time. Repeated measures of analysis of variation were conducted with one between-groups factor being type of surgery. Results: 196 patients were included in the study. The average age was 62.1 years, 151(76.6%) patients were female. Average BMI amongst all patients preoperatively was 29.58 +/- 5.21, and postoperatively 29.79 +/- 5.33, with an overall average increase in BMI of 0.2182 +/- 2.21. Upon subgroup analysis, all surgical cohorts yielded an increase in postoperative BMI (bunion +0.2489 +/- 2.06, double arthrodesis +0.4767 +/- 1.37, 1st MTP fusion +0.2293 +/- 2.07, midfoot arthrodesis +0.0251 +/- 3.10) although these changes did not reach significance (p value 0.425). There was no significant difference observed in changes in BMI between surgical groups (p value 0.958). BMI outcomes were normally distributed with acceptable equality of error variances (Levene’s test p- values &gt; 0.270). Conclusion: The current statistics surrounding the prevalence of overweight and obesity are staggering. The results of this study demonstrate that elective orthopaedic surgery of common foot and ankle procedures do not facilitate a change in BMI one year postoperatively, despite the goal of reducing chronic pain and increasing physical function, which is often cited as the primary restriction to exercise amongst patient populations. Additional studies are warranted to further elucidate changes in BMI to adequately council patients regarding postoperative expectations. Study Data Summary

An examination of non-wearable methods for fall detection

Amidst the emergence of an aging global population, elderly healthcare has evolved into a pressing societal concern. The World Health Organization reports that approximately 646,000 individuals across the globe succumb to fatal falls annually. Notably, those aged over 60 experience the highest mortality rate, representing the most significant portion of these deaths. Given these stark statistics, there has been a surge of interest in researching fall detection methodologies. This article delves into non-wearable fall detection techniques, emphasizing their various classifications and applications. Initially, we provide an overview of distinct categories within the non-wearable fall detection landscape. Following this, each method is elaborated upon, elucidating its mechanisms and practical applications. To complement this, a brief discourse on prevalent machine learning algorithms employed in fall detection is presented. In culmination, a comparative analysis of each technique is provided, highlighting their respective merits and limitations. The objective is to furnish readers with a holistic perspective on the current state of non-wearable fall detection. As we gaze towards the horizon, it becomes evident that advancing this domain is paramount to safeguarding our elderly and reducing preventable fatalities.

AN OVERVIEW OF CURRENT VACCCINES FOR THE PROPHYLAXIS OF BACTERICAL INFECTIONS

Antibacterial vaccines play a central role in modern medicine by providing an effective approach to combating infectious diseases caused by bacteria. The importance of these vaccines lies in their ability to stimulate the immune system to recognise and neutralise bacterial pathogens, or exotoxins produced by them, thereby preventing, or mitigating the severity of bacterial infections. The development and widespread use of antibacterial vaccines have contributed significantly to reducing the global burden of diseases such as pneumonia, meningitis, and sepsis. Today, the global increase in vaccine-preventable diseases is a worrying trend that is closely linked to the emergence and advocacy of anti-vaccination policies. According to the latest World Health Organisation report, vaccination coverage in Serbia has declined over the past decade, jeopardising the collective immunity and led to recent outbreaks of vaccine-preventable diseases such as whooping cough and measles. Understanding the significance of antibacterial vaccines underscores their importance in promoting individual and community immunity, which ultimately leads to a healthier population and the prevention of antibiotic resistance. This paper summarises the main characteristics of the different types of antibacterial vaccines, such as whole cell vaccines, subunit vaccines and toxoid vaccines, and provides an overview of the types of bacterial antigens contained in vaccines available for mandatory immunisation (vaccines against tuberculosis, diphtheria, tetanus, pertussis, Haemophilus influenzae and pneumoccus) or for non-mandatory immunisation (meningococcal vaccine, typhoid vaccine, cholera vaccine).