Objective: Instrument administration including accessibility control, schedule time for reservation, and periodical machine utilization are essential tasks for high-end molecular laboratory. Such repetitive work can be automated using information technology.Material and Methods: As a part of Laboratory Information Management System (LIMS), the Research Instrument Management System (RIMS) is an online application using a user-friendly platform constructed for efficiency of access, end-user communication, instrument reservation.Results: RIMS utilizes instrument information including the date of set up, machine identification, last preventive maintenance and financial record. Data logging and periodic reports are displayed as a graphical dashboard which is simple and flexible monitoring administration. The researchers are categorized into subgroups according to their experience in operating each instrument and facilitated reservation by the subgroups, i.e., unskilled researchers can make a reservation only after the have attended a training session.Conclusion: The system has now been launched with a continually improving process for fundamental equipment of translational medical research.