ABSTRACT Background and Objectives: Blood donation is a relatively safe procedure without any discomfort; however, if any unexpected or undesirable effects, i.e., an adverse donor reaction (ADR) does occur, it should be managed promptly and efficiently. The main aim of this study was to analyze the incidence of ADRs among blood donors. Methods: A prospective study was conducted from September 2020 to September 2022 at blood center. All ADRs in whole blood and apheresis donors were managed as per standard operating procedures. An ADR pro forma was filled, and the donor was given postdonation advice as per standard guidelines. The data collected were analyzed to find the incidence, risk factors, and causes of ADRs and to study its effect on repeat donation. Results: Among 83231 blood donations during the study period, ADRs were observed in 250 donors (0.30%). ADRs were most commonly noted in the age group of 18–30 years and were higher in first-time donors (69.6%) as compared to repeat donors (30.4%). The rate of ADR was higher in females (3.11/1000) as compared to males (3.00/1000) The most common type of ADR was vasovagal type (98%) followed by hematomas (2%). Conclusion: Younger, first-time, and female donors were more prone to ADRs in the present study. Better postdonation care and regular training of staff members in counseling, early identification, and management of ADR will aid in decreasing the severity and incidence of adverse reactions which further encourages repeat blood donations.
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