Remedy For Treatment Research Articles

Preventive and Remedial Measures to House Termite Infestations in Two Ikwerre Communities of Rivers State, Port Harcourt, Nigeria

From forests to human dwellings, infestations of woods by termites are on the increase. Despite the increasing occurrences of termite infestations in human dwellings in the Niger Delta region, there is still insufficient information about the preventive and remedial measures towards house termites by house-owners (HOs) in the region. Through a survey of Omuoko [n = (50%) = 82] and Omuihechi [n = (50%) = 57] communities in the Ikwerre area of Port Harcourt, this study analyzed a 139-house owner samples using standard methods. Data obtained show that 64.7% of HOs use preventive measures which include chemicals (43.2%), chemicals and non-wood materials (20.9%), and non-wood materials (0.6%). A sub-total of 73 HOs representing 52.5% of the total respondents use remedial measures with chemicals (34.2%) being dominant, followed by Chemicals and replacement (27.4%), Replacement (17.8%), Scraping (12.3%), Chemical and scrapping (6.8%), and cement (1.4%). This study indicates that old, wooden, and thatched houses are highly susceptible to termites’ infestations, thus deserving periodic preventive and remedial treatments through expert consultations and/or do-it-yourself methods.

Quest CCS facility: Halite damage and injectivity remediation in CO2 injection wells

The Quest CCS facility (located in Alberta, Canada) is a fully integrated carbon capture, transport and storage facility operated by Shell Canada. It continuously captures and stores about 1.1Mt of CO2 per year. While the initial injectivity for the Quest CO2 injection wells was very high, significant injectivity reductions have been observed. As dry CO2 is injected, water can evaporate from the brine into the CO2 driving precipitation of halite. Plugging of the perforation tunnel and pore throats in the near wellbore area can cause injectivity damage.One method to remediate halite damage is to inject a water-based fluid to dissolve the halite precipitate. Quest performed the first halite remediation treatment on one of the CO2 injector wells in 2020. The objective of this paper is to present the design, execution and results of this initial halite remediation treatment. An outline of the design of the halite remediation treatment will be provided. Subsequently the halite remediation treatment as executed in the field will be reviewed including the timing of operations and the pumping pressure and rate data. Finally, to evaluate the effectiveness of the treatment, skin analysis and injectivity trends pre and post remediation treatment shall be presented.

Comparison of Lost Circulation Material Sealing Effectiveness in Water-Based and Oil-Based Drilling Fluids and Under Conditions of Mechanical Shear and High Differential Pressures

Abstract A study was conducted to assess the performance of granular and fibrous lost circulation materials as preventative treatments and in remedial treatment of lost circulation in water-based and oil-based drilling fluids. For the preventative treatments, a factor that introduced increased mechanical wear on the particles was added to the hot-rolling process, to identify signs of deterioration of performance of certain materials. The study of remedial treatments of lost circulation was conducted on slotted discs with apertures of 750 µm and up to 5 mm and with a differential pressure of up to 34.5 MPa (5000 psi). To compare the sealing pressures of the different tests, a simple statistical analysis was introduced to differentiate between the peak holding pressures and the sustainable holding pressures of the various material and fluids combinations. The material degradation studies showed that CaCO3-based lost circulation materials rapidly experienced significant particle degradation after exposure to fluid shear and mechanical degradation and that this considerably reduced the sealing performance of the materials. Also, synthetic graphite-based products showed clear signs in particle size degradation and a significant reduction in sealing performance. Cellulose-based products showed superior resistance toward mechanical wear and only small changes in sealing performance. When comparing water-based and oil-based fluids, it was clear that granular lost circulation materials showed considerably lower sealing efficiency in oil-based drilling fluids compared to water-based drilling fluids. In contrast, cellulose-based materials showed similar sealing performance in oil-based fluids and water-based fluids.

Plaster beetle (psocid) infestation in buildings : Environmental management and control — a pragmatic approach

Plaster beetles (psocids) are active stocky and soft-bodied insects that are commonly found in new-build apartments, flats and housing blocks. They are also commonly called barklice or booklice because of their superficial resemblance to certain species of lice, and because they are found, sometimes in very large numbers, on mouldy books and papers in damp buildings or their basements and under loose, damp bark. Plaster beetles are either pale grey or pale brown in colour and may or may not have wings. They are common but harmless, unpleasant nuisance pests. Many live on bark and leaf surfaces feeding on algae, fungi or lichens. Others are found in leaf litter or in caves. A small number have extended their range to include buildings and building materials such as thatch, stored food stocks and museum exhibits. Plaster beetle infestation is mainly caused by damp and residual moisture, resulting in high levels of relative humidity (> 65–75 per cent) in the structural voids, ducting and insulation thereby allowing mould infestation. Psocids primarily feed on fungi and moulds for a few months in newly built houses after the completion of a building. Spraying with chemical treatments will deal with the symptoms of the problem but will not deal with the underlying causes of the infestation, namely damp, residual moisture and moulds. Heating treatment offered by some companies, whereby the building is heated to 45°C, should kill off psocids in the building; however, this does not address the underlying cause(s) of the problem and there is a risk of reinfestation. The author has advocated non-destructive investigations of buildings combined with correct diagnosis and identification of type and viability of both plaster beetle and mould infestation, as not all mould infestations are equally toxic or pathogenic. The author strongly believes, based on scientific, practical experience and successful case studies over the last 35 years, that environmental control of plaster beetle infestation and preventative maintenance are preferable to remedial conventional chemical spraying treatments. Rectifying building defects combined with drying out the building fabric and preventative maintenance should in most cases forestall the need for major interventions, and it is beyond doubt that these steps reduce the risk of reinfestation in buildings. The environmentally sustainable approach and the ongoing monitoring of the environmental conditions in buildings ensures the long-term health of building materials, health of the occupants and structures.

Ammonia level influences the assembly of dissimilatory nitrate reduction to ammonia bacterial community in soils under different heavy metal remediation treatments

Heavy metal remediation treatments might influence functional microbial community assembly. Dissimilatory nitrate reduction to ammonia (DNRA) contributes to the nitrogen retention processes in soil ecosystems. We assumed that remediation might reduce heavy metal toxicity and increase some available nutrients for the DNRA microbes, thus balancing the deterministic and stochastic process for DNRA community assembly. Here, we investigated the process of DNRA bacterial community assembly under different heavy metal remediation treatments (including control, biochar, limestone, rice straw, rice straw + limestone, and biochar + limestone) in an Alfisol soil. The abundance of DNRA bacteria diverged across treatments. The α-diversity of the DNRA bacterial community was correlated with pH, available phosphorus (AP), ammonium (NH4+), and extractable Fe (EFe). Metal Cd and Fe significantly affected the abundance of the nrfA gene. The β-diversity was associated with pH, NH4+, and EFe. Deterministic processes dominantly drove the assembly processes of the DNRA bacterial community. NH4+ level played an essential role in the assembly processes than the other soil physicochemical properties and metal availability. High, moderate, and low levels of NH4+ could advocate stochastic process plus selection, heterogeneous selection to stochastic process, and heterogeneous selection, respectively. Network analysis highlighted a predominant role of NH4+ in regulating DNRA bacterial community assembly. However, the relative abundance of modules and some keystone species also were influenced by pH and EFe, respectively. Therefore, the DNRA bacterial community assembly under different heavy metal remediation treatments in this study was dominantly driven by nitrogen availability. pH, phosphorus, and metal availability were auxiliary regulators on DNRA bacterial community.

Micellar Polymer Magnetic Microrobots as Efficient Nerve Agent Microcleaners

Micro-/nanorobot technology has developed rapidly in recent years due to their great potential to perform multiple tasks. Here, we develop magnetic microrobots prepared as polycaprolactone/Fe3O4 microspheres covered by micellar polyethyleneimine and use them to efficiently remove a nerve agent from contaminated water. The magnetic polymeric microrobots presented in this work removed around 60% of the nerve agent from water samples in a short time. The attractive performance of these magnetic microrobots offers a very promising approach to large-scale water treatment for environmental remediation.

Investigations on the Efficacy of Ozone as an Environmental Sanitizer in Large Supermarkets.

Awareness of the importance of the microbial contamination of air and surfaces has increased significantly during the COVID-19 pandemic. The aim of this study was to evaluate the presence of bacteria and fungi in the air and on surfaces within some critical areas of large supermarkets with and without an ozonation system. Surveys were conducted in four supermarkets belonging to the same commercial chain of an Apulian city in June 2021, of which two (A and B) were equipped with an ozonation system, and two (C and D) did not have any air-diffused remediation treatment. There was a statistically significant difference in the total bacterial count (TBC) and total fungal count (TFC) in the air between A/B and C/D supermarkets (p = 0.0042 and p = 0.0002, respectively). Regarding surfaces, a statistically significant difference in TBC emerged between A/B and C/D supermarkets (p = 0.0101). To the best of our knowledge, this is the first study evaluating the effect of ozone on commercial structures in Italy. Future investigations, supported by a multidisciplinary approach, will make it possible to deepen the knowledge on this method of sanitation, in light of any other epidemic/pandemic waves.

Special Issue: Advancement in Biomonitoring and Remediation Treatments of Pollutants in Aquatic Environments

A series of negative, attendant circumstances threaten the ecological equilibrium, the quality, and even the existence of the different aquatic ecosystems nowadays more than ever [...]

Early Postoperative Pain Control and Inflammation for Total Knee Arthroplasty: A Retrospective Comparison of Continuous Adductor Canal Block versus Single-Shot Adductor Canal Block Combined with Patient-Controlled Intravenous Analgesia.

Objective The aim of this study was to compare pain control and inflammation among patients who received a continuous adductor canal block (CACB) versus single-shot adductor canal block (SACB) combined with patient-controlled intravenous analgesia (PCIA) for total knee arthroplasty (TKA) analgesia in the first two days after surgery. Design Matched cohort retrospective study. Setting. University hospital. Patients. One hundred fifty-six patient charts were included in this study: 78 patients with CACB in Group A and 78 patients with SACB combined with PCIA in Group B. Patients were matched according to age, body mass index, and American Society of Anesthesiologists class. Measurements. The primary outcome of the study was Visual Analogue Scale (VAS) pain scores before operation (Pre) and at postoperative 6 (POH6), 12 (POH12), 24 (POH24), 30 (POH30), 36 (POH36), and 48 hours (POH48). Secondary outcomes included patient-controlled bolus, time of first postoperative ambulation, range of knee flexion and extension, inflammation cytokines on Pre and POH48, percentage of remedial analgesics treatment, incidence of adverse events and complications, hospital stay and cost, and Numerical Rating Scale (NRS) satisfaction scores at discharge. Main Results. Mean VAS scores at rest and with motion were lower in Group B than in Group A on all postoperative hours. At POH30, compared with Group A (1.1 ± 0.6), mean VAS scores at rest in Group B (0.9 ± 0.4) were lower (P=0.048), and compared with Group A (2.6 ± 0.7), mean VAS scores with motion in Group B (2.2 ± 0.8) were lower (P=0.001). The number of patient-controlled bolus was 4.3 ± 1.6 (95% CI 3.9–4.6) in Group A and 3.1 ± 1.3 (95% CI 2.8–3.4) in Group B, respectively (P < 0.001). Patients in Group B displayed better functional recovery and inflammation results at POH48 than Group A with respect to range of knee flexion and extension (117.8 ± 10.9° vs. 125.2 ± 9.4°, P < 0.001) and inflammation cytokines, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and interleukin-6 (IL-6) ((43.8 ± 16.1) vs. (36.8 ± 13.2), P=0.003; (34.9 ± 9.4 mg/L) vs. (29.6 ± 10.6 mg/L), P=0.001; (21.3 ± 8.7 pg/ml) vs. (14.0 ± 7.0 pg/ml), P < 0.001)). Conclusion SACB combined with PCIA in the first two days of patients undergoing TKA has better analgesic and beneficial effects on functional recovery and inflammation.

Protonated cross-linkable nanocomposite coatings with outstanding underwater superoleophobic and anti-viscous oil-fouling properties for crude oil/water separation

Superhydrophilic/underwater superoleophobic coatings that effectively prevent viscous oil contamination have been of considerable interest for the great potential in oil spill remediation and oilfield wastewater treatment. In the present work, a protonated cross-linkable nanocomposite coating with robust underwater superoleophobicity and intensified hydration capability is proposed through the synthesis of active polymeric nanocomplex (PNC), cross-linking reaction between PNC and hydrophilic chitosan (CS), and final protonation to further improve water affinity. Benefiting from the hierarchical structure and strong hydration capability induced by electrostatic interactions and hydrogen bondings, the nanocomposite coating coated textile exhibits excellent superhydrophilicity (within 0.28 s with water contact angle reaching 0°), underwater superoleophobicity (underwater crude oil contact angle at 160°), and ultralow oil adhesion even to highly viscous silicone oil. Moreover, the nanocomposite coating presents a robust chemical resistance, mechanical tolerance, and storage stability. Simultaneously, the nanocomposite coating adapts well to various porous substrates (e.g., stainless steel mesh and Ni sponge) with great anti-oil-fouling and self-cleaning performances. Importantly, the coating coated textile is successfully applied in crude oil/water separation with excellent efficiency and repeatability. The findings conceivably stand out as a new methodology to fabricate superhydrophilic/underwater superoleophobic materials with outstanding anti-viscous oil-fouling property for practically treating oily wastewater.

Abuse-Deterrent Formulations in Constraining the Abuse Potential of Prescription Medicines: A Myth or Truth.

Diverse pain killers used for the management of varied categories of pain are being misused in order to have extreme pleasant effects by a large number of populations. To overcome the misuse of prescription drugs, regulatory bodies have given stress on the development of abuse resistance. We studied numerous literatures: (1) Research and review papers including the guidelines for pain management, abuse, and abuse deterrence; (2) Description and categorization of pain along with the management approaches; (3) Advantages and disadvantages of the abuse-deterrent formulations. Abuse-deterrent formulations are the contemporary remedial treatment for pain with reduced prospects of being abused. But these comprise huge expense in contrast to the generic drugs as well as the non-deterrent branded equivalents. Many challenges are faced throughout the development of abuse-deterrent formulations. These formulations displayed a substantial drop in abuse incidences but it may lead to other modes of abuse, which may prove more harmful for the users.

Hydroxylamine enables rapid heterogeneous-homogeneous coupled Fenton sulfamethazine degradation on ferric phosphate

Heterogeneous-homogeneous coupled Fenton (HHCF) processes compromise the merits of rapid degradation and catalyst reusability, thus are very attractive for environmental remediation and water treatment. However, the development of HHCF processes suffers from the lack of desirable catalysts and Fe(III)/Fe(II) redox cycle (iron cycle) mediators. Herein we demonstrate the combination of hydrogen peroxide, ferric phosphate and hydroxylamine offers a promising HHCF process, where ferric phosphate and hydroxylamine serve as the catalyst and iron cycle mediator, respectively. Hydroxylamine can realize suitable iron release from ferric phosphate, effective iron cycle, and •OH consumption, resulting in efficient conversion of H2O2 to •OH for sulfamethazine removal. More importantly, the phosphorus release from ferric phosphate and nitrogen residual during this HHCF process are limited to reduce the risk of secondary pollution. This study clarifies the importance of iron dissolution and iron cycle on highly efficient Fenton processes, and also provides a promising antibiotic pollutant removal strategy.

Electrocoagulation vs. Integrate Electrocoagulation-Natural Zeolite for Treatment of Biowaste Compost Leachate—Whether the Optimum Is Truly Optimal

Natural zeolites are well-known materials widely applied in the environmental remediation treatment process. However, the integration of various treatment methods is exceedingly investigated for achieving satisfactory effluent quality. In this paper, the integration of electrocoagulation and natural zeolite was evaluated in the treatment of biowaste compost leachate in a single step. The influence of different distances of electrodes (1.5, 3, and 4.5 cm), stirring speed (70, 200, and 400 rpm), the addition of natural zeolite and electrolyte NaCl on the efficiency of treatment of biowaste compost leachate has been carried out. Process efficiency was evaluated by measuring the change of pH value, electrical conductivity, temperature, turbidity, chemical oxygen demand (COD), total Kjeldahl nitrogen (TNK), total solids, and sludge settling test. The Taguchi method was applied to optimize biowaste compost leachate treatment. Experiments are planned according to Taguchi’s L8 (24 41) orthogonal array. The stirring speed, electrode distance, electrolyte and zeolite addition, solution initial pH adjustment were chosen as controllable factors, and their impact on COD, turbidity, TNK, settling rate, and electrode consumption were studied. Results show that optimal conditions depend on the parameter of interest and that optimal values for a particular parameter are not always the optimum if the desired goal is considered.

Combined solar activated sulfate radical-based advanced oxidation processes (SR-AOPs) and biofiltration for the remediation of dissolved organics in oil sands produced water

• Effective degradation of dissolved organics in produced water by solar activated SR-AOPs. • SO 4 •− , • OH and 1 O 2 reactive species were formed during solar activated SR-AOPs. • Better performance by solar activated peroxymonosulfate compared to persulfate. • Excellent mineralization of dissolved organic by post-treatment biofilm filtration. • Microbial profiling indicated presence of hydrocarbons and carboxylic acid degraders. This study reported for the first time the potential of sequential solar activated sulfate radical advanced oxidation processes (SR-AOPs) and fixed bed biofiltration for the enhanced remediation of dissolved organics in oil sands process water (OSPW). The effect of initial sulfate precursors namely persulfate (PS) and monopersulfate (PMS) was examined on the degradation of naphthenic acid (NA) surrogates and various classes of organics in real OSPW. Effluents from solar activated SR-AOPs treatment of OSPW at specific conditions were subjected to biofiltration for 45 days. Fast and complete degradation of 5-phenylvalveric acid (PVA) and up to 99% degradation of various organics in OSPW were achieved by the solar activated SR-AOPs. Radical scavenger and spin-trap electroparamagnetic spectrometry analysis showed that hydroxyl ( • OH) and sulfate (SO 4 •− ) radicals were the major reactive species generated and participated in the oxidation of organics in SR-AOPs treatment with either PS or PMS along with a small proportion of singlet oxygen. The biofiltration post-treatment showed significant mineralization of dissolved organics in treated OSPW, achieving over 60% and 40% reduction in DOC and COD, respectively, surpassing most of the reported studies for such combined approach. The bacterial metataxonomic analysis indicated significant enrichment of hydrocarbons and carboxylic acid degraders ( Sphingomonas and Sphingopyxis ) in the biofilters treating PMS pre-treated OSPW. However, for biofilters treating raw OSPW and PS, the bacterial community was dominated by hydrocarbon degraders and methanotrophs. The treated OSPW was found completely non-toxic for the OSPW treated with PMS-9 h and biofiltration. This demonstrates the potential of combined treatment for the effective remediation of the oil sand industry effluent.

Understanding, controlling and optimising the cooling of waste thermal treatment beds including STARx Hottpads

STARx (Self-sustaining Treatment for Active Remediation ex situ) is a thermal treatment strategy for contaminated soils and organic wastes. Key to this technology is that organics are embedded in porous matrix beds (e.g. sand). STARx induces a self-sustaining smouldering combustion front that traverses the bed, burning away the embedded contaminants/wastes. The time and cost effectiveness of this technology is largely dictated by the time required for cooling of the hot, clean, porous matrix bed that remains after treatment. This study is the first to explore the cooling of these beds. A suite of novel simulations investigated the influence of key parameters on bed-cooling time. The results reveal that cooling time decreased nearly linearly with decreases of volume-averaged bed temperature and bed bulk density. Increased injection air fluxes led to the non-linear decrease of cooling time. Also, cooling time was negatively impacted by bed temperature inhomogeneity, which influenced preferential air flow through cooler regions of the bed, bypassing hotter regions. From these results, using lower bulk density bed materials, increased air fluxes and enhancing wall insulation to improve bed temperature homogeneity were identified as system optimisations to reduce cooling times. While the aim of this research is to improve the STARx cooling process, the results are also highly applicable to many similar engineering systems that involve hot porous bed cooling.

Enhanced remediation of a real HCH-polluted soil by the synergetic alkaline and ultrasonic activation of persulfate

The desorption of hydrophobic organic compounds (HOCs) and limited mass transfer in soil systems is a significant challenge for efficient soil remediation by oxidation treatments. The utilization of sonochemistry is a promising technology to enhance the decontamination of HOCs-polluted soils. In this work, ultrasound (US) was coupled to NaOH for activating persulfate (PS) to enhance the remediation of a real soil polluted with hexachlorocyclohexanes (HCHs) (ΣHCHs = 404 mg kg−1).Batch experiments (mass aqueous/soil ratio, VL/WS = 2) were performed to evaluate the effect of US on HOCs desorption and oxidation. Moreover, the influence of US power (0–245 W, corresponding to 0–91 W L-1 of US power density) and the initial oxidant concentration (CPS = 10–60 g L-1) on pollutants abatement, dechlorination degree, and oxidant consumption have been studied. Scanning electron microscopy (SEM) images verified that the US facilitates the breakdown of soil aggregates, enhancing the desorption of trichlorobenzenes (TCBs) (generated from HCHs alkaline hydrolysis) from the soil. Moreover, their subsequent oxidation is favouring because of higher radical species concentrations and the temperature rise. An increase in the US power up to 165 W accelerates the production rate of radicals, improving the pollutants’ degradation. The difference between pollutant oxidation and dechlorination decreases with increasing US power, associated with a lower concentration of intermediate chlorinated compounds. In the same way, the initial oxidant concentration plays a fundamental role in the remediation treatment. At the selected operating conditions (CPS = 60 g L-1, NaOH/PS = 2, 165 W), a pollutants degradation and dechlorination of 0.94 and 0.74, respectively, were achieved in just 3 h of reaction time.

Effects of Nickel Nanoparticles on Rhodococcus Cell Surface Morphology and Nanomechanical Properties

Nickel nanoparticles (NPs) are used for soil remediation and wastewater treatment due to their high adsorption capacity against complex organic pollutants. However, despite the growing use of nickel NPs, their toxicological towards environmental bacteria have not been sufficiently studied. Actinobacteria of the genus Rhodococcus are valuable bioremediation agents degrading a range of harmful and recalcitrant chemicals. Both positive and negative effects of metal ions and NPs on the biodegradation of organic pollutants by Rhodococcus were revealed, however, the mechanisms of such interactions, in addition to direct toxic effects, remain unclear. In the present work, the influence of nickel NPs on the viability, surface topology and nanomechanical properties of Rhodococcus cells have been studied. Bacterial adaptations to high (up to 1.0 g/L) concentrations of nickel NPs during prolonged (24 and 48 h) exposure were detected using combined confocal laser scanning and atomic force microscopy. Incubation with nickel NPs resulted in a 1.25–1.5-fold increase in the relative surface area and roughness, changes in cellular charge and adhesion characteristics, as well as a 2–8-fold decrease in the Young’s modulus of Rhodococcus ruber IEGM 231 cells. Presumably, the treatment of rhodococcal cells with sublethal concentrations (0.01–0.1 g/L) of nickel NPs facilitates the colonization of surfaces, which is important in the production of immobilized biocatalysts based on whole bacterial cells adsorbed on solid carriers. Based on the data obtained, cell surface functionalizing with NPs is possible to enhance adhesive and catalytic properties of bacteria suitable for environmental applications.

Does Adding Social Cognitive Remediation Therapy to Neurocognitive Remediation Therapy Improve Outcomes in Young People With a Severe Mental Illness?-The Advantage Trial.

IntroductionCognitive impairments are a common and significant issue for young people with a severe mental illness. Young people with schizophrenia, bipolar disorder and major depression all experience significant cognitive problems that impede their ability to return to work or study. These neurocognitive problems are frequently exacerbated by social cognitive deficits that interfere with their ability to integrate into the community and understand the social and emotional nuances about them. This study aimed to assess if the addition of a social cognitive remediation treatment to a neurocognitive remediation therapy improved functional outcome.MethodsFive youth mental health services were trained in both the Neuropsychological Educational Approach to Remediation (NEAR) and the Social Cognition and Interaction Training (SCIT) treatments. Participants were randomised between receiving either NEAR + SCIT or NEAR + treatment as usual (TAU) over a 20-week period, with all participants receiving the NEAR treatment first. Symptoms, neurocognition, social cognition and functioning were examined at baseline, end of treatment and at 3 months follow-up and compared between the two arms of the study. The primary outcome was function.ResultsThirty-nine participants were randomised to treatment (Schizophrenia spectrum = 28, Bipolar disorder = 7, Major Depression = 2). The trial was curtailed by Covid-related service restrictions. There was an overall significant improvement in function over time with a trend towards a greater improvement in the NEAR + SCIT arm. No changes in symptoms, neurocognitive or social cognitive measures were seen. While 74% completed treatment only 49% agreed to follow up at 3 months affecting our ability to interpret the findings. Attrition did not differ by arm.ConclusionsIn a pragmatic, service-based research project, treatment aimed at improving cognition enhanced functional outcome in young people with a range of severe mental illnesses. There was a trend towards improved function in young people who had a combined NEAR + SCIT approach.Clinical Trial RegistrationIdentifier: ACTRN12622000192785.

Mechanical thrombectomy via chronic occluded proximal artery for the endovascular treatment of acute ischemic stroke patients with large vessel occlusion

BackgroundMechanical thrombectomy (MT) can significantly improve the prognosis of acute ischemic stroke patients with large vessel occlusion. However, for patients with chronic occluded proximal artery, therapeutical strategies are limited because the endovascular route for MT is not readily accessible. MethodsHere, we introduce a safe and effective MT procedure via a chronic occluded proximal artery. We conducted a retrospective study of seven patients with acute ischemic stroke due to large artery occlusion (AIS-LVO) who underwent MT via a chronic occluded proximal artery for endovascular treatment. We analyzed the technical procedure of the MT and the clinical outcomes of these patients. ResultsThe distal thrombus was successfully removed in all patients by opening the occluded proximal artery, thus achieving revascularization with a Thrombolysis in Cerebral Infarction (TICI) of 2b/3. The average time from arterial puncture to reperfusion was 171.14 ± 36.56 min. Three patients had a good modified Rankin scale (mRS) score (0–2) at discharge. Among 4 patients with anterior circulation stroke, 2 recovered completely, 1 had anomic aphasia, and 1 had hemiplegia. Among 3 patients with posterior circulation stroke, 1 recovered completely, 1 had locked-in syndrome, and 1 was comatose. Four patients had good functional prognoses. ConclusionsMechanical thrombectomy procedure via a chronic occluded proximal artery can be used in patients with well-established collateral compensatory vessels. It is safe and effective in improving the prognosis of patients. It can be used as a remedial treatment strategy for patients with AIS-LVO.

Effects of DA-6 and EDDS on Growth and Cd Uptake by Solanum nigrum L. and on the Soil Bacterial Community Structure

The effects of the plant growth regulator DA-6 and chelator EDDS on the growth, Cd absorption, and soil bacterial community structure of Solanum nigrum L. on Cd-polluted soil were examined through a pot experiment, so as to evaluate the practical application effects of different remediation treatments. The results showed that the addition of DA-6 alone and the combined application of DA-6 and EDDS could promote the growth of S. nigrum L., and the shoot fresh weight increased by 24.58% and 19.57%, respectively, compared with that in the control. At the same time, the chlorophyll content and antioxidant enzyme activity of S. nigrum L. leaves also increased, whereas the content of malondialdehyde decreased. The application of DA-6 and EDDS also significantly increased the content of soil available Cd and promoted the absorption of Cd by S. nigrum L. Compared with that in the control, the extraction amount of Cd from S. nigrum L. shoots was significantly increased by 39.42% (DA-6), 30.17% (EDDS), and 51.04% (DA-6+EDDS), respectively. It was also found that the application of EDDS alone significantly reduced the ACE index of the soil bacterial community and significantly increased the Simpson index, and the abundance of the Lysobacter genus in the soil was significantly reduced. After the combination of DA-6 and EDDS, the diversity and taxonomic composition of the soil bacterial community were improved.