Remarkable Recovery Research Articles

Stem cell factor protects against chronic ischemic retinal injury by modulating on neurovascular unit

Retinal ischemia is a significant factor in various vision-threatening diseases, but effective treatments are currently lacking. This study explores the potential of stem cell factor (SCF) in regulating the neurovascular unit as a therapeutic intervention for retinal ischemic diseases. A chronic retinal ischemia model was established in Brown Norway rats using bilateral common carotid artery occlusion (BCCAO). Subsequent SCF treatment resulted in a remarkable recovery of retinal function, as indicated by electroretinogram, light/dark transition test, and optokinetic head tracking test results. Histological examination demonstrated a significant increase in the number of retinal neurons and an overall thickening of the retina. Immunofluorescence confirmed these findings and further demonstrated that SCF treatment regulated retinal remodeling. Notably, SCF treatment ameliorated the disrupted expression of synaptic markers in the control group's BCCAO rats and suppressed the activation of Müller cells and microglia. Retinal whole-mount analysis revealed a significant improvement in the abnormalities in retinal vasculature following SCF treatment. Transcriptome sequencing analysis revealed that SCF-induced transcriptome changes were closely linked to the Wnt7 pathway. Key members of the Wnt7 pathway, exhibited significant upregulation following SCF treatment. These results underscore the protective role of SCF in the neurovascular unit of retinal ischemia rats by modulating the Wnt7 pathway. SCF administration emerges as a promising therapeutic strategy for retinal ischemia-related diseases, offering potential avenues for future clinical interventions.

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection-biochemical and histopathological insights.

Background: Liver disease is a serious health concern in today's world, posing a challenge to both healthcare providers and pharmaceutical companies. Most synthetic drugs and chemicals cause liver damage accounting for approximately 10% of acute hepatitis and 50% of acute liver failure. Purpose: The present study aimed to evaluate the hepato-protective activity of an extract of chicory formulation assisted by silver nanoparticles against carbon tetra chloride (CCl4)-induced hepatic damage in rat's liver. Methods: Rats of the Wistar strain (Rattus norvegicus) were used to test the in vivo hepato-protective efficacy at various doses. Rats were randomly divided into nine groups, each containing six rats. The groups were as follows: first group (control), second group (CCl4), third group, silymarin (20mg/kg of body weight), fourth group (CCl4+chicory) (1.75mg/kg of b. wt), fifth group (CCl4 + chicory at the dose of 2.35mg/kg), sixth group (CCl4 + chicory of 3.25mg/kg), seventh group (CCl4 +AgNPs 1.75mg/kg of b. wt.), eighth group (CCl4 + AgNPs 2.35mg/kg of body weight), and ninth group (CCl4 + AgNPs 3.25mg/kg of b. wt.). Blood samples were taken 24h after the last administration (i.e., 30th day). The blood samples were analyzed for different serum enzymes such as ALP (alkaline phosphatase), ALT (alanine transaminase), bilirubin (Blr), triglyceride, and cholesterol. Histology liver sections were performed. Results: Treatment with AgNPs and chicory extract showed significant hepato-protective activity in a dose-dependent manner. In three doses, the chicory extract at a rate of 3.25mg/kg of body weight significantly reduced elevated levels of biochemical markers in comparison to CCl4-intoxicated rats. Histology of the liver sections from CCl4-treated rats revealed inflammation of hepatocytes, necrosis, cytoplasmic degeneration, vacuolization, and a deformed central vein. The chicory formulation extract exhibited a remarkable recovery percentage in the liver architecture that was higher than the drug (i.e., silymarin). While treatment with AgNPs also repaired the degenerative changes and restored the normal form of the liver, chicory formulation extract possessed more hepato-protective potential as compared to AgNPs by regulating biochemical and histo-pathological parameters. Conclusion: This study can be used as confirmation of the hepato-protective potential of chicory compounds for possible use in the development programs of drugs to treat liver diseases.

Phát triển ngành công nghiệp Thành phố Hồ Chí Minh: Thực trạng và những vấn đề đặt ra

This study aims to evaluate the current state of industrial development in Ho Chi Minh City and analyze the problems posed during that development process. The research paper uses descriptive statistics method, analytial methods, evaluation and synthesis methods and use secondary data sources which was collected from Ho Chi Minh City Statistical Yearbook for the period 2010-2022. The results of the study show that since 2010 until now, the city’s industry has increased in the size of GDP contribution, the city’s industry has experienced remarkable recovery and development since the covid-19 pandemic; the industry has had a shift in the production of high-value-added products and is geared towards exports, brings revenue to the state budget, and contributes to creating jobs, increasing income and stabilizing life for workers. Besides the achieved results, in the development process, the city’s industry currently tend to reduce its share of the city’s GDP and is facing a number of limitations and difficulties. On that basis, the article proposes some recommendations to contribute to the development of Ho Chi Minh City’s industry in the near future.

Synthesis and Characterization of Anti‐fouling Ultrafiltration Nanocomposite Membranes Integrated with S‐β Zeolite Nanoparticles for Oily Wastewater Treatment

AbstractMembrane separation has been proven to be highly effective in oily wastewater treatment, although fouling remains a persistent challenge. This study explored the incorporation of S‐β zeolite nanoparticles into an ultrafiltration membrane, forming a nanocomposite to tackle fouling and enhance water flux recovery. Porous nanoparticles were synthesized using sol‐gel and hydrothermal methods, featuring a remarkable surface area of 450 m2/g and pore sizes ranging from 50 to 175 nm according to BET results. These nanoparticles were integrated into the membranes at various concentrations using the phase inversion technique. The presence of S‐zeolite in the membrane was confirmed through FTIR, EDX, and SEM analyses. The S‐β1 nanocomposite membrane demonstrated exceptional antifouling properties, particularly at higher concentrations of oily wastewater. Its outstanding performance is attributed to its enhanced hydrophilicity and average pore size of 13±3 nm, which prevents fouling formation. Compared to other membranes, S‐β1 exhibited remarkable water flux recovery, reaching 100 % at an oil concentration of 50 ppm and 72 % at 1000 ppm. These results highlight the significant advantages of this nanocomposite in reducing fouling and improving the water flux recovery in oily wastewater treatment.

Polyethylene Glycol-Mediated Axonal Fusion Promotes Early Sensory Recovery After Digital Nerve Injury: A Randomized Clinical Trial

Background. Peripheral nerve repair is limited by Wallerian degeneration coupled with the slow and inconsistent rates of nerve regrowth. In more proximal injuries, delayed nerve regeneration can cause debilitating muscle atrophy. Topical application of polyethylene glycol (PEG) during neurorrhaphy facilitates the fusion of severed axonal membranes, immediately restoring action potentials across the coaptation site. In preclinical animal models, PEG-fusion resulted in remarkable early functional recovery. Methods. This is the first randomized clinical trial comparing functional outcomes between PEG-fusion and standard neurorrhaphy. Participants with digital nerve transections were followed up at 2 weeks, 1 month, and 3 months postoperatively. The primary outcome was assessed using the Medical Research Council Classification (MRCC) rating for sensory recovery at each timepoint. Semmes-Weinstein monofilaments and static two-point discrimination determined MRCC ratings. Postoperative quality of life was measured using the Michigan Hand Questionnaire (MHQ). Results. Forty-eight transected digital nerves (25 control, 23 PEG) across twenty-two patients were analyzed. PEG-fused nerves demonstrated significantly higher MRCC scores at 2 weeks (OR 16.95, 95% CI: 1.79 – 160.38, p = 0.008) and 1 month (OR 13.40, 95% CI: 1.64 – 109.77, p = 0.009). Participants in the PEG cohort also had significantly higher average MHQ scores at 2 weeks (Hodge’s g 1.28, 95% CI: 0.23 – 2.30, p = 0.0163) and 1 month (Hodge’s g 1.02, 95% CI: 0.04 – 1.99, p = 0.049). No participants had adverse events related to the study drug. Conclusion. PEG-fusion promotes early sensory recovery and improved patient well-being following peripheral nerve repair of digital nerves.

Combined effect of Cerium oxide nanoparticles loaded scaffold and photobiomodulation therapy on pain and neuronal regeneration following spinal cord injury: an experimental study.

Spinal cord injury (SCI) remained one of the challenges to treat due to its complicated mechanisms. Photobiomodulation therapy (PBMT) accelerates neuronal regeneration. Cerium oxide nanoparticles (CeONPs) also eliminate free radicals in the environment. The present study aims to introduce a combined treatment method of making PCL scaffolds as microenvironments, seeded with CeONPs and the PBMT technique for SCI treatment. The surgical hemi-section was used to induce SCI. Immediately after the SCI induction, the scaffold (Sc) was loaded with CeONPs implanted. PBMT began 30min after SCI induction and lasted for up to 4weeks. Fifty-six male rats were randomly divided into seven groups. Glial fibrillary acidic protein (GFAP) (an astrocyte marker), Connexin 43 (Con43) (a member of the gap junction), and gap junctions (GJ) (a marker for the transfer of ions and small molecules) expressions were evaluated. The behavioral evaluation was performed by BBB, Acetone, Von Frey, and radiant heat tests. The SC + Nano + PBMT group exhibited the most remarkable recovery outcomes. Thermal hyperalgesia responses were mitigated, with the combined approach displaying the most effective relief. Mechanical allodynia and cold allodynia responses were also attenuated by treatments, demonstrating potential pain management benefits. These findings highlight the potential of PBMT, combined with CeONPs-loaded scaffolds, in promoting functional motor recovery and alleviating pain-related responses following SCI. The study underscores the intricate interplay between various interventions and their cumulative effects, informing future research directions for enhancing neural repair and pain management strategies in SCI contexts.

Impact of CoFe2O4 Magnetic Nanoparticles on the Physical and Mechanical Properties and Shape Memory Effect of Polylactide

The acceleration in advancements of smart materials and non-contact controlled devices in the field of 4D printing is facilitated by the use of magnetically responsive shape memory polymer (SMP) composites. This study is dedicated to the development of promising shape memory materials based on polylactic acid (PLA) and cobalt ferrite (CoFe2O4) nanoparticles. The activation of the shape memory effect (SME) in magnetic nanoparticle composites was achieved by applying a high-frequency alternating magnetic field (HFAMF). The PLA/CoFe2O4 composites exhibited a remarkable shape recovery ratio (>84%) and underwent rapid heating when exposed to HFAMF. The interaction of these composites with mouse adipose-derived mesenchymal stem cells demonstrated adequate cytocompatibility. The rapid magnetosensitive behavior and high shape recovery characteristics of PLA/CoFe2O4 composites make them promising candidates for biomedical applications.

Collective privacy recovery: Data-sharing coordination via decentralized artificial intelligence.

Collective privacy loss becomes a colossal problem, an emergency for personal freedoms and democracy. But, are we prepared to handle personal data as scarce resource and collectively share data under the doctrine: as little as possible, as much as necessary? We hypothesize a significant privacy recovery if a population of individuals, the data collective, coordinates to share minimum data for running online services with the required quality. Here, we show how to automate and scale-up complex collective arrangements for privacy recovery using decentralized artificial intelligence. For this, we compare for the first time attitudinal, intrinsic, rewarded, and coordinated data sharing in a rigorous living-lab experiment of high realism involving real data disclosures. Using causal inference and cluster analysis, we differentiate criteria predicting privacy and five key data-sharing behaviors. Strikingly, data-sharing coordination proves to be a win-win for all: remarkable privacy recovery for people with evident costs reduction for service providers.

Leaf-like ZIF-L as self-sacrificed template via acid induced removal for stronger negatively charged PES membranes based on RTIPS method

In this paper, ZIF-L was blended with citric acid (CA) and polyethersulfone (PES) to prepare a casting solution. A novel negatively charged ultrafiltration (UF) membrane (ZIF-L/CA/PES) was obtained using the reverse thermally induced phase separation (RTIPS) method. The hydrophilic carboxyl groups present in CA not only imparted high hydrophilicity and negative charge to the membrane surface, enhancing the membrane’s selectivity and contamination resistance, but also created an acidic environment to attack the Zn atoms in ZIF-L by the ionized H+ from CA, resulting in the generation of micro-defective pores and an improvement in permeability. Additionally, the results showed that membranes generated through the RTIPS process exhibit uniform porous surfaces and spongy cross-sections, enhancing membrane performance. The optimized membranes demonstrated the capability to achieve a pure water flux of up to 2267 L/m2h with 93.1 % humic acid (HA) retention, and a remarkable membrane flux recovery rate of 75.8 %, suggesting the crucial roles played by CA and ZIF-L in the separation process. In conclusion, hydrophilic anti-fouling UF membranes with a high negative charge and excellent permeation selectivity were fabricated by establishing micro-defective channels through the incorporation of carboxylic acid and ZIF-L, combined with the RTIPS process.

Fully Reversible and Super-Fast Photo-Induced Morphological Transformation of Nanofilms for High-Performance UV Detection and Light-Driven Actuators.

Flexible and highly ultraviolet (UV) sensitive materials garner considerable attention in wearable devices, adaptive sensors, and light-driven actuators. Herein, a type of nanofilms with unprecedented fully reversible UV responsiveness are successfully constructed. Building upon this discovery, a new system for ultra-fast, sensitive, and reliable UV detection is developed. The system operates by monitoring the displacement of photoinduced macroscopic motions of the nanofilms based composite membranes. The system exhibits exceptional responsiveness to UV light at 375nm, achieving remarkable response and recovery times of < 0.3s. Furthermore, it boasts a wide detection range from 2.85µWcm-2 to 8.30mWcm-2, along with robust durability. Qualitative UV sensing is accomplished by observing the shape changes of the composite membranes. Moreover, the composite membrane can serve as sunlight-responsive actuators for artificial flowers and smart switches in practical scenarios. The photo-induced motion is ascribed to the cis-trans isomerization of the acylhydrazone bonds, and the rapid and fully reversible shape transformation is supposed to be a synergistic result of the instability of the cis-isomers acylhydrazone bonds and the rebounding property of the networked nanofilms. These findings present a novel strategy for both quantitative and qualitative UV detection.

Recyclable high-performance triboelectric nanogenerator enabled by dynamic covalently crosslinked polymers

Triboelectric nanogenerators (TENGs), being at the forefront of energy harvesting technologies, possess the ability to convert ambient energy sources into electrical power. However, the low energy density and non-recyclability of the tribolayers severely hinder its further application. To address this crucial issue, we propose an innovative approach by incorporating imine linkages into fluorine-containing polymers, creating a high-performance TENG with recyclability. The integration of imine linkages not only enhances the electrical output of TENG devices but also ensures their long-term sustainability as an energy solution. Notably, TENG devices utilizing this recyclable material demonstrate remarkable contact electrification performance, achieving a short-circuit current of up to 29.5 μA and an output voltage of up to 964 V. Furthermore, the efficient degradation and re-generation of the recyclable material facilitate a remarkable recovery of over 80% in the output of the refabricated TENG. To improve the energy utilization efficiency of the TENG, a power management circuit (PMC) based on a DC-DC buck converter is integrated to regulate the TENG without requiring an additional power supply. These findings offer crucial insights for advancing high-performance, recyclable TENG devices, which play a pivotal role in the development of sustainable energy harvesting technologies.

Analysis of Italian Economic Fluctuations Based on Keynesian Framework

After the coronavirus-caused global recession, governments implemented various contingency measures to revive their economies worldwide. Despite improving digital marketing and international business relations, adverse effects still need to be addressed, and the issue takes time and money to resolve. Italy is one of the EU's most economically powerful countries, but COVID-19 has hit it hardest. This article will analyze relevant data and examine the causes of statistical fluctuations to explain Italy's economy. There are various reasons why Italy was so heavily infected. This study uses the concept of aggregate demand in Keynesian economics to analyze Italys economic model and gross domestic product (GDP) composition. In addition, by looking at the policies and other influential factors, the paper explores the current economic situation the Italian government is in. By providing some overview and further explanation of the data, the paper underscores that Italy has made a remarkable recovery after COVID-19 using investment support. However, the government is now too dependent on it, and its GDP structure has to change to improve its performance in solving the surging public debt and deficit issues.

Application of power battery under thermal conductive silica gel plate in new energy vehicles

This study aims to improve the performance of automotive battery thermal management systems (BTMS) to achieve more efficient heat dissipation and thus reduce hazards during driving. Firstly, the research parameters and properties of composite thermally conductive silicone materials are introduced. Secondly, the heating principle of the power battery, the structure and working principle of the new energy vehicle battery, and the related thermal management scheme are discussed. Finally, the research results are presented from the experimental test and controller design. In addition, to achieve the research goal, the composite thermally conductive silica gel plate (CSGP) material is studied in detail and parametrically analyzed, and the heating mechanism of the power battery is discussed in depth. The temperature characteristics after adding CSGP are experimentally tested, and the controller of the BTMS of the new energy vehicle is designed, including hardware circuits and software modules. The findings show that the temperature characteristics of the battery module have obvious limitations without CSGP. When the battery module operates at a 4C magnification, the temperature exceeds the safety threshold by 38.4%, with particular potential safety risks. Then, the maximum temperature of the battery module with CSGP can be controlled within 50 °C, and the temperature characteristics are prominently improved. Lastly, the controller of the BTMS is tested, and the results reveal that it has remarkable voltage recovery ability. According to the research results, the performance of automotive BTMS can be significantly improved, and better heat dissipation can be effectively achieved by adding CSGP. This helps reduce the hazards of driving. Moreover, the designed controller performs well in voltage recovery, providing solid theoretical support for further developing the CSGP battery management system.

Application of the International Classification of Functioning, Disability and Health Model in Recurrent Guillain-Barré Syndrome: A Case Report

The present case report utilises the International Classification of Functioning, Disability and Health (ICF) model to assess the health condition and its impact on various health domains of a 46-year-old male who experienced recurrent Guillain-Barré Syndrome (GBS) for the second time within three years. The patient presented with sudden difficulty swallowing solid food and bilateral lower limb weakness, struggling to rise from a sitting position. The report explores the patient’s ICF profile, highlighting the effect of GBS on his daily life and recovery process. The patient’s remarkable recovery can be attributed to several factors, despite the challenges faced. These factors include good socio-economic status, motivation, family support and consistent physiotherapy. Together, these elements played pivotal roles in facilitating the recovery process.

Successful revascularization therapy in altered mental state patient with posterior circulation stroke and left subclavian artery partial obstruction: a case report and review of literature

Background: This case report highlights the successful revascularization therapy and favorable functional outcome in a rare and challenging case involving basilar artery occlusion and left subclavian artery partial obstruction. Case Presentation: We report a patient presented with a high National Institutes of Health Stroke Scale score and altered mental state following collapse. Timely intervention, with multidisciplinary team approach including mechanical thrombectomy and intravenous thrombolysis, led to a remarkable neurological recovery. The discussion emphasizes the significance of prompt revascularization in cases of posterior circulation stroke and underscores the need for further research on multiple arterial obstructions. Conclusion: This case illustrates the potential for positive prognostic indicators even in complex scenarios, ultimately improving patient outcomes in such critical conditions.

Portable smartphone-enabled dydrogesterone sensors based on biomimetic polymers for personalized gynecological care.

Dydrogesterone, a frequently prescribed synthetic hormone integral to the treatment of diverse gynecological conditions, necessitates precise quantification in complex human plasma. In this study, the development of a portable, smartphone-based electrochemical sensor employing screen-printed gold electrodes (SPAuEs) modified with a biomimetic, molecularly imprinted poly(methacrylic acid-co-methyl methacrylate) (MIP) is presented for dydrogesterone detection in human plasma. FTIR spectroscopy illustrates the transformation of a pre-polymer mixture into a polymerized matrix, while SEM reveals a uniform MIP/SPAuE surface morphology. The sensor fabrication protocol, encompassing MIP/SPAuE composition, polymerization solvent, incubation time, and scan rate, is optimized to achieve enhanced sensitivity. The MIP/SPAuEs sensor exhibits a linear sensor response to dydrogesterone within the concentration range of 1-500 nM, as evidenced by cyclic and differential pulse voltammetry. The MIP/SPAuE sensor demonstrates exceptional sensitivity, recording 8.2 × 10-3 μA nM-1, with a sub-nanomolar limit of detection (LOD = 370 pM), and low limit of quantification (LOQ = 1.12 nM), along with appreciable selectivity over common interferents. In real-world clinical applications, the designed sensor is effectively employed for the rapid and precise determination of dydrogesterone in human blood plasma, achieving a remarkable recovery of 81%. Furthermore, MIP/SPAuE coatings possess suitable stability over 15 days, indicating the robustness of the sensor material for multiple rounds of analysis. The developed sensor provides a sensitive, selective, and cost-effective solution for monitoring dydrogesterone in plasma during various gynecological disorders, allowing for personalized healthcare applications.

Late Hypoglossal-facial latero-terminal anastomosis: Effective reanimation for total facial paralysis post-vestibular schwannoma resection - A compelling case report of remarkable recovery.

Late Hypoglossal-facial latero-terminal anastomosis: Effective reanimation for total facial paralysis post-vestibular schwannoma resection - A compelling case report of remarkable recovery.

A case report on paediatric verruca vulgaris: A homoeopathic journey to remarkable recovery

A case report on paediatric verruca vulgaris: A homoeopathic journey to remarkable recovery

Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin

The uncontrolled use of ciprofloxacin (CIP) has led to increased resistance in patients and potential health issues such as kidney disorders, digestive disorder, and liver complications. This study addresses these concerns by introducing an innovative electrochemical sensor utilizing a screen-printed electrode (SPE) enhanced with a novel rGO-SnO2 nanocomposite for the precise monitoring of CIP concentration. Through square wave voltammetry (SWV), this sensor demonstrates unparalleled sensitivity and accuracy in determining CIP levels. These analyses validated the superior performance of the SPE/rGO-SnO2 electrode, revealing CIP potential range of 0.85–1.50 V with irreversible oxidation reaction and an exceptional signal-to-background (S/B) ratio of 1.91, surpassing the 1.21 ratio achieved by the SPE/rGO electrode. The SPE/rGO-SnO2 electrode also exhibited the highest active surface area (0.0252 cm2), facilitating faster transfer electron. Crucially, the SPE/rGO-SnO2 electrode exhibited an impressively low limit of detection (LOD) at 2.03 μM within a concentration range of 30–100 μM for CIP, setting a new benchmark for sensitivity (9.348 μA/μM) in CIP detection. The %RSD value was less than 5 % indicating that this modified electrodes exhibit good precision and stability. The real-world applicability of this developed methods was exemplified through its successful implementation in the analysis of river water and milk, achieving remarkable recovery rates of 101.2 % and 97.7 %, respectively. Consequently, the SPE modified with rGO-SnO2 nanocomposite emerges as a highly promising and effective tool for precise and sensitive CIP measurement, offering unparalleled performance metrics and opening avenues for enhanced environmental and health monitoring.

Genetic diversity of a recovering European roller (Coracias garrulus) population from Serbia.

The European Roller (Coracias garrulus), a long-distance migratory bird, faced a considerable decline in breeding pairs throughout Europe at the end of the 20th century. Due to conservation efforts and the installation of nesting boxes, the population of the European Roller in Serbia has made a remarkable recovery. Here, we used the variability of nucleotide sequences of the mitochondrial DNA (mtDNA) control region and 10 microsatellite loci to assess the genetic diversity and structuring, phylogeographic patterns and demographic history of this species using 224 individuals from Serbia. Our results showed moderate level of genetic diversity (HO = 0.392) and a slightly elevated level of inbreeding and homozygosity (FIS = 0.393). Genetic structuring based on microsatellite data indicated three genetic clusters, but without a clear spatial pattern. High haplotype diversity (Hd = 0.987) of the mtDNA control region sequences was detected, and neutrality tests indicated a recent demographic expansion. The phylogeographic analysis, which also included previously published sequences of the mtDNA control region, supported the subdivision into two distinct European and Asian haplogroups (ΦST = 0.712). However, the results of our study showed that a larger number of haplotypes sampled in Serbia are clustered in the Asian haplogroup as compared to previous studies, indicating a historically continuous distribution of this species and possibly a wider distribution of the subspecies Coracias garrulus semenovwi. Our results suggest that the European Roller population in Serbia is genetically stable, with no evidence of recent bottlenecks, and emphasize the importance of artificial nest boxes for promoting and maintaining population dynamics of European Rollers.