The objective was to examine the microshear bond strength values of different dual resin cements to computer-aided design (CAD)/computer-aided manufacturing (CAM)-created ceramics containing lithium disilicate, which underwent different surface treatments. Two dual resin cements (RelyX ARC and RelyX Ultimate) and three surface treatments of lithium disilicate ceramic blocks (Ceramic Primer (CP; containing silane) plus Adper Scotchbond Multipurpose (ASM) adhesive; CP plus Single Bond Universal (SBU) adhesive; and SBU adhesive alone) were tested. The SBU adhesive includes silane in its formulation. Each sample underwent a microshear test and bond strength values were subjected to analysis of variance (ANOVA) followed by Tukey's test (α=0.05). Fracture patterns were also observed with light microscopy. RelyX ARC treated with CP+ASM or CP+SBU presented resistance values that were significantly higher than the same treatments for RelyX Ultimate. Conversely, for the blocks treated with SBU alone, the mean resistance value for RelyX Ultimate was higher than that of RelyX ARC. Regarding the different types of treatment for each resin, the mean resistance value of RelyX ARC treated with CP+ASM was significantly highest, followed by treatment with CP+SBU and SBU treatment alone. Meanwhile, RelyX Ultimate treated with CP+ASM or CP+SBU presented resistance values that were significantly higher than SBU treatment alone. In all of the groups, an adhesive fracture pattern was predominantly observed. The present results indicate that silanization is important for ASM and SBU adhesives to be effective.