Event Abstract Back to Event Desktop 3D-bioprinter: Printing evaluation of polycaprolactone Mohd Syahir A. Hamzah1, Muhammad A. Murad1, Saiful I. Abdul Razak1, 2* and Muhammed R. Abdul Kadir2 1 Universiti Teknologi Malaysia, IJN-UTM Cardiovascular Engineering Centre, Malaysia 2 Universiti Teknologi Malaysia, Medical Devices and Technology Group, Faculty of Biosciences and Medical Engineering, Malaysia Currently the transplantation of vital organs such as kidney, liver, heart and lung is the only treatment for their end-stage failure. Because of the lack of donor organs, millions of patients are dying during the waiting period every year. In addition, ethical and religious problems in receiving organs from other people are also serious and still controversial. To close this transplantation gap, tissue engineering approaches offer the promise of restored tissues and organs through the combination of material scaffolds and a patient’s own cells. Recently, methods have been developed to spatially encode and design materials using 3D biofabrication method. 3D bioprinting of structured living cells/organs is relatively very new particularly in Malaysia. We have recently received a desktop 3D-Bioprinter, Biobots (USA) in our lab (See Fig. 1). Though the printing of cells encapsulated within hydrogel is feasible using this technique, the supporting host material need to be studied beforehand. The supporting biocompatible material chosen in this study was polycaprolactone (PCL). PCL has been approved by the Food and Drug Administration (FDA) in wide range of biomedical applications such as drug delivery system, sutures and being investigated as scaffold in tissue engineering. Several parameters to print the PCL were studied such as pressure and speed. The print construct was designed to be a two layer with various thicknesses. It was demonstrated that the system able to fabricate complex structure with controlled size. The printing stability correlates with the pressure and speed of the extrusion process. It was found that the optimum printing parameters for polycaprolactone was at speed of 1 mm/s, layer height of 0.1 mm, barrel temperature of 90 oC, and pressure of 105 psi. The printed construct is shown in Fig. 2. Extrusion based 3D bioprinting was demonstrated to be able to fabricate PCL construct with define structure with optimized parameters. Our next target is to filled empty pores of the scaffold with cell encapsulated hydrogel. We expect that this preliminary report would jumpstart the research on 3D bioprinting in Malaysia. Figure 1 Figure 2 Acknowledgements The authors would like to thank Ministry of Higher Education Malaysia for providing financial assistance through Fundamental Research Grant Scheme 2016. Keywords: Tissue Engineering, Biomaterials, polycaprolactone, Additive manufacturing, 3D bioprinting Conference: 6th Malaysian Tissue Engineering and Regenerative Medicine Scientific Meeting (6th MTERMS) 2016 and 2nd Malaysian Stem Cell Meeting, Seberang Jaya, Penang, Malaysia, 17 Nov - 18 Nov, 2016. Presentation Type: Oral Topic: Biomaterials and Tissue Regeneration Citation: Hamzah MA, Murad MA, Abdul Razak SI and Abdul Kadir MR (2016). Desktop 3D-bioprinter: Printing evaluation of polycaprolactone. Front. Bioeng. Biotechnol. Conference Abstract: 6th Malaysian Tissue Engineering and Regenerative Medicine Scientific Meeting (6th MTERMS) 2016 and 2nd Malaysian Stem Cell Meeting. doi: 10.3389/conf.FBIOE.2016.02.00001 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Dec 2016; Published Online: 19 Dec 2016. * Correspondence: Dr. Saiful I Abdul Razak, Universiti Teknologi Malaysia, IJN-UTM Cardiovascular Engineering Centre, Skudai, Johor, 81310, Malaysia, saifulizwan@utm.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mohd Syahir A Hamzah Muhammad A Murad Saiful I Abdul Razak Muhammed R Abdul Kadir Google Mohd Syahir A Hamzah Muhammad A Murad Saiful I Abdul Razak Muhammed R Abdul Kadir Google Scholar Mohd Syahir A Hamzah Muhammad A Murad Saiful I Abdul Razak Muhammed R Abdul Kadir PubMed Mohd Syahir A Hamzah Muhammad A Murad Saiful I Abdul Razak Muhammed R Abdul Kadir Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.