In the context of the 21st century, the landscape of science education in Indonesia has undergone significant transformations, driven by technological advancements and evolving pedagogical approaches. This study aims to explore these developments, focusing on the current trends and challenges faced by educators and learners in the field of science education. Employing a mixed-methods approach, the research integrates both quantitative and qualitative data, including surveys of science educators and students, interviews with educational experts, and analysis of educational policy documents. This comprehensive methodology allows for a nuanced understanding of the state of science education in Indonesia, encompassing perspectives from various stakeholders. The findings reveal a paradigm shift towards more interactive and technology-integrated teaching methods, highlighting an increased emphasis on developing critical thinking and problem-solving skills among students. However, challenges such as unequal access to technological resources, varying levels of teacher preparedness for new teaching modalities, and the need for curriculum updates to reflect contemporary scientific advancements are prominent. The study concludes that while there is a positive trend towards more dynamic and engaging science education in Indonesia, addressing these challenges is crucial for ensuring equitable and effective science education for all students in the 21st century. This research provides valuable insights for policymakers, educators, and curriculum developers in enhancing the quality and relevance of science education in Indonesia.