Related Variables Research Articles

Perturbations in elite female soccer matches: a conceptual and practical method to analyse variability and regularity between field zones and the spatial development of phase transitions

ABSTRACT In this study, perturbations in elite women’s soccer matches (UEFA Women’s Champions League 2021–2022) were examined. Their variability and regularity were determined considering field zones positioning. The perturbation actions were divided into single (one action only; SPA) and combined (two or more actions; CPA). From 266 perturbations, the “pass” was the most used action. The degree of centrality of the perturbation origin zones showed that zones 8 and 15 for SPA and, zones 8 and 9 for CPA were most the popular. Concerning destination zones, for SPA, zones 17 and 14 showed higher degrees and for CPA, zones 14 and 11. The coefficient of relative variability between the zones of origin (0.35) and destination (0.34) suggested a pattern of high variability. However, the relative coefficient of variability between the spatial development of the underlying phase transition highlighted relative predictability (0.19). In summary, the results suggest that elite women´s soccer players employ the pass action more frequently to change the stable state of the match. Additionally, it was observed high uncertainty regarding where, in terms of origin and destination zones, the underlying perturbation will occur. However, from one phase transition to the next, there is some regularity of the spatial development.

Lockbox enrichment facilitates manipulative and cognitive activities for mice

Background Due to the lack of complexity and variety of stimuli, conventional housing conditions of laboratory mice do not allow these animals to fully express their behavioral repertoire, including manipulative and cognitive activities. Therefore, we designed mechanical puzzles, so-called lockboxes, for mice that can be provided in their home cages. We investigated the impact of the lockbox enrichment on their phenotype and affective state when compared to conventional housing and super-environmental enrichment. Methods Young adult female C57BL/6JCrl mice were examined before and after 2-month exposure to the different types of enrichment in a phenotyping test battery, including tests for trait and state anxiety-related behavior, calorimetric measurements, body weight measurements, and the analysis of stress hormone metabolite concentrations as well as sequential problem-solving abilities. At the end of the study, adrenal gland weights were determined and pathohistological evaluation was performed. For all continuous variables, the relative variability was calculated. Results We demonstrated that lockbox enrichment decreased trait anxiety-related behavior compared to conventional housing in the Grid Exploratory Paradigm. In contrast, the different types of enrichment neither influenced state anxiety-related behavior in the Open Field and Elevated Plus Maze Test nor physiological variables (i.e., bodyweight, resting metabolic rate, stress hormone metabolite concentrations, and adrenal gland weights). Lockbox enrichment improved sequential problem-solving when compared to super-environmental enrichment. Regardless of the housing condition, the relative variability increased in most variables over time, although the coefficient of variation decreased for some variables, especially in animals with access to the lockbox enrichment. A pathohistological evaluation revealed no evidence of toxicopathological effects associated with the material from which the lockbox enrichment was made. Conclusions Overall, the lockbox enrichment revealed beneficial effects on the affective state and sequential problem-solving abilities of laboratory mice. The reproducibility was demonstrated not to be compromised by lockbox enrichment, similar to super-environmental enrichment.

Brazilian undergraduates' and dentists' knowledge on preventing, diagnosing and managing dentin hypersensitivity: A cross-sectional questionnaire study.

To analyse the knowledge of dental undergraduates and dentists on the prevention, diagnosis and management of dentin hypersensitivity (DH); to compare their knowledge scores; and to understand the related variables using a regression model. An original online questionnaire investigated the attitudes, self-reported knowledge ('how much they thought they knew') and real knowledge ('how much they really knew') of 132 students and 338 dentists. Data were analysed descriptively, both knowledge scores were compared using Mann-Whitney and Wilcoxon signed-rank tests and data were subjected to two multiple linear regression analyses considering real knowledge scores as the dependent variable (α < 0.05). The self-reported knowledge on DH was higher than the real knowledge for both students and dentists, but dentists presented the highest scores. Gingival recession and acidic diet were reported as the main predisposing factors for DH by undergraduates and dentists. Students normally managed DH with dietary and hygiene instructions followed by a desensitizing agent application, while dentists managed with occlusal adjustments. The mechanism of glutaraldehyde/HEMA and bioactive fillers on DH is widely unknown by students and dentists. The majority of the questioned individuals cannot differentiate DH from sensitivity of caries or molar-incisor hypomineralization. Both students and dentists overestimate their knowledge of DH, revealing deficiencies in prevention, diagnosis and management. Students' knowledge improves towards the end of the Dentistry course, while younger dentists and PhD holders are more knowledgeable. Institutions should implement ongoing DH education for undergraduates and conduct interventions for experienced professionals, especially older ones.

Assessing the mental health of slum dwellers: an ordinal logistic approach

BackgroundStress, depression and anxiety are prevalent mental health concerns that are getting worse every day in the context of rapidly expanding megacities, where a rising number of people live in slums. The purpose of this study is to evaluate the state of mental health and related variables underlying mental health issues among the impoverished population.MethodologyA total of 384 slum residents from the Khulna division responded to our questionnaire, which included the DASS-21 and other pertinent questions. Using ordinal logistic regression, the significant factors were extracted.ResultsThe Cronbach’s reliability coefficient for the DASS-21 scale lies between 0.79 and 0.89 which indicates the high reliability of the DASS-21 scales. According to the findings, roughly 72.7%, 84.1%, and 69% of participants slum dwellers experienced anxiety, depression, and anxiety problems respectively. The result of ordinal logistic regression shows, slum dwellers of female gender (B = 0.669*, 95% CI 0.141, 1.197), married (B = 1.506*, 95% CI 0.119, 2.893), having only one earning member in the family (B = 1.224*, 95% CI 0.526, 1.922), day laborers (B = 2.294*, 95% CI 1.115, 3.473), not being able to educate children due to financial problem (B = 0.558*, 95% CI 0.183, 0.932) were more likely to report high levels of anxiety, depression, and stress.ConclusionThe study finds that a significant portion of people who live in slums struggle with mental health issues. It also points to the need for further support, intervention, and study on Khulna's slum inhabitants who are experiencing mental health issues. The authors anticipate that the results will spur policymakers and government representatives to enhance financing for slum dwellers and employ psychological intervention strategies, both of which will aid in achieving the Sustainable Development Goal.

Influence on surgical approach in hepatocholangiocarcinoma: A demographic and socioeconomic analysis.

e16280 Background: Hepatocholangiocarcinoma (HCC-CC) is a rare and aggressive malignancy of the liver that contains histopathological features of both hepatocellular carcinoma and cholangiocarcinoma. Surgery is the mainstay of treatment, and the surgical approaches used include radical hepatic resection, laparoscopic, and robotic surgery. There has yet to be a study that explores the impact of demographic features on the choice of surgical modality in patients with HCC-CC. The National Cancer Database (NCDB) was analyzed to determine the effects of demographic features on surgical modality and overall survival. Methods: A retrospective cohort analysis utilizing the NCDB included 2,449 patients diagnosed with HCC-CC (ICD-8180/3) between 2004-2020. Surgical modality was categorized into either open or minimally invasive by the preliminary treatment. Minimally invasive techniques included robotic-assisted and minimally invasive. Race, sex, age at diagnosis, income level, insurance used, distance from the facility, and the status of the facility as an academic center on the surgical modality were compared using Pearson Chi-squared tests or independent samples t-test as pertinent. Multivariate analysis with binary logistic regression was used to analyze the following categorical variables in relation to choice of surgical modality: race, sex, income, insurance, sex, and facility type. Surgical treatment modality on overall survival was analyzed by the Kaplan-Meier method. Exclusion criteria included missing data. Results: Most cases analyzed were White (75.8%), male (67.5%), and had government insurance as the primary payor at diagnosis (60.6%). Of the cases analyzed, 625 underwent surgery (25.5%). Patients who underwent minimally invasive surgery were more likely to be government-insured than patients who underwent open surgery (69.8% vs. 55.6%, P &lt; 0.05). Patients who underwent open surgery were younger on average (61.4 vs. 66.0 years, P &lt; 0.05). There was no significant difference in distance from residence to the treatment facility between the two surgical approaches. Multivariate analysis showed that patients treated at academic centers were less likely to receive minimally invasive surgery (28.1%) over open surgery (71.9%; P = 0.041, 95% CI 0.469-0.985) without statistical significance for race, sex, income, or insurance. The average survival time was significantly longer in open vs minimally invasive surgery (67.9 vs. 55.3 months, P &lt; 0.05). Conclusions: We identified that patients who underwent open surgery had significantly better overall survival with an average difference of 12.6 months. Even after accounting for other factors, the choice of surgical modality was significantly influenced by treatment at an academic institution. Patients receiving care at an academic facility are more likely to receive open surgery leading to overall increased survival.

Health checkups during the pandemic and clinical impact of COVID-19 in children with neuromuscular disease.

Introduction. Children with neuromuscular disease (NMD) require chronic health care (CHC) and may develop severe COVID-19. Objectives. To describe CHC for children with NMD during the pandemic and the course of COVID-19 in this group. Population and methods. Prospective, single-center cohort. Patients aged 2 to 18 years with ≥ 1 year of follow-up prior to the pandemic were included. Demographic variables in relation to CHC and COVID-19 were collected from medical records and via telephone surveys. Results. A total of 226 patients with a median age of 11.3 years were included; 71% were males. They had muscular dystrophy (55.7%) and spinal muscular atrophy (23%). When comparing the first year of the pandemic with the previous year, 30% did not have a health checkup and 25% did not receive kinesiotherapy. Others did, but with a lower frequency. A total of 52 COVID-19 cases were reported; 82% were symptomatic: 88.4% were mild/moderate and 11.6%, severe. No patient died. Conclusions. The pandemic had a negative impact on CHC, and COVID-19 cases were mostly mild.

A theory of fluid–solid coupling in a porous medium for evaluating bioelastomers-assisted tissue remodeling using ultrasound

A theory of fluid–solid coupling in a porous medium for application to the ultrasonic evaluation of tissue remodeling using bioelastomers is presented in this paper. A theoretical model was developed by considering the soft porous bioelastomer as a fluid-saturated solid. Taking into account the relative motion between the fluid and solid in an aggregate, we derived an expression for a characteristic fluid–solid coupling parameter that can be employed as a measure of tissue recovery. Four cases were studied to investigate the dependence of the fluid–solid coupling parameter on related variables. The theory has potential applications in the acellular in situ tissue engineering for noninvasive monitoring of the complex mechanical remodeling process of tissue regeneration and bioelastomer degradation.

The Diagnosis and Initial Management of Children Presenting With Premature Loss of Primary Teeth Associated With a Systemic Condition.

Background and objective Pediatric dentists face a serious challenge when encountering cases of primary teethlost too soon due to systemic disorders such as diabetes mellitus, congenital heart disease, and chronic kidney disease. Prompt identification and treatment are necessary to minimize problems in these patients. This study aimed to better understand and enhance clinical outcomes in pediatric dentistry treatment by investigating diagnostic modalities and early therapy methods for kids wholose their primary teeth too soon because of systemic disorders. Methodology We conducted a retrospective observational study to examine the early loss of primary teeth in children aged 6-10 years with a history of systemic diseasesat Naseer Teaching & MMC-General Hospital, Peshawar; Hayatabad Medical Complex, Peshawar; DHQ Teaching Hospital, Kohat; and Fauji Foundation Hospital, Multan from January to December 2022. After carefully gathering data from medical records, a sample of 360 patients meeting the inclusion criteria was examined. SPSS Statistics version 27 (IBM Corp., Armonk, NY) was used for the statistical analysis. Demographic characteristics, clinical manifestations, and management approaches were compiled using descriptive statistics. For categorical data, frequency distributions and percentages were determined, and for continuous variables, means and standard deviations (SD) were calculated. Regression analysis was conducted to analyze relationships between related variables and treatment outcomes. A p-value <0.05 was considered statistically significant. Results The majority of patients were aged between six and eight years, and the cohort had an equal gender distribution. Dental problems including malocclusion (n=175, 48.61%) and early tooth loss (n=245, 68.06%) were common, as were systemic illnesses like genetic disorders (n=45, 12.50%) and endocrine abnormalities (n=67, 18.61%). Diagnostic procedures were often carried out, such as radiographic exams (n=256, 71.11%) and blood tests (n=123, 34.17%). Dietary supplements (n=60, 16.67%) and dental procedures (n=75, 20.83%) constituted the bulk of the treatment. Significant treatment outcomes that demonstrated the efficacy of the therapies were as follows: high patient satisfaction (n=213, 59.17%), improved oral health (n=255, 70.83%), and symptom relief (n=187, 51.94%). Conclusion Our findingshighlight the significant impact of certainpractical methods for identifying and treating early tooth loss in pediatric patients with systemic illnesses, leading topatient satisfaction in terms of symptom relief and enhanced dental health.

O perfil dos egressos de um mestrado profissional: uma contribuição para o entendimento da relação formação-trabalho no SUS

ABSTRACT This article presents the profile of graduates, the effects of training, and the professional trajectory of the Professional Master’s Course in Public Health graduates at the Aggeu Magalhaes Institute. Of the 99 invited graduates who completed the program between 2013-2020, 54 responded to a questionnaire applied through the Lime Survey software. The descriptive and cross-sectional study used absolute and relative frequency cross-tabulation variables in the analysis, with the instrument covering the following themes: identification of the graduate and program/course; professional activity before and at the end of the program and expectations; current employment status and formation effects; evaluation of the formative trajectory. Among the respondents, most are female, aged between 31-40 years, trained as nurses, self-declared as black or brown-skinned, not having a disability, predominantly residing in Pernambuco, and did not enter through a quota system. As an effect on their professional life, it was found that the program increased prestige/recognition among colleagues, qualified them for activities they were already performing and also different activities, and brought salary increases leading to changes in personal and professional lives. The results are consistent with scientific findings in the same context, and the tool developed by FIOCRUZ made it possible to understand the relationship between education and work.

Predicting the critical organizational behavior and culture of the Turkish construction industry's occupational groups for determining the success of the construction business

Organizational culture is connected to people's capacity to organize themselves internally and adapt to the outside environment. Contracting companies were asked to complete a questionnaire based on organizational culture characteristics. This study intends to make a substantial theoretical contribution by demonstrating a broader perspective on exposing the essential cultural features using a quantitative approach with the fewest possible questions. Exploratory factor analysis and Principal Component Analysis were used to identify the most critical variables and extract a more manageable number of components from multiple related variables. Twenty-eight variables were reduced to thirteen to eliminate statistical cross-loading. Furthermore, the organizational culture was simplified from eight to three dimensions. Thirteen factors were created based on cultural habits in the construction sector, with three inclusive dimensions: multiple motivational, one–bipolar, and many bipolar. This study provides a more succinct survey that quantifies cultural habits and their influence on sectoral performance.

Occupation and demand for health services in Italy: Ways and means to reduce the opportunity costs imposed on patients

This paper explores whether and to which extent employment condition and working hours influence individuals’ decision process in consuming primary care. The hypothesis is that the higher the workers’ opportunity cost in terms of earning forgone, the less the demand for General Practitioner (GP) visits. Using survey data provided by the Italian National Institute of Statistics (ISTAT), we estimate a negative binomial regression model of GP visits as a function of employment related variables, controlling for a rich set of individual demographic characteristics, socio-economic variables, health status, supply and geographical factors. We show that self-employed workers, managers and cadres use significantly less primary care services notwithstanding the access is free. We conclude that they have higher opportunity costs than white and blue collars since they suffer more from the loss of earnings related to the absence from work. Self-employed individuals often face barriers to accessing healthcare services, such as lack of employer-sponsored health insurance and concerns about lost income during time off for medical appointments. As a result, they may delay seeking healthcare until their condition becomes more severe, leading to poorer health outcomes. Managers and cadres, on the other hand, may have greater access to healthcare services due to higher income levels and better job benefits. However, they may still face challenges such as long working hours and job-related stress, which can impact their ability to prioritize their health and seek timely medical care.From a policy perspective, our results suggest potential policy interventions aimed at addressing barriers to healthcare access for self-employed workers and promoting equitable healthcare utilization across different employment groups. Policy recommendations may include measures to enhance financial support (tax deductions for medical expenses, subsidies for health insurance premiums, or grants to cover the costs of healthcare-related absences from work), increase healthcare accessibility (enhancing the availability of mobile clinics, and extending operating hours for primary care facilities to accommodate the needs of working individuals) and raise awareness about preventive care among self-employed workers (workplace wellness programs, and incentives for regular health check-ups, screenings and healthy lifestyle choices, can encourage managers and self-employed workers to prioritize preventive measures). These policy implications are essential for ensuring equitable and universal access to healthcare services for all workers, regardless of their employment status.

The differences of learning outcomes in students archery skill according to physiological ability

This study aimed to determine the learning outcomes of students' archery skills in terms of physiological ability factors in the results of the initial, mid, and final shots. This is comparative quantitative research to determine the extent of variation or differences between related variables. Data analysis in this study used descriptive statistics and inferential one-way ANOVA. The research sample was students of the FIK PJKR study program class of 2019/2020. The result of the one-way ANOVA test is the Sig. 0.003 0.05 means there is no difference in the results of the middle and final shots. The results conclude no significant difference between the two variants in the average shot yield (browse). This study concluded that physiological ability factors contributed to archery skills, including cardiovascular endurance, muscle strength, respiratory tract, blood pressure, dehydration, etc.

Choice of antiretroviral therapy has low impact on weight gain.

Antiretroviral therapy (ART) containing integrase inhibitors (INSTIs) and/or tenofovir alafenamide (TAF) has been associated with greater weight gain. Yet few studies have delineated between exposure to 'anchor' drugs [protease inhibitors (PI), nonnucleoside reverse transcriptase inhibitors (NNRTI) or INSTIs] and exposure to nucleoside reverse transcriptase inhibitors (NRTIs). In this cohort of antiretroviral drug-naive patients who initiated ART from 2008-2022, we analyzed BMI gain for eight contemporary 'anchor' drugs and three contemporary NRTIs during the first 3 years of ART. We censored patients if they stopped, switched, or added another antiretroviral drug to their regimen. We used generalized estimating equations (GEE) to assess the association between BMI gain and choice of ART and a nonlinear mixed model for the marginal coefficients of determination. We adjusted for time, baseline demographic and HIV-characteristics, and time-updated HIV and substance use-related variables. The median BMI gain in 4 194 patients over 3 years was + 1.9 kg/m 2 [interquartile range (IQR) 0.1-4.1]. Most patients were black (55%) and men (77%). Multivariable modeling from 20 528 BMI measurements revealed that the type of ART accounted for just 9% of the predicted BMI change. Only efavirenz (EFV) and tenofovir disoproxil fumarate (TDF) were independently associated with (lower) weight gain but no differences were observed between INSTIs, PIs, and rilpivirine, or between TAF and abacavir. The choice of initial ART had little impact on weight gain. INSTIs or TAF were not independently associated with weight change after ART initiation, but EFV and TDF were.

Large greenhouse gases emissions from lakes in Inner Mongolia, China

Lakes are important component of the regional carbon cycle and a significant sources of greenhouse gases (GHGs) to the atmosphere. However, the regional variations in carbon dioxide (CO2) and methane (CH4) emissions, as well as the factors regulating these emissions are poorly constrained. To investigate the regional GHG emission from lakes and their potential influencing factors, we conducted field measurements in 13 lakes in Inner Mongolia from July to August 2020. We found that the studied lakes were predominantly sources of atmosphere CO2 and CH4. The CO2 partial pressure (pCO2) exhibited supersaturation in 80 % of samplings, but all samplings of CH4 partial pressure (pCH4) showed supersaturation. Moreover, the average pCH4 is 40 times greater than that in the atmosphere. The lakes emitted substantial amounts CO2 and CH4 with average values of 25.8 ± 4.9 mmol m−2 d−1 and 2.1 ± 0.3 mmol m−2 d−1, respectively. At the regional scale, the dynamics of pCO2 and pCH4 are regulated by combination of various environmental factors. CO2 emissions from studied lakes decreased with the catchment net primary productivity (NPP), normalized difference vegetation index (NDVI), and nighttime lights which is indicative of urbanization. Conversely, CH4 fluxes increased with NPP, NDVI, and nighttime lights. We conclude that terrestrial carbon-cycling related variables and human activities significantly affect CO2 and CH4 emissions from lakes by transporting different nutrients, but they show opposite trends. Our results also exhibited that the freshwater lakes are the main contributors of CH4, while saline lakes are the main contributors of CO2. We suggest that increased human activity leads to changes in terrestrial carbon-cycle related processes which affects lake carbon emissions by altering the amount of nutrients input to the lakes.

Triple-layer joint optimization of capacity and operation for integrated energy systems by coordination on multiple timescales

The introduction of energy conversion and storage devices, such as power-to-gas (P2G) and seasonal energy storage, can realize the multi-timescale electricity, heat and natural gas complementarity for integrated energy systems (IESs), promoting renewable energy consumption. However, this brings a large number of decision variables, strong coupling, and nonlinearity, increasing the complexity and difficulty of the optimal design for IESs. Therefore, this study proposes a generic triple-layer optimal design framework for IESs via coordination on multiple timescales. The proposed framework decomposes the optimal design of IESs into long-, medium-, and short-timescale optimization layers that are tractable. The long-timescale optimization layer realizes the seasonal source–load matching by incorporating a refined electricity–gas complementarity model; medium-timescale optimization layer utilizes the inter-day energy transfer to deal with extreme loads caused by rare weather conditions; and short-timescale optimization layer aims to realize real-time energy balances and gain economic benefits by intraday peak shaving. Each layer not only optimizes related capacity and operation variables jointly for its own timescale but also exchanges coupling information with adjacent layers via designed interactive iteration mechanisms. The implementation of the proposed framework is further investigated in the design of an electricity–gas–heating–cooling coupled IES. Finally, a case study is performed to verify the feasibility and effectiveness of the proposed optimal design method. Simulation results show that the proposed method realizes source–load matching across multiple timescales, reducing the annualized total cost of the IES by 2.4 % and 3.3 % compared to the conventional single-timescale optimal design method under the grid connection and off-grid modes, respectively. The renewable energy consumption and device utilization rate of the optimized IES exhibit obvious improvements. In particular, the wind energy consumption of the IES increases by 15 times after introducing P2G and seasonal energy storage. Furthermore, sensitivity analyses indicate that the natural gas price considerably affects the optimization of the capacity configuration and economic performance of the IES, far exceeding that of the electricity price.

Examining the Relationship Between E-Cigarette Status and Wearable Device Use on Physical Activity Levels in U.S. Adults.

The aim of this analysis is to investigate physical activity levels amongst e-cigarette users based on their wearable device use. Cross-sectional secondary data analysis using 2017 Behavioral Risk Factor Surveillance Survey (BRFSS). Data from the 2017 BRFSS were used. 5,562 U.S. adults (age 18+). Self-reported physical activity related variables from U.S. adults (age 18+). Separate unadjusted and adjusted linear regression models were performed for each of the dependent variables using survey analysis. Non-users of wearable devices and e-cigarettes account for 96.6% (95%CI [95.7, 97.6]) of the sample, whereas users of wearable devices and e-cigarettes account for 3.3% (95%CI [1.2, 5.4]) of the sample. Those who use e-cigarettes participate in almost 50% less vigorous physical activity minutes per week than nonusers, 46 (95%CI [0.43, 91.57]) and 93 (95%CI [80.59, 106.34]) minutes respectively. Individuals who use e-cigarettes and use wearable devices were found to spend significantly more time in total physical activity per week in both the unadjusted and adjusted linear regressions, P = =0.01 and P = =0.04 respectively. The use of e-cigarettes, wearable devices, or both technologies may influence the physical activity levels of its users. Additional research is needed to better understand the association between physical activity levels and the usage of these technologies.

Dual-Tasks in Soccer: Effects of Players' Experience and Task Condition on Physical Performance.

In this study, we examined whether experience level and various dual motor and cognitive or single tasks influenced young soccer players' physical performance during small-sided games. Participants were 72 players from U-13 (n = 36) and U-17 (n = 36) groups who participated in 3-to-a-side small-sided games under four experimental conditions: control, a secondary motor task, an additional related secondary cognitive task, and an additional secondary non-specific task. We used GPS devices to measure physical performance in terms of distances covered and accelerations at different thresholds. We found no significant interaction effect between player experience and task condition (p = .540), meaning that dual tasks had comparable effects on players of different experience levels. There were significant main effects of both experience level (p < .001) and condition (p < .001) on most physically related variables. Older players outperformed younger ones, particularly in high-intensity actions. While secondary motor tasks decreased physical performance, secondary cognitive tasks, irrespective of specificity, did not impair players' performances. In conclusion, experience level did not influence the players' physical response to dual tasks, and a secondary motor task was more disruptive to physical performance than either of two types of secondary cognitive tasks. Cognitive tasks can be incorporated into soccer training without compromising physical performance.

Impact of Body Mass Index in the Cardioverter Efficacy of Amiodarone in Persistent Atrial Fibrillation.

Amiodarone is an anti-arrhythmic drug that has extensive tissue distribution and substantial storage in the fat tissue. Different studies have described some implications of body fat composition in its pharmacokinetics and pharmacodynamics. However, no clinical studies have described its implications for clinical efficacy. We studied 878 patients with persistent atrial fibrillation (AF) treated with a regimen of amiodarone and referred to electrical cardioversion (ECV), included prospectively in two Spanish registries. We analyzed the influence of body mass index (BMI), as well as overweight and obesity, in the efficacy of amiodarone for achieving pharmacologic cardioversion to sinus rhythm (SR) before ECV. A total of 185 patients (21.1%) reverted to SR before ECV. Patients who reverted to SR had a lower BMI than those who did not revert (27.45 ± 4.36 kg/m2 vs. 29.11 ± 4.09 kg/m2; p < 0.001). We observed a progressively lower probability of reverting to SR in overweight and obese patients (normal weight 28.3%, overweight 21.3%, obesity 13.1%; p < 0.001). In the logistic regression, BMI (kg/m2) adjusted for other related variables remained as the main factor inversely related to reversion to SR (OR = 0.904 × kg/m2); CI 75% 0.864-0.946). We observed a negative relationship between an increased BMI and the efficacy of amiodarone for reversion to SR, suggesting a negative clinical impact of excess body fat in its efficacy.

A real-time simulation model of water quality with the impact of internal pollution for water source reservoir.

The water source reservoirs are the important urban water source in northern China. Although external pollution has been greatly improved, the internal pollutants in reservoirs continue to accumulate with the complex deposition and release processes, resulting in potential risks to water supply safety. To address the aforementioned issue, this paper proposed a simulation model of water quality named ECOlab EU1-WSR to simulate the spatio-temporal changes of water quality under the influence of internal pollution for the water source reservoirs. Based on the analysis of the water quality characteristics and the distribution of benthic vegetation in the reservoir, a three-dimensional hydrodynamic model was established based on MIKE3, the corresponding parameters and the related state variables were set, the ECOlab EU1-WSR model was established by secondly developing the original ECOlab EU1 template, and the real-time dynamic outputs of pollutant content in sediment were added to link the water quality index with sediment nutrition index for better revealing the impact of the internal pollution on the water quality. The performance of the model was evaluated by the case application on the water quality simulation of Daye reservoir and the optimization of the connection project between Daye reservoir and Xueye reservoir in Shandong Province China. The results showed that the model can accurately and simultaneously simulate the pollution in water and sediment by the comparative verification of hydrodynamics, water temperature, and water quality. Moreover, the model can effectively reflect the influence of the accumulation, deposition, and release of internal pollution on water quality by analyzing the correlation between the content of various pollution in water body and those in sediment, such as the total nitrogen and total phosphorus in the water body at the bottom of the water intake, were negatively correlated with the total nitrogen and total phosphorus in the sediments with correlation coefficients of 0.538 and 0.917, respectively. In addition, the optimal water inlet position and water flow rate of the connection project can be optimized and determined by using the model to effectively control water quality. The established model will be a useful tool for the design and management of a reservoir, the interconnection projects, and other water bodies by adaptively recoded.

QUANTIFYING HIPPOCAMPAL SHAPE ASYMMETRY IN ALZHEIMER'S DISEASE USING OPTIMAL SHAPE CORRESPONDENCES.

Hippocampal atrophy in Alzheimer's disease (AD) is asymmetric and spatially inhomogeneous. While extensive work has been done on volume and shape analysis of atrophy of the hippocampus in AD, less attention has been given to hippocampal asymmetry specifically. Previous studies of hippocampal asymmetry are limited to global volume or shape measures, which don't localize shape asymmetry at the point level. In this paper, we propose to quantify localized shape asymmetry by optimizing point correspondences between left and right hippocampi within a subject, while simultaneously favoring a compact statistical shape model of the entire sample. To account for related variables that have an impact on AD and healthy subject differences, we build linear models with other confounding factors. Our results on the OASIS3 dataset demonstrate that compared to volumetric information, shape asymmetry reveals fine-grained, localized differences that inform us about the hippocampal regions of most significant shape asymmetry in AD patients.