This study evaluated the effect of using two dietary levels (20 or 40% of the diet) sugar beet pulp (SBP) with or without enzymes mixture supplement (Smizyme) at a level of 0.3g/kg diet on growth performance, nutrients digestibility, some blood parameters, immune response, antioxidant activity and economic profit of growing rabbits. Seventy five weaned New Zealand White (NZW) rabbits, six weeks old, with an average live body weight 729.52± 18.97g were randomly divided into five groups (fifteen rabbits, each). Rabbits were fed on 5 experimental diets as follows: diet 1: A control without SBP,2, 3fed diets 20 and 40%SBPwithout enzymes mixture and 4, 5 fed diets 20 and 40%S BP with enzymes mixture .The growth trail lasted about 8 weeks The results indicated that, inclusion of 40% SBP with enzymes mixture in rabbit diet significantly increased final body weight, daily body weight gain, improve feed conversion, relative growth rate and performance index, dressing% and also gave the highest economical efficiency than those fed control diet. Digestibility coefficients of DM, CP, EE, NFE significantly increased with replacement 20 or 40% SBP with enzymes mixture in rabbit diets. Feeding on40% SBP with enzymes mixture increased significantly digestibility coefficients of OM and CF as compared to rabbits fed control diet. Albumin/ Globulin ratio, AST and Catalase were significantly increased with replacement 20 or 40% SBP with enzymes mixture in rabbit diets compared to control. However, total cholesterol and Malondialdehyde significantly decreased with replacement 40% SBP with enzymes mixture in rabbit diet as compared with control diet. Feeding rabbits on 40% SBP with enzymes mixture achieved significantly higher IgG and IgM than those fed control diet. Conclusively, it could be recommended replacement sugar beet pulp SBP up 40% with enzymes mixture of the rabbit diets to improve the performance, antioxidant status, immunity functions and economic return of the growing rabbits.