Objectives: The general goal of present research is to study factors affecting improvement of efficiency and effectiveness among staffs of Shiraz University of medical science. This is an applied research in terms of objective and this is a descriptive co relational research in terms of information collection. Information was collected by library in field form. Methods: Statistical population includes all personnel of Shiraz University of medical science (900 people). Concerning Cochran's table, the number of samples was 269. The simple random sampling was used. The researcher-conducted questionnaire has been used to collect information and to study factors affecting the improvement of efficiency and effectiveness among personnel of Shiraz University of medical science. The questionnaires were designed based on Five-point Likert scale and the questionnaire contains 27 items. The validity and reliability of the questionnaire were confirmed. Various statistical methods have been applied to analyze data resulted from the questionnaire. Descriptive statistical method, relative frequency distribution table and percentage diagrams have been used in descriptive part of the research. Kolmogorov-Smirnov, Pearson correlation as well as Friedman tests have been used to study data normality in inferential statistical section. Results: Results indicated that there was a significant relationship between organizational culture, incentive, technological factors, staffs' training and the effectiveness and efficiency of personnel of Shiraz University of medical science. The sequence of efficiency indicators of personnel of Shiraz University of medical science shows that organizational culture of personnel of Shiraz University of medical science is in the first place using Friedman test. Incentive, technological factors and staff training are in the second, third and fourth place respectively. Furthermore, Friedman test of the sequence of effectiveness indicators of personnel of Shiraz University of medical science indicates that technology with mean of 5 is in the first place. Incentive, staff training and organizational culture are in the second, third and fourth place respectively. Conclusion: It is suggested that indicators of organizational culture and technology are paid attention by authorities for organizational effectiveness and efficiency. Peer Review History: Received 29 September 2017; Revised 12 February; Accepted 20 February, Available online 15 March 2018 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Ahmed Tagelsir Mohamed Ali, National University, Sudan, ahmedtagelsir7@hotmail.com Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com Similar Articles: THE EVALUATION OF THE POSITION OF HEALTH AND SAFETY SYSTEM IN MULTI-LEVEL STRATEGIC MANAGEMENT OF STAFFS IN SHIRAZ UNIVERSITY OF MEDICAL SCIENCE