Background: The most significant factor contributing to discomfort at work for tailors is musculoskeletal disorders. Once musculoskeletal discomfort manifests in any area, it often lasts for a year or more. Implementing ergonomics research can boost productivity while giving workers a better, more pleasant working environment. A tool called REBA is used to evaluate a person's ergonomic risk factors. Its goal is to construct a posture analysis system to identify musculoskeletal concerns in a range of tasks by segmenting the body and separately coding each part. The influence and severity of musculoskeletal symptoms on occupational groups have been evaluated using the NMQ. Aims of the Study: To find out the prevalence of work-related Musculoskeletal Disorders and its correlation with Ergonomic risk assessment among Tailors from south Gujarat. Objective of Study: Primary Objective: To find out prevalence of work-related MSDs in tailors. Secondary Objective: To find out its correlation of work-related MSDs with Ergonomic risk assessment among tailors. Materials and Method: In this cross-sectional study, total 150 tailors were taken based on inclusion criteria. Convenient sampling method is selected with age group 25 to 50 years. Work related Musculoskeletal disorders assessed by Nordic whereas Ergonomics risk assessment done by REBA. Result: The result shows that there is high prevalence of lower back pain (34%) in acute work-related MSD and neck pain (26%) in chronic work-related MSD. There are significant correlation of acute neck, shoulder and lower back pain with Rapid Entire Body Assessment (REBA) score and significant correlation of chronic neck, shoulder, elbow, wrist and lower back pain with REBA.