Topicality. Ukraine is in difficult circumstances related to the military aggression of a neighboring country. These circumstances affected the socio-economic conditions: the fall in the level of GDP, the reduction of production processes, internal and external migration of the population, a decrease in the pace of technological development, a decrease in the number of business entities, a decrease in the capacities of enterprises, an increase in unemployment, a decrease in the welfare and quality of life of the population. Undoubtedly, this led to structural changes in the economy of Ukraine and its regions.Aim and tasks. The purpose of this scientific article is to develop the theoretical foundations of the study of structural changes in resource provision of the entrepreneurial sector. This goal made it possible to formulate the following tasks: define the concept of "resource provision of the entrepreneurial sector"; to improve the classification of structural changes: by levels of management (from the point of view of the types of structural changes and the potential capabilities of the system as a result of overcoming them); to systematize theories of economic growth and smoothing of structural changes in the economy; generalize the principles of overcoming structural changes in resource provision and the ways of their implementation in the economy of Ukraine.Materials and Methods. This study was carried out on the basis of the use of the comparative method, elementary theoretical analysis and synthesis, methods of empirical research, the method of scientific knowledge, classification and analogy, the method of scientific knowledge. Data of the Statistical Service of Ukraine, materials of scientific publications and researches, own scientific developments were also used.Research results. The impact of structural changes on such areas as: socio-societal; spatial and territorial; technological and production; organizational and managerial; foreign economic/international. The changes themselves are considered at the following levels: global, state, regional, branch, local, entrepreneurial (firm), as well as in various spheres of activity (economy, society, resource provision, etc.). The work classifies structural changes by management levels: global (world) changes; national (macroeconomic) changes; regional (territorial) changes; sectorial (industry) changes and entrepreneurial (micro) changes. In addition, structural changes are classified by functional component: technical and technological; institutional; reproductive; territorial and spatial. The main challenges of the Ukrainian economy in peacetime and wartime have been identified. The main methods ("cost-output", structural analysis, portfolio analysis, econometric analysis, cluster analysis, analysis of the dynamics of transactional and transformational costs) and structural change approaches (evolutionary, institutional, synergistic, cybernetic, structural, neoclassical, innovative-technological) are considered. Let's consider the main theories of the growth of the economy of the country and its regions according to the feature of the unification of territories (cumulative growth, the natural occurrence of negative structural changes, the relationship between the occurrence of negative structural changes and economic growth, the regulation of negative structural changes, technological growth, the impact of innovative development on negative structural changes).Conclusions. The effectiveness and efficiency of business activity consists in the identification of negative structural changes, the development of a methodological apparatus for their elimination, the regulatory and legal provision of these processes, the development of regulatory mechanisms, the identification of responsible persons and a clear communication process between them. Thus, the key to overcoming negative structural changes in the economy can be: strengthening of state management and regulation; balancing market self-regulation at the national, regional and local levels; state initiative and participation in regional transformation processes; development of theoretical and methodological approaches and principles to overcome negative shifts in the development of the country and its regions.This scientific article was carried out within the framework of the NDR "Mechanisms of structural transformation of the entrepreneurial sector of Ukraine on the basis of resilient economic development" (code: 3.1.8.84/B).