Regulation Of Behavior Research Articles

On the issue of the effectiveness of the civil law method in the regulation of health protection relations

The subject of the study is the rights of citizens to health protection, as well as the possibility of their transformation in the direction of strengthening the legal nature of these relations. In the context of the dominance of the sectoral approach in law, the author develops ideas about subjective law as an effective regulator of patient behavior. The opinion is expressed that the responsibility of the subject's independent choice can give a new impetus to improving the level of quality indicators of medical care, ensuring the timeliness, qualification and comprehensiveness of examinations. An attempt has been made to shift the focus in the process of streamlining relations from the subject of legal regulation to methods. New opportunities have been identified to increase the level of the legal nature of court decisions that can take into account the objective need to expand the scope of private law (civil) ways of influencing the patient on the medical process. The dialectical method has become the main research method. The conditions for improving medical care are revealed, taking into account the differences between public law and civil law regulatory methods in solving problems of law enforcement practice. The scientific novelty is that the examples of legal practice have provided new knowledge necessary for the development of existing doctrinal approaches in legal science. The limitations of the sectoral approach in law, due to the high degree of dynamism of society, are convincingly argued. It has been established that orientation to the subject of legal regulation, as an unconditionally dominant factor in choosing a strategy and tactics for streamlining relations, does not always ensure the completeness of the legal nature of judicial acts. The emphasis of legal regulation in health protection is focused on the priority use of public law (or "organizing") methods that guarantee the mass provision of medical care designed for everyone. The possibility of providing quality indicators of care to a specific patient with special health characteristics and conditions for receiving it is still secondary. It is necessary to actively apply civil law methods of protecting the right to health protection, while skillfully using the resource potential of the law.

Practical resources for effective postpartum parenting (PREPP): a randomized controlled trial of a novel parent-infant dyadic intervention to reduce symptoms of postpartum depression

BackgroundThere is little known about the effectiveness of psychological interventions to prevent postpartum depression that focus on the birthing parent and infant dyad. Risk factors for PPD include depression during pregnancy, low parenting self-efficacy, and disrupted parental nocturnal sleep. The brief Practical Resources for Effective Postpartum Parenting (PREPP) intervention is designed for pregnant individuals at-risk for postpartum depression, providing them with 1) caregiving strategies aimed at reducing infant fuss and cry behavior and increasing infant sleep, 2) self-reflection and mindfulness skills and 3) psychoeducation about the postpartum period and infant behavior. The aims are to set more realistic postpartum expectations, enhance parenting confidence and sleep via supporting infant regulatory behavior, improve parental affect regulation and ultimately reduce the risk of postpartum depression. ObjectiveAssess the effectiveness of PREPP compared to enhanced treatment as usual in reducing symptoms of depression and anxiety and episodes of infant fuss and cry behavior and improving parental and infant sleep in the early postpartum. Study designA randomized controlled trial was conducted of 175 pregnant individuals. Inclusion criteria were standard prenatal care for a singleton pregnancy, aged 18 to 45 and at increased risk of PPD as determined by a score of ≥19 on the Predictive Index of Postnatal Depression or ≥7 on the Edinburgh Postnatal Depression Scale. Participants assigned to the PREPP group (n=88) received 3 coaching sessions and 2 phone check-ins. Participants assigned to the enhanced treatment as usual group (n=87) received 3 sessions which included psychoeducation, mood assessments, and clinical referral and follow-up as indicated. Assessments were conducted at 28 to 32 weeks and 34 to 39 weeks gestation, and at 6, 12 and 16 weeks postpartum and included measures of parental depression, anxiety and sleep (Edinburgh Postnatal Depression Scale, Patient Health Questionnaire (PHQ-9), Hamilton Rating Scales of Depression and Anxiety and Pittsburgh Sleep Quality Index) and infant sleep and fuss and cry behavior (Baby Day Diary). ResultsCompared to enhanced treatment as usual, PREPP significantly reduced depressive symptoms at 6, 12 and 16 weeks postpartum with medium to large effect sizes (d=0.7-0.98). Compared to enhanced treatment as usual, participants receiving PREPP reported less of a decline in sleep quality at 6 weeks postpartum (p=0.035) and the effect size was large (d=0.83). Moreover, parents receiving the PREPP intervention reported less infant fussing and crying, with the largest effect for morning crying (p<.001; d=-1.48). ConclusionThe results provide evidence that PREPP, initiated during pregnancy, reduced symptoms of parental depression and infant fuss and cry behavior in the early postpartum, compared to enhanced treatment as usual, in a sample at-risk for postpartum depression.

Behavioural and neuroendocrine responses in alpacas (Vicugna pacos) to the shearing procedure

Shearing is a necessary procedure which can cause stress in alpacas. Reactions to stressful situations can include behavioural and physiological changes in an animal's effort to maintain homeostasis. There has been limited investigation on stress mechanisms in terms of behaviour and physiological changes in alpacas, with a focus on heart rate and cortisol in faeces and saliva. This study aimed to determine alpaca behaviour and the concentrations of selected neuroendocrine indicators (cortisol, dopamine, noradrenaline, serotonin, thyroxine) at: pre-shearing (3 days before shearing), on the day of shearing and post-shearing (5 and 10 days after shearing). This study examined 20 alpacas. Compared with the behaviour observed before shearing, shearing performed by the standing method caused only an acute behavioural stress response on the day of shearing and no change 5 and 10 days after shearing. Higher stress activity during shearing was not strongly correlated with the intensity of their everyday reactions to the environment. In contrast, noradrenaline increased and thyroxine decreased after the shearing procedure, changes indicative of mid-term stress symptoms. There were significant correlations between some behavioural and neuroendocrine indicators, confirming the involvement of cortisol, serotonin and noradrenaline in the mechanisms of alpaca behavioural regulation.

Effects of Classroom Management Strategies on Students’ Behavior Regulation in Boarding Secondary Schools in Rwanda: A Case of Muhanga District

This study aims to investigate the effect of classroom management strategies on students’ behavior regulation in boarding secondary schools in Rwanda, a case of Muhanga district. The study was guided by three specific objectives which are to determine the influence of establishing clear classroom rules on students’ engagement and academic performance in boarding secondary schools in Muhanga district, to determine the effect of proactive planning in teaching on behavior regulation in boarding secondary schools in Muhanga district, Rwanda, to assess the effect of gamified personal learning plans in teaching on students’ behavior regulation in boarding secondary schools in Muhanga district. The study was guided and supported by social learning theory. Survey with mixed- approaches was employed in this study. The target population in this research was 5750 respondents including 5290 boarding secondary school students, 414 teachers, 23 directors of discipline and 23 boarding school head teachers. Directors of discipline and head teachers were selected through purposive sampling while simple random sampling was used to select teachers and students. The study used questionnaires for teachers and students and interview guide for directors of discipline and head teachers in data collection due to their availability and daily responsibilities. Data analysis employed SPSS, version 22.0 and data were summarized into means, percentage, standard deviation, correlation coefficients and coefficients of regression. The findings highlighted the significant impact of clear classroom rules on students’ behavior, with 73.8% of students affirming their positive influence and a high mean score of 4.232. While 54.4% reported consistent enforcement, some inconsistencies remain. Teachers overwhelmingly agreed on the importance of these rules in reducing disruptions, achieving a perfect mean score of 5.000, though only 26.9% feel they communicate rules consistently. Proactive planning shows mixed results, with low scores for technology use in lessons (2.293) but more support for structured environments (3.404). Additionally, gamified personal learning plans (GPLPs) are positively perceived by students and teachers, with 53.8% believing they enhance focus and strong support for rewards in maintaining discipline.

INTERVENTIONS POUR PROMOUVOIR LE DEVELOPPEMENT EXECUTIF CHEZ LES ENFANTS ET ADOLESCENTS (CHAPITRE 24)

Researchers and developers of tests of executive functioning and behavior rating scales designed to assess executive skills have all organized andcategorized executive skills somewhat differently. For instance, the developers of the Behavior Rating Inventory of Executive Function (Gioia, Isquith, Guy, &amp; Kenworthy, 2000 have defined two broad categories of skills, those involved in behavior regulation (e.g., impulse control, emotion control) and those that are more metacognitive in nature (e.g., working memory, task initiation, planning/organization). More recently, Barkley (2011), in developing the Barkley Deficits in Executive Functioning Scale, identified five broad categories of executive functioning (e.g., self-regulation of emotion, time management, organization/problem solving). In our work with parents and teachers, we have identified 11 individual executive skills that we believe figure prominently in understanding why some children tackle activities of daily living, including schoolwork, homework, chores, and daily routines, more successfully than others. Table 24.1 lists these skills, along with brief definitions, and a description of the most common exemplars of problems associated with each executive skill.

A dynamic evolutionary game to discourage enterprise “greenwashing”

To meet the increasing consumer demand for green products and services, governments have increased their regulation of enterprise production behaviors so that enterprises may choose “greenwashing” to obtain the premium of green products at the lowest cost under government regulation. The increase of greenwashing hinders green innovation by enterprises. To quantify this problem and seek solutions to promote enterprises cleaner production and sustainable development, we established a tripartite evolutionary game model for enterprises, consumers, and governments. Using the model, we analyzed the stability of their strategy combinations through simulations and explored the impact of some parameters on the strategy selection. We found that (1) the combination of enterprises adopting true green, consumers buying green products, and weak government regulation was the most environmentally friendly and low-cost strategy solution in the tripartite game system. (2) An increase in government penalties or subsidies to enterprises, as well as a reduction of the extra cost of producing green products, can improve the probability that enterprises will adopt cleaner production. Based on the results, the government should define reasonable subsidies and penalties, guide enterprises to assume their social responsibility, and stimulate consumer green demand. Enterprises should improve their moral qualities, actively engage in green innovation, and increase investment in green product research to guide the game system towards the ideal state.

Differences between uncapping and removal behaviors in Apis cerana from the perspective of long non-coding RNAs

BackgroundHygienic behavior, a specialized form of immune response evolved in social insects, plays a crucial role in safeguarding colonies from disease spread. In honeybee colonies, such behavior typically entails the dual steps of uncapping and removal of unhealthy and deceased brood. Although in recent years, numerous studies have examined the development of hygienic behavior, the mechanisms underlying the division in the performance of uncapping and removal have yet to be sufficiently elucidated. In this regard, long non-coding RNAs (lncRNAs) have been evidenced to be engaged in regulating the physiological activities of honeybees; however, whether lncRNAs are likewise involved in the uncapping and removal tasks has not been clarified.ResultsIn this study, the strong hygienic Apis cerana worker bees were used and the processes of uncapping and removal behaviors in three colonies were assayed with freeze-killed brood in the field. We then sequenced the antennal RNAs of honeybees to identify differentially expressed lncRNAs and performed lncRNA-mRNA association analysis to establish the differences between uncapping and removal. We detected 1,323 differentially expressed lncRNAs in the antennae, and the findings of lncRNA-mRNA association analyses revealed that the target genes of differentially expressed lncRNAs between uncapping and removal worker bees were predominantly linked to response to stimulus, receptor activity, and synapse. Notably, among the lncRNAs enriched in cellular response to stimulus, XR_001766094.2 was exclusively expressed in the uncapping worker bees. Based on these findings, we hypothesize that XR_001766094.2 plays a key role in distinguishing uncapping from removal behaviors by responding to external stimulus, thereby suggesting that the division of hygienic behaviors is governed by differential thresholds of responsiveness to environmental cues.ConclusionWe characterized differences in the uncapping and removal behaviors of worker bees from a perspective of lncRNAs. Uncapping bees may be equipped with a more rapid stimulatory response and more acute olfactory sensitivity, contributing to the rapid hygienic behavior in honeybee colonies. Our results thus establish a foundation for potential lncRNA-mediated gene expression regulation in hygienic behavior.

Development and Effectiveness of Dialectical Behavioral Therapy-Based Emotion Regulation Skills Training for Adolescents

Development and Effectiveness of Dialectical Behavioral Therapy-Based Emotion Regulation Skills Training for Adolescents

Quantification of multi-task predation reveals behavioural regulation and attentional processes in mantids

Quantification of multi-task predation reveals behavioural regulation and attentional processes in mantids

“We are an active family”: a randomized trial protocol to evaluate a family-system social identity intervention to promote child physical activity

BackgroundRegular engagement in moderate-to-vigorous physical activity (MVPA) during childhood yields a myriad of health benefits, and contributes to sustained MVPA behaviors into adulthood. Given the influence of parents on shaping their child’s MVPA behaviour, the family system represents a viable target for intervention. The purpose of this study is to compare the effects of two intervention conditions designed to increase child MVPA: (1) A standard education + planning intervention providing information about benefits, action planning, and coping planning; and (2) An augmented physical activity education + planning intervention that includes the components of the standard intervention, as well as a focus on family identity promotion and developing as an active member of the family.MethodsA two-arm parallel single-blinded randomized trial will compare the two conditions over 6 months. Eligible families have at least one child aged 6–12 years who is not meeting the physical activity recommendations within the Canadian 24-Hour Movement Guidelines (i.e.,<60 min/day of MVPA). Intervention materials targeting family identity promotion will be delivered online via zoom following baseline assessment, with booster sessions at 6-weeks and 3-months. Child MVPA will be measured by wGT3X-BT Actigraph accelerometry at baseline, 6-weeks, 3-months, and 6-months as the primary outcome. At these same time points, parent cognition (e.g., attitudes, perceived control, behavioral regulation, habit, identity) and support behaviours, and parent-child co-activity will be assessed via questionnaire as secondary outcomes. Child-health fitness measures will be also administered through fitness testing at baseline and 6-months as secondary outcomes. Finally, upon completion of the trial’s 6-month measures, a follow-up end-of-trial interview will be conducted with parents to examine parents’ experiences with the intervention.ResultsSo far, 30 families have been enrolled from the Southern Vancouver Island and Vancouver Lower Mainland area. Recruitment will be continuing through 2026 with a target of 148 families.DiscussionThis study will contribute to the understanding of effective strategies to increase child physical activity by comparing two intervention approaches. Both provide parents with education on physical activity benefits, action planning, and coping planning supports. However, one intervention also incorporates components focused on promoting an active family identity and involving all family members in physical activity together. The findings from this study have the potential to inform the design and implementation of public health initiatives aimed at improving physical activity participation in children and guide the development of more effective interventions that leverage the crucial role of parents and the family system in shaping children’s physical activity behaviors.Trial RegistrationThe clinical trial registration ID is NCT05794789. This trial was registered with clinicaltrials.gov on March 2nd, 2023, with the last updated release on September 28th, 2023.

FORMATION OF PROFESSIONAL AND ENVIRONMENTAL RESPONSIBILITY IN FUTURE ENVIRONMENTALS AS A SUBJECT OF COMMUNICATIVE INTERACTION WITH BUSINESS SUBJECTS

The article reveals the problem of the formation of professional environmental responsibility in future ecologists as a subject of communicative interaction with business entities. The categories “social environmental responsibility”, “professional environmental responsibility”, “positive individual professional environmental responsibility” were considered. It has been established that positive individual professional environmental responsibility differs from the above-mentioned qualities by a higher level of generalization, as it contains, in addition to legal and social aspects, an ethical aspect, which is the main motivated and natural regulator of individual behavior, striving for an ecologically appropriate, ecologically safe and healthy lifestyle for themselves, other members of society and nature. The structural and functional characterization of professional and environmental responsibility as a unity of three components: value, information-cognitive and behavioral. The definition of the concept of “professional and environmental responsibility of future ecologists” is presented as an integral, interactive, ethical and professionally significant quality of the individual, which manifests itself in the free choice of positive (useful for man, society and nature), ecologically appropriate, safe and competent activities in the system of “man-society-nature”, aimed both at its self-preservation and self-realization, as well as at achieving the strategic setting of the transition of humanity and the Earthʼs biosphere to sustainable co-evolution. It is inserted that the problem of formation of professional and environmental responsibility among future ecologists is fundamentally different from the problem of the functioning of the model of formation of professional and environmental responsibility in them as an expectation of the desired future. The structural and functional characteristics of the main construct of the developed model of the formation of professional environmental responsibility of future ecologists as a unity of three components are presented.

Patterns of News Consumption during the COVID-19 Pandemic Crisis: A 2.5 Year Longitudinal Study in the Netherlands

ABSTRACT During major long-term crises, such as the COVID-19 pandemic, news media are crucial sources of information for the public. This study aimed to explore the frequency of COVID-19-related news consumption based on (1) phase of the pandemic, (2) socio-demographic characteristics, and (3) news information channels. The study used a dynamic cohort design with 18 rounds of data collection, including 306,692 responses from 83,180 unique respondents in the Netherlands from 17 April 2020 to 11 September 2022. Results showed that the frequency of general COVID-19-related news media consumption varied throughout the pandemic, following a general decreasing trend with relative spikes often coinciding with periods of stricter behavioural regulations. TV news, newspapers, and online news websites were the most popular news information channels among the respondents. Furthermore, multilevel regression analyses identified several socio-demographic factors influencing news consumption and preferred channels, namely age, migration background, living status, health status, and trust in government — these results remained stable throughout the pandemic. This study highlights the importance of selecting appropriate news channels to effectively reach different socio-demographic groups and shows that during a prolonged crisis, news consumption about the crisis fluctuates with worsening conditions but generally follows a decreasing trend.

Assessing the Impact of Visual Arts Teaching on Critical Thinking and Behavior Regulation

Background: Visual arts education has been suggested to influence cognitive and behavioral outcomes, yet its specific effects on critical thinking and behavior regulation remain underexplored. The effect of visual arts education on these domains forms the topic of the present study, which employs a mixed approach research design. Aim: To assess the impact of visual arts education on the improvement of critical thinking and self-regulation in students. Methodology: A quasi-experimental approach was employed with 80 individuals, with 40 in the experimental group Report Phrase receiving education in visual arts and 40 in the control group receiving non-visual arts education. CTST and BRI assessment tools were used to acquire quantitative data about the participants, utilizing the independent and paired sample T-tests. Data collected from participants include interviews, focus group discussions, self-administered, and thematic analysis. A repeated measures ANOVA was used to analyse the data. Result: Statistical findings depicted improvements in the quantitative aspect; critical thinking skills improved from 70.0 to 75.3 with p&lt;0.001 and behavior regulation improved from 65.0 to 69.2 with p&lt;0.001 in the experimental-group in contrast to the control-group. The thematic analysis found striking increases in attention, impulse control, task completion, creativity, collaboration, affect expression, and self-esteem of experimental-group participants. Based on the findings of the Repeated Measures ANOVA, significant enhancements were observed in both domains for critical thinking and behavior regulation with effect size estimates of 0.40 and 0.30, respectively. Conclusion: The development of critical thinking and behavior control in students is greatly impacted by art instruction. Quantitative and qualitative data both support the utility of using visual arts interventions for cognitive and behavioral development and inform practice in art education.

Cadherin 16 promotes sensory gating via the endocrine corpuscles of Stannius.

Sensory thresholds enable animals to regulate their behavioral responses to environmental threats. Despite the importance of sensory thresholds for animal behavior and human health, we do not yet have a full appreciation of the underlying molecular-genetic and circuit mechanisms. The larval zebrafish acoustic startle response provides a powerful system to identify molecular mechanisms underlying establishment of sensory thresholds and plasticity of thresholds through mechanisms like habituation. Using this system, we identify Cadherin 16 as a previously undescribed regulator of sensory gating. We demonstrate that Cadherin 16 regulates sensory thresholds via an endocrine organ, the corpuscle of Stannius (CS), which is essential in zebrafish for regulating Ca 2+ homeostasis. We further show that Cadherin 16 regulates whole-body calcium and ultimately behavior through the hormone Stanniocalcin 1L, and the IGF-regulatory metalloprotease, Papp-aa. Finally, we demonstrate the importance of the CS through ablation experiments that reveal its role in promoting normal acoustic sensory gating. Together, our results uncover a previously undescribed brain non-autonomous pathway for the regulation of behavior and establish Ca 2+ homeostasis as a critical process underlying sensory gating in vivo .

Regulações motivacionais para a prática de exercício físico e a relação com as necessidades psicológicas básicas

To investigate and correlate the relationship between motivational regulation and the fulfilment of basic psychological needs among university students. A total of 329 university students took part in this study. The instruments used to analyze motivational regulation were the Physical Exercise Behaviour Regulation Questionnaire — 3 and the Basic Psychological Needs Satisfaction Scale. The Statistic Package for Social Sciences software was used. Basic psychological needs are positively related to the more internal constructs of motivational regulation (intrinsic and integrated), as well as to the self-determination index. The results show that there is a relationship between the constructs of the self-determination theory, since the higher the levels of satisfaction of basic psychological needs, the greater the more self-determined motivational regulations, favoring positive behavior with regard to physical exercise.

Карьерная ориентация «профессиональная компетентность» как фактор успешного освоения роли врача студентами медицинских специальностей

Introduction. The article reflects the results of the study that made it possible to identify the connection between subjective personality traits and the severity of career orientation, manifested in the desire to improve their knowledge and skills in the chosen field among medical university students. The maturity of the studied career motivation can be an important factor determining the success of future doctors mastering role-related professional behavior. Theoretical analysis. The results of modern research allow us to talk about the importance of the formation of a career orientation “professional competence” for the successful self-realization of young doctors, but do not reveal the features of its relationship with the structural components of the subjective organization of an individual in the conditions of interpersonal interaction. Empirical analysis. Connections were found between motivation for self-improvement in the chosen professional activity, the ability to exercise self-control in communication conditions, as well as manifested ego positions in communication and self-regulation styles. Conclusion. The formation of a career orientation “professional competence” can be an important factor in the successful development of professional role behavior by medical students, subject to the actualization of subjective properties in the conditions of interpersonal interaction: volitional regulation of behavior, the optimal combination of required and demonstrated behavior in communication, the use of optimal styles of self-regulation and interaction strategies.

Preschoolers’ Attentional and Behavioral Regulation: Differential Pathways through Poverty and Parenting

This study explored specificity in the associations between early poverty and preschoolers’ behavioral and attentional regulation. In particular, there was an emphasis on delineating contextual factors (i.e., material hardship and household chaos) and parenting processes (i.e., maternal aggravation and maternal acceptance) as sequential mechanisms. The sample included 2850 families from the Future of Families and Child Wellbeing Study. Results suggested that early poverty in infancy (age one) was associated with behavioral regulation and attentional regulation in preschool years (age five). Material hardship mediated the link between early poverty and behavioral regulation, while household chaos mediated the link between early poverty and attentional regulation. Additionally, maternal aggravation mediated the association between material hardship and behavioral regulation, while maternal acceptance mediated the associations between household chaos and attentional and behavioral regulation. Findings informed targeted interventions to alleviate hardship and chaos and promote positive parenting practices to bolster children’s self-regulation.

Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior.

Placozoa are millimeter-sized, flat, irregularly shaped ciliated animals that crawl on surfaces in warm oceans feeding on biofilms, which they digest externally. They stand out from other animals due to their simple body plans. They lack organs, body cavities, muscles and a nervous system and have only seven broadly defined morphological cell types, each with a unique distribution. Analyses of single cell transcriptomes of four species of placozoans revealed greater diversity of secretory cell types than evident from morphological studies, but the locations of many of these new cell types were unknown and it was unclear which morphological cell types they represent. Furthermore, there were contradictions between the conclusions of previous studies and the single cell RNAseq studies. To address these issues, we used mRNA probes for genes encoding secretory products expressed in different metacells in Trichoplax adhaerens to localize cells in whole mounts and in dissociated cell cultures, where their morphological features could be visualized and identified. The nature and functions of their secretory granules were further investigated with electron microscopic techniques and by imaging secretion in live animals during feeding episodes. We found that two cell types participate in disintegrating prey, one resembling a lytic cell type in mammals and another combining features of zymogen gland cells and enterocytes. We identified secretory epithelial cells expressing glycoproteins or short peptides implicated in defense. We located seven peptidergic cell types and two types of mucocytes. Our findings reveal mechanisms that placozoans use to feed and protect themselves from pathogens and clues about neuropeptidergic signaling. We compare placozoan secretory cell types with cell types in other animal phyla to gain insight about general evolutionary trends in cell type diversification, as well as pathways leading to the emergence of synapomorphies.

Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species.

The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in neurodevelopmental disorders including schizophrenia and autism spectrum disorder. Mouse studies have identified neuronal populations within the LS that express a variety of molecular markers, including vasopressin receptor, oxytocin receptor, and corticotropin releasing hormone receptor, which control specific facets of social behavior. Despite its critical role in regulating social behavior and notable gene expression patterns, comprehensive molecular profiling of the human LS has not been performed. Here, we conducted single nucleus RNA-sequencing (snRNA-seq) to generate the first transcriptomic profiles of the human LS using postmortem human brain tissue samples from 3 neurotypical donors. Our analysis identified 5 transcriptionally distinct neuronal cell types within the human LS that are enriched for TRPC4, the gene encoding Trp-related protein 4. Differential expression analysis revealed a distinct LS neuronal cell type that is enriched for OPRM1, the gene encoding the μ-opioid receptor. Leveraging recently generated mouse LS snRNA-seq datasets, we conducted a cross-species analysis. Our results demonstrate that TRPC4 enrichment in the LS is highly conserved between human and mouse, while FREM2, which encodes FRAS1 related extracellular matrix protein 2, is enriched only in the human LS. Together, these results highlight transcriptional heterogeneity of the human LS, and identify robust marker genes for the human LS.

Identifying PTSD and Complex PTSD Profiles in Child Victims of Sexual Abuse

ABSTRACT Post-traumatic stress disorder (PTSD) symptoms are frequent in child victims of sexual abuse. Authors argued that early trauma could lead to alterations in development that go far beyond the primary symptoms of PTSD and have proposed that Complex PTSD (C-PTSD) involving alterations in attachment, biology, affect regulation, consciousness, behavioral regulation, cognition, and self-concept, may better describe children experiencing chronic trauma at an early developmental stage. The aim of the study was to disentangle the diversity of profiles in child victims of sexual abuse based on the C-PTSD framework. Latent profile analysis was used to identify distinct subgroups in a sample of 861 sexually abused children aged 6 to 12. Children and their non-offending parents completed questionnaires evaluating PTSD symptoms and measures documenting alterations in development characteristics of C-PTSD. Latent profile analysis identified a best-fitting model consisting of three profiles: PTSD (40.7% of children), Resilient (32.8% of children), and C-PTSD (26.5% of children). Compared to others, children in the C-PTSD profile were more likely to have experienced more forms of interpersonal trauma and showed impairments in several domains. Findings underscore the importance of tailoring interventions to efficiently address the needs of young victims of sexual trauma.