We recently reported that Norwegian musicians have a higher prevalence of insomnia symptoms compared to a representative community sample (Prevalence Difference 6.9, 95% Confidence Interval 3.9–10.0). Further, musicians and artists generally report higher mental and work related stress compared to the regular workforce. Still, few studies have investigated interactions between musicians´ work and individual life and insomnia. In the present study, we investigate how personality traits and psychosocial work variables were related to insomnia among musicians. All members of the Norwegian Musician’s Union who were eligible (n= 4168) were invited to participate in the online questionnaire study. A total of 2121 individuals (51%) participated. Of these, 656 (30.9%) worked full time as professional performing musicians and constitute the study sample in the present study. Insomnia was measured with the Bergen Insomnia Scale. We used hierarchical multiple regression analyses to examine how age, work hours per week, personality traits, demands, control, efforts, support, rewards and work-family conflict were related to insomnia scores. The variables investigated explained 22% of the variance in insomnia among musicians (F=(11,532)=13.961, p=.000). In the full model, extraversion, neuroticism and high demands were significantly, positively related to insomnia, while social support was negatively related to insomnia. Age, work hours per week, openness, agreeableness, conscientiousness, control or work-family conflict were not related to insomnia score. Although we cannot conclude about causality, our results support that personality traits of musicians partly may explain their insomnia symptoms. Work conditions and psychosocial variables may be difficult to measure for musicians because of large differences in work context, but high levels of demands and low social support may contribute to developing insomnia symptoms among full-time musicians. The Norwegian ExtraFoundation for Health and Rehabilitation and Statistics Norway.