Ground surface-air temperature difference (GATD) is the primary source of sensible heat flux from the ground surface, and vegetation inevitably affects it by altering the ground surface characteristics. However, the relationship between vegetation and GATD in the permafrost region has not been well-elucidated. Using meteorological station data, National Oceanic and Atmospheric Administration Climate Data Record Normalized Difference Vegetation Index (NOAA CDR NDVI) data, and some auxiliary data, this study aims to investigate the patterns of GATD in the Northeast China permafrost region and quantify the response of GATD to vegetation changes. The study employs trend analysis, Geodetector, and correlation analysis methods. The results show that the GATD in the Northeast China permafrost region decreased from west to east and the annual mean GATD exhibited an upward from 1982 to 2020. The relationship between NDVI and GATD trend is non-linear, in areas with low vegetation, vegetation changes amplify the GATD trend, while in areas with high vegetation, vegetation changes inhibit the GATD trend. Furthermore, the rate of GATD increase is higher in the discontinuous permafrost (DP) region than in the sporadic permafrost (SP) and isolated permafrost (IP) regions, suggesting that the DP region may have experienced a faster ground surface state change process. The findings of this study will provide new insights for evaluating permafrost degradation and studying the resulting ecological environmental effects in the permafrost region.