To change the economic processes and stabilize the socio-political situation, the authorities need an effective set of tools and methods of socio-economic management. They require new and better means of strategic planning that provide a controlled development of the national economy. This research features advanced forms and methods of econometric modeling in the regional socio-economic system. The research relied on the strategizing methodology developed by Professor V.L. Kvint, as well as the Strategist’s Office software that makes it possible to construct mathematical models of economic processes for a particular region. The predictive analytical model covered ten basic economic processes. This article introduces some factors and indicators defined for the transport infrastructure based on the index approach. The experimental part focused on the case of the North-Western and Volga Federal Districts. The set of tasks for regional development strategizing ranges from the theoretical and methodological provisions to the development of a digital twin of a regional economic system designed with the help of tools that provide information support for analysis, assessment, and forecasting. Regional strategizing is considered as a model of a regional socio-economic system defined as a structure that includes a number of autonomous subsystems with certain objective and measurable indicators.
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