A reasonable regional integrated energy system (RIES) structure is the key to achieving its economic and efficient operation. However, in actual engineering construction, only the maximum load is considered as a prerequisite for energy design, which leads to waste of energy allocation. In view of this, this article proposes an electricity-thermal-cooling RIES energy stations and networks planning model that coordinates the operation of multiple-user loads, energy networks, and energy stations based on the idea of load clustering. Firstly, an average peak valley difference rate covering electricity, thermal, and cooling loads was proposed to evaluate the load characteristics of the RIES. Secondly, based on the load cluster characteristics and network costs of RIES, a RIES planning optimization framework is proposed, which includes load cluster division, RIES site selection and network planning, and RIES capacity planning. Thirdly, based on the P-median model and load cluster characteristics, establish an RIES location and network layout model. Fourthly, establish an RIES capacity planning model with the goal of annual total cost and carbon emissions. Finally, Dijkstra, improved particle swarm optimization, and VIKOR were used to solve the model. The results showed that the proposed model reduced the annual total cost by 7.13 % and the annual carbon emissions by 3.72 %.