Human Development and its regional disparity is an area of topical interest. In this paper, we consider space as an instrumental variable in understanding this disparity and explore spatial interdependence in human development across districts of West Bengal using alternate indicators of human development. This study uses both the standard United Nations Development Programme (UNDP) technique and an alternative methodology to construct a sub-national human development index. Spatial interdependence is measured using Moran's I coefficient and Local Indicators of Spatial Autocorrelation (LISA) cluster maps. Spatial regression is used to evaluate the spatial association between the Human Development Index as the dependent variable and a few independent variables. A high degree of clustering in all three dimensions of human development is observed among the southern districts of West Bengal. The pattern of cluster maps indicates the presence of both the growth pole process and the metropole-periphery process in the state. Spatial regression results indicate that the share of socially backward class population and urbanization rate are important variables affecting regional human development patterns. The findings of this study suggest policies targeted to promote social inclusion and urbanization linked with better access to economic opportunities in the lagging areas can help reduce regional imbalances.