Regions Of Central America Research Articles

Abstract IA05: Epidemiologic, environmental, and molecular disparities in gastrointestinal cancer among Hispanics

Abstract IA05: Epidemiologic, environmental, and molecular disparities in gastrointestinal cancer among Hispanics

Valley Fever in the UK? - The importance of a travel history

Summary Coccidioidomycosis, also known as Valley Fever, is a fungal infection caused by the inhalation of spores, and is endemic in the Southwestern United States; regions of Mexico, Central America and South America. 1 It therefore came as a surprise to isolate this infection from a patient in a seaside town in North Yorkshire, UK. Coccidioidomycosis is caused by either Coccidioides immitis or Coccidioides posadasii , and once inhaled they are highly infectious, and can cause a wide variation in clinical manifestation and imaging findings.1 Most infections primarily involve the lungs, and are self-limiting and resolve over a period of weeks to months. 2 Occasionally the infection can spread to cause a very serious disseminated disease. The radiographic findings can be nonspecific and variable, often raising concern for many differential diagnoses such as malignancy, other infections or granulomatous conditions. 1,3 Relevance This was an interesting case of a female patient in the UK presenting with nonspecific respiratory symptoms, and eventually being diagnosed with a fungal infection typically found in the Southwestern United States. Take Home Messages It highlights the importance of enquiring about a travel history, and conducting appropriate imaging, even when the initial picture points towards a less exotic, more sinister diagnosis.

Prickly PalmAcrocomiaspp. (Arecaceae) endocarps: first records from Irish waters and a review of NW European records

Although at least 34 species of Prickly Palm (Acrocomia) have been described, the genus is currently considered to be represented by only three valid species: A. aculeata, A. hassleri, and A. (Gastrococos) crispa. Acrocomia species are only found in subtropical regions of South and Central America and the Caribbean Islands. Acrocomia diaspores (fruits and endocarps) are naturally dispersed by domestic mammals, wild mammals, bats, birds, reptiles and humans. However, some empty non-viable endocarps inevitably find their way into rivers and eventually float out to sea where they are widely dispersed by oceanic currents and at least some occasionally reach NW European waters from the Caribbean region via the Gulf Stream and North Atlantic Drift. The current review collates all known records of Acrocomia endocarps found stranded in NW Europe, including the first two reported from Irish waters and four previously unpublished UK records. Although the identification of Acrocomia endocarps currently defies effort...

Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection.

Coccidioidomycosis is a potentially life-threatening mycosis endemic to the Southwestern USA and some arid regions of Central and South America. A vaccine against Coccidioides infection would benefit over 30-million people who reside in or visit the endemic regions. Vaccine candidates against systemic fungal infections come in many forms. Live attenuated vaccines are derived from disease-causing pathogens and generally stimulate excellent protective immunity. Since attenuated vaccines contain living microbes, there is a degree of unpredictability raising concerns regarding safety and stability. Generation of a subunit vaccine has initiated efforts to design a safe reagent suitable for administration to humans at risk of coccidioidomycosis. Epitope-based vaccines allow for eliciting specific protective immune responses and removal of potentially detrimental sequences to improve safety. This chapter describes methods for the identification of T cell epitopes derived from Coccidioides antigens, design, and production of a recombinant vaccine containing multiple T cell epitopes, and evaluation of its protective efficacy and vaccine immunity against pulmonary Coccidioides infection using a strain of transgenic mice that express a human MHC II molecule.

Tropical precipitation anomalies and d -excess evolution during El Niño 2014-16

The last 2014-16 El Nino event was among the three strongest episodes on record. El Nino considerably changes annual and seasonal precipitation across the tropics. Here, we present a unique stable isotope data set of daily precipitation collected in Costa Rica prior to, during, and after El Nino 2014-16, in combination with Lagrangian moisture source and precipitation anomaly diagnostics. δ2H composition ranged from -129.4 to +18.1 (‰) while δ18O ranged from -17.3 to +1.0 (‰). No significant difference was observed among δ18O (P = 0.0186) and δ2H (P = 0.664) mean annual compositions. However, mean annual d-excess showed a significant decreasing trend (from +13.3 to +8.7 ‰) (P < 0.001) with values ranging from +26.6 to -13.9 ‰ prior to and during the El Nino evolution. The latter decrease in d-excess can be partly explained by an enhanced moisture flux convergence across the southeastern Caribbean Sea coupled with moisture transport from northern South America by means of an increased Caribbean Low Level Jet regime. During 2014-15, precipitation deficit across the Pacific domain averaged 46% resulting in a very severe drought; while a 94% precipitation surplus was observed in the Caribbean domain. Understanding these regional moisture transport mechanisms during a strong El Nino event may contribute to a) better understanding of precipitation anomalies in the tropics and b) re-evaluate past stable isotope interpretations of ENSO events in paleoclimatic archives within the Central America region. This article is protected by copyright. All rights reserved.

Global Potential Distribution of Bactrocera carambolae and the Risks for Fruit Production in Brazil.

The carambola fruit fly, Bactrocera carambolae, is a tephritid native to Asia that has invaded South America through small-scale trade of fruits from Indonesia. The economic losses associated with biological invasions of other fruit flies around the world and the polyphagous behaviour of B. carambolae have prompted much concern among government agencies and farmers with the potential spread of this pest. Here, ecological niche models were employed to identify suitable environments available to B. carambolae in a global scale and assess the extent of the fruit acreage that may be at risk of attack in Brazil. Overall, 30 MaxEnt models built with different combinations of environmental predictors and settings were evaluated for predicting the potential distribution of the carambola fruit fly. The best model was selected based on threshold-independent and threshold-dependent metrics. Climatically suitable areas were identified in tropical and subtropical regions of Central and South America, Sub-Saharan Africa, west and east coast of India and northern Australia. The suitability map of B. carambola was intersected against maps of fruit acreage in Brazil. The acreage under potential risk of attack varied widely among fruit species, which is expected because the production areas are concentrated in different regions of the country. The production of cashew is the one that is at higher risk, with almost 90% of its acreage within the suitable range of B. carambolae, followed by papaya (78%), tangerine (51%), guava (38%), lemon (30%), orange (29%), mango (24%) and avocado (20%). This study provides an important contribution to the knowledge of the ecology of B. carambolae, and the information generated here can be used by government agencies as a decision-making tool to prevent the carambola fruit fly spread across the world.

Partial Characterization of the Proteolytic Properties of an Enzymatic Extract From "Aguama" Bromelia pinguin L. Fruit Grown in Mexico.

Plant proteases are capable of performing several functions in biological systems, and their use is attractive for biotechnological process due to their interesting catalytic properties. Bromelia pinguin (aguama) is a wild abundant natural resource in several regions of Central America and the Caribbean Islands but is underutilized. Their fruits are rich in proteases with properties that are still unknown, but they represent an attractive source of enzymes for biotechnological applications. Thus, the proteolytic activity in enzymatic crude extracts (CEs) from wild B. pinguin fruits was partially characterized. Enzymes in CEs showed high proteolytic activity at acid (pH 2.0-4.0) and neutral alkaline (pH 7.0-9.0) conditions, indicating that different types of active proteases are present. Proteolytic activity inhibition by the use of specific protease inhibitors indicated that aspartic, cysteine, and serine proteases are the main types of proteases present in CEs. Activity at pH 3.0 was stable in a broad range of temperatures (25-50°C) and retained its activity in the presence of surfactants (SDS, Tween-80), reducing agents (DTT, 2-mercapoethanol), and organic solvents (methanol, ethanol, acetone, 2-propanol), which suggests that B. pinguin proteases are potential candidates for their application in brewing, detergent, and pharmaceutical industries.

PIN45 - Cost-Effective Analysis Of The Dengue Vaccine In Costa Rica

During the period 2010-2014, Costa Rica had the second highest incidence of dengue in the region of Central America, the Caribbean and Mexico, and such position was affected by the 2013 outbreak, with nearly 50,000 registered cases; this fact, together with the investments carried out in the country for control and prevention, makes dengue a relevant concern for public health and the authorities. This study carries out a cost-effectiveness analysis of the dengue vaccine using the public information available from the Ministry of Health, the Social Security Fund, and the National Institute for Research and Education of Costa Rica for the period 2008-2015. Since the public health system coverage is larger than 80%, private health care costs are not considered. A dynamic, compartmental and deterministic, transmission model of the disease¹ was used in data calibration and scenario projection for the period 2017-2026. Six different scenarios are analyzed, including no-vaccination (NV), i.e., the case in which the country continues with the present measures; the most ambitious vaccination scenario includes a routine vaccination at the age of 9 years and 16 catch-up cohorts (R9+16). By using as a reference the WHO² criterion for assessing health interventions —from the social perspective, considering indirect effect and under-reporting— the maximum price per dose for the intervention to be cost-effective is estimated in U$73.9 for a routine vaccination in the nine year-old risk population (R9), U$80.5 for a vaccination in the nine to fifteen year-old population (R9+6). Additionally, when the health impact is analyzed in terms of reduction (%) of the total dengue cases by scenario, the results are the following: -23% (R9) and -38% (R9+6). These results show that implementing an immunization schedule could be an effective and efficient way to fight dengue.

How rare is rare? Quantifying and assessing the rarity of the bush dog Speothos venaticus across the Amazon and other biomes

AbstractThe bush dog Speothos venaticus is a medium-sized Neotropical canid. It is considered to be rare and its biology and population parameters are still poorly understood. The Amazon is one of the main strongholds of this species and is important for maintaining viable populations, as the region still holds extensive tracts of pristine habitat. We gathered field data from camera-trap studies throughout the Brazilian Amazon to estimate the relative abundance of the species and gain an understanding of its rarity, and how this compares with estimates from other vegetative formations and for sympatric hypercarnivores. We focused on three pristine or partially disturbed sites and one fragmented site. The estimated relative abundance of the species was 0.060–0.185 individuals per 100 trap-days, confirming that the species is rare. The bush dog's abundance in the Amazon is equivalent to that in all other areas outside the Basin. The mean group size recorded was c. 2.5 individuals. There were no differences in group sizes between forests in the Amazon and in other regions of Central America; however, there were significant differences between forests and open habitats. A combination of competition/predation, habitat structure/integrity, and disease may be acting synergistically in determining the abundance and rarity of bush dogs.

Head and neck cancer burden and preventive measures in Central and South America

Rationale and objectiveCentral and South America comprise one of the areas characterized by high incidence rates for head and neck cancer. We describe the geographical and temporal trends in incidence and mortality of head and neck cancers in the Central and South American region in order to identify opportunities for intervention on the major identified risk factors: tobacco control, alcohol use and viral infections. MethodsWe obtained regional- and national-level incidence data from 48 population-based cancer registries in 13 countries and cancer deaths from the WHO mortality database for 18 countries. Age-standardized incidence (ASR) and mortality (ASMR) rates per 100,000 person-years were estimated. ResultsBrazil had the highest incidence rates for oral and pharyngeal cancer in the region for both sexes, followed by Cuba, Uruguay and Argentina. Cuba had the highest incidence and mortality rates of laryngeal cancer in the region for males and females. Overall, males had rates about four times higher than those in females. Most countries in the region have implemented WHO recommendations for both tobacco and alcohol public policy control. ConclusionHead and neck squamous-cell cancer (HNSCC) incidence and mortality rates in the Central and South America region vary considerably across countries, with Brazil, Cuba, French Guyana, Uruguay and Argentina experiencing the highest rates in the region. Males carry most of the HNSCC burden. Improvement and implementation of comprehensive tobacco and alcohol control policies as well as the monitoring of these factors are fundamental to prevention of head and neck cancers in the region.

When Terminal Illness Is Worse Than Death: A Multicenter Study of Health-Care Providers' Resuscitation Desires.

To investigate how a terminal illness may affect the health-care providers' resuscitation preferences. We conducted a cross-sectional survey in 9 health-care institutions located in 4 geographical regions in North and Central America, investigating attitudes toward end-of-life practices in health-care providers. Statistical analysis included descriptive statistics and χ2 test for the presence of associations ( P < 0.05 being significant) and Cramer V for the strength of the association. The main outcome measured the correlation between the respondents' present code status and their preference for cardiopulmonary resuscitation (CPR) in case of terminal illness. A total of 852 surveys were completed. Among the respondents, 21% (n = 180) were physicians, 36.9% (n = 317) were nurses, 10.5% (n = 90) were medical students, and 265 participants were other staff members of the institutions. Most respondents (58.3%; n = 500) desired "definitely full code" (physicians 73.2%; n = 131), only 13.8% of the respondents (physicians 8.33%; n = 15) desired "definitely no code" or "partial support," and 20.9% of the respondents (n = 179; among physicians 18.4%; n = 33) had never considered their code status. There was an association between current code status and resuscitation preference in case of terminal illness ( P < .001), but this association was overall quite weak (Cramer V = 0.180). Subgroup analysis revealed no association between current code status and terminal illness code preference among physicians ( P = .290) and nurses ( P = .316), whereupon other hospital workers were more consistent ( P < .01, Cramer V = .291). Doctors and nurses have different end-of-life preferences than other hospital workers. Their desire to undergo CPR may change when facing a terminal illness.

Globalization and women’s and girls’ health in 192 UN-member countries

Purpose – The purpose of this paper is to explore the relationship between the ratification of the United Nations’ (UN’s) Convention on the Elimination of All Forms of Discrimination against Women (CEDAW) and women’s and girls’ health outcomes using a unique longitudinal data set of 192 UN-member countries that encompasses the years from 1980 to 2011. Design/methodology/approach – The authors focus on the impact of CEDAW ratification, number of reports submitted after ratification, years passed since ratification, and the dynamic impact of CEDAW ratification by utilizing ordinary least squares (OLS) and panel fixed effects methods. The study investigates the following women’s and girls’ health outcomes: total fertility rate, adolescent fertility rate, infant mortality rate, maternal mortality ratio, neonatal mortality rate, female life expectancy at birth (FLEB), and female to male life expectancy at birth. Findings – The OLS and panel country and year fixed effects models provide evidence that the impact of CEDAW ratification on women’s and girls’ health outcomes varies by global regions. While the authors find no significant gains in health outcomes in European and North-American countries, the countries in the Northern Africa, sub-Saharan Africa, Southern Africa, Caribbean and Central America, South America, Middle-East, Eastern Asia, and Oceania regions experienced the biggest gains from CEDAW ratification, exhibiting reductions in total fertility, adolescent fertility, infant mortality, maternal mortality, and neonatal mortality while also showing improvements in FLEB. The results provide evidence that both early commitment to CEDAW as measured by the total number of years of engagement after the UN’s 1980 ratification and the timely submission of mandatory CEDAW reports have positive impacts on women’ and girls’ health outcomes. Several sensitivity tests confirm the robustness of main findings. Originality/value – This study is the first comprehensive attempt to explore the multifaceted relationships between CEDAW ratification and female health outcomes. The study significantly expands on the methods of earlier research and presents novel methods and findings on the relationship between CEDAW ratification and women’s health outcomes. The findings suggest that the impact of CEDAW ratification significantly depends on the country’s region. Furthermore, stronger engagement with CEDAW (as indicated by the total number of years following country ratification) and the submission of the required CEDAW reports (as outlined in the Convention’s guidelines) have positive impacts on women’s and girls’ health outcomes.

FIRST REPORT OF LEAF SPOT CAUSED BY COLLETOTRICHUM KAHAWAE ON AMERICAN SWEETGUM (LIQUIDAMBAR STYRACIFLUA) IN ITALY

Liquidambar styraciflua (American sweetgum, Altingiaceae) is a deciduous tree native to warm temperate areas of eastern North America and tropical montane regions of Mexico and Central America. In Italy it is a popular ornamental tree. During summer–fall 2014, a new leaf spot was observed on 30-year-old plants of L. styraciflua, at temperatures ranging between 15 and 26°C and high relative humidity. All of the five plants in a private garden close to Biella (northern Italy) were affected. Seventy to eighty percent of leaves showed necrotic spots, 10 to 60 mm in diameter, with a purple margin, often interesting the margins of the leaves. Colletotrichum sp. was consistently recovered with a frequency of 70% from several isolations from infected leaf tissues carried out on potato dextrose agar (PDA) amended with 25 mg/l of streptomycin sulphate (Bailey and Jeger, 1992). Hyaline, cylindrical, aseptate and thin walled conidia (13.0 to 18.7 x 3.8 to 5.9, average 16.2 x 4.7 μm size) were abundantly produced in acervuli in a gray mycelium on PDA medium. DNA was extracted with E.Z.N.A. Plant DNA Kit (Omega Bio-Tek) and PCR reactions were performed using primers ITS1/ITS4, and primers T1 (O’Donnell and Cigelink, 1997) and βt2b (Glass and Donaldson, 1995). The 499 bp and 725 bp products were sequenced (GenBank accession Nos. KT375326 and KT375325, respectively) and confirmed to correspond to Colletotrichum kahawae. Pathogenicity tests were performed under growth chamber at 24 to 26°C and 12 h photoperiod by spraying L. styraciflua leaves with 1x105 conidia/ml or sterile water covered with plastic bags for 5 days. About 7 to 10 days after inoculation, lesions developed only on inoculated leaves and Colletotrichum sp. was consistently reisolated. This is the first report of Colletotrichum kahawae on American sweetgum in Italy as well as worldwide. Due to the increased number of report of C. kahawae in Italy on species such as olive, mango and cultivated rocket, the adoption of preventative strategies to contain the spread of this pathogen is suggested.

Isotopic composition in precipitation and groundwater in the northern mountainous region of the Central Valley of Costa Rica

ABSTRACTThe linkage between precipitation and recharge is still poorly understood in the Central America region. This study focuses on stable isotopic composition in precipitation and groundwater in the northern mountainous region of the Central Valley of Costa Rica. During the dry season, rainfall samples corresponded to enriched events with high deuterium excess. By mid-May, the Intertropical Convergence Zone poses over Costa Rica resulting in a depletion of 18O/16O and 2H/H ratios. A parsimonious four-variable regression model (r2 = 0.52) was able to predict daily δ18O in precipitation. Air mass back trajectories indicated a combination of Caribbean Sea and Pacific Ocean sources, which is clearly depicted in groundwater isoscape. Aquifers relying on Pacific-originated recharge exhibited a more depleted pattern, whereas recharge areas relying on Caribbean parental moisture showed an enrichment trend. These results can be used to enhance modelling efforts in Central America where scarcity of long-term data limits water resources management plans.

Deep data science to prevent and treat growth faltering in Maya children.

The Maya people are descended from the indigenous inhabitants of southern Mexico, Guatemala and adjacent regions of Central America. In Guatemala, 50% of infants and children are stunted (very low height-for-age), and some rural Maya regions have >70% children stunted. A large, longitudinal, intergenerational database was created to (1) provide deep data to prevent and treat somatic growth faltering and impaired neurocognitive development, (2) detect key dependencies and predictive relations between highly complex, time-varying, and interacting biological and cultural variables and (3) identify targeted multifactorial intervention strategies for field testing and validation. Contributions to this database included data from the Universidad del Valle de Guatemala Longitudinal Study of Child and Adolescent Development, child growth and intergenerational studies among the Maya in Mexico and studies about Maya migrants in the United States.

Measuring waste to reduce waste in CTP

Subject area Operations Management Quality Management. Study level/applicability The case can be used in a number of course contexts, including undergraduate and graduate courses in operations management and quality management. Case overview Central Tobacco Plant (CTP) is a tobacco processing and packaging company, operating in the Central America and Caribbean region. This case focuses on a waste measurement exercise conducted in the cigarette production department of CTP, which was commissioned by George Edwards, the Secondary Manufacturing Department Manager. The reason for the exercise was the announcement that CTP could possibly face a plant audit, where a poor result could cause the shifting of manufacturing of some products, or, in the worst case scenario, all of it product lines, to one of the larger, and more efficient manufacturing plants in the Central America and Caribbean region. The waste measurement exercise is carried out as a three-week student–industry project by two students pursuing an MSc programme at the local university, who are mentored by both Edwards and by a university supervisor. At the end of the exercise, Edwards needs to consider the appropriateness of the current waste measurement system, the quantities of waste produced and opportunities to reduce waste. Expected learning outcomes The case has four primary learning objectives: to illustrate the role of performance measurement in process improvement, to explore the perspective of lean manufacturing in waste management, to apply basic quality tools in the analysis of a manufacturing process and to identify opportunities for process improvement. Supplementary materials Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes. Subject code CSS 9: Operations and Logistics

Interannual variability of the midsummer drought in Central America and the connection with sea surface temperatures

Abstract. The midsummer drought (MSD) in Central America is characterised in order to create annual indexes representing the timing of its phases (start, minimum and end), and other features relevant for MSD forecasting such as the intensity and the magnitude. The MSD intensity is defined as the minimum rainfall detected during the MSD, meanwhile the magnitude is the total precipitation divided by the total days between the start and end of the MSD. It is shown that the MSD extends along the Pacific coast, however, a similar MSD structure was detected also in two stations in the Caribbean side of Central America, located in Nicaragua. The MSD intensity and magnitude show a negative relationship with Niño 3.4 and a positive relationship with the Caribbean low-level jet (CLLJ) index, however for the Caribbean stations the results were not statistically significant, which is indicating that other processes might be modulating the precipitation during the MSD over the Caribbean coast. On the other hand, the temporal variables (start, minimum and end) show low and no significant correlations with the same indexes.The results from canonical correlation analysis (CCA) show good performance to study the MSD intensity and magnitude, however, for the temporal indexes the performance is not satisfactory due to the low skill to predict the MSD phases. Moreover, we find that CCA shows potential predictability of the MSD intensity and magnitude using sea surface temperatures (SST) with leading times of up to 3 months. Using CCA as diagnostic tool it is found that during June, an SST dipole pattern upon the neighbouring waters to Central America is the main variability mode controlling the inter-annual variability of the MSD features. However, there is also evidence that the regional waters are playing an important role in the annual modulation of the MSD features. The waters in the PDO vicinity might be also controlling the rainfall during the MSD, however, exerting an opposite effect at the north and south regions of Central America.

Development of a reverse transcription loop-mediated isothermal amplification assay for the detection of vesicular stomatitis New Jersey virus: Use of rapid molecular assays to differentiate between vesicular disease viruses

Vesicular stomatitis (VS) is endemic in Central America and northern regions of South America, where sporadic outbreaks in cattle and pigs can cause clinical signs that are similar to foot-and-mouth disease (FMD). There is therefore a pressing need for rapid, sensitive and specific differential diagnostic assays that are suitable for decision making in the field. RT-LAMP assays have been developed for vesicular diseases such as FMD and swine vesicular disease (SVD) but there is currently no RT-LAMP assay that can detect VS virus (VSV), nor are there any multiplex RT-LAMP assays which permit rapid discrimination between these ‘look-a-like’ diseases in situ. This study describes the development of a novel RT-LAMP assay for the detection of VSV focusing on the New Jersey (VSNJ) serotype, which has caused most of the recent VS cases in the Americas. This RT-LAMP assay was combined in a multiplex format combining molecular lateral-flow devices for the discrimination between FMD and VS. This assay was able to detect representative VSNJV’s and the limit of detection of the singleplex and multiplex VSNJV RT-LAMP assays were equivalent to laboratory based real-time RT-PCR assays. A similar multiplex RT-LAMP assay was developed to discriminate between FMDV and SVDV, showing that FMDV, SVDV and VSNJV could be reliably detected within epithelial suspensions without the need for prior RNA extraction, providing an approach that could be used as the basis for a rapid and low cost assay for differentiation of FMD from other vesicular diseases in the field.

Deep data science to prevent and treat growth faltering in Maya children.

The Maya people are descended from the indigenous inhabitants of southern Mexico, Guatemala and adjacent regions of Central America. In Guatemala, 50% of infants and children are stunted (very low height-for-age), and some rural Maya regions have >70% children stunted. A large, longitudinal, intergenerational database was created to (1) provide deep data to prevent and treat somatic growth faltering and impaired neurocognitive development, (2) detect key dependencies and predictive relations between highly complex, time-varying, and interacting biological and cultural variables and (3) identify targeted multifactorial intervention strategies for field testing and validation. Contributions to this database included data from the Universidad del Valle de Guatemala Longitudinal Study of Child and Adolescent Development, child growth and intergenerational studies among the Maya in Mexico and studies about Maya migrants in the United States.

Temporal and latitudinal trends of p,p'-DDE in eggs and carcasses of North American birds from 1980 to 2005.

The use of 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane (DDT) in agriculture in the United States and Canada was prohibited in the early 1970s; however, it continued to be used restrictively in Mexico until 2000. Forty years later, 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE), continues to be detected in eggs and bird carcasses in North America. The use of DDE has been associated with reproductive failure of several avian species, primarily through eggshell thinning. To assess the temporal and latitudinal distribution of p,p'-DDE in North America, the authors examined DDE concentrations reported in bird tissues in the scientific literature published between 1980 and 2009. Overall, the majority of supported models suggested that DDE concentrations in birds were greater in the upper mid-latitudes (38°-48°) than in other parts of North America. However, spatial trends of DDE seemed to be influenced by regions with large amounts of data, such as the Great Lakes area. Concentrations of p,p'-DDE in eggs averaged 2.5 μg/g, 3.2 μg/g, and 29.5 μg/g wet weight in 1980 and decreased to 1.64 μg/g, 0.87 μg/g, and 1.01 μg/g wet weight by the mid-2000s for the central, eastern, and western North America regions, respectively. The results indicate that, over time, all DDE residues observed in birds have decreased significantly in North America. Environ Toxicol Chem 2016;35:1340-1348. © 2016 SETAC.