Abstract Comprehensive water quality control is a fundamental requirement for environmental preservation and the sustainable development of communities around the globe. To showcase the importance of local quality controls in identifying the sources of pollution, a case study was conducted to analyze the quality of drinking water from different locations along the Cauvery River from Mettur to Trichy (200 km) in Tamil Nadu, India. The quality of water samples from different locations was indexed and compared with the World Health Organization and Indian Standards of water quality. The results indicate some high local values of TDS, hardness, and chloride content. These high values may be due to effluents from industries, dying factories, and sewage from the urban areas on the banks of the Cauvery River. This is most prevalent near Mohanur, where industrial waste and effluents were directly linked into the river. The results emphasize the importance of local quality control for accurately pinpointing the factors affecting the environment.