The design of a mineral slurry transportation system is difficult because of the non-Newtonian nature of the flow at high slurry concentrations. The behavior of the slurry depends on many physio-chemical properties such as particle density, particle size distribution (PSD), particle shape, chemical composition, pH etc. This work presents a comparative study between three preferred methods of scale-up of the head loss in larger diameter pipelines, namely Bowen’s Method, rheological method and Wilson’s Method. The performance of each method is validated with the pipe loop test data in a 200 DN pipeline. A high concentration (>50% by weight) iron ore concentrate slurry was used for carrying out the above study. This work would be beneficial for engineers involved in the design and maintenance of the slurry pipelines with respect to the choice of the scale-up methods available for estimation of the head loss for a time independent, homogenous, non-Newtonian particulate slurry for both laminar and turbulent regime.