Physical Activity Regimes Research Articles

The Impact of a Healthy Lifestyle on Lower Urinary Tract Symptoms and Erectile Function: A Prospective Study.

Background and Objectives: The impact of lifestyle on lower urinary tract symptoms has been deeply evaluated in recent years; however, studies in the young population are missing. The aim of this study is to evaluate the impact of alcohol intake, tobacco and cannabinoid smoking, physical activity, and dietary regime on urinary symptoms and sexual function in young adults under 30 years of age. Methods: A prospectively enrolled population of healthy young adults of both sexes under 30 years of age was selected. Young people with comorbidities were excluded. All participants were assessed by completing an anonymous questionnaire which included questions on medical history, lifestyle, smoking and alcohol intake, urinary symptoms, and sexual function only in male subjects. The questionnaire was postponed in case there was an acute pathology. Results: Overall, 802 young adults were prospectively enrolled, of whom 44% were male and 56% female, with a median age of 26 (23/28) years. In our population, 580/818 (70.9%) subjects presented an IPSS ≥ 3. In the analysis of the association between urinary symptoms and smoking, smokers presented urinary symptoms more frequently than nonsmokers (76% vs. 61%; p < 0.05). No association between urinary symptoms and alcohol intake, cannabinoid smoking, physical activity, and dietary regimen was recorded. On multivariable analysis, smokers had an almost doubled risk of urinary symptoms compared to nonsmokers (OR: 1.78; p = 0.001). Conclusions: In conclusion, we demonstrated how even in the young population there can be a correlation between LUTSs and different lifestyles.

Legg – Calve – Perthes disease: Modification of the experimental design and its morphological criteria

Legg – Calve – Perthes disease (LCPD) is the most common femoral head osteonecrosis in children. Until now, the knowledge of etiology, pathogenesis and clinical signs is partial and does not provide a coherent view of the disease. Despite modern advances in understanding and diagnosing of the disease, surgical interventions and stress release remain the standard treatment methods. Now there is a need to develop both new strategies for studying the pathogenesis of the disease and choosing methods of its treatment.The aim. Reproduction and development of morphological criteria for the early stage of Legg – Calve – Perthes disease (stages 1–2 by the modified Waldenström classification system).Materials and methods. The research involved 6 young gray giant rabbits (Flandres) aged 3–4 months. The early stages of LCPD were simulated by the pathophysiological model of Kuzhelivsky I.I. et al. (2016) with paraarticular adrenaline injections along with physical activity. We modified the physical activity regime for the subjects by daily free range for 1.5–3 hours.Results. The experiment confirmed the validity of the modified simulation and designed its morphological criteria. The osteochondropathy process was verified histologically, we also revealed the classic signs of damage to subchondral bone and hyaline cartilage as well as abnormal vascularization of cartilage sites and pathological neoangiogenesis.Conclusion. The technique of non-traumatic osteonecrosis simulation in young rabbits featured initial results in reproducing the pathological links of osteonecrosis process. The cartilage tissue featured the loss of isogeneity in chondrocytes structure and their column-like arrangement; its delamination and replacement with fibrous tissue, including fibroblast-like cells and collagen fibers; cartilage neovascularization and persistent mixed hyperemia. In the bone marrow, only the activation of the red blood cell line was noted. The bone tissue featured the abnormality of osteon structure with a mosaic arrangement of trabeculae as well as lacunar resorption, and osteoblast degeneration.

Lockdown influence on diet and physical activity of seniors; has it weight consequences?

Many studies draw attention to the negative consequences of the pandemic or lockdown on the well-being and lifestyle of different sections of the population. This study considers whether changes occurred in dietary regime and level of physical activity during three periods - before the pandemic, during the lockdown, and during the present in older Slovak adults. We also investigate whether individual weights changed during the pandemic. The study has a cross-sectional design. We collected 436 questionnaires from older adults (60+) living in Slovakia; 277 come from the first phase of online data collection (04/2022-06/2022) in university students of the third age, and 159 from the second phase of offline collection (07/2022-11/2022) in social service facilities. We monitored if there were any changes within the observed periods in the variables of diet regime, physical activity, and BMI. The database has been processed in IBM SPSS Statistics. During the lockdown, the frequency of physical activity decreased (p < 0.001), the quality of movement worsened (p < 0.001), and the time respondents devoted to physical activity during the week decreased (p < 0.001). At present, the variables have increased. Within the dietary regimen, statistically significant changes occurred in appetite and non-alcoholic beverage intake (p = 0.002). However, there were no significant changes in the number of daily meals (p = 0.190), or the amount of alcohol consumed (p = 0.066). The BMI of older men and women did not change after the pandemic (p = 0.519), and it did not differ between men and women either before the pandemic (p = 0.281) or after it (p = 0.449). Also there is no difference between UTA students and social facility living seniors before the pandemic (0.933) and now (0.317). The results showed that even though physical activity significantly decreased during the lockdown, the older adults in our study did not eat more during the lockdown, nor did they gain weight. However, this probably had negative consequences for the quality of their movement. It is essential to simultaneously create compensatory measures while implementing future anti-epidemic (or other) measures. They would help maintain the desired amount of physical activity or other healthy habits on an optimal level.

Ovarian reserve, metabolic and neuroendocrine profiles of cadets from Air Force Academy: a pilot study.

Intensive physical activity and rigid dietary regimes can act as modifiers of neuroendocrine axes in women, inducing hormonal disorders and related menstrual irregularities such as functional hypothalamic amenorrhea (FHA). It would be important to evaluate if such disturbances may worsen female fertility. The aim of this study was to evaluate ovarian reserve markers and neuroendocrine axis in young military academy female cadets with years of training and occurrence of FHA. This is a prospective pilot study involving young female cadets from the Military Academy training program. Ovarian reserve markers and metabolic and neuroendocrine factors in the early follicular phase were measured with blood tests and transvaginal ultrasound. The study group consisted of 11 women belonging to the first year of training and the control group of 33 women belonging to the second to sixth year of training. No differences were found about ovarian reserve markers between the two groups. Moreover, the occurrence of FHA did not modify the ovarian reserve compared to eumenorrhea in both groups. Women from the study group showed significantly higher levels of fasting Insulin (42.18±26.14 uUI/mL versus 11.9±10.2 ng/mL, P value <0.001) and insulin-like growth factor 1 (310.06±67.90 uUI/mL versus 248.67±61.57 uUI/mL, P value = 0.015) compared with control group. Both intense physical training and FHA do not appear to impact the ovarian reserve of young female cadets. Although preliminary, these findings seem reassuring about the reproductive health of these women and their future fertility.

Motivating servicemen with health problems to engage in physical training physical training

The importance of physical training today is undoubtedly relevant in solving the problems of military personnel's readiness to fulfill the assigned tasks of military and professional activities. It is known that one of the leading factors affecting the health of servicemen with disabilities is compliance with the regime of physical activity, which in turn is facilitated and played an important role by physical training and sports. The systematic formation of the need for physical training and sports depends primarily on the individual, his or her preferences, beliefs and interests, i.e. motivation. Therefore, one of the priority areas of activity of specialists involved in the rehabilitation and adaptation of servicemen with disabilities is the formation of motivation in physical training and sports in the conditions that have developed in our country after the invasion of the Russian aggressor. The article is devoted to highlighting and analyzing the problematic issues that require special attention in terms of helping to integrate servicemen who have health problems or have been severely injured during hostilities into the social environment and further motivate them to participate and engage in physical education activities.

Maintaining psychophysical resilience through fitness programs

Physical activity represents the key to a strong and resilient body. A rationally organized regime of physical activity has a number of positive effects on all systems of the body, both at the physical level and at the psychological level. To determine the influence of fitness programs on the physical and psychological state, level and lifestyle, as well as to study the subjective attitude of people to their own psychophysical state and physical condition, an online sociological survey was conducted. The results of the sociological research made it possible to state the positive influence of fitness for the formation of the psychophysical stability of the personality of a modern person.

The Influence of Physical Activity Regime on Body Composition in Teenagers With and Without Intellectual Disabilities

This study aims to assess several morphofunctional parameters in female teenagers with and without intellectual disability to characterise normality and its disturbances. More precisely, the purpose was to examine the factors contributing to the differences in body composition elements between groups, such as the physical activity level. To evaluate these parameters, we used bioelectrical impedance analysis technology (BIA), most commonly used in studies concerning body composition because it is non-invasive, quick, with high data fidelity; it can be easily moved to various locations and applied straightforwardly among populations with diverse types of intellectual disability. Our research sample comprised 212 subjects (boys and girls) aged 17.1±0.6, divided into six groups by gender and type of intellectual disability. The study found influences of physical activity level on body composition components. In addition, we report a highly significant relationship for p&lt;0.05, body mass index and the independent variable (No. of min./week) in some groups.

Integrative Oncology Approaches to Supporting Immune Checkpoint Inhibitor Treatment of Solid Tumours.

The goal of this review was to examine the role and practical applications of integrative oncology strategies in supporting immune checkpoint inhibitor (ICI) treatment of adult solid tumours. Beyond tumour-intrinsic factors, several patient-associated factors affect ICI response, including germline genetics, systemic inflammation, the gut microbiota, and diet. Current promising supportive interventions include a Mediterranean-style diet with over 20 g of fibre, regular exercise, use of live biotherapeutics, minimisation of PPI and antibiotic use, and ensuring vitamin D repletion, with many other integrative oncology approaches under study. Caution around medical cannabis use in patients on ICIs is advised due to previously documented adverse impact on overall survival, while VAE (Viscum album extract) therapy studies have not highlighted any safety concerns so far. With expanding ICI use, it is important to investigate and apply low-cost integrative oncology strategies to support better treatment outcomes and minimise adverse events. Further research may lead to pre-treatment assessment of both tumour and patient-associated biomarkers and personalised multimodal prehabilitation care plans, as well as on-treatment support with targeted nutrition, physical activity, and supplementation regimes, including both systemic inflammation and gut microbiome modulating strategies. Given the emerging understanding of chronic stress impact on ICI treatment outcomes, mind-body approaches require further investigation.

Predictors of sustained physical activity: behaviour, bodily health, and the living environment.

This study examined the determinants of sustained physical activity. Eighty-four participants undertook a 7-weeks walking regime (i.e., a 1-h biometrically-monitored walk, at least 5days/week), with bioelectrical impedance (BIA) and total cholesterol capillary blood measurements performed before and after programme. To investigate behavioural habit formation, 7weeks after walking termination, all participants were interviewed and (health) re-tested. Data were modelled with an artificial neural network (ANN) cascading algorithm. Our results highlight the successful prediction of continued physical activity by considering one's physical fitness state, the environmental living context, and risk for cardiovascular disease. Importantly, those artificial neural network models also taking body mass index (BMI) and blood cholesterol as predictors excel at predicting walking continuation (i.e., predictions with 93% predictability). These results are first to highlight the type and importance of available physiological drivers in maintaining a sustained physical activity regime such as walking. They are discussed within the framework of habit formation and the nowadays health and/or wellbeing focus.

Рак желчного пузыря: заболеваемость, факторы риска, диагностика

Aim. To analyze current data on the incidence, risk factors, diagnostic methods and prevention of gallbladder cancer (GBC). Key points. GBC is a malignant tumor arising from the epithelium of the gallbladder, characterized by local and vascular invasion, extensive regional lymphogenous and hematogenous metastasis. GBC is the most common malignant tumor of the biliary tract, characterized by high malignancy and low 5-year survival rate. In international recommendations, gastrointestinal tract is considered as a natural stage of the course of biliary pathology: dyskinesia — cholecystitis — cholelithiasis — GBC. Globally, the incidence of GBC varies significantly among different geographic regions, reaching 27 per 100,000 population in Chile. In Russia, according to the Federal State Statistics Service, the incidence of GBC in 2019 was 1.4 per 100 thousand among men, and 2.5 per 100 thousand among women. The incidence of GBC is associated with female gender and increasing age. In the pathogenesis of gallstones, decisive importance is attached to long-term inflammatory changes in the epithelium due to mechanical trauma to the mucous membrane of the gallbladder by stones and a probable increase in the proportion of secondary bile acids in the bile. In the diagnosis of GBC, the recommendations of the Japanese Society of Hepato-Biliary-Pancreatic Surgery, in the first step, particular importance is attached to ultrasound examination of the abdominal organs and biochemical blood test. For a more detailed study, computed tomography, magnetic resonance imaging, magnetic resonance cholangiopancreatography, endosonography, retrograde cholangiopancreatography, oral cholangioscopy and positron emission tomography are useful. Gallstone disease is one of the five most significant risk factors. The remaining 4 leading risk factors for GBC — ethnicity, genetic predisposition, lifestyle factors (excess weight) and biliary tract infections — are common risk factors for patients with cholelithiasis. The risk of developing GBC increases significantly in patients with stones larger than 2 cm and with the duration of the pathology for more than 5 years. Another significant risk factor for GBC is patients with gallbladder polyps, therefore the article presents the main recommendations of European associations for the management of patients with gallbladder polyps. Conclusion. GBC is currently considered as a possible and natural stage in the course of cholelithiasis. The risk of developing GBC increases significantly in patients with cholelithiasis and gallbladder polyps. Considering the above, diagnosis of possible complications in elderly patients with cholecystitis and gallstone disease should include a thorough clinical, laboratory and instrumental examination. Preventive measures for people with risk factors for GBC should include optimizing diet, weight loss, and, if possible, expanding the physical activity regime. Taking ursodeoxycholic acid preparations helps reduce the content of hydrophobic bile acids in bile and reduces the likelihood of complications of biliary pathology. Keywords: gallbladder cancer, cholelithiasis, gallbladder polyps, diagnosis, morbidity.

Age and gender as factors affecting adolescent`s physical activity regime

Introduction: In general, physical activity (PA) decreases with age. Changes in the volume of PA and the movement mode are non-linear from the point of view of age and gender. In the lives of young people, there is a critical period accompanied by a decrease in the goals of PA performed in the daily regime. This study aimed to identify changes in the level of PA due to the age and gender of adolescents. Materials and Methods: The physical activity regime was analyzed using the final activity summary score of the Physical Activity Questionnaire for Adolescents (PAQ-A). A total of 417 children at the age of 11-18 years were tested (girls n = 245; boys n = 172). Analysis of the effect of gender, age, and their interactions with the volume of physical activity (PA) was carried out using two-way ANOVA and multiple comparisons of the means of individual age groups with post-hoc Tukey HSD analysis. The independent t-test was used to evaluate the effect of the gender factor. Results: The data presented showed a linear decrease in PA in the PA regime of pupils from 11 to 18 years of age, regardless of gender. Conclusions: PA volume in adolescence generally decreases with increasing age. The critical period appears to be the 14th year of life for girls and the 16th year for boys.

A stepped down physical activity support program for military service veterans: The Active Choices pilot study.

Referral to supervised physical activity (PA) programs is an effective treatment for military service veterans (MSVs) suffering from a range of chronic diseases. However, many MSVs fail to maintain PA regimes once discharged from supervision. This pilot study assessed Active Choices, a stepped-down program to support MSVs in the transition from allied health treatment to self-managed PA. Participants were 34 Australian MSVs (mean [SD] age = 61 [15.8] years) who were completing supervised referral to an exercise physiologist or physiotherapist. MSVs stepped-down to Active Choices and received a 12-week, evidence-based PA support program (2020-2021). Analyses compared within-group changes in accelerometer-assessed PA at three time points (Weeks 0, 12, and 24; linear mixed model). Program retention, PA choices, and allied healthcare service costs were also evaluated. Relative to baseline (64 [26] min/day), mean (SD) moderate-to-vigorous PA increased (74 [28] min/day; p < .05) and was maintained (62 [28] min/day) at weeks 12 and 24, respectively. Retention in the program was high (86% [29/34 participants] completion rate at 12 weeks), with water-based group activities the most popular PAs of choice (14/24 activities). Average allied healthcare service costs during the study were lower than typical costs for MSVs (60.51 vs. 97.06 AUD/week). The findings highlight the potential of Active Choices to support MSVs in the transition from supervised to self-managed MVPA. SO WHAT?: The program could promote the health of veterans and reduce costs for ongoing referral if impact is replicated at scale.

Uncontrolled blood pressure and associated factors in adult hypertensive patients undergoing follow-up at public health facility ambulatory clinics in Bishoftu town, Ethiopia: a multi-center study

BackgroundUncontrolled blood pressure is an important medical and public health problem in developing countries like Ethiopia. Improving the management of hypertension requires a better comprehension of the factors influencing blood pressure control and the application of interventions. But in clinical practice, blood pressure is still not adequately controlled. Thus, this study aimed to assess uncontrolled blood pressure and associated among adult hypertensive patients on follow-up at public health facility ambulatory clinics in Bishoftu, Ethiopia.MethodsA hospital-based cross-sectional study was conducted among 398 adult hypertensive patients who were on treatment and follow-up from April to May 31, 2022. Systematic random sampling was used to select study participants. Data were collected using an interviewer-administered, semi-structured questionnaire and chart review. The Eighth Joint National Committee (JNC 8) criteria was applied to define blood pressure control status. Binary logistic regression analysis was used to model the association between dependent and independent variables. An adjusted odds ratio and 95% confidence interval were used to measure the strength of the association. Finally, at a p-value < 0.05, statistical significance was proclaimed.ResultOf the total study participants, 249(62.6%) were male. The mean age was 62.26 ± 11.55 years. The overall proportion of uncontrolled blood pressure was 58.8% (95% CI: 54–64). Salt intake (AOR = 2.51; 95% CI: 1.49–4.24), lack of physical activity (AOR = 1.40; 95% CI: 1.10–2.62), habitual coffee consumption (AOR = 4.52; 95% CI: 2.67–7.64), higher BMI (AOR = 2.08; 95% CI: 1.24–3.49), and non-adherence to antihypertensive medications (AOR = 2.31; 95% CI: 1.3–3.89) were independent predictors of uncontrolled blood pressure.ConclusionMore than half of the hypertensive patients in this study had uncontrolled blood pressure. Healthcare providers and other accountable stakeholders should urge patients to follow salt restriction, physical activity, and antihypertensive medication regimes. Reduced coffee consumption and weight maintenance are other crucial blood pressure control measures.

The Relationship between the Frontal QRS-T Angle on ECG and Physical Activity Level in Young Adults.

The heart's electrical activity has been the subject of numerous research concerning various physiological parameters. The frontal QRS-T angle (FQRST) is an advanced ECG variable with clinical epidemiological utility. This study aimed to determine the relationship between FQRST and physical activity exposure among young adults. We recorded the ECG with 12 leads of 124 participants (mean age 20.28 ± 2.23 years, age range 18-27 years). Next, we measured their physical activity level (PAL) with the International Physical Activity Questionnaire-Short Form (IPAQ), which categorizes activity into three classes: low, moderate, or high. An inferential analysis, based on the Kruskal-Wallis H test and Mann-Whitney U test, revealed a statistically significant difference in FQRST between the three groups of subjects, classified by their PAL (p < 0.001). We also identified a significant regression model between the body mass index (BMI) and the FQRST (p < 0.001). The physical activity regime of young adults significantly influences the concordance between ventricular depolarization and repolarization, reflected in the FQRST's width. Also, we found a regression model between FQRST and BMI with statistical significance.

ВЛИЯНИЕ РАСШИРЕННОГО ДВИГАТЕЛЬНОГО РЕЖИМА НА ПОКАЗАТЕЛИ УМСТВЕННОЙ РАБОТОСПОСОБНОСТИ ДЕТЕЙ 5–6 ЛЕТ

The mental performance of children aged 5–6 years old, recorded in the conditions of regular and extended physical activity regimes of a preschool educational institution, corresponded to the characteristics of the age development of preschoolers in the senior group of kindergarten. An expanded regime of physical activity, including additional rhythmic gymnastics classes and exercises in the pool, contributes to a more pronounced increase in the speed and stability of mental work of children 5–6 years old in daily and weekly dynamics in comparison with the traditional organization of physical activity.

Физическая активность и качество жизни больных с хронической недостаточностью кровообращения на фоне физической реабилитации

The purpose of this study: to assess the quality of life and exercise tolerance against the background of the use of physical rehabilitation in patients with CHF. Methods. The article presents the results of a study of the quality of life of 50 patients (20 men and 30 women) with coronary heart disease (CHD) complicated by CHF I-III FC observed in the framework of the Disease management programs (DMPs). The average age of the patients was 61.5±1.5 years. The QoL of patients was assessed using the SF-36 questionnaire before and 6 months after the rehabilitation measures. Within 6 months, both groups received standard basic therapy. Group 1, in addition, was engaged in the generally accepted version of the complex of physical exercises, which included morning exercises, aerobic training in the form of dosed walking. The work was carried out according to the standards of the operating procedures of the office of the DMPs, including the selection of a physical activity regime and a self-management program providing for the patient's participation in the preparation of an action plan. Results. The results showed that the clinical condition of the patients of both groups improved against the background of the therapy. However, in group 1, these results on the SHOCK scale and on the distance of a 6-minute walk were significantly better. A comparative analysis of the data in groups 1 and 2 after treatment revealed more significant changes in the parameters of QoL in group 1 (the increase in PF was by 48.6%, RP by 66.1%, RE by 48.6% and VT by 52.4%), while in group 2 these values they were slightly lower and corresponded to PF -39%, RP-48.2%, RE -35.7% and VT - 37.2 (p&lt;0.05), which indicates a positive effect of the use of physical activity in the rehabilitation of patients with CHF. Conclusion. Assessment of the clinical condition of patients with chronic circulatory insufficiency using the SHOCK and exercise tolerance scale. revealed an improvement in performance after the use of metered physical activity . The results of the use of physical training in the system of coordinated and integrated medical interventions in the DMPs for the rehabilitation of patients with CHF in a polyclinic indicates the possibility of improving the quality of life due to PF, RP, VT and RE.

Artifcial intelligence capabilities in evaluating effectiveness of non-medicinal treatment of obesity in children

Introduction. Non-drug therapy for obesity cannot always guarantee a positive result, which forces doctors and scientists from all over the world to look for new methods for analyzing the effectiveness of treatment, including using artifcial intelligence. Its active implementation can significantly improve the quality of diagnosis and prognosis of the disease. Purpose of the study. To evaluate the possibilities of using the artifcial intelligence system in predicting the effectiveness of non-drug therapy for obesity in children.Materials and methods. An artifcial neural network was built using the Statistica Neural Networks software package based on data from patients who were hospitalized at the Voronezh Children's Clinical Hospital of the VSMU n.a. N.N. Burdenko.Results. The study group included 60 children (30 boys and 30 girls), aged 8 to 16 years. We selected the parameters that, in our opinion, have the most signifcant impact on the effect of non-drug treatment of obesity: the presence and frequency of inpatient treatment; obesity complications; compliance with the regime of physical activity and dietary recommendations; dynamics of body weight during non-drug treatment. After training, the neural network MLP 5-5-1 was selected with determination coeffcients of 0.925231; 0.981940; 0.936712 for training, test and control samples. The learning error is 0.105782, the learning algorithm is BFGS. The activation function of hidden neurons is hyperbolic, and the output function is identical.Conclusion. The results of the study show that an artifcial neural network can be used to evaluate the effectiveness of non-drug treatment with a minimum error.

Physical education as a factor in the healthcare of students in distance learning. The article considers the issue of physical education of students in the conditions of distance learning, which is due to the introduction of quarantine measures caused by

It is believed that the task of physical education in the new realities of distance education is the need to ensure students understand the threats of lack of physical activity, as well as help by all possible means to compensate for its lack in the daily routine. The question of ways to ensure the effectiveness of physical education of students in distance learning has been studied. It is determined that the purpose of physical education in distance learning is to form an idea of using all possible forms of physical education, adapted to today's realities to ensure compliance with the regime of physical activity, as much as possible with quarantine security measures. It is established that the organization of effective distance learning, and adaptation of the educational process of physical education to the requirements of today is to ensure physical development by increasing the physical activity of student youth. The leading task of physical education in distance learning is defined as the opportunity to demonstrate that by staying at home you can stay active, lead a healthy lifestyle, engage in physical self-development, and understand that there is no quarantine for physical activity. It was found that the content of physical education in distance learning should be formed to ensure the strengthening of healthcare and hardening of the body of students. The pedagogical conditions which promote maintenance of efficiency of physical training of students in the conditions of distance learning are allocated. Such conditions are presented as a result of purposeful selection, construction, and application of elements of content, methods (techniques), as well as organizational forms of physical education to achieve a certain goal, motivation, and incentive for effective healthcare of students. As a result, it was determined that distance learning requires radical changes and modernization of approaches to the organization of physical education of students to ensure the effectiveness of its goals.

A unifying model to estimate the effect of heat stress in the human innate immunity during physical activities

Public health is threatened by climate change and extreme temperature events worldwide. Differences in health predispositions, access to cooling infrastructure and occupation raises an issue of heat-related health inequality in those vulnerable and disadvantaged demographic groups. To address these issues, a comprehensive understanding of the effect of elevated body temperatures on human biological systems and overall health is urgently needed. In this paper we look at the inner workings of the human innate immunity under exposure to heat stress induced through exposure to environment and physical exertion. We couple two experimentally validated computational models: the innate immune system and thermal regulation of the human body. We first study the dynamics of critical indicators of innate immunity as a function of human core temperature. Next, we identify environmental and physical activity regimes that lead to core temperature levels that can potentially compromise the performance of the human innate immunity. Finally, to take into account the response of innate immunity to various intensities of physical activities, we utilise the dynamic core temperatures generated by a thermal regulation model. We compare the dynamics of all key players of the innate immunity for a variety of stresses like running a marathon, doing construction work, and leisure walking at speed of 4 km/h, all in the setting of a hot and humid tropical climate such as present in Singapore. We find that exposure to moderate heat stress leading to core temperatures within the mild febrile range (37, 38],^{circ }hbox {C}, nudges the innate immune system into activation and improves the efficiency of its response. Overheating corresponding to core temperatures beyond 38,^{circ }hbox {C}, however, has detrimental effects on the performance of the innate immune system, as it further induces inflammation, which causes a series of reactions that may lead to the non-resolution of the ongoing inflammation. Among the three physical activities considered in our simulated scenarios (marathon, construction work, and walking), marathon induces the highest level of inflammation that challenges the innate immune response with its resolution. Our study advances the current state of research towards understanding the implications of heat exposure for such an essential physiological system as the innate immunity. Although we find that among considered physical activities, a marathon of 2 h and 46 min induces the highest level of inflammation, it must be noted that construction work done on a daily basis under the hot and humid tropical climate, can produce a continuous level of inflammation triggering moieties stretched at a longer timeline beating the negative effects of running a marathon. Our study demonstrates that the performance of the innate immune system can be severely compromised by the exposure to heat stress and physical exertion. This poses significant risks to health especially to those with limited access to cooling infrastructures. This is due in part to having low income, or having to work on outdoor settings, which is the case for construction workers. These risks to public health should be addressed through individual and population-level measures via behavioural adaptation and provision of the cooling infrastructure in outdoor environments.

Влияние различных режимов физических нагрузок на состояние системы гемостаза и концентрацию белка ирисина в эксперименте

Nowadays, research on non-drug methods to preserve health and increase life expectancy is considered relevant. It is a well-known fact that moderate physical activity has a direct impact on longevity. The hemostatic system plays a vital role in adaptation to physical activities, and changes in its indicators can negatively affect the cardiovascular system in response to physical stress. In 2012, the hormone irisin was discovered, which levels decrease with aging. Irisin is a protein synthesized during physical activity, which prevents aging-associated diseases, including hypertension, Parkinson’s and Alzheimer’s diseases. This research aims to develop an optimal regime of physical activity that would preserve the hemostasiological parameters within the normal range and lead to increased concentrations of irisin in blood. The studies were performed on young Wistar male rats. The experimental animals were subjected to physical exertion in the form of walking on a treadmill at a speed of 6-8 m/min for 30 days. The animals of the first experimental group were subjected to daily 2-hour physical activity periods. The animals of the second experimental group were subjected to 2-hour physical activity periods three times a week (Monday, Wednesday, Friday). It was discovered that in the first experimental group, with signs of hypercoagulation, the level of irisin increased by 130%. In the second experimental group, no signs of hypercoagulation were revealed. Herewith, irisin concentration increased by 225%. Thus, the most effective exercise regime for rats is coercive walking on a treadmill for 2 hours at a speed of 6-8 m/min three times a week for 30 days.