Влияние различных режимов физических нагрузок на состояние системы гемостаза и концентрацию белка ирисина в эксперименте

Abstract

Nowadays, research on non-drug methods to preserve health and increase life expectancy is considered relevant. It is a well-known fact that moderate physical activity has a direct impact on longevity. The hemostatic system plays a vital role in adaptation to physical activities, and changes in its indicators can negatively affect the cardiovascular system in response to physical stress. In 2012, the hormone irisin was discovered, which levels decrease with aging. Irisin is a protein synthesized during physical activity, which prevents aging-associated diseases, including hypertension, Parkinson’s and Alzheimer’s diseases. This research aims to develop an optimal regime of physical activity that would preserve the hemostasiological parameters within the normal range and lead to increased concentrations of irisin in blood. The studies were performed on young Wistar male rats. The experimental animals were subjected to physical exertion in the form of walking on a treadmill at a speed of 6-8 m/min for 30 days. The animals of the first experimental group were subjected to daily 2-hour physical activity periods. The animals of the second experimental group were subjected to 2-hour physical activity periods three times a week (Monday, Wednesday, Friday). It was discovered that in the first experimental group, with signs of hypercoagulation, the level of irisin increased by 130%. In the second experimental group, no signs of hypercoagulation were revealed. Herewith, irisin concentration increased by 225%. Thus, the most effective exercise regime for rats is coercive walking on a treadmill for 2 hours at a speed of 6-8 m/min three times a week for 30 days.