Regenerative Technologies Research Articles

Advances in three-dimensional printing of hydrogel formulations for vascularized tissue and organ regeneration.

Over the last decades, three-dimensional (3D) printing has emerged as one of the most promising alternative tissue and organ regeneration technologies. Recent advances in 3D printing technology, particularly in hydrogel-derived bioink formulations, offer promising solutions for fabricating intricate, biomimetic scaffolds that promote vascularization. In this review, we presented numerous studies that have been conducted to fabricate 3D-printed hydrogel vascularized constructs with significant advancements in printing integumentary systems, cardiovascular systems, vascularized bone tissues, skeletal muscles, livers, and kidneys. Furthermore, this work also discusses the engineering considerations, current challenges, proposed solutions, and future outlooks of 3D bioprinting.

Cutting-edge regeneration technologies for saturated adsorbents: a systematic review on pathways to circular wastewater treatment system.

Adsorption seemed like an excellent physicochemical process employed for wastewater treatment. In the last few decades, significant improvements have been made in efficiency and economy to remove contaminants from wastewater using several adsorbents. However, less attention was paid to the regeneration of used adsorbents. Aside from the adsorbent's high adsorption performance, the disposal of spent adsorbents is an environmental concern. Regeneration is an important aspect to stimulate the adsorption efficiency of the spent adsorbent for wastewater treatment. This article reviews the various regeneration techniques like electrochemical regeneration, biological regeneration, thermal regeneration, ultrasound regeneration, and chemical regeneration in detail that have been performed for the renewal of saturated adsorbents. In the ultrasonic regeneration technique, Fe3O4-loaded coffee waste hydrochar adsorbent showed 100% regeneration efficiency (RE) after 1.3h at the power consumption of 300 W/L. Electrochemical regeneration of granular activated carbon, Nyex, graphene and titanium dioxide composite, and Nyex 1000 showed 100% RE after 3, 0.16, 0.12, and 1.5h, respectively, with electrolyte Na2SO4 and NaCl. In the regeneration technique, powdered activated carbon showed 90% RE after 48-72h. Immobilized fungal biomass (Rhizopus nigricans) adsorbent showed 111-115% RE with base (0.01 N NaOH, NaHCO3, and Na2CO3) solvent. The present study addresses issues including waste generation, adsorbent potential and efficiency, eco-friendly techniques, and the release of adsorbed pollutants in regenerating saturated adsorbents. The mechanisms of adsorbent regeneration were thoroughly examined, highlighting the significance of the regeneration process in adsorption. Furthermore, this review discusses the advantages of hybrid regeneration techniques like microwave-activated ultraviolet-advanced oxidation, electro-peroxide approach, electrochemical and electrothermal methods, and the secondary use of spent adsorbents as catalysts, fertilizer, cementitious materials, secondary adsorbent bio-fuels, etc. Using saturated adsorbents is a practical technology for sustainable wastewater treatment that has the potential to minimize pollution and promote a circular economy. This review concludes with a discussion of the present challenges in the regeneration of the used adsorbents, as well as future directions for ensuring the system's feasibility from an economic and environmental standpoint for use on an industrial scale.

Water-Induced Integrated Regeneration of Cathode Materials from Spent Sodium-Ion Batteries.

The increasingly accumulated end-of-life batteries require high-efficiency regeneration technology for sustainable development. However, the existing recycling methods are highly restricted in a direct additive process due to the inconsistent content of alkaline ions within various spent materials and then failure to recover them together. Here, a subtractive process is introduced for the integrated regeneration of spent cathode materials, which successfully transforms the cathode materials with an unknown Na+ content to the desodiation phase together via water only. Because water and Na salt in NaOH solution are reused together after enough CO2 is absorbed, the regeneration process exhibits net zero emission and ∼100% recovery efficiency. Meanwhile, the regenerated materials display a similar cyclability to the pristine ones, while the former reserves 50.2% of production costs and half of the production time compared to the coprecipitation method. Furthermore, the integrated regeneration of single and polycrystals at various states as well as their mixtures is also verified following the same route. Accordingly, the water-induced subtractive process achieves the integrated recycling of end-of-life sodium-ion batteries and promotes the scale-up application and sustainable development of green energies.

Changes in the division rate of bone marrow cells in Wistar rats after exposure to nanosecond microwave pulses of different intensities

One of the promising areas of regenerative technologies is the stimulation of proliferative activity of stem cells and, accordingly, the rate of their self-renewal, by exposure to nanosecond repetitive pulsed microwave radiation (RPMs). The article presents data on the effect of nanosecond RPMs on the rate of division of mesenchymal stem cells from the femur of Wistar rats. Material and methods. Data are presented on the effect of nanosecond repetitively pulsed microwave radiation carrier frequency of 9.4 GHz, pulse repetition rate of 13 Hz, 50 pulses, peak power flux density of 140, 210, and 310 W/cm2, absorbed energy value in 50 pulses at a depth of 1 cm, respectively 699, 1049 and 1549×10–6 J/cm3 on the division rate of mesenchymal stem cells from the femur of laboratory rats Wistar. The effect of the exposure was assessed by the change in the number of cells in the culture 24 and 72 hours after a single irradiation with RPMs with different intensity. Results. Depending on the intensity of RPM, both an increase and inhibition of cell division rate were observed, that is, the response had a phasic character. The most pronounced stimulating acceleration of cell division is exerted by RPMs with a peak power flux density of 140 W/cm2, and the effect is realized at the maximum rate after 24 h. Conclusions. The most probable biophysical and physiological mechanisms for the formation of the effects of changes in the rate of self-renewal of stem cells induced by RPMs are considered.

The small forest: a laboratory for sustainability and regenerative production

El Bosque Pequeño is an innovative project located in Entre Ríos, Argentina, that integrates sustainability, regenerative and circular production, and nature-based solutions. This space, conceived as a sustainability laboratory, combines agricultural, educational and community practices to promote environmental conservation and harmonious coexistence between people and their environment. The proposal focuses on bioclimatic construction, efficient water management, the incorporation of native biodiversity, sustainable beekeeping and agricultural production, and the use of regenerative technologies such as composting and beneficial microorganisms. These practices not only mitigate environmental impact, but also generate applicable knowledge for rural and peri-urban development. From an educational approach, experiential, disruptive and continuous learning is promoted, which fosters cognitive and socioemotional skills, such as critical thinking and teamwork. This model combines cultural and sports activities, such as karate, to reinforce the values of coexistence and co-prosperity, while the preservation of a familiar historical legacy connects participants with their cultural context. El Bosque Pequeño represents an example of how participatory action research can transform a space into a sustainable model, combining education, production and conservation to address current social and environmental challenges.

Research Progress in Catalytic Desorption of Organic Amine CO2 Absorbent Solution

In this paper, the research status of CO2 catalytic desorption regeneration technology in amine absorption system was reviewed. The types, characteristics, advantages and disadvantages of heterogeneous catalysts and the challenges faced were introduced in detail, The main factors affecting the desorption and regeneration performance of catalysts were summarized. Finally, the current situation of catalytic desorption regeneration for CO2 capture after combustion was analyzed, and the future research trend was prospected.

A Study on the Exploration of the Development Process of Regenerative Applications of Energy Technologies in Industrial Warehouse Buildings: Bibliometric Research from 2004 to 2024

Due to the high energy consumption characteristics of industrial warehouse buildings, the demand for energy regeneration technology is increasingly urgent. In recent years, with the rapid development of building energy technology, warehouse building energy regeneration technology has made remarkable progress in energy conservation and sustainable development. A deep understanding of the previous research progress and trends can provide the scientific basis for guiding subsequent in-depth research. Through the bibliometric analysis of 145 journal articles collected from the Web of Science (WoS) database between 2004 and 2024, this research has studied the research trends and progress on the application of energy regeneration in industrial warehouse buildings. This study first revealed the overall development trend of energy regeneration technology in warehouse buildings through quantitative analysis, indicating that related research is growing rapidly. Core scholars in the field such as Lund H. and Mathiesen B.V., as well as major journals such as Energy and Sustainability, have been identified through the analysis of the literature. Five core research themes, including energy efficiency improvement and regeneration technology, renewable energy system design, life cycle sustainable technology, renewable energy utility assessment, and policy support and energy consumption simulation, were identified through cluster analysis. Through evolutionary analysis, this study demonstrates the development process of energy regeneration in warehouse buildings and the critical role played by advances in new energy technologies in the field of warehouse construction. On this basis, this study proposes current key research directions, including energy life cycle assessment, energy regeneration environment optimization, and energy system management. The research on the energy regeneration of warehouse buildings has gradually become an important cross-subject of architecture and energy technology, providing technical support for the transformation of low-carbon storage buildings. The analysis of the current research status, evolutionary logic, and research trends can provide scientific references for further in-depth research and technological applications in this field.

Bone regeneration in rabbit cranial defects: 3D printed polylactic acid scaffolds gradually enriched with marine bioderived calcium phosphate

ObjectiveThis study aimed to evaluate the in vivo biocompatibility, mechanical performance and osteoconductive potential of 3D-printed polylactic acid (PLA) scaffolds enriched with marine bioderived calcium phosphate (bioCaP) for bone tissue engineering. Materials and MethodsPLA-bioCaP composite scaffolds were specifically designed for the rabbit cranial defect model by 3D printing, with a uniform distribution of open square-shaped pores and contributions in bioCaP. Physicochemical and mechanical characterization and the evaluation of biological response are presented. ResultsThe scaffolds demonstrated mechanical properties comparable to human bones, integration with the host bone, and osteoconductive behavior promoting cell ingrowth from the defect edge. Strong mineralized tissue ingrowth through the scaffolds’ pores was observed, providing notable support to the host bone. In quantitative terms, micro-CT and histomorphometry analysis post-implantation revealed no significant differences in bone regeneration across all groups. ConclusionThe 3D-printed scaffolds with perpendicular patterning, open porosity, and proposed composition displayed satisfactory mechanical properties, biocompatibility, and osteoconductive response. The scaffolds promoted bone regeneration at similar levels as the PLA. The highest contribution of bioCaP promoted a positive influence in certain histomorphometric parameters; however, it did not significantly improve their osteogenic capability. Further research is required to optimize scaffold composition and enhance their osteogenic potential. Clinical RelevanceThis study presents a significant advancement in bone tissue engineering through the development of personalized composite scaffolds for bone-related applications. The clinical implications of this research are profound, especially considering the increasing demand for functional bone regeneration technologies capable of producing cost-effective producing cost-effective customized scaffolds.

Rapid Capture Perfluorooctanoic Acid and Perfluorooctane Sulfonate at Environmentally Relevant Concentrations via the ‘mesh trap’ of Triazine-Based Polymer Network: Mechanism and Photocatalytic regeneration

Per- and polyfluoroalkyl substances (PFAS) pose a serious threat to groundwater (GW) environment worldwide due to their difficulty in removal and high toxicity. In this study, the ‘mesh trap’ of triazine-based polymerization network (SNW-1) demonstrated rapid capture performance for Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) at environmentally relevant concentrations (1μg/L). The SNW-1 can remove more than 90% of PFOA and PFOS within 300s and still maintain superior performance under four common GW anions and different [pH]0 (3 - 10). The removal degree of PFOA and PFOS is almost undetectable without SNW-1 dosage. Theoretical calculations were used to simulate the adsorption process and interfacial reaction mechanism in SNW-1/PFOA (Eads = -1.6717eV) and SNW-1/PFOS (Eads = -1.2695eV) systems. The adsorption of SNW-1/PFOA is stronger than SNW-1/PFOS. The typical van der Waals weak interactions between SNW-1 and PFOA were confirmed, which is slightly stronger than SNW-1/PFOS. In addition, SNW-1 regeneration in this paper was achieved in a photocatalytic activated peroxydisulfate (PDS) system which was different with previous reports. The desorption rates of PFOA and PFOS adsorbed on the surface of SNW-1 and the defluorination rate in the photocatalytic regeneration system were also tested. The photocatalytic regeneration mechanism between SNW-1 and PDS was electron transfer. And the electron transfer can be divided into three stages: strong adsorption of SNW-1/PDS (Eads = -2.1618eV), electron transfer from SNW-1 to PDS and PDS cleavage. This study has a broad application prospect in the field of in-situ rapid resistance control of GW in PFAS contaminated sites and provides a theoretical support for environmentally friendly adsorbent regeneration technology.

Facilitating Cathode Regeneration via Defect‐Driven Prelithiation

AbstractDirect regeneration of electrode materials has been in the spotlight due to its potential resource recovery and environmental benefits, especially for LiNixCoyMnzO2 (NCM) cathode materials. Yet, prior studies have predominantly emphasized innovating regeneration methods, overlooking the intrinsic defects of spent NCM and their effects in the regeneration process. This study proposes a mechanism aimed at facilitating lithiation regeneration by modulating the surface defects of spent NCM. The generation of oxygen defects in degraded NCM intensifies the adsorption of lithium source, effectively reducing the energy barrier for Li+ migration from surface to bulk. Simultaneously, mechanical energy is employed to alter the local thermodynamic state to provide a driving force for lithium migration, allowing it to undergo a prelithiation reaction before roasting. The temperature range in which the phase transition occurs during the roasting process becomes more concentrated. This contributes to increasing opportunities for lithium insertion and accelerates the repair of crystal structure, resulting in favorable properties of regenerated materials. This strategy innovatively exploits the inherent defects of spent NCM, proposes the critical role of synergistically regulating defect kinetic and thermodynamic features in facilitating regeneration, providing a unique perspective for the design of direct NCM regeneration technology.

Design and In Vivo Testing of an Anatomic 3D-Printed Peripheral Nerve Conduit in a Rat Sciatic Nerve Model.

Background: Three-dimensional (3D) printer technology has seen a surge in use in medicine, particularly in orthopedics. A recent area of research is its use in peripheral nerve repair, which often requires a graft or conduit to bridge segmental defects. Currently, nerve gaps are bridged using autografts, allografts, or synthetic conduits. Purpose: We sought to improve upon the current design of simple hollow, cylindrical conduits that often result in poor nerve regeneration. Previous attempts were made at reducing axonal dispersion with the use of multichanneled conduits. To our knowledge, none has attempted to mimic and test the anatomical topography of the nerve. Methods: Using serial histology sections, 3D reconstruction software, and computer-aided design, a scaffold was created based on the fascicular topography of a rat sciatic nerve. A 3D printer produced both cylindrical conduits and topography-based scaffolds. These were implanted in 12 Lewis rats: 6 rats with the topographical scaffold and 6 rats with the cylindrical conduit. Each rodent's uninjured contralateral limb was used as a control for comparison of functional and histologic outcomes. Walking track analysis was performed, and the Sciatic Functional Index (SFI) was calculated with the Image J software. After 6 weeks, rats were sacrificed and analyses performed on the regenerated nerve tissue. Primary outcomes measured included nerve (fiber) density, nerve fiber width, total number of nerve fibers, G-ratio (ratio of axon width to total fiber width), and percent debris. Secondary outcomes measured included electrophysiology studies of electromyography (EMG) latency and EMG amplitude and isometric force output by the gastrocnemius and tibialis anterior. Results: There were no differences observed between the cylindrical conduit and topographical scaffold in terms of histological outcomes, muscle force, EMG, or SFI. Conclusion: This study of regeneration of the sciatic nerve in a rat model suggests the feasibility of 3D-printed topographical scaffolds. More research is required to quantify the functional outcomes of this technology for peripheral nerve regeneration.

The Future of Biohybrid Regenerative Bioelectronics.

Biohybrid regenerative bioelectronics are an emerging technology combining implantable devices with cell transplantation. Once implanted, biohybrid regenerative devices integrate with host tissue. The combination of transplant and device provides an avenue to both replace damaged or dysfunctional tissue, and monitor or control its function with high precision. While early challenges in the fusion of the biological and technological components limited development of biohybrid regenerative technologies, progress in the field has resulted in a rapidly increasing number of applications. In this perspective the great potential of this emerging technology for the delivery of therapy is discussed, including both recent research progress and potential new directions. Then the technology barriers are discussed that will need to be addressed to unlock the full potential of biohybrid regenerative devices.

Development and Application of Green Catalysts: Challenges, Optimization, and Future Perspectives

This paper comprehensively reviews the development and application of green catalysts in modern chemical industries, with a focus on analyzing the significant advantages of various types of green catalysts, such as metal-organic frameworks (MOFs) and enzyme catalysts, in improving reaction efficiency, reducing energy consumption, and minimizing by-product generation. The paper delves into the design and synthesis of green catalysts, optimization of reaction conditions, and technologies for catalyst recycling and regeneration, highlighting their key roles in enhancing catalyst performance. Despite challenges such as high material costs, complex synthesis processes, and issues with stability and durability in practical applications, continuous technological innovation and process improvements offer promising solutions. As global attention to sustainable development grows, green catalysts are expected to have broad applications in emerging fields such as carbon capture and utilization, renewable energy conversion, and environmental remediation, thereby driving the green transformation and low-carbon development of the chemical industry and providing strong technical support for achieving global sustainability goals.

Review Paper on Development of Mini Refrigerator

Abstract: This project focuses on the innovative development of a regenerative magnetic suspension system that uses permanent magnets to capture energy from the vibrations and movements of vehicles, aiming to improve energy efficiency and sustainability within the automotive sector. Unlike conventional suspension systems that dissipate energy as heat, this design utilizes highperformance neodymium magnets and wound copper coils to convert mechanical energy into electrical energy via electromagnetic induction as the vehicle moves across varying terrains. The energy recovered through this process can potentially power auxiliary vehicle systems such as sensors, lights, and infotainment units, thereby contributing to overall vehicle efficiency. Preliminary simulations and calculations indicate a substantial potential for energy recovery, positioning the system as a cost-effective and practical solution that can be integrated into existing vehicle architectures with minimal modifications. By leveraging readily available materials, this project addresses the challenges of energy waste in conventional suspensions while promoting sustainable practices. The research not only advances regenerative technologies within the automotive industry but also paves the way for future innovations in vehicle design and broader engineering applications

Three-Dimensional Scaffolds Designed and Printed Using CAD/CAM Technology: A Systematic Review

The objective of this work is to review the literature on the use of three-dimensional scaffolds obtained by printing for the regeneration of bone defects in the maxillofacial area. The research question asked was: what clinical experiences exist on the use of bone biomaterials manufactured by CAD/CAM in the maxillofacial area? Prospective and retrospective studies and randomized clinical trials in humans with reconstruction area in the maxillofacial and intraoral area were included. The articles had to obtain scaffolds for bone reconstruction that were designed by computer processing and printed in different materials. Clinical cases, case series, in vitro studies and those that were not performed in humans were excluded. Six clinical studies were selected that met the established inclusion criteria. The selected studies showed heterogeneity in their objectives, materials used and types of regenerated bone defects. A high survival rate was found for dental implants placed on 3D-printed scaffolds, with rates ranging from 94.3% to 98%. The materials used included polycaprolactone, coral-derived hydroxyapatite, biphasic calcium phosphate (BCP) and bioceramics. The use of CAD/CAM technology is seen as key for satisfying variations in the shapes and requirements of different fabrics and size variations between different individuals. Furthermore, the possibility of using the patient’s own stem cells could revolutionize the way bone defects are currently treated in oral surgery. The results indicate a high survival rate of dental implants placed on 3D-printed scaffolds, suggesting the potential of this technology for bone regeneration in the maxillofacial mass.

A Sendai virus-based expression system directs efficient induction of chondrocytes by transcription factor-mediated reprogramming.

Cartilage rarely heals spontaneously once damaged. Osteoarthritis (OA) is the most common degenerative joint disease among the elderly; however, effective treatment for OA is currently lacking. Autologous chondrocyte implantation (ACI), an innovative regenerative technology involving the implantation of healthy chondrocytes, may restore damaged lesions. Chondrocytes for ACI may potentially be induced from differentiated somatic cells using retrovirus (RV)-mediated transduction of three reprogramming factors (SOX9, KLF4, and c-MYC). However, the efficiency of the current induction system needs to be improved and the safety issues arising from the genomic integration of the vector DNA have to be addressed. To solve these problems, we used an RNA vector, termed the replication-defective and persistent Sendai virus vector (SeVdp), to express reprogramming factors for chondrocyte induction. Our results showed that the SeVdp-based vector induced chondrocytes more efficiently than the RV vector, probably because of robust and rapid expression of the transgenes, without any apparent integration of the SeVdp vector. The induced chondrocytes formed cartilage-like tissues when injected subcutaneously into mice. Thus, the SeVdp-based system for inducing chondrocytes may act as a foundation for developing safer and more effective treatments for damaged cartilage.

Pt‐Mo₂N Catalyst Formed by Inverse Sintering for the Reverse Water‐Gas Shift Reaction

AbstractThe reverse water‐gas shift (RWGS) reaction is significant for the resource utilization of CO2. However, this reaction requires high temperatures and metal catalysts are prone to agglomeration, leading to loss of activity. In this work, a Pt catalyst supported on Mo₂N formed via phase transition and metal reverse sintering under a high‐temperature NH₃ atmosphere is developed. This catalyst exhibits excellent RWGS activity, achieving a CO production rate of 294.8 mmolgcat−1 h−1 at 623 K, with CO selectivity maintained at 93%. Moreover, under continuous testing conditions for 100 h, the catalyst's activity shows no significant decline. Notably, further investigation reveals that the surface reaction mechanism at 623 K differs from the previously reported associative mechanism, instead following a redox mechanism in the presence of H₂. This research not only provides a deeper theoretical understanding of the mechanism of CO2 hydrogenation but also offers valuable insights for developing novel and efficient metal catalyst regeneration technologies.

Role of Non-Mesh Grafts in Surgical Treatment of Stress Urinary Incontinence

Stress urinary incontinence refers to a multifactorial disease characterized by involuntary urination associated with a sudden increase in intra­abdominal pressure. Millions of females around the world suffer from stress incontinence each year. Conservative methods of treatment and physical rehabilitation are considered to be ineffective, thereby driving the need for surgical treatment. Sling surgeries comprise a widely used surgical technique for the treatment of stress urinary incontinence due to their affordability and minimal time investment. Introduction of synthetic polypropylene mesh prostheses in the treatment of stress incontinence made them the most common material. However, the accumulated experience and complications associated with the use of mesh grafts contribute to the recent decline in the popularity of synthetic slings and give rise to the search for and development of alternative materials for the surgical treatment of stress urinary incontinence. Since the need for treatment of urinary incontinence remains high, fascia autograft surgeries have been proposed, even though they require an additional surgical procedure and expose the patient to complications at the donor site of the graft. In addition, surgeons use allografts and xenografts, and regenerative technology is developing in this field. Considering high social significance of this problem, the present paper is aimed at reviewing the scientific literature concerning grafts for the treatment of stress incontinence.

Green regeneration and recycling technology for spent graphite in lithium batteries: Biofilm coating-heat treatment repair process

With the explosive growth in graphite demand and the blowout retirement of lithium-ion batteries (LIBs), the recycling of spent graphite (SG) in anode materials has gradually become a hotspot due to its potential for achieving economic and environmental benefits, as well as contributing to the sustainable development of LIBs industry. An innovative green regeneration technology of SG based on bio-cycle leaching is proposed, and its repair and regeneration mechanism is discussed. The results show that bio-cycle leaching can effectively remove and enrich the metal impurities from SG while utilizing the extracellular polymeric substances secreted by strains to mediate and aggregate strong adhesion of strains on the surface, forming a biofilm to coat graphite and smooth its surface. Heat treatment can repair the crystal structure of SG while breaking down the biofilm into amorphous carbon to create a carbon core-shell structure. Under the optimal conditions, the regenerated graphite exhibits electrochemical properties similar to commercial graphite, with the initial charge capacity, initial coulomb efficiency, and cyclic capacity stability after 100 cycles at 0.1 C rate of 329.11 mAh/g, 92.9 %, and 96.4 %, respectively. This study represents a new thinking in SG recycling and contributes to realizing a complete closed-loop LIB recycling process.

Innovative Regenerative Technologies for Enhancing Resilience in Salinity‐Stressed Rice Fields Along the Indonesian Coast: Promoting Net‐Zero Farming Practices to Adapt to Climate Change

ABSTRACTRice cultivation significantly contributes to greenhouse gas (GHG) emissions, particularly methane released from flooded paddy fields, exacerbating climate change. At the same time, rice farming is highly sensitive to climate conditions, with climate change introducing various abiotic stresses, notably salinity stress. This is especially critical in coastal regions like Indonesia, where rising sea levels and land degradation worsen the salinity challenge. This review systematically examines salinity stress in coastal rice cultivation, the impact of climate change on salinity dynamics and crop performance, and the potential of innovative regenerative technologies to enhance resilience and create low‐salinity, net‐zero agricultural systems. We conducted a systematic literature review following PRISMA guidelines, supplemented by a bibliometric analysis using Scopus, employing keywords such as “salinity stress”, “rice”, “agriculture”, “climate change” and “regenerative”. From an initial 2,191 articles, 18 were deemed eligible for further analysis. Findings indicate that increased soil salinity adversely affects rice production, yet innovative strategies such as rhizomicrobiome engineering, salt‐tolerant rice varieties, regenerative soil amendments, irrigation management, agricultural practices offer viable solutions to mitigate salinity stress. Furthermore, adopting net‐zero farming practices can help achieve carbon neutrality in agriculture while significantly reducing GHG emissions. This review highlights the need for a collaborative approach among scientists, farmers, and policymakers to scale these innovations, ensuring their implementation not only in Indonesia but also in other regions facing similar challenges, thereby promoting food security and environmental sustainability in the face of climate change.