To fundamentally enhance the internal construction of higher vocational colleges and improve the quality of talent cultivation has become an urgent issue to address. The key to enhancing the quality of talent cultivation lies in, based on a thorough consideration of the characteristics of higher vocational students, starting from the talent cultivation system, and focusing on the construction and reform of courses, teaching, and faculty. The OBE educational philosophy emphasizes a results-oriented approach to talent cultivation, centering on the student, stimulating learning enthusiasm, and promoting the internalization of students' knowledge, abilities, and values into their learning and career paths, reflecting a lifelong learning concept. This article, taking the characteristics of e-commerce majors in vocational colleges as an example, and using CK Vocational College as a case study, delves into the OBE educational philosophy and analyzes the issues faced by the college in the practical teaching of e-commerce majors in four aspects: the definition of learning outcomes, the implementation process of practical teaching, the construction of an evaluation system for practical teaching effects, and the career planning of students. Additionally, this article designs a practical teaching model for talent cultivation in the e-commerce major at CK Vocational College, covering the definition of learning outcomes, implementation paths, outcome assessment, and feedback optimization.