Reference Ones Research Articles

Spectroscopic and computational study of chromone derivatives with antitumor activity: detailed DFT, QTAIM and docking investigations

Theoretical investigations of three pharmaceutically active chromone derivatives, (E)-3-((2,3,5,6-tetrafluorophenyl)hydrazono)methyl)-4H-chromen-4-one (TPC), (E)-3-((2-(2,4,6-trifluorophenyl)hydrazono)methyl)-4H-chromen-4-one (FHM) and(E)-3-((2-(perfluorophenyl)hydrazono)methyl)-4H-chromen-4-one (PFH) are reported. Molecular geometries, vibrational spectra, electronic properties and molecular electrostatic potential were investigated using density functional theory. Quantum theory of atoms in molecules (QTAIM) study shows that the maximum of ellipticity parameters in the existing bonds in TPC, FHM and PFH, attributes to the bonds involving in aromatic region points toward the π-bond interactions in the molecules. Based on energy gap (1.870, 1.649 and 1.590 eV) and electrophilicity index (20.233, 22.581 and 23.203 eV) values of TPC, FHM and PFH, we can conclude that all molecules have more biological activity. The molecular electrostatic potential maps were calculated to provide information on the chemical reactivity of the molecule and also to describe the intermolecular interactions. All these studies including docking studies, help a lot in determining the biological activities of chromone derivatives. Activities of chromone derivatives are compared with 5-fluorouracil and azathioprine (antitumor, antiproliferative standards) and were found to be higher than reference ones.

Effect of high temperature on physical, mechanical and microstructure properties of alkali-activated slag pastes blended with ceramic waste material

This paper presents the influence of ceramic waste powder (CWP) inclusion on the physico-mechanical properties and microstructure analysis of alkali-activated pastes prior and after exposure to elevated temperatures. Such geopolymer specimens were designed upon replacing ground granulated blast-furnace slag (GGBFS) with CWP at ratios of 0%, 5%, 10%, 15% and 20%, by mass. The water absorption and compressive strength (wet and dry) of non-exposed samples were determined at curing ages of 1, 7, 14 and 28 days. After that, the specimens were exposed to high temperatures of 200, 400, 600 and 1000 °C with a heating rate of 5 °C/min. The characteristics of tested samples such as visual inspection, residual compressive strength and microstructure were evaluated. Techniques as Fourier Transform Infrared spectroscopy (FTIR), Thermogravimetric Analysis (TGA/DTG) and Scanning Electron Microscopy (SEM) were used for studying molecular and microstructure of geopolymer composite. Results indicated that the inclusion of CWP with slag in composite structure based geopolymer enhanced the physico-mechanical properties and microstructure of mixtures before and after thermal exposure. The specimens made of 15% CWP displayed superior thermal stability in terms of remaining compressive strength and microstructure than the reference ones.

Полиморфизм ДНК собак (Canis familiaris L.). V. Однонуклеотидные замены

The features of the nuclear genome of dogs, including a number of reference ones, are briefly considered, paying the greatest attention to single-nucleotide DNA polymorphism in the form of so-called SNPs. It is noted that the detection of SNPs implies two processes in the form of their de novo detection by DNA sequencing, including whole genome sequencing, as well as the detection of already known SNPs in genomes during replicative studies on the large experimental material. Some attention is paid to specialized databases and web-resources on canine SNPs. The issues of DNA registration of individual dogs on the basis of single-nucleotide polymorphism are touched upon, which can have various applications, including forensic purposes and for dog control, contributing to the elimination of stray dogs as a class.

Behaviour of hydrodynamic journal bearing under the combined influence of textured surface and Non-Newtonian Rabinowitsch fluid model

In the present study, the static characteristics of hydrodynamic circular journal bearings of finite length are highlighted, using the combined influences of textured surface and non-Newtonian lubricants behavior, obeying to the Rabinowitsch fluid model. The associated nonlinear Rabinowitsch-Reynolds equation has been discretized using finite differences scheme and solved by the mean of Elrod’s algorithm taking into account the presence of cylindrical textures on full/optimum bearing surface. Following to the absence of textures on the bearing surface or the non-Newtonian fluid behavior, the obtained results are in good agreement with the reference ones. The hydrodynamic lubrication static performances are computed for various parameters such as textures location; eccentricity ratio and the rheological coeffcient. The results suggest that texturing the bearing’s convergent zone enhances significantly the load carrying capacity and reduces the friction coeffcient, whereas texturing the full bearing surface may leads to bad performances. It is also noticed that the pseudoplastic lubricant coeffcient decreases the bearing performances (load capacity and pressure) compared to Newtonian fluid cases. Considering the optimal arrangement of textures on the contact surface, a significant improvement in terms of load capacity and friction can be achieved, especially at low pseudoplasticity effect.

Effects of Scleral Contact Lenses for Keratoconus Management on Visual Quality and Intraocular Pressure.

PurposeTo evaluate the visual acuity level achieved by scleral contact lens (CL) fitting in patients affected by keratoconus and to evaluate possible intraocular pressure (IOP) changes during the scleral CL wear using a transpalpebral tonometer.MethodsIn a prospective case series a comparison was made between visual acuity obtained with glasses, RGP and 16.8mm diameter scleral CL in 30 consecutive patients affected by keratoconus. IOP was tested during scleral CL wear by transpalpebral Diaton Tonometer (DT) and also by Goldmann Applanation Tonometer (GAT) before and after scleral CL wear.ResultsThe mean logMAR visual acuity improved from 0.2±0.25SD with glasses and 0.1±0.02SD with RGP, to −0.002±0.041SD when using the scleral CL (p<0.05). The mean IOP value before scleral CL wear was 12.93mmHg±2.20SD when measured with GAT and 7.85mmHg±2.27SD when measured with DT. During scleral CL wear, IOP was assessed through DT, with a mean value of 8.86mmHg±2.36SD; values were stable after 8 hours of scleral CL use. Immediately after scleral CL removal, the mean IOP measured with GAT was 12.85mmHg ±2.40SD and the mean IOP measured with DT was 7.66mmHg±1.88SD. Therefore, during scleral CL wear, it was evidenced a small but statistically significant increase of the mean IOP value (1.01mmHg; p<0.01), with a reversion to values prior to application when scleral CL was removed.ConclusionScleral CLs remarkably improved visual acuity in keratoconus patients when compared to glasses or RGP contact lenses. Even if it was evidenced a small increase of the mean IOP value during their wear, it may not be significant in otherwise healthy eyes. Statistical analysis demonstrated good agreement between GAT and DT but their numerical values presented a constant gap, that should be taken into account when there is a need to relate the DT values to the reference ones.

Solution of two-dimensional diffusion–advection problems for non-isotropic media with spatially variable velocity field by the boundary element method

This work presents a boundary element method formulation for the solution of the diffusion–advection problem. The formulation, developed for two-dimensional problems, for non-isotropic media, considers a spatially variable velocity field. The only way to deal with such a kind of problem is employing a steady-state fundamental solution. Consequently, the basic BEM equation presents one domain integral related to the velocity components, and another one related to the time derivative of the variable of interest, which is approximated using a backward finite difference scheme. BEM results are compared with an available analytical solution in the first part of the first example, and with the results provided by a finite element method formulation, taken as reference ones, in the second part of the first example and in the second example. From the comparisons, one can observe a good agreement between the results furnished by the proposed formulation and the analytical and reference solutions.

Monitoring the extraction process of acidic polysaccharides in Poria cocos by near infrared spectroscopy combined with chemometrics

In this work, an analytical model based on near infrared spectroscopy is proposed to predict the main active ingredients of Poria cocos (PC) during the extraction process, acidic polysaccharides. In order to improve the prediction quality, various pretreatment methods and variable selection methods were carefully compared and the partial least squares method was used to relate the predicted values to the reference ones. As a result, a robust and optimal model was obtained, where the coefficient of determination, root mean square error and mean absolute error were 0.9618, 4.05% and 3.26% for calibration, and 0.9609, 4.17% and 3.31% for prediction, respectively. The residual prediction deviation reached 5.15. Such satisfying results clearly showed that the present model had very good prediction ability and thus had great potential for monitoring of the extraction process of PC in the pharmaceutical manufacturing.

Distributed synchronisation control of unknown nonlinear systems with an active leader

This paper investigates the optimal synchronisation problem for unknown nonlinear heterogeneous multi-agent systems (MASs) with an active leader and disturbances. Due to the external input signal of the active leader, the resulted uncooperative behaviours and unpredictability increase difficulty to derive the analytical solution of the coupled Bellman equation. To this end, we develop a distributed model reference adaptive critic learning algorithm with a hierarchical and distributed synchronisation control framework, which transforms the synchronisation problem of unknown nonlinear MASs into that of defined reference ones. Moreover, the algorithm extends our previous work to the distributed MASs, so that it is guaranteed that all the agents reach an agreement with the minimised transient errors and robustness against the disturbances and the neural network (NN) approximation errors. It is proved that the local neighbour tracking errors and the NN weight estimation errors are uniformly ultimately bounded via Lyapunov stability theory. A simulation example for multi-manipulator systems demonstrates the effectiveness of the algorithm.

Influence of irrigated mineralized waters on properties of ordinary chernozem in the conditions of Prysamaria Dniprovske

Irrigation of lands in arid climates helps to solve the problem of water deficit of soils in order to increase their fertility. However, under the influence of mineralized waters used for irrigation, there is a degradation of chemical, physico-chemical, water-physical and physical properties of soils. Soil monitoring is one of the effective mechanisms that allowsassessing the current state of soils and predicting the negative consequences of economic activity in the future. The area where the research was conducted is in the zone of insufficient moisture where there is an annual deficit of water balance of soils. Irrigation in the studied areas began in the mid-70s of the last century and lasted until 1992. The waters of the Samara River were used for this purpose. The total mineralization of water during the growing season reaches 3515 mg/dm3. It is possible to estimate the degree of transformation of soils that have been under the influence of irrigation waters for a long time in relation to the indicators of virgin soils. The zonal soils of the research area are CalcicChernozems. The analysis of macromorphological indicators showed that irrigation soils differ from the reference ones by the thickness of the organogenic horizon, density and structure. The results of the analysis of the aqueous extract of the reference soils show the absence of salinization with water-soluble salts. Their content varies in the range from 0.051 to 0.078 %. A maximum of one salt is observed in the soil profile, namely in the transitional horizon at a depth of 45–63 cm. Below this depth, the content of water-soluble salts progressively decreases. The total content and distribution of water-soluble salts in the soil profile of irrigated soils has some differences from the reference soils. In the upper part of the humus horizon, the total amount of water-soluble salts is smaller, which can be attributed to the effects of machining and better aeration, as well as the intensive removal of their vegetation. Below these horizons, the amount of water-soluble salts progressively increases and reaches a maximum in the soil-forming rock. The nature of the distribution in the soil profile and the total amount of salts isnot typical for Calcic Chernozems and ismore similar to those of Gleyic Calcic Chernozems. The maximum amount of water-soluble salts is concentrated in the parent rock. Their percentage indicates the absence of salinity in both studied soils. But guided by the method of calculating the content of toxic water-soluble salts in the soil, in the reference soils, this figure reaches 0.21 t/ha in a meter layer of soil, and in irrigation 0.42 t/ha. The results of studies of physicochemical parameters show that a higher content of metabolic calcium is characteristic of the reference soils, and its distribution in the soils along the profile of both options is relatively similar. In contrast, the distribution of exchangeable magnesium in the soil profile varies greatly, especially in the reference soils. In irrigated soils, the ratio of exchangeable calcium to magnesium is more stable and varies in the range from 4.2 to 7.9, which may be the result of prolonged irrigation. According to the obtained physicochemical parameters, irrigation soils have weak salinity in the lower part of the transition horizon. This indicator, together with the ratio of exchangeable calcium to magnesium, indicates eluvial-illuvial processes that for some time contributed to the redistribution in the soil profile of both water-soluble salts and exchangeable cations. Evaluation of the degree of salinity of soils showed the absence of salinization in the reference soils, as well as in the upper part of the humus horizons of irrigated soils. Given the buffering of irrigated soils, weak salinity is present only in the upper part of the transition horizon.

Towards a regional, automated full moment tensor inversion for medium to large magnitude events in the Iranian plateau

Considering the high seismicity rate of the Iranian plateau, the development and implementation of an automated routine for near-real-time determination of earthquake point source parameters would be extremely beneficial, e.g., for dedicated seismological studies, constraining the regional stress field, and shakemap assessment. We discuss the implementation of a fast, automated regional moment tensor inversion routine, based on SeisComP3 and KIWI tool packages. To assess the routine efficiency, we used a dataset including 90 earthquakes spatially distributed within all seismotectonic provinces of Iran, recorded at local to regional distances, with magnitudes in the range MN 4.5–7.3. Resolved moment tensor solutions and source parameters are in most cases in good agreement with reference ones from global and regional catalogs. However, we identify consistent differences in magnitudes and depths, with respect to global catalogs, which can be attributed to a higher resolution of our approach, using local and regional data and considering regional velocity models. The depth estimations are shallower than in reference global catalogs but compatible with the tectonic settings of the Iranian region. The analysis of the selected dataset is accompanied by a test run of automated processing for 8 months of online operation, from July 2019 to February 2020. The processing time in online routine, with an average of ~ 23 min, mostly depends on the magnitude, number of stations, azimuthal coverage, data quality, and complexity of the crustal model, so that computation times may vary significantly for earthquakes located in different Iranian provinces.

Thermal and mechanical analyses of colored mortars produced using Brazilian iron ore tailings

The State of Minas Gerais is responsible for almost half of the value generated by the mining industry. However, this activity generates thousands of tons per day of different tailings. In this work, the main objective was to evaluate the mechanical and thermal properties of colored coating mortars produced with iron ore tailings (IOT), raw and calcined, as a substitute for Portland cement. The flexural tensile and compressive strength, thermal conductivity and the solar absorptance were performed in mortars. The results showed that the mortars produced with IOT to substitute Portland cement presented the same properties of the reference ones but the solar absorptance varied according to the firing temperature and the amount of cement replaced by IOT. Thus, the decision to use a greater amount of IOT to replace cement must pass not only through the analysis of mechanical properties, but also must consider the final product, in this case, mortars, and its specific performance in buildings.

Secondary production is an underutilized metric to assess restoration initiatives

Secondary production is an integrative measure of the accumulation of heterotrophic biomass through time and can be a valuable tool to design, implement, and assess restoration initiatives. To highlight applications of secondary production in restoration contexts, we identify recent papers from the literature, use these to make generalizations about how the concept is applied, and examine why it may not be utilized more commonly. We identified 21 papers that empirically quantified secondary production to compare pre/post-restoration or assess restored sites relative to reference ones. Every study was aquatic, suggesting that secondary production is an underutilized tool in terrestrial restoration studies. We discuss various ways that food web perspectives inform restoration secondary production outcomes, such as through shifts in aquatic basal resource pools and alleviation of nutrient limitation, changes which ripple through food webs supporting higher trophic level production. Despite challenges inherent to calculating secondary production, the approach holds much promise—it is a composite metric simultaneously reflecting components of ecosystem structure and dynamics that restoration initiatives target.

Direct measurement and correction of both megavoltage and kilovoltage scattered x-rays for orthogonal kilovoltage imaging subsystems with dual flat panel detectors.

PurposeTo measure the scattered x‐rays of megavoltage (MV) and kilovoltage (kV) beams (MV scatter and kV scatter, respectively) on the orthogonal kV imaging subsystems of Vero4DRT.MethodsImages containing MV‐ and kV‐scatter from another source only (i.e., MV‐ and kV‐scatter maps) were acquired for each investigated flat panel detector. The reference scatterer was a water‐equivalent cuboid phantom. The maps were acquired by changing one of the following parameters from the reference conditions while keeping the others fixed: field size: 10.0 × 10.0 cm2; dose rate: 400 MU/min; gantry and ring angles: 0°; kV collimator aperture size at isocenter: 10.0 × 10.0 cm2: tube voltage: 110 kV; and exposure: 0.8 mAs. The average pixel values of MV‐ and kV‐scatter (i.e., the MV‐ and kV‐scatter values) at the center of each map were calculated and normalized to the MV‐scatter value under the reference conditions (MV‐ and kV‐scatter value factor, respectively). In addition, an MV‐ and kV‐scatter correction experiment with intensity‐modulated beams was performed using a phantom with four gold markers (GMs). The ratios between the intensities of the GMs and those of their surroundings were calculated.ResultsThe measurements showed a strong dependency of the MV‐scatter on the field size and dose rate. The maximum MV‐scatter value factors were 2.0 at a field size of 15.0 × 15.0 cm2 and 2.5 at a dose rate of 500 MU/min. The maximum kV‐scatter value was 0.48 with a fully open kV collimator aperture. In the phantom experiment, the intensity ratios of kV images with MV‐ and kV‐scatter were decreased from the reference ones. After correction of kV‐scatter only, MV‐scatter only, and both MV‐ and kV‐scatter, the intensity ratios gradually improved.ConclusionsMV‐ and kV‐scatter could be corrected by subtracting the scatter maps from the projections, and the correction improved the intensity ratios of the GMs.

Experimental and numerical study on static behaviour of uniplanar CFDST-CHS T-joints

Experimental and numerical study on static behaviour of uniplanar T-joints between circular concrete-filled double-skin steel tube (CFDST) chord and circular hollow section (CHS) brace, i.e., CFDST-CHS T-joints for short, are presented in this paper. Twelve uniplanar T-joint specimens, including 10 joints with circular CFDST chords and 2 reference ones with CHS chords, were tested under specified boundary conditions. The experimental parameters included hollow ratio of the chord (χ), brace to chord diameter ratio (β) and axial compression ratio of the chord (n). The failure patterns, load versus displacement (strain) curves and bearing capacities of the specimens were collected and analysed. The composite tubular T-joint specimens showed better structural performance than the reference steel ones. For the CFDST-CHS T-joint specimens, the failure patterns change from the local buckling of CHS brace to the compression-bending failure of CFDST chord with the increase of β. With the local buckling failure of CHS brace, the bearing capacity of the composite tubular T-joint specimens increases with the growing of χ and β. However, with the compression-bending failure of CFDST chord, the bearing capacity of the composite tubular T-joint specimens increases with the rising of n. Advanced numerical simulation on the structural performance of uniplanar CFDST-CHS T-joints was implemented using finite element analysis (FEA) method, and the accuracy of the predicted responses was evaluated against the experimental results. Finally, based on the FEA results, the simplified method for the bearing capacity prediction of the composite tubular T-joints was proposed.

Calculation of Waves in an Elastic-Plastic Body Based on ENO Modifications of the Godunov Method

The efficiency of two ENO modifications of the Godunov method for calculation axisymmetric problems of the dynamics of elastic-plastic bodies, namely a UNO scheme of the second-order of accuracy and a TVD scheme of the second order of accuracy outside the solution extremes where it decreases to the first order, has been numerically studied. The efficiency of the modifications is estimated by comparing the results of calculation of a number of problems on the propagation of spherical and cylindrical waves in a body with the results of reference solutions and the Godunov method. The exact and numerical solutions are used as reference solutions, the latter are obtained on fine grids. It is shown that for all the problems considered, the solutions by the TVD and UNO schemes are much closer to the reference ones than those by the Godunov method. The TVD and UNO schemes are characteristic of significantly less smearing of sharp wave fronts and a more accurate resolution of extrema. At the same time, the wave profiles and the extrema are reproduced by the UNO scheme somewhat better than by the TVD scheme.

Material optimization of tri-directional functionally graded plates by using deep neural network and isogeometric multimesh design approach

The paper is aimed at enhancing computational performance for optimizing the material distribution of tri-directional functionally graded (FG) plates. We exploit advantages of using a non-uniform rational B-spline (NURBS) basis function for describing material distribution varying through all three directions of functionally graded (FG) plates. Two-dimensional free vibration and buckling behaviors of multi-directional (1D, 2D and 3D) FG plates analyzed by using a combination of generalized shear deformation theory (GSDT) and isogeometric analysis (IGA) is first proposed. This approach can help to save a significant amount of computational cost while still ensure the accuracy of the solutions. The effectiveness and reliability of the present method are demonstrated by comparing it to other methods in the literature. The obtained results are in excellent agreement with the reference ones. More importantly, data sets consisting of input-output pairs are randomly generated from the analysis process through iterations for the training process in deep neural networks (DNN). DNN is utilized as an analysis tool to supplant finite element analysis to reduce computational cost. By using DNN, behaviors of the multi-directional FG plates are directly predicted from those material distributions. Optimal material distributions of tri-directional FG plates under free vibration or compression in various volume fraction constraints are found by using modified symbiotic organisms search (mSOS) algorithm for the first time. Moreover, an isogeometric multimesh design technique is also used to diminish a large number of design variables in optimization. Optimal results obtained by DNN are compared with those of IGA to verify the effectiveness of the proposed method.

Meshfree thermomechanical crack growth simulations with new numerical integration scheme

This paper presents for the first time an improved meshfree particle method without the need for background cells in terms of numerical integration for thermal-mechanical crack growth analysis. In this work, both adiabatic and isothermal crack surfaces are considered. Asymptotic solutions-based enriched functions are incorporated into the approximation scheme to mathematically capture jump across crack surfaces of both the temperature and displacements, as well as the singularities of heat fluxes and stresses in the vicinity of crack tip. Once the stress intensity factors (SIFs) are evaluated, the direction of crack growth can be determined. The meshfree analysis is based on radial point interpolation method (RPIM), in which Cartesian transformation method (CTM) is adopted for numerical integration, instead of the conventional Gaussian quadrature. The utilization of Gaussian scheme requires background cells in shape of quadrilaterals or triangles. In contrast, the CTM is advantageous in the manner that the background cells are no longer required, leading to truly meshfree formulation. The novel contribution of the current work is the extension of CTM scheme in which the integration domain is updated according to crack growth. The crack surfaces are viewed as part of the boundaries of the problem domain. Therefore, it is guaranteed that no discontinuities exist within the domain. The accuracy of the proposed approach is demonstrated by comparison of computed results with reference ones from analytical solution, and other existing numerical methods.

Modeling Light Exposure of Quartz Grains During Mortar Making: Consequences for Optically Stimulated Luminescence Dating

ABSTRACTDating lime mortar shows great potential for establishing the chronology of a construction. The basic premise of mortar dating by optically stimulated luminescence (OSL) is that quartz in the sand used for making mortar has been optically zeroed during the preparation process (optical bleaching). The moment to be dated is the last exposure of sand grains to light, before being embedded within the masonry and hidden from light. However, the main problem is the frequent partial and heterogeneous bleaching of grains, and this led us to use the single grain technique (SG-OSL) systematically. Some theoretical and experimental aspects of a new statistical treatment (the EED model, as exponential exposure distribution) are detailed and discussed. Our experience shows that SG-OSL dating of mortars is successful in a majority of situations. In a minority of cases (around 15%) difficulties originate when there is inappropriate OSL behavior of grains, and thus OSL dating is not possible. In the other cases, good agreement was obtained between OSL ages and the reference ones for a series of samples from a variety of ages and situations, even in the case of poorly bleached material. Anyway, the present situation of OSL dating methodology justifies the systematic use of SG-OSL in the dating of masonry today.

Under-Ice Microalgae and Algae of the Interstitial Icy Water Functioning in Lake Baikal Littoral Zone

The results of field studies of the species composition and productive parameters (biomass, photosynthesis rate, chlorophyll a content, and assimilation numbers) of microalgae in the plankton and the interstitial icy waters of Lake Baikal southern littoral area obtained in March 2018 are presented. A comprehensive study of the ice and phytoplankton algae showed that their productive activity was relatively low at most stations. Their higher values observed near river mouths with significant anthropogenic pollution were caused by both the additional nutrient input and development of small-sized algae, primarily of phytoflagellates, which indicate water pollution by organic matter inflowing to Lake Baikal with its tributaries. Using the principal component method, we failed to reveal reliable correlation between the primary producers and the microorganisms decomposing organic matter into mineral substances (the correlation coefficient was 0.49). The differences between the stations subject to anthropogenic impact and the reference ones indicate that access to easily mineralized organic matter promoted the massive development of phytoflagellates. Although large-cell diatoms common in the lake were absent, primary production at these sites reached 100 to 280 mg C m−2, which was comparable with the values obtained for abundant diatom blooms during the under-ice period. High functional potential of the algae at the areas subject to anthropogenic impact results in significant biomass accumulation, which leads eutrophication of the littoral zone and may lead to increased primary production of the pelagic zone.

Disproporations and Development of Regional Insurance Markets and Managing Them

The current stage of development of the Russian insurance market in most regions is accompanied by imbalances in its development — a mismatch between the level of development of the regional insurance market and the needs of the region for insurance protection, as well as large deviations of insurance indicators at the regional level from their reference values, for example, the best or average across the insurance market countries. Therefore, the study of the causes of such imbalances, as well as the development of managerial decisions to reduce and eliminate them, is extremely relevant. The article contains an analysis of imbalances in the development of regional insurance markets and their respective regions, as well as a list of measures to reduce them. It also contains an analysis and assessment of imbalances in the development of regional insurance markets (RIM) due to deviations in the real quality and cost of services provided by the region from the reference ones. Particular attention is paid to identifying regional risks that determine the types of insurance that are priority for the region in question. The study used the method of experimental comparative analysis, deduction and statistical methods. The proposed approach to identifying imbalances in the development of RIM and the formation of managerial decisions to reduce them can be used to increase the effectiveness of the functioning of RIM, assessed by the two proposed criteria. The results of the work can be used to develop and implement national and regional strategies for socio-economic development, including the use of insurance as an institution of social and financial protection against risks.