This paper aims at optimizing the energy performance of an innovative integrated collector-storage solar water heater (ICSSWH) prototype. The system incorporates a high-vacuum gap, which significantly reduces convective thermal losses, and a serpentine absorber system coated with a low-E layer to minimize radiative thermal losses.The methodology is based on a detailed dynamic simulation model, implemented in the MatLab environment, suitable conceived to accurately predict the energy performance and economic profitability of the ICSSWH under various weather conditions and energy market prices. This approach aims to initially identify the most influential geometrical, thermophysical and optical parameters that impact the energy performance of the system through the assessment of different objective functions. After identifying the most influential parameters, the range of existence with the interval step for each variable is defined, and the optimization procedure is conducted to determine the optimal set of variables that maximize/minimize the selected objective functions.To demonstrate the effectiveness of the proposed methodology, a proof of concept was conducted to optimize the energy performance of novel ICSSWH by considering nineteen parameters with the aim of maximizing/minimizing three different objective functions. The results of this analysis yielded various sets of optimised parameters for the ICSSWH. Therefore, by implementing the set of optimised parameters into the dynamic simulation model, the energy performance of the optimised and non-optimised ICSSWH collectors was evaluated in 42 different weather zones and compared to a reference case scenario.